Salma Imran Patel

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Scholarly Contributions

Journals/Publications

• Mashaqi, S., Mansour, H. M., Alameddin, H., Combs, D., Patel, S., Estep, L., & Parthasarathy, S. (2020). Matrix metalloproteinase-9 as a messenger in the crosstalk between obstructive sleep apnea and comorbid systemic hypertension, cardiac remodeling, and ischemic stroke: a literature review. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.
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  Obstructive sleep apnea is a common sleep disorder. There is a strong link between sleep related breathing disorders and cardiovascular and cerebrovascular diseases. Matrix metalloproteinase-9 (MMP-9) is a biological marker for extracellular matrix degradation which plays a significant role systemic hypertension, myocardial infarction and post-MI heart failure, and ischemic stroke. This manuscript reviews MMP-9 as an inflammatory mediator and a potential messenger between OSA and OSA-induced comorbidities.
• Patel, S. I. (2020). Reopening an Academic Dental Sleep Medicine and Orofacial Pain Clinic Amid COVID-19. Journal of Dental Sleep Medicine, Volume 7(Special Article 2, Issue 7.3). doi:http://dx.doi.org/10.15331/jdsm.7140
• Patel, S. I., Combs, D., & Parthasarathy, S. (2020). Sleep apnea 20/20: a 20-year cohort that continues to inform the next 20 years. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 16(S1), 27-28.
• Patel, S. I., Ackerman, M. J., Shamoun, F. E., Geske, J. B., Ommen, S. R., Love, W. T., Cha, S. S., Bos, J. M., & Lester, S. J. (2019). QT prolongation and sudden cardiac death risk in hypertrophic cardiomyopathy. Acta cardiologica, 74(1), 53-58.
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  Risk assessment for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) remains complex. The goal of this study was to assess electrocardiogram (ECG)-derived risk factors on SCD in a large HCM population Methods: Retrospective review of adults with HCM evaluated at Mayo Clinic, Rochester, MN from 1 December 2002 to 31 December 2012 was performed. Data inclusive of ECG and 24-hour ambulatory Holter monitor were assessed. SCD events were documented by ventricular fibrillation (VF) noted on implantable cardioverter defibrillator (ICD), or appropriate VT or VF-terminating ICD shock.
• Patel, S. I., Shamoun, F. E., Esser, H., Parthasarathy, S., Ackerman, M. J., Geske, J. B., Ommen, S. R., Love, W. T., Sommers, V. K., Chahal, A. A., Bos, J. M., Cha, S. S., & Lester, S. J. (2019). Sleep Disordered Breathing in Hypertrophic Cardiomyopathy. Sleep and Vigilance. doi:10.1007/s41782-019-00080-6
• Firth, C., Shamoun, F., Cha, S., Zhang, N., Patel, S., Wennberg, P., Amer, H., Wadei, H., Heilman, R., & Keddis, M. (2018). Cardiac Troponin T Risk Stratification Model Predicts All-Cause Mortality Following Kidney Transplant. American journal of nephrology, 48(4), 242-250.
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  We evaluated the role of increased cardiac troponin T (cTnT), vascular, and cardiac diseases in predicting 5 and 10-year all-cause mortality after kidney transplantation.
• Joppa, S. A., Salciccioli, J., Adamski, J., Patel, S., Wysokinski, W., McBane, R., Al-Saffar, F., Esser, H., & Shamoun, F. (2018). A Practical Review of the Emerging Direct Anticoagulants, Laboratory Monitoring, and Reversal Agents. Journal of clinical medicine, 7(2).
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  Millions of patients in the United States use anticoagulation for a variety of indications, such as the prevention of stroke in those with atrial fibrillation (AF) and the treatment and prevention of venous thrombosis. For over six decades warfarin was the only available oral anticoagulant, but now several DOACs are available and their use has become more prevalent in recent years. In spite of this increased use, many physicians remain reluctant to prescribe DOACs due to concerns about bleeding and reversibility.
• Patel, S. I., Gay, P., Morgenthaler, T. I., Olson, E. J., Shamoun, F. E., Kashyap, R., Herold, D., McNamara, S., & Selim, B. (2018). Practical Implementation of a Single-Night Split-Titration Protocol With BPAP-ST and AVAPS in Patients With Neuromuscular Disease. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 14(12), 2031-2035.
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  At the sleep laboratory, noninvasive positive pressure ventilation titration protocols in patients with neuromuscular disease (NMD) are based on standard pressure cycle devices in a spontaneous/timed mode (BPAP-ST). Experience integrating protocols on average volume-assured pressure support (AVAPS) mode is limited, prompting us to develop a practical single-night titration protocol that provides information to assist clinicians and patients as they decide between BPAP-ST and AVAPS modes.
• Parsons, C., Patel, S. I., Cha, S., Shen, W. K., Desai, S., Chamberlain, A. M., Luis, S. A., Aguilar, M. I., Demaerschalk, B. M., Mookadam, F., & Shamoun, F. (2017). CHADS-VASc Score: A Predictor of Thromboembolic Events and Mortality in Patients With an Implantable Monitoring Device Without Atrial Fibrillation. Mayo Clinic proceedings, 92(3), 360-369.
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  To determine if the CHADS-VASc score (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, stroke or transient ischemic attack, vascular disease, age 65-74 years, sex category) predicts thromboembolism and death in patients without atrial fibrillation in a population with implantable cardiac monitoring devices.
• Patel, S. I., Chakkera, H. A., Wennberg, P. W., Liedl, D. A., Alrabadi, F., Cha, S. S., Hooley, D. D., Amer, H., Wadei, H. M., & Shamoun, F. E. (2017). Peripheral arterial disease preoperatively may predict graft failure and mortality in kidney transplant recipients. Vascular medicine (London, England), 22(3), 225-230.
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  Patients with end-stage renal disease undergoing kidney transplant often have diffuse atherosclerosis and high cardiovascular morbidity and mortality rates. We analyzed the correlation of peripheral arterial disease (PAD), here quantified by an abnormal ankle-brachial index (ABI) measured within the 5 years prior to kidney transplant, with graft failure and mortality rates (primary end points) after adjusting for known cardiovascular risk factors (age, sex, smoking history, hypertension, diabetes, stroke, known coronary artery disease or heart failure, years of dialysis). Of 1055 patients in our transplant population, 819 had arterial studies within the 5 years prior to transplant. Secondary end points included myocardial infarction; cerebrovascular accident; and limb ischemia, gangrene, or amputation. Low ABI was an independent and significant predictor of organ failure (OR, 2.77 (95% CI, 1.68-4.58), p
• Patel, S. I., Cherington, C., Scherber, R., Barr, K., McLemore, R., Morisky, D. E., Cha, S., Mookadam, F., & Shamoun, F. (2017). Assessment of Patient Adherence to Direct Oral Anticoagulant vs Warfarin Therapy. The Journal of the American Osteopathic Association, 117(1), 7-15.
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  Direct oral anticoagulants (DOACs) may be as effective as, and at times safer than, warfarin. Because DOACs do not require regular serum level monitoring, patients' interaction with the health care system may be reduced. To the authors' knowledge, although studies have evaluated warfarin adherence, few studies have evaluated the real-world adherence to DOACs.
• Patel, S. I., Miller, B. W., Kosiorek, H. E., Parish, J. M., Lyng, P. J., & Krahn, L. E. (2017). The Effect of Dogs on Human Sleep in the Home Sleep Environment. Mayo Clinic proceedings, 92(9), 1368-1372.
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  To objectively assess whether a dog in the bedroom or bed disturbs sleep.
• Tafur, A. J., Shamoun, F. E., Patel, S. I., Tafur, D., Donna, F., & Murad, M. H. (2017). Catheter-Directed Treatment of Pulmonary Embolism: A Systematic Review and Meta-Analysis of Modern Literature. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 23(7), 821-829.
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  We summarize the evidence for the safety and efficacy of catheter-directed thrombolysis (CDT) with and without ultrasound-assisted therapy for treating submassive and massive pulmonary embolism (PE) in a systematic review. The primary efficacy outcome was mortality. Outcomes were pooled across studies with the random-effects model. Twenty-four studies enrolled 700 patients in total; 653 received mechanical thromboembolectomy treatments for PE (mortality rate, 9% [95% confidence interval (CI), 6%-13%], P = .12; rate of minor complications, 6% [95% CI, 2%-13%]). In the ultrasound-accelerated thrombolysis (USAT) studies, the mortality rate was 4% (95% CI, 1%-11%) and in the non-USAT studies, it was 9% (95% CI, 6%-13%). Secondary safety outcomes were all bleeding events, which occurred in 12% (95% CI, 7%-20%) of the USAT studies and in 10% (95% CI, 5%-20%) of the non-USAT studies. Current clinical evidence does not prove USAT is superior over CDT methods.
• Patel, S. I., Thompson, B. M., McLemore, R. Y., Temkit, M., Schlinkert, R. T., Apsey, H. A., & Cook, C. B. (2016). Relationship between the timing of preoperative medical visits and day-of-surgery glucose in poorly controlled diabetes. Future science OA, 2(2), FSO123.
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  This study evaluated referral patterns for preoperative evaluations of patients with poorly controlled diabetes mellitus (DM) and determined whether intervals between evaluations and surgery day were associated with preoperative glucose levels.
• Patel, S., Cain, R., Neailey, K., & Hooberman, L. (2016). Exploring Patients' Views Toward Giving Web-Based Feedback and Ratings to General Practitioners in England: A Qualitative Descriptive Study. Journal of medical Internet research, 18(8), e217.
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  Patient feedback websites or doctor rating websites are increasingly being used by patients to give feedback about their health care experiences. There is little known about why patients in England may give Web-based feedback and what may motivate or dissuade them from giving Web-based feedback.
• Patel, S. I., Obeid, H., Matti, L., Ramakrishna, H., & Shamoun, F. E. (2015). Cerebral Venous Thrombosis: Current and Newer Anticoagulant Treatment Options. The neurologist, 20(5), 80-8.
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  Cerebral venous thrombosis (CVT) is rare and involves thrombosis of the veins and sinuses of the brain, most commonly the superior sagittal sinus. Approximately 5 CVT cases occur per 1 million persons in western countries. CVT causes 0.5% of strokes. Early diagnosis is crucial to prevent such outcomes as hydrocephalus, intracranial hypertension, and further seizures. Standard medical treatment of CVT consists of low-molecular-weight heparin and endovascular thrombolysis. Small case reports have found that the newer oral anticoagulants can be used for CVT treatment; however, they are associated with increased risk of bleeding and other adverse effects.
• Patel, S. I., Rodríguez, P., & Gonzales, R. J. (2015). The Implementation of an Innovative High School Mentoring Program Designed to Enhance Diversity and Provide a Pathway for Future Careers in Healthcare Related Fields. Journal of racial and ethnic health disparities, 2(3), 395-402.
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  Although the population of diverse applicants applying to medical school has increased over recent years (AAMC Diversity in Medical Education: Facts and Figures 2012); efforts persist to ensure the continuance of this increasing trend. Mentoring students at an early age may be an effective method by which to accomplish diversity within the applicant pool. Having a diverse physician population is more likely able to adequately address the healthcare needs of our diverse population.
• Files, J. A., Schwedt, T. J., Mayer, A. P., David, P. S., Vargas, B. B., Chang, Y. H., Hunt, M., Patel, S., Ko, M. G., Tozer, B. S., Burstein, R., & Dodick, D. W. (2014). Imploding and exploding migraine headaches: comparison of methods to diagnose pain directionality. Headache, 54(6), 1010-8.
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  The study aims to compare methods of determining headache directionality (imploding, exploding, and/or ocular headaches) in women with migraine, investigate the concordance between physician assignment and patient self-assignment of pain directionality, and evaluate whether patients assigned their headaches to the same direction when queried using different methods. Directionality of migraine headache pain (imploding, exploding, or ocular) may reflect differences in the underlying pathogenesis of individual migraine attacks among and within individuals. Emerging evidence suggests that directionality of pain in migraine sufferers may predict response to onabotulinumtoxin A. The best method of determining headache directionality in migraine sufferers has not been systematically explored.
• Mayer, A. P., Blair, J. E., Ko, M. G., Patel, S. I., & Files, J. A. (2014). Long-term follow-up of a facilitated peer mentoring program. Medical teacher, 36(3), 260-6.
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  Mentoring plays an important role in career success of academic medical faculty. New mentoring models such as peer mentoring have emerged.

Proceedings Publications

• Combs, D., Abraham, I. L., Hsu, C., Morgan, W. J., Patel, S. I., & Parthasarathy, S. (2019, December). Comparison of parent and child treatment preferences for obstructive sleep apnea. In Chest.

Presentations

• Berryhill, S., Morton, C. J., Dean, A., Berryhill, A., Provencio-Dean, N., Patel, S. I., Estep, L., Combs, D., Gerald, L. B., Krishnan, J. A., & Parthasarathy, S. (2020, June). Effect of Wearables on Sleep in Healthy Individuals: A Randomized Cross-Over Trial and Validation Study. 2020 meeting of the Associated Professional Sleep Societies. Philadelphia, PA.
• Huang, F., Patel, S. I., Combs, D., & Parthasarathy, S. (2020, June). Mortality and hospitalization in patients with heart failure and sleep apnea: A retrospective study of positive airway pressure therapy in medicare beneficiaries. 2020 meeting of the Associated Professional Sleep Societies. Philadelphia, PA.
• Parthasarathy, S., Kukafka, D. S., Antonescu, C., Patel, S. I., Combs, D., Quan, S. F., & Lee-Iannotti, J. K. (2020, June). Test Characteristics of a machine learned Electronic Medical Record Extractable tool for OSA Case Identification in a Community-based Population. 2020 meeting of the Associated Professional Sleep Societies. Philadelphia, PA.
• Patel, S. I., Vasquez, M., Huang, F., Guerra, S., Combs, D., & Parthasarathy, S. (2020, June). Positive Airway Pressure Therapy to Treat Sleep Disordered Breathing Impacts Number of Hospitalizations in Patients with Heart Failure. 2020 meeting of the Associated Professional Sleep Societies. Philadelphia, PA.
• Parthasarathy, S., Skrepnek, G. H., Combs, D., Quan, S. F., DeArmond, R. L., Provencio, N., Sarah, B., Wendel, C., & Patel, S. I. (2019, June). Effects of peer support participation on peer mentors. 2019 meeting of the Associated Professional Sleep Societies. San Antonio, TX.
• Patel, S. I. (2019, Fall). Cardiorespiratory Interactions Leading to Death in Obstructive Sleep Apnea. Innovations and Inventions Conference. University of Arizona.
• Patel, S. I. (2019, Fall). Comparison of Various Forms of PAP Therapies for Sleep-disordered Breathing in Heart Failure. Sleep Review Journal Webinar. Online Webinar with 300+ attendees.

Poster Presentations

• Parthasarathy, S., Lopez, S., Provencio-Dean, N., Estep, L., Mashaqi, S., Patel, S. I., & Combs, D. (2020, June). Objective differences in sleep timing between African Americans and Non-Hispanic Whites. 2020 meeting of the Associated Professional Sleep Societies. Philadelphia, PA.
• Patel, S. I., Vasquez, M., Huang, F., Guerra, S., Combs, D., & Parthasarathy, S. (2020, June). Positive Airway Pressure Therapy to Treat Sleep Disordered Breathing Impacts Number of Hospitalizations in Patients with Heart Failure. 2020 meeting of the Associated Professional Sleep Societies. Philadelphia, PA.
• Berryhill, S., Patel, S. I., Provencio, N., Combs, D., Havens, C. M., Morton, C. J., & Parthasarathy, S. (2019, June). Cloud-Based Evaluation Of Wearable-Derived Sleep Data In Insomnia Trials. 2019 meeting of the Associated Professional Sleep Societies. San Antonio, TX.
• Combs, D., Abraham, I. L., Hsu, C., Morgan, W. J., Patel, S. I., & Parthasarathy, S. (2018, December). Comparison of parent and child treatment preferences for obstructive sleep apnea. 2019 meeting of the Associated Professional Sleep Societies. San Antonio, TX.
• Combs, D., Abraham, I. L., Hsu, C., Morgan, W. J., Patel, S. I., & Parthasarathy, S. (2019, December). Comparison of parent and child treatment preferences for obstructive sleep apnea. 2019 meeting of the Associated Professional Sleep Societies. San Antonio, TX.
• Parthasarathy, S., Morton, C. J., Havens, C. M., Combs, D., Provencio, N., Patel, S. I., & Berryhill, S. (2019, June). Cloud-Based Evaluation Of Wearable-Derived Sleep Data In Insomnia Trials. 2019 meeting of the Associated Professional Sleep Societies. San Antonio, TX.
• Parthasarathy, S., Quan, S. F., Desai, B., Patel, S. I., Combs, D., Kulkarni, H., Partha, M., Berryhill, S., Wendel, C. W., Morton, C. J., & Provencio, N. (2018, December). EMR- And Clinic-Based Approaches For Recruiting Peer Support For Sleep Apnea. 2019 meeting of the Associated Professional Sleep Societies. San Antonio, TX.
• Patel, S. I., Combs, D., Parthasarathy, S., Morton, C. J., & DeArmond, R. (2019, June). Sex as a Biological Variable on the Inflammatory Effects of Intermittent Hypoxia. 2019 meeting of the Associated Professional Sleep Societies. San Antonio, TX.
• Patel, S. I., Vasquez, M., Guerra, S., Combs, D., & Parthasarathy, S. (2019, November). Treatment of Sleep Disordered Breathing With Positive Airway Pressure Therapy Reduces The Number of Hospitalizations In A Large Cohort Of Patients With Heart Failure. 2019 American Heart Association Scientific Sessions. Philadelphia, PA.
• Provencio, N., Morton, C. J., Wendel, C. W., Berryhill, S., Partha, M., Kulkarni, H., Combs, D., Patel, S. I., Desai, B., Quan, S. F., & Parthasarathy, S. (2018, December). EMR- And Clinic-Based Approaches For Recruiting Peer Support For Sleep Apnea. 2019 meeting of the Associated Professional Sleep Societies. San Antonio, TX.
• Berryhill, S., Parthasarathy, S., Morton, C. J., Patel, S. I., Havens, C. M., Provencio, N., Combs, D., Combs, D., Provencio, N., Havens, C. M., Morton, C. J., Patel, S. I., Berryhill, S., & Parthasarathy, S. (2019, June). Cloud-Based Evaluation Of Wearable-Derived Sleep Data In Insomnia Trials. 2019 meeting of the Associated Professional Sleep Societies. San Antonio, TX.
• Provencio, N., Parthasarathy, S., Morton, C. J., Quan, S. F., Desai, B., Wendel, C. W., Berryhill, S., Patel, S. I., Partha, M., Combs, D., Kulkarni, H., Kulkarni, H., Partha, M., Combs, D., Berryhill, S., Patel, S. I., Wendel, C. W., Desai, B., Morton, C. J., , Quan, S. F., et al. (2018, December). EMR- And Clinic-Based Approaches For Recruiting Peer Support For Sleep Apnea. 2019 meeting of the Associated Professional Sleep Societies. San Antonio, TX.