Thaddeus Wesley Warren Pace
- Associate Professor, Nursing
- Assistant Professor, Psychology
- Associate Professor, Psychiatry
No activities entered.
No activities entered.
Creating/Testing Behavior IntNURS 782 (Spring 2019)
DNP ProjectNURS 922 (Spring 2019)
Honors ThesisPSY 498H (Spring 2019)
Research PreceptorshipNURS 791A (Spring 2019)
DNP ProjectNURS 922 (Fall 2018)
DissertationNURS 920 (Fall 2018)
Honors ThesisPSY 498H (Fall 2018)
PsychNeuro Found and Clin ImplNURS 721 (Fall 2018)
DNP ProjectNURS 922 (Summer I 2018)
DissertationNURS 920 (Summer I 2018)
Creating/Testing Behavior IntNURS 782 (Spring 2018)
DNP ProjectNURS 922 (Spring 2018)
DissertationNURS 920 (Spring 2018)
Honors Directed ResearchPSYS 492H (Spring 2018)
PracticumNURS 694 (Spring 2018)
DNP ProjectNURS 922 (Fall 2017)
DissertationNURS 920 (Fall 2017)
PracticumNURS 694 (Fall 2017)
PsychNeuro Found and Clin ImplNURS 721 (Fall 2017)
Research PreceptorshipNURS 791A (Fall 2017)
DNP ProjectNURS 922 (Summer I 2017)
DissertationNURS 920 (Summer I 2017)
Evidence Based PracticeNURS 751 (Summer I 2017)
Independent StudyNURS 799 (Summer I 2017)
Creating/Testing Behavior IntNURS 782 (Spring 2017)
DNP ProjectNURS 922 (Spring 2017)
DissertationNURS 920 (Spring 2017)
Research PreceptorshipNURS 791A (Spring 2017)
DNP ProjectNURS 922 (Fall 2016)
DissertationNURS 920 (Fall 2016)
Honors ThesisPSY 498H (Fall 2016)
Independent StudyPSY 499 (Fall 2016)
PsychNeuro Found and Clin ImplNURS 721 (Fall 2016)
DNP ProjectNURS 922 (Summer I 2016)
DissertationNURS 920 (Summer I 2016)
- Badger, T. A., & Pace, T. W. (2017). Depression in families.. In Encyclopedia of Nursing Research, 4th ed.. New York, New York: Springer.
- Aguilar-Raab, C., Jarczok, M. N., Warth, M., Stoffel, M., Winter, F., Tieck, M., Berg, J., Negi, L. T., Harrison, T., Pace, T. W., & Ditzen, B. (2018). Enhancing Social Interaction in Depression (SIDE study): protocol of a randomised controlled trial on the effects of a Cognitively Based Compassion Training (CBCT) for couples. BMJ open, 8(9), e020448.More infoPositive social interactions (PSIs) and stable relationships can exert substantial benefits on health. However, patients suffering from depression benefit less from these health-promoting effects. Moreover, relationship quality and even partners' health has been found to be negatively affected by depressive symptomatology, which may result in overall impairments in social functioning of a romantic couple. Psychobiological research indicates that these impairments may be accompanied by a maladaptive regulation of the patient's neuroendocrine response to external stressors. Concerning the improvement of social functioning, first studies showed promising results of "Cognitively Based Compassion Training (CBCT®)". However, randomised trials are still scarce. Previous programmes did not involve participation of the patient's romantic partner. Therefore, the present study aims to investigate whether a CBCT® programme adapted for couples (CBCT®-fC) can improve depressive symptoms, distress, social interaction skills and the neurobiological regulation of stress.
- Kaplan, D. M., Raison, C. L., Milek, A., Tackman, A. M., Pace, T. W., & Mehl, M. R. (2018). Dispositional mindfulness in daily life: A naturalistic observation study. PloS one, 13(11), e0206029.More infoMindfulness has seen an extraordinary rise as a scientific construct, yet surprisingly little is known about how it manifests behaviorally in daily life. The present study identifies assumptions regarding how mindfulness relates to behavior and contrasts them against actual behavioral manifestations of trait mindfulness in daily life. Study 1 (N = 427) shows that mindfulness is assumed to relate to emotional positivity, quality social interactions, prosocial orientation and attention to sensory perceptions. In Study 2, 185 participants completed a gold-standard, self-reported mindfulness measure (the FFMQ) and underwent naturalistic observation sampling to assess their daily behaviors. Trait mindfulness was robustly related to a heightened perceptual focus in conversations. However, it was not related to behavioral and speech markers of emotional positivity, quality social interactions, or prosocial orientation. These findings suggest that the subjective and self-reported experience of being mindful in daily life is expressed primarily through sharpened perceptual attention, rather than through other behavioral or social differences. This highlights the need for ecological models of how dispositional mindfulness "works" in daily life, and raises questions about the measurement of mindfulness.
- Quinn, A. M., Williams, A. R., Sivilli, T. I., Raison, C. L., & Pace, T. W. (2018). The plasma interleukin-6 response to acute psychosocial stress in humans is detected by a magnetic multiplex assay: comparison to high-sensitivity ELISA. Stress (Amsterdam, Netherlands), 21(4), 376-381.More infoCirculating concentrations of interleukin (IL)-6, an inflammatory biomarker widely assessed in humans to study the inflammatory response to acute psychological stress, have for decades been quantified using enzyme-linked immunosorbent assay (ELISA). However, biobehavioral researchers are increasingly using cytokine multiplex assays instead of ELISA to measure IL-6 and other cytokines. Despite this trend, multiplex assays have not been directly compared to ELISA for their ability to detect subtle stress-induced changes of IL-6. Here, we tested the prediction that a high-sensitivity multiplex assay (human Magnetic Luminex Performance Assay, R&D Systems, Minneapolis, MN) would detect changes in IL-6 as a result of acute stress challenge in a manner comparable to high-sensitivity ELISA. Blood was collected from 12 healthy adults immediately before and then 90 and 210 min after the start of the Trier Social Stress Test (TSST), an acute laboratory psychosocial stress challenge. In addition to quantifying IL-6 concentrations in plasma with both multiplex and ELISA, we also assessed concentrations of tumor necrosis factor-alpha, IL-8, IL-10, IL-5, and IL-2 with multiplex. The multiplex detected IL-6 in all samples. Concentrations strongly correlated with values determined by ELISA across all samples (r = 0.941, p
- Carrington, J. M., Pace, T. W., Sheppard, K. G., Dudding, K. M., & Stratton, D. (2017). Using Twitter to Teach Evidence-Based Practice in Doctor of Nursing Practice Degree Program. Clinical nurse specialist CNS, 31(6), 349-352.
- Mehl, M. R., Raison, C. L., Pace, T. W., Arevalo, J. M., & Cole, S. W. (2017). Natural language indicators of differential gene regulation in the human immune system. Proceedings of the National Academy of Sciences of the United States of America, 114(47), 12554-12559.More infoAdverse social conditions have been linked to a conserved transcriptional response to adversity (CTRA) in circulating leukocytes that may contribute to social gradients in disease. However, the CNS mechanisms involved remain obscure, in part because CTRA gene-expression profiles often track external social-environmental variables more closely than they do self-reported internal affective states such as stress, depression, or anxiety. This study examined the possibility that variations in patterns of natural language use might provide more sensitive indicators of the automatic threat-detection and -response systems that proximally regulate autonomic induction of the CTRA. In 22,627 audio samples of natural speech sampled from the daily interactions of 143 healthy adults, both total language output and patterns of function-word use covaried with CTRA gene expression. These language features predicted CTRA gene expression substantially better than did conventional self-report measures of stress, depression, and anxiety and did so independently of demographic and behavioral factors (age, sex, race, smoking, body mass index) and leukocyte subset distributions. This predictive relationship held when language and gene expression were sampled more than a week apart, suggesting that associations reflect stable individual differences or chronic life circumstances. Given the observed relationship between personal expression and gene expression, patterns of natural language use may provide a useful behavioral indicator of nonconsciously evaluated well-being (implicit safety vs. threat) that is distinct from conscious affective experience and more closely tracks the neurobiological processes involved in peripheral gene regulation.
- Segrin, C., Badger, T. A., Sikorskii, A., Crane, T. E., & Pace, T. W. (2017). A dyadic analysis of stress processes in Latinas with breast cancer and their family caregivers. Psycho-oncology.More infoBreast cancer diagnosis and treatment negatively affect quality of life for survivors and their family caregivers. The stress process model has been useful for describing the cascade of social and psychological experiences that culminate in degraded quality of life for both survivors and their family caregivers. This study is designed to test theoretically specified predictors of negative psychosocial outcomes in a dyadic context.
- Sikorskii, A., Wyatt, G., Lehto, R., Victorson, D., Badger, T., & Pace, T. (2017). Using SMART design to improve symptom management among cancer patients: A study protocol. Research in nursing & health, 40(6), 501-511.More infoIn this in-progress sequential multiple assignment randomized trial (SMART), dyads of solid tumor cancer patients and their caregivers are initially randomized to 4 weeks of reflexology or meditative (mindfulness) practices provided by/with their caregiver in the patient's home or to a control group. After 4 weeks, intervention group dyads in which patients do not show improvement in fatigue (non-responders) are re-randomized to either receive additional time with the same therapy during weeks 5-8 or to add the other therapy. The aims are (1) to compare reflexology and meditative practices groups during weeks 1-4 on patients' fatigue severity, summed symptom inventory score, depressive symptoms, and anxiety, so as to determine the relative effectiveness of these therapies and the characteristics of responders and non-responders to each therapy. (2) Among reflexology non-responders based on fatigue score at week 4, to determine patient symptom outcomes when meditative practices are added during weeks 5-8, versus continuing with reflexology alone. (3) Among meditative practices non-responders based on fatigue score at week 4, to determine patient symptom outcomes when reflexology is added during weeks 5-8, versus continuing with meditative practices alone. (4) To compare improvements in patient symptom outcomes among the three groups created by the first randomization. (5) To explore which dyadic characteristics are associated with optimal patient symptom outcomes, to determine tailoring variables for decision rules of future interventions. The trial has a target of 331 dyads post-attrition and has 150 dyads enrolled. We are overcoming challenges with dyadic recruitment and retention while maintaining fidelity.
- Powers, A., Michopoulos, V., Conneely, K., Gluck, R., Dixon, H., Wilson, J., Jovanovic, T., Pace, T. W., Umpierrez, G. E., Ressler, K. J., Bradley, B., & Gillespie, C. F. (2016). Emotion Dysregulation and Inflammation in African-American Women with Type 2 Diabetes. Neural plasticity, 2016, 8926840.More infoC-reactive protein (CRP), a marker of systemic inflammation, has been associated with major depressive disorder (MDD) and posttraumatic stress disorder (PTSD). Emotion dysregulation is a transdiagnostic risk factor for many psychological disorders associated with chronic inflammatory state. The objective of this study was to determine whether inflammation is associated with emotion dysregulation in women with type 2 diabetes mellitus (T2DM). We examined associations between trauma exposure, MDD, PTSD, emotion dysregulation, and CRP among 40 African-American women with T2DM recruited from an urban hospital. Emotion dysregulation was measured using the Difficulties in Emotion Regulation Scale. PTSD and MDD were measured with structured clinical interviews. Child abuse and lifetime trauma load were also assessed. Analyses showed that both emotion dysregulation and current MDD were significantly associated with higher levels of CRP (p < 0.01). Current PTSD was not significantly related to CRP. In a regression model, emotion dysregulation was significantly associated with higher CRP (p < 0.001) independent of body mass index, trauma exposure, and MDD diagnosis. These findings suggest that emotion dysregulation may be an important risk factor for chronic inflammation beyond already known risk factors among women with T2DM, though a causal relationship cannot be determined from this study.
- Reed, R. G., O'Connor, M. F., Pace, T. W., Raison, C. L., & Butler, E. A. (2016). Dyadic Coping and Salivary Interleukin-6 Responses to Interpersonal Stress. Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43).More infoDysregulated immune responses to stress are a potential pathway linking close relationship processes to health, and couples' abilities to cope with stress together (dyadic coping) likely impact such immune responses. Most stress research has focused on immune reactivity, whereas knowledge of immune recovery remains limited. The present study examined how acute interpersonal stress affects immune reactivity and recovery, as well as whether dyadic coping moderates these effects. Healthy couples (N = 24) completed the Dyadic Coping Inventory and provided saliva samples 4 times each day for 5 days, including 2 days before a laboratory dyadic stressor (discussing an area of disagreement), the day of, and 2 days after. Four additional saliva samples were taken throughout the laboratory stressor. Saliva samples were assayed for interleukin (IL)-6. Multilevel models that adjusted for demographic and health variables indicated that partners low in dyadic coping showed immune reactivity to the stressor whereas partners high in dyadic coping did not. Dyadic coping did not moderate immune recovery, which had occurred by 5 hr poststressor across all participants. Results suggest that partners low in dyadic coping show increased reactivity of immune responses to interpersonal stress. Enhancing dyadic coping in couples may impact not only their mental health and relationship quality, but also their risk of stress-related immune disorders. (PsycINFO Database Record
- Dodds, S. E., Pace, T. W., Bell, M. L., Fiero, M., Negi, L. T., Raison, C. L., & Weihs, K. L. (2015). Feasibility of Cognitively-Based Compassion Training (CBCT) for breast cancer survivors: a randomized, wait list controlled pilot study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 23(12), 3599-608.More infoThis study assessed the feasibility of a meditation-based program called Cognitively-Based Compassion Training (CBCT) with breast cancer survivors. Enrollment and participant satisfaction with a novel intervention, adherence to program requirements, and differences between the intervention group and wait list controls on self-report measures were also assessed. Additionally, cortisol, a stress-related endocrine biomarker, was assessed.
- Haroon, E., Woolwine, B. J., Chen, X., Pace, T. W., Parekh, S., Spivey, J. R., Hu, X. P., & Miller, A. H. (2014). IFN-alpha-induced cortical and subcortical glutamate changes assessed by magnetic resonance spectroscopy. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(7), 1777-85.More infoCytokine effects on behavior may be related to alterations in glutamate metabolism. We therefore measured glutamate concentrations in brain regions shown to be affected by inflammatory stimuli including the cytokine interferon (IFN)-alpha. IFN-alpha is known to alter neural activity in the dorsal anterior cingulate cortex (dACC) and basal ganglia in association with symptoms of depression and increases in peripheral cytokines including the tumor necrosis factor (TNF) and its soluble receptor. Single-voxel magnetic resonance spectroscopy (MRS) was employed to measure glutamate concentrations normalized to creatine (Glu/Cr) in dACC and basal ganglia of 31 patients with hepatitis C before and after ∼ 1 month of either no treatment (n = 14) or treatment with IFN-alpha (n = 17). Depressive symptoms were measured at each visit using the Inventory of Depressive Symptoms-Clinician Rating (IDS-C) and the Multidimensional Fatigue Inventory. IFN-alpha was associated with a significant increase in Glu/Cr in dACC and left basal ganglia. Increases in dACC Glu/Cr were positively correlated with scores on the IDS-C in the group as a whole, but not in either group alone. Glu/Cr increases in left basal ganglia were correlated with decreased motivation in the group as a whole and in IFN-alpha-treated subjects alone. No Glu/Cr changes were found in the right basal ganglia, and no significant correlations were found between Glu/Cr and the inflammatory markers. IFN-alpha-induced increases in glutamate in dACC and basal ganglia are consistent with MRS findings in bipolar depression and suggest that inflammatory cytokines may contribute to glutamate alterations in patients with mood disorders and increased inflammation.
- Smith, A. K., Conneely, K. N., Pace, T. W., Mister, D., Felger, J. C., Kilaru, V., Akel, M. J., Vertino, P. M., Miller, A. H., & Torres, M. A. (2014). Epigenetic changes associated with inflammation in breast cancer patients treated with chemotherapy. Brain, behavior, and immunity, 38, 227-36.More infoInflammation has been associated with fatigue during and after various types of breast cancer treatments. We examined whether prior chemotherapy was associated with DNA methylation patterns that could explain persisting inflammation and/or fatigue in women treated for breast cancer. Prior to breast radiation therapy, DNA was extracted from peripheral blood mononuclear cells (PBMCs) of 61 Stage 0-IIIA breast cancer patients who had received partial mastectomy with or without chemotherapy. DNA methylation was assessed at >485,000 CpG sites across the genome along with fatigue and plasma inflammatory markers previously associated with fatigue. Compared to non-chemotherapy-treated, women who had received chemotherapy exhibited significantly decreased methylation at eight CpG sites (p
- Mehta, D., Klengel, T., Conneely, K. N., Smith, A. K., Altmann, A., Pace, T. W., Rex-Haffner, M., Loeschner, A., Gonik, M., Mercer, K. B., Bradley, B., Müller-Myhsok, B., Ressler, K. J., & Binder, E. B. (2013). Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder. Proceedings of the National Academy of Sciences of the United States of America, 110(20), 8302-7.More infoChildhood maltreatment is likely to influence fundamental biological processes and engrave long-lasting epigenetic marks, leading to adverse health outcomes in adulthood. We aimed to elucidate the impact of different early environment on disease-related genome-wide gene expression and DNA methylation in peripheral blood cells in patients with posttraumatic stress disorder (PTSD). Compared with the same trauma-exposed controls (n = 108), gene-expression profiles of PTSD patients with similar clinical symptoms and matched adult trauma exposure but different childhood adverse events (n = 32 and 29) were almost completely nonoverlapping (98%). These differences on the level of individual transcripts were paralleled by the enrichment of several distinct biological networks between the groups. Moreover, these gene-expression changes were accompanied and likely mediated by changes in DNA methylation in the same loci to a much larger proportion in the childhood abuse (69%) vs. the non-child abuse-only group (34%). This study is unique in providing genome-wide evidence of distinct biological modifications in PTSD in the presence or absence of exposure to childhood abuse. The findings that nonoverlapping biological pathways seem to be affected in the two PTSD groups and that changes in DNA methylation appear to have a much greater impact in the childhood-abuse group might reflect differences in the pathophysiology of PTSD, in dependence of exposure to childhood maltreatment. These results contribute to a better understanding of the extent of influence of differences in trauma exposure on pathophysiological processes in stress-related psychiatric disorders and may have implications for personalized medicine.
- Torres, M. A., Pace, T. W., Liu, T., Felger, J. C., Mister, D., Doho, G. H., Kohn, J. N., Barsevick, A. M., Long, Q., & Miller, A. H. (2013). Predictors of depression in breast cancer patients treated with radiation: role of prior chemotherapy and nuclear factor kappa B. Cancer, 119(11), 1951-9.More infoDepression is common during and after breast cancer treatment. However, the role of specific therapeutic modalities and related biologic mechanisms remains unclear. Radiation is an essential component of breast-conserving therapy and may contribute to depression in patients with breast cancer through the activation of inflammatory pathways.
- Cruze, A., Pace, T. W., Hoyth, L., Nair, R. L., & Zeiders, K. H. (2018, September). Latino adolescents’ psychological and physiological response to the 2016 U.S. presidential election. International Society of Psychoneuroendocrinology Annual Conference. Newport Beach, CA.
- Pace, T. W., Badger, T. A., Segrin, C. G., Sikorskii, A., & Crane, T. E. (2018, April / Spring). Saliva C-reactive Protein and Diurnal Cortisol Rhythm in Hispanic Breast Cancer Survivors and Their Informal Caregivers: Relationship with Cancer Treatments and Health-Related Quality of Life. Western Institute of Nursing Annual Conference. Spokane, WA, United States: Western Institute of Nursing.
- Pace, T. W., Sikorskii, A., Segrin, C. G., Badger, T. A., & Crane, T. E. (2018, Fall). Personalizing Symptom Management Interventions: Symptom Burden among Latinas with Breast Cancer and Their Informal Caregivers. State of the Science Congress. Washington DC: American Academy of Nursing.
- Pace, T. W., Sikorskii, A., Segrin, C. G., Badger, T. A., & Crane, T. E. (2018, Spring). Body Mass Index and Depression among Latina Breast Cancer Survivors. American Psycosocial Oncology Society Annual Meeting. Tucson, AZ: American Psycosocial Oncology Society.
- Pace, T. W., Sikorskii, A., Segrin, C. G., Badger, T. A., & Crane, T. E. (2018, Spring). Depression and Anxiety is Associated with Body Mass Index, but not Fatigue among Latina Breast Cancer Survivors. Western Institute of Nursing Annual Meeting. Spokane, WA: Western Institute of Nursing.
- Pace, T. W. (2017, August). Overcoming Stress to Promote Wellness in Survivorship. Kellman Beat Cancer Boot Camp monthly meeting. Udall Park, Tucson, AZ: Kellman Beat Cancer Boot Camp.More infoI presented my research and spoke about the mechanisms of wellness interventions in front of a sizable group of cancer survivors and their families at this event in Tucson.
- Sikorskii, A., Wyatt, G., Pace, T. W., Badger, T. A., & Victorson, D. (2016, December). Using SMART design to improve symptom management among cancer patients.. Cancer Prevention and Control Seminar. University of Arizona Cancer Center.
- Weihs, K. L., Raison, C. L., Pace, T. W., Dodds, S., Bell, M., Eparvier, L., & Fiero, M. (2015, July). Feasibility and Effects of Cognitively-Based Compassion Training (CBCT) on Psychological Well-Being in Breast Cancer Survivors: A Randomized, Wait List Controlled Pilot Study. 2015 World Congress of Psycho-Oncology. Washington, D.C.: American PsychoOncology Society.
- Gillespie, C. C., Dickson, D., Gluck, R., Munhoz, A., Mendoza, H., Rochat, C., Carter, S., Jovanovic, T., Fani, N., Lott, A., Bradley, B., Ressler, K., Umpierrez, G., Schwartz, A., Pace, T. W., & Michopoulos, V. (2017, December). Alterations in Glucocorticoid, Immune, and Metabolic Regulation are Associated with Post-Traumatic Stress Disorder in African-American Women with Type II Diabetes Mellitus. American College of Neuropsychopharmacology 56th Annual Meeting. Palm Spring, CA: American College of Neuropsychopharmacology.
- Pace, T. W., DeBlois, M., Walsh, M. E., Toomey, R. B., & Hernandez-Ainza, A. (2017, Spring). Depression, anxiety, and perceived social support as potential mediators for disparities in stress-hormonal regulation in transgender youth.. Mindfulness Research Conference. Seattle, WA.
- Pace, T. W., Pace, T. W., McEwen, M. M., Rosenfeld, A. G., Rosenfeld, A. G., & McEwen, M. M. (2016, April). Symptom biomarkers in Mexican American women with diabetes & heart disease.. Western Institute of Nursing Communicating Nursing Research Conference. Anaheim CA: Western Institute of Nursing.More infoThis was work from our Emmons grant.
- McEwen, M. M., Rosenfeld, A. G., & Pace, T. W. (2016, October). Concept Paper: Innovative, biobehavioral, symptom self-management approach to filling the existing gap in knowledge for Mexican-American women with co-occurring T2DM and IHD.. NIMHD program officers meeting.More infoConcept paper: We proposed an innovative, bio-behavioral, symptom self-management approach to filling the existing gap in knowledge for Mexican-American women with co-occurring T2DM and IHD.