Robert R Klein
- Associate Professor, (Clinical Scholar Track)
- M.D. Medicine
- University of Utah, Salt Lake City, Utah, United States
- Pathology Residents' Appreciation Award
- Spring 2018
- John R Davis, MD, Outstanding Resident Teaching Award
- Spring 2016
- C George Ray, MD, Outstanding Post-Sophomore Fellowship Teaching Award
- Spring 2014
Licensure & Certification
- Arizona Medical License, Arizona Medical Board (2003)
- Diplomate in combined Anatomic and Clinical Pathology, American Board of Pathology (2003)
No activities entered.
Surgical PathologyPATH 850A (Fall 2020)
Surgical PathologyPATH 850A (Spring 2020)
Surgical PathologyPATH 850A (Fall 2019)
Surgical PathologyPATH 850A (Fall 2018)
Surgical PathologyPATH 850A (Spring 2018)
Surgical PathologyPATH 850A (Fall 2016)
Anatomic PathologyPATH 850A (Spring 2016)
- Gilman, K., Camden, J., Klein, R., Zhang, Q., Weisman, G., & Limesand, K. H. (2019). P2X7 receptor deletion suppresses γ-radiation-induced hyposalivation.. American Journal of Physiology, Regulatory, Integrative and Comparative Physiology. doi:10.1152/ajpregu.00192.2018
- Eshghi, A., Klein, R., Eshghi, N., & Kuo, P. H. (2018). F-FDG PET/CT for the Evaluation of Primary Eosinophilic Granuloma of the Hypothalamus. Journal of nuclear medicine technology, 46(3), 290-291.More infoA 21-y-old man who presented with polyuria and polydipsia was discovered to have diabetes insipidus due to eosinophilic granuloma of the hypothalamus. F-FDG PET/CT, which was performed as a metastatic work-up, revealed an intensely F-FDG-avid hypothalamic mass and no other sites of disease.
- Chen, H., Klein, R., Arnold, S., Wang, Y., Chambers, S., & Zheng, W. (2017). Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection. Journal of visualized experiments : JoVE.More infoCurrently, it is widely accepted that the vast majority of ovarian high-grade serous carcinoma (HGSC) originate from the fallopian tube. However, due to the lack of markers or tools for the ovarian cancer identification, the early detection of HGSC remains challenging. Direct sampling of the fallopian tube can enhance sensitivity for detection of neoplastic cells when the tumor is not grossly visible. We developed a procedure to collect fallopian tube cells directly from freshly received surgical specimens, which has shown excellent correlation with histological findings. This approach lays a foundation for the future utility of minimally invasive laparoscopic screening in high-risk patient populations.
- Vanderbilt, D. B., Ho, Q. A., Goyal, U., Bell, R. C., Klein, R. R., & Yi, S. K. (2017). HPV-related nasopharyngeal and cervical cancer in a married couple in North America. Practical radiation oncology.
- Klein, R. (2016). Association of Antemortem Central Nervous System (CNS) Symptoms and Location of Aortic Dissections; A Retrospective Study from 2001-2014.. Academic Forensic Pathology, 6(3), 517-523.
- Klein, R. (2016). Clinical Translation of Tumor Acidosis Measurements with AcidoCEST MRI. Molecular Imaging & Biology. doi:10.1007/s11307-016-1029-7
- Klein, R. (2016). Communicating Uncertainty in Surgical Pathology Reports: A Survey of Staff Physicians and Residents at an Academic Medical Center. Academic Pathology, 3. doi:10.1177/2374289516659079
- Klein, R. R. (2015). Cytologic Diagnosis of Coccidioidomycosis: Spectrum of Findings in Southern Arizona Patients Over a 10-Year Period. Diagnostic Cytopathology, 4(6), S14. doi:10.1016/j.jasc.2015.09.032
- Klein, R. R. (2015). Fallopian Tube Cytology in Patients Undergoing Salpingo-Oophorectomy. American Journal of Clinical Pathology, 144(Suppl 2), A075. doi:10.1093/ajcp/144.suppl2.075
- Wang, Y., Mang, M., Wang, Y., Wang, L., Klein, R., Kong, B., & Zheng, W. (2015). Tubal origin of ovarian endometriosis and clear cell and endometrioid carcinoma. American journal of cancer research, 5(3), 869-79.More infoCurrent research has strongly proposed that contrary to prior beliefs, many ovarian epithelial cancers (OECs) do not, as their name suggests, originate in the ovaries. Recent findings regarding both high-grade and low-grade serous carcinomas has implicated the fallopian tube as a cell source for these OECs, but until now, there has been little insight into the cellular source for clear cell and endometrioid carcinomas. In this commentary review article, we aimed to discuss the new findings that support the possible contribution from the fallopian tube in clear cell and endometrioid carcinomas. Specifically, we have provided results that showcased ovarian surface epithelia (OSE) and ovarian epithelial inclusions (OEIs) as having mesothelial and tubal origins and have strongly recognized the secondary müllerian system and the ability for tubal epithelia to implant upon the ovarian surface as contributing to fallopian tube-derived OEIs (F-OEIs). We have provided initial indications of these F-OEIs and their relationship to endometriosis and then clear cell and endometrioid carcinomas and subsequently offer our new proposal of a probable tubal origin. This new proposal is a paradigm that drastically changes the understanding behind the origin of these OECs and has significant clinical implications in the near future.