Laura E Meinke

Interests

Teaching

Use of simulation in procedural skill and patient care acquisition by learners at all levels of medical training.

Research

Graduate Medical Education and predictors of success in medical careers. Efficacy of educational models in physician training.

Courses

Scholarly Contributions

Books

• Meinke, L. E. (2012). ICU Workbook; Emergency Medicine & Critical Care Clerkship.
• Meinke, L. E., Knepler, J., Patel, N., Middleton, E., Roesch, J., & Wong-McKinstry, E. (2012). Pulmonary Pocket Reference Book. Börm Bruckmeier Publishing LLC.
• Meinke, L. E. (2011). Asthma Pocket Card Set. Börm Bruckmeier Publishing, LLC.

Journals/Publications

• Acharya, D., Reddy, S. M., Meinke, L. E., & Kendall, M. R. (2020). COVID-19 and ST elevations-keep an open mind: a case report.. European heart journal. Case reports, 4(6), 1-4. doi:10.1093/ehjcr/ytaa269
  More info

  Coronavirus disease 2019 (COVID-19) has been associated with a range of cardiovascular manifestations, including myocardial injury and thrombo-embolism. Pulmonary embolism (PE) causing anteroseptal/anterior ST elevations that mimic myocardial infarction have previously been described. This phenomenon is thought to be related to right ventricular injury from large emboli..A 48-year-old woman with history of type 2 diabetes mellitus and hypertension presented to her local hospital with fever, cough, nausea, and dyspnoea. A test for SARS-CoV-2 was taken, and she was discharged with instructions to self-quarantine. She was subsequently notified of a positive SARS-CoV-2 result. Three days later, she re-presented with worsening dyspnoea and respiratory failure requiring intubation. On hospital Day 6, she became acutely hypoxic and hypotensive. Telemetry was noted to have ST changes, prompting ECG that revealed sinus tachycardia with prominent new ST elevations in her precordial leads. Transthoracic echocardiogram showed normal left ventricular function; however, the right ventricle was moderately dilated with positive McConnell's sign. Due to her unstable clinical state and high suspicion for PE, she was treated with tenecteplase 50 mg i.v. with complete resolution of her ST elevations and improved oxygenation..Given the high rates of thrombo-embolic events in COVID-19 patients, PE should be in the differential diagnosis of ST elevation, particularly in younger patients with few risk factors for coronary artery disease.
• Nyquist, A., & Meinke, L. (2020). TO TUBE OR NOT TO TUBE: A CASE OF SPONTANEOUS BACTERIAL EMPYEMA. Chest, 158(4), A1238. doi:10.1016/j.chest.2020.08.1127
• Wickstrom, K., Sears, S., & Meinke, L. (2019). Medical image of the month: Double aortic arch. Southwest Journal of Pulmonary and Critical Care, 18(5), 120-121. doi:10.13175/swjpcc019-19
• Ampel, N. M., Raz, Y., Meinke, L., Chaudhary, S., Ateeli, H., & Knox, K. S. (2017). Coccidioidomycosis among persons undergoing lung transplantation in the coccidioidal endemic region. Transplant Infectious Disease, 19(4), e12713. doi:10.1111/tid.12713
• Meinke, L. E. (2017). Coccidioidomycosis among persona undergoing lung transplantation in the coccidioidal endemic region. Transplant Infectious Disease. doi:10:1111/itd.12713
• Meinke, L. E. (2017). Pericardial Effusion: A Rare Side Effect of TNF-Alpha Blocking Agent. Journal of Clinical Rheumatology, 23 (5), 296-7.
• Kaur, M., Adusei, C., Elaini, T., & Meinke, L. E. (2015). Medical image of the week: superior vena cava syndrome. Southwest J Pulm Crit Care, 11(3), 114-5.
• Mazursky, K., Natt, B., & Meinke, L. E. (2015). Medical image of the week: acute amiodarone pulmonary toxicity. Southwest J Pulm Crit Care, 11(4), 189-90.
• Natt, B., Mazursky, K., & Meinke, L. E. (2015). Medical image of the week: acute amiodarone pulmonary toxicity. Southwest Journal of Pulmonary and Critical Care, 11(4), 189-190.
• Park, W. G., Rouse, R. V., Kahng, L. S., Bastidas, J. A., Meinke, L. E., & Soetikno, R. M. (2006). Giant Gastric Ulcers in Chronic Spinal Cord Injury Patients. Digestive Endoscopy, 19(1), 36-39.
• Wong, C., Park, S., Walker, C., & Meinke, L. E. (2015). Medical image of the week: septated pleural effusion. Southwest J Pulm Crit Care, 11, 110-1.
• Baalachandran, R., Mahmoud, N., & Meinke, L. E. (2014). Medical image of the week: pneumomediastinum. Southwest J Pulm Crit Care, 9(3), 189-90.
• Baalachandran, R., Mahmoud, N., & Meinke, L. E. (2014). Medical image of the week: pulmonary herniation. Southwest J Pulm Crit Care, 9(4), 197-8.
• Strawter, C., & Meinke, L. E. (2014). Medical image of the week: pulmonary arteriovenous malformations. Southwest J Pulm Crit Care, 9(4), 238-9.
• Ateeli, H., Meinke, L. E., Campion, J., Cantu, C., & Flores, M. (2013). An Unusual Cause of Refractory Life-Threatening Hemoptysis: A Multidisciplinary Challenge. Chest, 144(4), 624A.
• Chaudhary, S., Knox, K. S., Raz, Y., & Meinke, L. E. (2010). Coccidioidomycosis in Lung Transplant Recipients in an Endemic Area. American College of Clinical Pharmacy.
• Hiller, K., Meinke, L. E., & Reilly, K. (2010). Integrating Critical Care into a Mandatory Emergency Medicine Curriculum: A Novel Approach to Longitudinal Experience. Clerkship Directors in Emergency Medicine National Conference.
• Holty, J. E., Gould, M. K., Meinke, L., Keeffe, E. B., & Ruoss, S. J. (2009). Tuberculosis in liver transplant recipients: a systematic review and meta-analysis of individual patient data. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 15(8), 894-906.
  More info

  Mycobacterium tuberculosis (MTB) causes substantial morbidity and mortality in liver transplant recipients. We examined the efficacy of isoniazid latent Mycobacterium tuberculosis infection (LTBI) treatment in liver transplant recipients and reviewed systematically all cases of active MTB infection in this population. We found 7 studies that evaluated LTBI treatment and 139 cases of active MTB infection in liver transplant recipients. Isoniazid LTBI treatment was associated with reduced MTB reactivation in transplant patients with latent MTB risk factors (0.0% versus 8.2%, P = 0.02), and isoniazid-related hepatotoxicity occurred in 6% of treated patients, with no reported deaths. The prevalence of active MTB infection in transplant recipients was 1.3%. Nearly half of all recipients with active MTB infection had an identifiable pretransplant MTB risk factor. Among recipients who developed active MTB infection, extrapulmonary involvement was common (67%), including multiorgan disease (27%). The short-term mortality rate was 31%. Surviving patients were more likely to have received 3 or more drugs for MTB induction therapy (P = 0.003) and to have been diagnosed within 1 month of symptom onset (P = 0.01) and were less likely to have multiorgan disease (P = 0.01) or to have experienced episodes of acute transplant rejection (P = 0.02). Compared with the general population, liver transplant recipients have an 18-fold increase in the prevalence of active MTB infection and a 4-fold increase in the case-fatality rate. For high-risk transplant candidates, isoniazid appears safe and is probably effective at reducing MTB reactivation. All liver transplant candidates should receive a tuberculin skin test, and isoniazid LTBI treatment should be given to patients with a positive skin test result or MTB pretransplant risk factors, barring a specific contraindication. Liver Transpl 15:894-906, 2009. (c) 2009 AASLD.
• Knox, K. S., & Meinke, L. (2009). Role of bronchoalveolar lavage diagnostics in fungal infections. Clinics in chest medicine, 30(2), 355-65, viii.
  More info

  Although a biopsy may need to be performed in complicated patients, bronchoalveolar lavage (BAL) is an important adjunct to the diagnosis of pulmonary and disseminated fungal infections. Culture is the gold standard for diagnosis in many instances, but cytologic and morphologic analysis is often diagnostic. Although newer molecular and antigen techniques may be applied to BAL samples, the role of such tests is yet to be defined for many pathogens.
• Meinke, L. E. (2009). The Institute of Medicine Resident Work Hours Recommendations: A Program Director's Viewpoint. Journal of Clinical Sleep Medicine, 5(1), 1.
• Shieh, L., Maggio, P., Mihm, F., Meinke, L. E., Bowes, K., Lee, J., Sedehi, D., Tokareva, I., Szaflarski, N., & Hopkins, J. (2009). Reducing latrogenic Pneumothorax: Making Central Venous Catheter Placement Safer. Society of Hospital Medicine, 24(1).
• Meinke, L. E. (2007). Ultrasound-Guided Central Venous Catheterization in the Hospitalized Adult. Standford Medicine.
• Soetikno, R. M., Rouse, R. V., Park, W. G., Meinke, L., Kahng, L. S., & Bastidas, J. A. (2007). GIANT GASTRIC ULCERS IN CHRONIC SPINAL CORD INJURY PATIENTS. Digestive Endoscopy, 19(1), 36-39. doi:10.1111/j.1443-1661.2007.00666.x
  More info

  Gastric ulcers cause significant morbidity and mortality to patients with spinal cord injuries. Case reports of three patients with gastric ulcers and chronic spinal cord injuries. Review of the medical literature using MEDLINE ranging from 1975 to 2004. We describe three cases of severe, complicated gastric ulcers in this population. Two cases involve gastric ulcers that eroded into major mesenteric arteries, leading to one fatality. One of these cases revealed a gastric ulcer that looked like a mass because of intralumenal herniation of serosal fat. Diagnosis of ulcer disease is challenging in this patient population as they often do not endorse focal symptoms. Gastroenterologists and other practitioners evaluating chronic spinal cord injury patients should be aware of the potential for giant gastric ulcers, even with benign clinical presentations.
• Meinke, L. E., Chitkara, R., & Krishna, G. (2006). Advances in the Management of Chronic Obstructive Pulmonary Disease. Expert Opinion in Pharmacotherapy, 8(1), 23-37.

Proceedings Publications

• Meinke, L., Bailey, M., Kumar, K., Meadows, C., & Mahmoud, N. (2019). Pulmonary Mycetoma Due to Concurrent Aspergillus and Neocystalidium Dimidiatum Infection. In ATS 2019.
• Patel, N. K., & Meinke, L. (2012). A Rare Cause Of Necrotizing Fasciitis In A Patient With Systemic Lupus Erythematosus. In C56. PULMONARY AND NON-PULMONARY CRITICAL CARE: GREAT CASES!.
• Sobonya, R., Meinke, L. E., & Luraschi-monjagatta, C. (2010). A Rare Cause of Massive Hemoptysis. In C46. ALIENS AND UFO'S: INTERESTING INFECTIONS AND CURIOUS CANCERS.

Presentations

• Mikhael, D. M., Meinke, L. E., Ellis, S. C., & Scott, S. (2019, May). Innovations Quickfire: Residents as Teachers. Graduate Medical Education (GME). Tucson, AZ.
• Cho, A., & Meinke, L. E. (2009, September/Fall). Straight Up Breathing. Arizona Chapter Meeting. Phoenix, AZ: American College of Physicians.
• Prescher, H., Biffar, D. E., Meinke, L. E., Jarred, J. E., Brooks, A. J., & Hamilton, A. J. (2014, Summer). Video-guided versus direct laryngoscopy: considerations for using simulation to teach inexperienced medical students. SummerSim.
• Biffar, D. E., Hamilton, A. J., Grisham, L. M., Jarred, J. E., Preschur, H., Brooks, A. J., & Meinke, L. E. (2012, January). Video Laryngoscopy is Superior to Direct Laryngoscopy for Airway Management Training. 12th International Meeting on Simulation in Healthcare.
• Biffar, D. E., Hamilton, A. J., Grisham, L. M., Jarred, J. E., Preschur, H., Brooks, A. J., & Meinke, L. E. (2012, January/Winter). Video Laryngoscopy is Superior to Direct Laryngoscopy for Airway Management Training. 12th International Meeting on Simulation in Healthcare.
• Poojary, I., Meinke, L. E., & Chaudhary, S. (2011, January/Winter). Pulmonary Arterial Hypertension When Seen in HIV Clinical Case Puzzlers. CHEST. Honolulu, HI.
• Chaudhary, S., Knox, K. S., Raz, Y., & Meinke, L. E. (2010, October/Fall). Coccidioidomycosis in Thoracic Transplants. Infectious Disease Conference at the University of Arizona. Tucson, AZ.
• Luraschi, C., & Meinke, L. E. (2010, May/Spring). A Rare Cause of Massive Hemoptysis. American Thoracic Society 2010 International Conference. New Orleans, LA.
• Onadeko, O., Snyder, L. S., Sobonya, R., & Meinke, L. E. (2010, May/Spring). Flu-like illness causing massive hemoptysis. American Thoracic Society International Conference. New Orleans, LA.

Poster Presentations

• Meinke, L. E., & Nyquist, A. (2020, October). To Tube or Not to Tue: A Case of Spontaneous Bacterial Empyema.. Eposter presentation, CHEST Annual Meeting, October 18-21, 2020.
• Dalabih, M. R., Gibson, B., Millius, R., Meinke, L. E., & Carr, G. E. (2014, May). Multi-vessel Fribromuscular Dysplasia: A Diagnostic Dilemma. American Thoracic Society.
• Patel, N., & Meinke, L. E. (2012, May). A Rare Cause of Necrotizing Fasciitis in a Patient with Systemic Lupus Erythematosus. American Thoracic Society. San Francisco, CA.
• Meinke, L. E., Onadeko, O., & Sam, A. R. (2011, May/Spring). AN UNUSUAL CASE OF LACTIC ACIDOSIS. Society of Critical Care Medicine Meeting. San Diego, CA.
• Meinke, L. E., Onadeko, O., & Sam, A. R. (2011, May/Spring). An Unusual Cause of Lactic Acidosis. Society of Critical Care Medicine Meeting. San Diego, CA.

Case Studies

• Meinke, L. E., Acharya, D., m, k., & s, r. (2020. COVID-19 and ST elevations - keep an open mind: a case report(pp 1-4).

Others

• Meinke, L. E., Wickstrom, K., & Sears, S. (2019, May). Medical Image of the Month: Double Aortic Arch. Southwest J Pulm Crit Care.