Ilana B Addis

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Scholarly Contributions

Chapters

• Addis, I. B., Rapkin, A. J., Raman, S. S., Rackley, R. R., Pushkar, D. U., Podnar, S., Swash, M., Peters, K. M., Petero, V. G., Payne, C. K., Paraiso, M. F., Padmanabhan, P., Ouslander, J. G., O'Donnell, P. D., Norton, P., Nitti, V. W., Ng, L., Natale, F., Muir, T. W., , Moy, M. L., et al. (2008). Social Impact of Urinary Incontinence and Pelvic Floor Dysfunction. In Female Urology. doi:10.1016/b978-1-4160-2339-5.50048-3

Journals/Publications

• Addis, I. B. (2021). Laparoscopic pectopexy for patients with intraabdominal adhesions, lumbar spinal procedures and other contraindications to sacrocolpopexy: A case series.. American Journal of Obstetrics and Gynecology Global Reports.
• Addis, I. B. (2021). Laparoscopic uterosacral ligament suspension versus sacrospinous ligament fixation for apical prolapse: perioperative outcomes.. Gynecological Surgery., 18(15).
• Addis, I. B., Gabra, M., Winget, V., & Heusinkveld, J. (2021). 35 Mesh erosion risk for laparoscopic sacral colpopexy with total hysterectomy. American Journal of Obstetrics and Gynecology. doi:10.1016/j.ajog.2021.04.060
• Addis, I. B., Hatch, K. D., Heusinkveld, J., Winget, V., & Gabra, M. (2021). 71 Laparoscopic sacrocolpopexy and laparoscopic uterosacral ligament suspension: Operative outcomes and recurrence rate. American Journal of Obstetrics and Gynecology. doi:10.1016/j.ajog.2021.04.096
• Heusinkveld, J., Hatch, K., Addis, I., Gabra, M., Winget, V., & Torabi, M. T. (2021). Laparoscopic Uterosacral Ligament Suspension versus Sacrospinous Ligament Fixation for Apical Prolapse: Perioperative Outcomes. Gynecologic Surgery. doi:10.21203/rs.3.rs-208585/v1
• Addis, I. B., Hatch, K. D., Heusinkveld, J., Kahn, S., Howard, D., Gabra, M., & Winget, V. (2020). Resident Involvement in Laparoscopic Sacrocolpopexy: A Review of Operative Times and Surgical Outcomes. Journal of Minimally Invasive Gynecology. doi:10.1016/j.jmig.2020.08.258
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  Study Objective To evaluate laparoscopic sacrocolpopexy operative times, complication rates and long-term surgical outcomes at one academic institution with significant trainee involvement. Design This is a retrospective chart review of laparoscopic sacrocolpopexy cases. Setting Cases took place in an operating room at a large academic medical center. Patients were in dorsal lithotomy position with five abdominal laparoscopic trocar sites. Patients or Participants A series of 181 consecutive laparoscopic sacrocolpopexy cases (with or without concomitant procedures) were examined between February 2014 and August 2019. Interventions None. Measurements and Main Results Descriptive statistics were used to compare primary outcomes with published literature. The average operative time was 139.9 minutes, compared to 180-190 minutes noted in other studies. Four cases of intraoperative cystotomy (2.2%) and one enterotomy (0.6%) were noted compared to 5-6% and 1.4% respectively in the literature (Sheyn et al 2019). There were 16 cases of postoperative urinary tract infection (8.8%). At their most recent postoperative visit, which occurred on average at postoperative day 278, recurrent prolapse was noted in 11.7% of patients and 3.9% of those patients underwent a subsequent repair to correct their prolapse. Other complications included 0.6% small bowel obstruction, 1.1% mesh erosion and 7.7% de-novo stress urinary incontinence; all of these were less than those documented in the literature. The overall complication rate was 15.4% compared to 18% in the literature (Nosti et al 2014). Conclusion This institutional demonstrates short operative times, low complication rates and favorable outcomes with resident involvement in laparoscopic sacrocolpopexy. This indicates advanced urogynecology procedures can be performed with significant resident involvement without compromising operative time and surgical outcomes.
• Addis, I. B., Hatch, K., Gabra, M., Heusinkveld, J., & Winget, V. (2020). 015 The Impact of Incontinence Procedures at the Time of Vaginal Vault Suspension on Pelvic Pain and Dyspareunia: A Study of Sexually Active Women with Post Hysterectomy Prolapse. The Journal of Sexual Medicine. doi:10.1016/j.jsxm.2020.04.251
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  Pelvic organ prolapse is becoming more prevalent and reoperation rate is about thirty percent. Stress urinary incontinence often coexists with apical prolapse. The CARE trial found placement of a prophylactic colposuspension at the time of sacrocolpopexy reduces the rate of de-novo stress urinary incontinence. Though stress urinary incontinence negatively impacts sexual function and self image, some studies have indicated that incontinence procedures worsen self-reported sexual function. Anterior repairs and anterior dissections for suburethral sling procedures area associated with increased risk of pelvic pain; minimally invasive procedures yield the best patient satisfaction with regard to pain.
• Addis, I. B., Heusinkveld, J., Hatch, K. D., Winget, V., & Gabra, M. (2020). 67: Rate of ureteral compromise and recurrent prolapse following laparoscopic uterosacral ligament suspension: A retrospective study. American Journal of Obstetrics and Gynecology. doi:10.1016/j.ajog.2019.12.107
• Cardenas-Trowers, O. O., Borgstrom, M., & Addis, I. (2019). Associations Between Type and Route of Hormone Use on Urinary Incontinence and Pelvic Organ Prolapse in Premenopausal and Postmenopausal Women. Female pelvic medicine & reconstructive surgery, 24(2), 100-104.
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  The aim of this study was to evaluate the associations between type and route of hormone use and urinary incontinence (UI) and pelvic organ prolapse (POP) in premenopausal and postmenopausal women.
• Cardenas-Trowers, O., Meyer, I., Markland, A. D., Richter, H. E., & Addis, I. (2019). A Review of Phytoestrogens and Their Association With Pelvic Floor Conditions. Female pelvic medicine & reconstructive surgery, 24(3), 193-202.
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  Urinary incontinence, pelvic organ prolapse, and fecal incontinence are pelvic floor disorders (PFDs) disproportionately experienced by postmenopausal women. Limited data exist suggesting that phytoestrogens may have an impact on the pathophysiology and symptom of PFDs.
• Cardenas-Trowers, O., Meyer, I., Richter, H. E., Addis, I., & Markland, A. D. (2019). Association of Urinary Phytoestrogens With Pelvic Organ Prolapse and Fecal Incontinence Symptoms in Postmenopausal Women. Female pelvic medicine & reconstructive surgery, 25(2), 161-166.
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  The aim of this study was to investigate the association between urinary phytoestrogen levels with symptoms of pelvic organ prolapse (POP) and fecal incontinence (FI) in postmenopausal women.
• Mercer, L., Sandsmark, E. K., Mercer, L., Garcia, C., & Addis, I. B. (2019). LARC: Looking At Retention of Contraception [2P]. Obstetrics & Gynecology, 133(1), 170-171. doi:10.1097/01.aog.0000558891.12782.fd
• Addis, I. B. (2018). A Review of Phytoestrogens and Their Association with Pelvic Floor Conditions. Female Pelvic Medicine & Reconstructive Surgery.
• Addis, I. B. (2018). The late-career obstetrician–gynecologist. American College of Obstetricians and Gynecologists, 131(6), e200-e204. doi:June 2018
• Addis, I. B., Borgstrom, M., & Cardenas-Trowers, O. O. (2017). Prevalence of Urinary Incontinence and Pelvic Organ Prolapse Symptoms in Pre- and Post-menopausal Women.. Female Pelvic Medicine and Reconstructive Surgery.
• Cardenas-trowers, O., Borgstrom, M., & Addis, I. B. (2017). Associations between Type and Route of Hormone Use on Urinary Incontinence and Pelvic Organ Prolapse in Pre- and Post-menopausal Women.. International Journal of Urogynecology.
• Cardenas-trowers, O., Borgstrom, M., & Addis, I. B. (2017). Prevalence of Urinary Incontinence and Pelvic Organ Prolapse Symptoms in Pre- and Post-menopausal Women.. International Journal of Urogynecology.
• Jensen, J. T., Addis, I. B., Hennebold, J. D., & Bogan, R. L. (2017). Ovarian Lipid Metabolism Modulates Circulating Lipids in Premenopausal Women. The Journal of clinical endocrinology and metabolism, 102(9), 3138-3145.
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  The premenopausal circulating lipid profile may be linked to the hormonal profile and ovarian lipid metabolism.
• Carbonell, L., Addis, I. B., & Hatch, K. D. (2016). Demographic and outcome data of women undergoing bilateral sacrospinous ligament fixation. American Journal of Clinical and Experimental Obstetrics and Gynecology.
• Hatch, K. D., Hatch, K. D., Carbonell, L., & Addis, I. B. (2015). Demographic and Outcome Data of Women Undergoing Bilateral Sacrospinous Ligament Fixation [372]. Obstetrics & Gynecology, 125, 116S. doi:10.1097/01.aog.0000463725.49643.c3
• Jensen, J. T., Addis, I. B., Hennebold, J. D., & Bogan, R. L. (2017). Ovarian Lipid Metabolism Modulates Circulating Lipids in Premenopausal Women. Journal of Clinical Endocrinology & Metabolism. doi:https://doi.org/10.1210/jc.2016-3456
• Nuno, V. L., Mohler, M. J., Mohler, J., & Addis, I. B. (2012). Teaching geriatrics to gynecology residents: are American Congress of Obstetricians and Gynecologists learning objectives being met?. Journal of the American Geriatrics Society, 60(9), 1789-90. doi:10.1111/j.1532-5415.2012.04132.x
• Yaffe, K., Vittinghoff, E., Quan, J., Kuppermann, M., Huang, A. J., Hanes, V., Grady, D., & Addis, I. B. (2008). The effect of ultralow-dose transdermal estradiol on sexual function in postmenopausal women.. American journal of obstetrics and gynecology, 198(3), 265.e1-7. doi:10.1016/j.ajog.2007.09.039
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  This study was undertaken to examine the effect of ultralow-dose transdermal estradiol on sexual function in postmenopausal women..Analysis of data from a multicenter, randomized, double-blind, placebo-controlled trial of a 0.014 mg/day transdermal estradiol patch in 417 women aged 60 to 80 years. Sexual function was assessed by self-administered questionnaires at baseline and 4, 12, and 24 months. A linear effects model was used to assess treatment effects using data from all on-study assessments..Women randomly assigned to estradiol had a 4.3 point greater improvement in the vaginal pain/dryness domain relative to placebo (95% CI = 0.3-8.4, P = .04). No significant differences in frequency of sexual activity or other sexual function domains (desire, satisfaction, problems, or orgasm) were observed between treatment groups (P > or = .10 for all)..Ultralow-dose estradiol resulted in modest improvement in sexual function related to vaginal pain and dryness, but not in other domains of sexual function.
• Vittinghoff, E., Stuenkel, C. A., Lin, F., Ireland, C. C., Hulley, S. B., & Addis, I. B. (2006). Sexual Activity and Function in Postmenopausal Women With Heart Disease. The Journal of Urology, 175(2), 661-661. doi:10.1016/s0022-5347(05)00382-4
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  Objective: To examine the prevalence and correlates of sexual activity and function in postmenopausal women with heart disease. Methods: We included baseline self-reported measures of sexual activity and the sexual problem scale from the Medical Outcomes Study in the Heart and Estrogen/Progestin Replacement Study (HERS), a study of 2,763 postmenopausal women, average age 67 years, with coronary disease and intact uteri. We used multivariable linear and logistic regression to identify independent correlates of sexual activity and dysfunction. Results: Approximately 39% of the women in HERS were sexually active, and 65% of these reported at least 1 of 5 sexual problems (lack of interest, inability to relax, difficulty in arousal or in orgasm, and discomfort with sex). In multivariable analysis, factors independently associated with being sexually active included younger age, fewer years since menopause, being married, better self-reported health, higher parity, moderate alcohol use, not smoking, lack of chest discomfort, and not being depressed. Among the 1,091 women who were sexually active, lower sexual problem scores were associated with being unmarried, being better educated, having better self-reported health, and having higher body mass index. Conclusion: Many women with heart disease continue to engage in sexual activity into their 70s, and two thirds of these report discomfort and other sexual function problems. Physicians should be aware that postmenopausal patients are sexually active and address the problems these women experience. (Obstet Gynecol 2005;106:121–7) Level of Evidence: II-2
• Wassel-fyr, C. L., Vittinghoff, E., Thom, D. H., Eeden, S. K., Brown, J. S., & Addis, I. B. (2006). Sexual activity and function in middle-aged and older women.. Obstetrics and gynecology, 107(4), 755-64. doi:10.1097/01.aog.0000202398.27428.e2
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  Data on the sexual activity of middle-aged and older women are scant and vary widely. This analysis estimates the prevalence and predictors of sexual activity and function in a diverse group of women aged 40-69 years..The Reproductive Risk Factors for Incontinence Study at Kaiser (RRISK) was a population-based study of 2,109 women aged 40-69 years who were randomly selected from long-term Kaiser Permanente members. Women completed self-report questionnaires on sexual activity, comorbidities, and general quality of life. Logistic and linear regression and proportional odds models were used when appropriate to identify correlates of sexual activity, frequency, satisfaction, and dysfunction..Mean age was 55.9 (+/- 8) years and nearly three fourths of the women were sexually active. Of the sexually active women, 60% had sexual activity at least monthly, approximately two thirds were at least somewhat satisfied, and 33% reported a problem in one or more domains. Monthly or more frequent sexual activity was associated with younger age, higher income, being in a significant relationship, a history of moderate alcohol use, and lower body mass index (BMI) (all P < .05). Satisfaction with sexual activity was associated with African-American race, lower BMI, and higher mental health score (all P < .05). More sexual dysfunction was associated with having a college degree or greater, poor health, being in a significant relationship, and a low mental health score (all P < .05)..Middle-aged and older women engage in satisfying sexual activity, and one third reported problems with sexual function. Demographic factors as well as some issues associated with aging can adversely affect sexual frequency, satisfaction, and function..II-3.
• Lukacz, E. S., Walters, M. D., Thompson, P. K., Rogers, R. G., Qualls, C., Olsen, A., Lukacz, E. S., Kammerer-doak, D., & Addis, I. B. (2005). Nitrofurantoin monohydrate macrocrystals prevented urinary tract infection after suprapubic catheterization. Evidence-based Obstetrics & Gynecology, 7(3), 151-152. doi:10.1016/j.ebobgyn.2005.05.002
• Vittinghoff, E., Stuenkel, C. A., Lin, F., Ireland, C. C., Hulley, S. B., & Addis, I. B. (2005). Sexual activity and function in postmenopausal women with heart disease.. Obstetrics and gynecology, 106(1), 121-7. doi:10.1097/01.aog.0000165276.85777.fb
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  To examine the prevalence and correlates of sexual activity and function in postmenopausal women with heart disease..We included baseline self-reported measures of sexual activity and the sexual problem scale from the Medical Outcomes Study in the Heart and Estrogen/Progestin Replacement Study (HERS), a study of 2,763 postmenopausal women, average age 67 years, with coronary disease and intact uteri. We used multivariable linear and logistic regression to identify independent correlates of sexual activity and dysfunction..Approximately 39% of the women in HERS were sexually active, and 65% of these reported at least 1 of 5 sexual problems (lack of interest, inability to relax, difficulty in arousal or in orgasm, and discomfort with sex). In multivariable analysis, factors independently associated with being sexually active included younger age, fewer years since menopause, being married, better self-reported health, higher parity, moderate alcohol use, not smoking, lack of chest discomfort, and not being depressed. Among the 1,091 women who were sexually active, lower sexual problem scores were associated with being unmarried, being better educated, having better self-reported health, and having higher body mass index..Many women with heart disease continue to engage in sexual activity into their 70s, and two thirds of these report discomfort and other sexual function problems. Physicians should be aware that postmenopausal patients are sexually active and address the problems these women experience..II-2.
• Vittinghoff, E., Stuenkel, C. A., Lin, F., Hulley, S. B., & Addis, I. B. (2004). 1201: Effects of Postmenopausal Hormone Therapy on Sexual Function: The Hers trial. The Journal of Urology, 171(4S), 317-317. doi:10.1016/s0022-5347(18)38438-6
• Wassel-fyr, C. L., Vittinghoff, E., Thom, D. H., Subak, L. L., Ragins, A. I., Eeden, S. K., Brown, J. S., & Addis, I. B. (2004). 886: Sexual Activity and Function in Middle Aged and Older Women. The Journal of Urology, 171(4S), 235-235. doi:10.1016/s0022-5347(18)38135-7
• Wassel-fyr, C. L., Vittinghoff, E., Thorn, D. H., Subak, L. L., Ragins, A. I., Eeden, S. K., Brown, J. S., & Addis, I. B. (2004). 139: Urinary Incontinence: New Insights Into Racial Differences. The Journal of Urology, 171(4S), 36-37. doi:10.1016/s0022-5347(18)37401-9
• Wassel-fyr, C. L., Vittinghoff, E., Thorn, D. H., Subak, L. L., Ragins, A. I., Eeden, S. K., Brown, J. S., & Addis, I. B. (2004). 152: Urinary Incontinence: The Cost Burden for Women. The Journal of Urology, 171(4S), 40-40. doi:10.1016/s0022-5347(18)37414-7
• Vogt, V., Summitt, R. L., Porter, W. E., Horton, T. R., & Addis, I. B. (2003). Intrinsic sphincter deficiency: association with historical, physical, and urodynamic findings. Obstetrics & Gynecology, 101(4), S114. doi:10.1016/s0029-7844(02)03033-8
• Addis, I. B., & Corrigan, P. W. (1995). Effects of extraneous stimuli on social cue perception in schizophrenia. Psychiatry Research-neuroimaging. doi:10.1016/0165-1781(94)02603-x
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  Competing hypotheses that explain the effects of emotionally arousing, extraneous auditory stimuli on the social cue perception of schizophrenic patients were examined in this study: 1. (1) extraneous arousing stimuli enhance patients' cue perception; 2. (2) extraneous stimuli distract patients, and cue perception is diminished. Twenty-five patients with DSM-III-R diagnoses of schizophrenia completed a cue-perception task in which half of the videotaped vignettes included in the task were presented with simultaneous extraneous stimuli and half were not. Item difficulty and consistency across extraneous stimuli conditions were matched on standardization and cross-validation samples. Results showed that schizophrenic subjects were significantly more sensitive to cues when exposed to extraneous stimuli, thereby supporting the first hypothesis. This effect was also observed in a subgroup of schizophrenic subjects who demonstrated a distraction decrement on another test of short-term recall. The presence of extraneous stimuli interacted with perception of abstract cues; that is, schizophrenic subjects were particularly better at perceiving abstract cues when extraneous stimuli were presented simultaneously. Future research needs to determine characteristics of extraneous stimuli that enhance cue perception.
• Addis, I. B., & Corrigan, P. W. (1995). The effects of cognitive complexity on a social sequencing task in schizophrenia. Schizophrenia Research. doi:10.1016/0920-9964(94)00072-g
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  Information processing research has suggested that the schizophrenia patient's performance on cognitive tasks is significantly diminished by the complexity of that task. The effects of cognitive complexity on a social cognitive task-sequencing actions that describe a social situation-were examined in this study. A task comprising short and long temporal sequences was administered to 26 subjects with DSM III-R diagnosis of schizophrenia. Differences in discriminating power across the short and long sequences in this task were diminished using standardization and cross-validation samples of normal control subjects. Results showed that schizophrenia patients earned significantly lower scores on the longer sequences. Additional analyses showed that the differential deficit was significantly associated with negative symptoms of social withdrawal and retardation but not with thinking disturbances associated with positive symptoms. Understanding deficits in processing situational schemata may lead to better models of the cognitive underpinnings of social functioning in schizophrenia.

Presentations

• Addis, I. B. (2022). Beyond Sacrocolpopexy: New Alternatives for Prolapse Repair. . International Continence Society Annual MeetingInternational Continence Society.
• Addis, I. B. (2022). Messages from the tower: Merging assertiveness and empathy for the team-oriented leader. . APGO Faculty Development SeminarAssociation of Professors of Obstetrics and Gynecology.
• Addis, I. B. (2021). Beyond Sacrocolpopexy: Mesh-Free Alternatives and New Techniques. . World Congress of Gynecology and ObstetricsFIGO.
• Addis, I. B. (2019, Spring). Catching Waves Like a Local: A Statewide Approach to Advocacy Builds Meaningful, Lasting Contributions in Health Care.. Association of Professors of Gynecology and Obstetrics Faculty Development Seminar.
• Addis, I. B. (2019, Spring). The More the Merrier: A Statewide Approach to Advocacy Builds Meaningful, Lasting Contributions in Health Care.. APGO/CREOG Annual Meeting. New Orleans.
• Addis, I. B. (2015, May 14, 2015). Is Acupuncture a Viable Aternative to Medication for Overactive Bladder in an Elderly Female Population?. American Geriatrics Society Annual. National Harbor, MD: American Geriatrics Society.
• Loredo, S., & Addis, I. B. (2015, February). An Analysis of Pathology Results of VIA Positive Patients Screened by a Trained General Practitioner. Western Regional Meeting, American Federation for Medical Research (WAFMR). California: American federation for Medical Research.

Poster Presentations

• Addis, I. B. (2022). Prevalence of urinary incontinence in female physicians: A cross-sectional study. . International Continence Society Annual Meeting.
• Addis, I. B. (2021).  Laparoscopic Sacrocolpopexy and Laparoscopic Uterosacral Ligament Suspension: Operative Outcomes and Recurrence Rate. . Society of Gynecologic Surgeons Annual Scientific Meeting.
• Addis, I. B. (2021). Prevalence of Urinary Incontinence in Female Physicians in Surgical versus Non-surgical Specialties. . American Urogynecologic Society Pelvic Floor Disorders Week.
• Addis, I. B. (2021, June). Laparoscopic Sacrocolpopexy and Laparoscopic Uterosacral Ligament Suspension: Operative Outcomes and Recurrence Rate. Society of Gynecologic Surgeons Annual Scientific Meeting 2021. Palm Springs California.
• Addis, I. B. (2021, October). Prevalence of Urinary Incontinence in Female Physicians in Surgical versus Non-surgical Specialties. PFD Week. Phoenix Arizona.
• Addis, I. B. (2020). Laparoscopic Uterosacral Ligament Suspension Compared to Sacrospinous Ligament Fixation: Complications and Recurrence Rate. . American Urogynecologic Society Pelvic Floor Disorders Week.
• Addis, I. B. (2020). Resident Impact on Laparoscopic Sacrocolpopexy Outcomes. Society for laparoscopic and robotic surgeons Minimally invasive surgery week.
• Addis, I. B. (2018, Fall). LARC: Looking At Retention of Contraception.. American College of Obstetricians and Gynecologists District VIII Annual District Meeting.
• Addis, I. B. (2017, Fall). Prevalence of urinary incontinence and pelvic organ prolapse symptoms in pre- and post- menopausal women. American Urogynecologic SocietyAUGS.
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  Poster Presentation
• Addis, I. B. (2017, fall). Association between type and route of hormone use on urinary incontinence and pelvic organ prolapse in pre- and post-menopausal women. American Urogynecologic SocietyAUGS.
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  Poster Presentation
• Loredo, S. M., & Addis, I. B. (2016, April). Low resource cervical cancer screening in El Salvador: Comparing visual screening with acetic acid (VIA) and pap smear use. American Society for Colposcopy and Cervical Pathology Annual Meeting. New Orleans: American Society for Colposcopy and Cervical Pathology.
• Addis, I. B. (2015, November). A novel protocol comparing acupuncture to usual care for overactive bladder in elderly women. Society for Acupuncture Research Annual Meeting. Cambridge, Mass: Society for Acupuncture Research.