Wei Zhou

Professor, Surgery
Chief, Division of Vascular Surgery
Member of the Graduate Faculty

Contact

(520) 626-6670
Arizona Health Sciences Center, Rm. 4402
Tucson, AZ 85724
zhouw@arizona.edu

Biography

1. Zhou W, Vasquez JC, O'Donnell MR, Paz BI. Clinical Manifestation of Gastrointestinal Granulocytic Sarcoma Requiring Surgical Treatment. The American Surgeon, Aug, 2001; 67(8): 764-6.

2. Du E, Overstreet K, Zhou W, Baird G, Baird S, Bouvet M, Haghighi P. A Case of Tumor-Like Splenic Extramedullary Hematopoiesis in an Asymptomatic Patient: Useage of Fine Needle Aspiration. Acta Cytologica, 2002 Nov-Dec; 46(6): 1138-42

3. Zhou W, Katz M, Baird S, Bouvet M. Metachronous Double Parathyroid Adenoma Involving Two Different Cell Types: Chief Cell and Oxyphil Cell. Endocrine Practice, 2003; 9(6): 522-525

4. Zhou W, Bush RL, Lin PH, Lumsden AB. Treatment Options of Iatrogenic Pelvic Vein Injuries: Conventional Operative versus Endovascular Approach. Vascular and Endovascular Surgery, 2004; 38(6) 569-73

5. Zhou W, Bush RL, Lin PH, Lumsden AB, Radiation Induced Venous Stenosis Treatment Options. Journal of Vascular Surgery, 2004: 40(1):179-182.

6. Bush RL, Lin PH, Bates JT, Mureebe L, Zhou W, Lumsden AB. Pharmacomechanical Thrombectomy for the Treatment of Symptomatic Lower Extremity Deep Venous Thrombosis: A Safety and Feasibility Study. Journal of Vascular Surgery, 2004; 40(4):965-70

7. Zhou W, Lin PH, Bush RL, Nguyen L, Lumsden AB. Acute Arterial Thrombosis Associated with Cocaine Abuse. Journal of Vascular Surgery, 2004: 40(2): 291-5

8. Lin PH, Bush RL, Lubbe DF, Cox MM, Zhou W, McCoy SA, Felkai D, Paladugu R, Lumsden AB. Carotid Artery Stenting with Routine Cerebral Protection in High Risk Patients. Journal of American Surgery 2004. 188 (6): 644-52

9. Watts K, Lin PH, Bush RL, Awad S, McCoy SA, Felkai D, Zhou W, Nguyen L, Guerrero M, Shenaq SA, Lumsden AB. The Impact of Anesthetic Modality on the Outcome of Carotid Endarterectomy. American Journal of Surgery 2004. 188 (6): 741-7

10. Lin PH, Bush RL, Yao Q, Lam R, Paladugu R, Zhou W, Chen C, Lumsden AB. Abdominal Aortic Surgery in Patients with Human Immunodeficiency Virus Infection. American Journal of Surgery, 2004. 188(6): 690-7

11. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Molecular Mechanisms and Clinical Applications of Ginseng Root for Cardiovascular Disease. Medical Science Monitor 2004; 10(8): 187- 92

12. Zhou W, Bush RL, Lin PH, Lumsden AB. Fibromuscular Dysplasia of the Carotid Artery – Image. Journal of American College of Surgeon 2004; 200(5): 807

13. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Effect of Ginkgo Biloba on Cardiovascular Disease. Cardiovascular Drug Review 2004; 22(4): 309-319

14. Zhou W, Bush RL, Lin PH, Lumsden AB. Inferior Vena Cava Occlusion Secondary to Filter Placement: Endovascular Therapy. Journal of Endovascular Therapy 2004; 11: 747-748

15. Zhou W, Bush RL, Lin PH, Hodge MD, Felkai DD, McCollum C, Noon, G, Lumsden AB. Fibromuscular Dysplasia of the Carotid Artery: Diagnosis with Duplex Ultrasonography. Journal for Vascular Ultrasound, 2005. 29(1): 9-13

16. Zhou W, Bush RL, Lin PH, Felkai DD, Spencer TA, Lumsden AB. Carotid Artery Pseudoaneurysm after Endovascular Stent Placement: Diagnosis and Follow-up Duplex Ultrasonography. Journal of Vascular Ultrasound, 2005. 29(1): 28-32

17. Zhou W, Terramani TT, Lin PH, Bush RL, Matsuura JH, Cox M, Lumsden AB. In-Situ Reconstruction with Cryopreserved Arterial Allograft in Mycotic Aneurysms or Aortoiliac Prosthetic Grafts Infection: a Multi-institutional Experience. Brazilian Vascular Journal 2005; 4(2): 123-128

18. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Ginsenoside Rb1 Blocks Homocysteine-Induced Endothelial Dysfunction. Journal of Vascular Surgery 2005; 41(5): 861-868

19. Chai H, Zhou W, Lin PH, Lumsden AB, Yao Q, Chen C. Ginsenosides block HIV protease inhibitor ritonavir-induced vascular dysfunction of porcine coronary arteries. American Journal of Physiology: Heart and Circulation Physiology. 2005; 288(6):2965-2971

20. Bush RL, Lin PH, Mureebe L, Zhou W, Peden EK, Lumsden AB. Routine Bivalirudin Use in Percutaneous Carotid Interventions. Journal of Endovascular Therapy, 2005 (12): 521-523

21. Lin PH, Bush RL, Zhou W, Peden EK, Lumsden AB. What’s the Learning Curve for Carotid Artery Stenting with Neuroprotection? Analysis of 200 Consecutive Cases at an Academic Institution. Perspective Vascular Surgery and Endovascular Therapy 17(2): 113-23, 2005

22. Bush RL, Kougias P, Guerrero MA, Lubbe D, Zhou W, Lumsden AB, Lin PH. A Comparison of Carotid Artery Stenting with Neuroprotection versus Carotid Endarterectomy under Local Anesthesia. American Journal of Surgery, 2005;190(5):696-700

23. Peden E, Zhou W, Bush RL, Lumsden AB, Lin PH. The case for thrombolysis for iliofemoral venous thrombosis. Semin Vasc Surg. 2005 Sep;18(3):139-47

24. Lin PH, Bush RL, Zhou W, Peden EK, Lubbe DF, Guerrero M, Henao EA, Kougias P, Mohiuddin I, and Lumsden AB. Carotid Artery Stenting with Neuroprotection: Assessing the Learning Curve and Treatment Outcome in 200 Consecutive Cases. Journal of American Surgeon, 2005. 190(6): 850-7

25. Zhou W, Rosenberg W, Lumsden AB, Li J. Successful Surgical Management of Infrarenal Inferior Vena Cava Agenesis in a Symptomatic Patient. Vascular, 2005. 13(6): 358-61

26. Zhou W, Bush RL, Bhama J, Lin PH, Safaya R, Lumsden AB. Repair of Anastomotic Abdominal Aortic Pseudoaneurysm Utilizing Sequential AneuRx Aortic Cuffs in an Overlapping Configuration. Annals of Vascular Surgery, 2006. 20(1): 17-22

27. Zhou W, Lin PH, Bush RL, Terramani TT, Matsuura JH, Cox M, Peden EK, Dardik A, Rosenthal D, Lumsden AB. In-Situ Reconstruction with Cryopreserved Arterial Allograft for Management of Mycotic Aneurysms or Aortoiliac Prosthetic Grafts Infection: a Multi-institutional Experience. Texas Heart Institution Journal, 2006. 33(1):

28. Kougias P, Lin PH, Bush BL, Peden EK, Zhou W, Lumsden AB. Carotid artery stenting - Current status and future directions. Minerva Cardioangiol, 2006. 54(1): 69-81.

29. Zhou W, Lin PH, Bush RL, Peden EK, Guerrero M, Kougias P, Lumsden AB. Management of in-sent restenosis after carotid artery stenting in high-risk patients. Journal of Vascular Surgery, 2006. 43(2): 305-12

30. Silberfein EJ, Lin PH, Bush RL, Zhou W, Lumsden AB. Aortic endograft infection due to Pasteurella multocida following a rabbit bite. Journal of Vascular Surgery, 2006. 43(2): 393-5

31. Zhou W, Lin PH, Bush RL, Chang B, Guerrero M, Terramani TT, Lubbe D, Nguyen L, Lumsden AB. Carotid Artery Aneurysm: Evolution of Management Over Two Decades. Journal of Vascular Surgery, 2006. 43(3): 493-6

32. Lin PH, Bush RL, Zhou W, Peden EK, Lumsden AB. Endovascular Treatment of Traumatic Thoracic Aortic Injury – Should this be the New Standard of Treatment? Journal of Vascular Surgery, 2006. 43(2suppl): A22-9

33. Zhou W, Reardon M, Lin PH, Bush RL, Peden EK. Endovascular Repair of a Proximal Aortic Arch Aneurysm: a Novel Approach of Supraaortic Debranching with antegrade endograft deployment. Journal of Vascular Surgery, 2006. 43(5): 1045-8

34. Zhou W, Lin PH, Bush RL, Peden EK, Lumsden AB. Endovascular Training of Vascular Surgeons: Have We Made Progress. Seminar in Vascular Surgery, 2006. 19(2): 122-6

35. Yallampalli S, Zhou W, Lin PH, Bush RL, and Lumsden AB. Delayed Deformation of Self-Expanding Stents Following Carotid Artery Stenting for Post-Endarterectomy Restenoses. Journal of Vascular Surgery, 2006, 44(2): 412-415

36. Zhou W, Lumsden AB, Li J. Laparoscopic Ligation of IMA for a Type II Endoleak: Combined Laparoscopic and Endovascular Approach. Surgical Laparoscopy, Endoscopy, and Percutaneous Techniques, 2006, 16(4): 272-275.

37. Ly T, Zhou W, Bush RL, Lumsden AB, Lin PH. Use of Parietal Peritoneum for Aortic Stump Coverage Following Removal of an Infected Aortic Prosthesis. Vascular and Endovascular Surgery, 2006, 40(4): 334-7

38. Zhou W, Bush RL, Lin PH, Lumsden AB. Laser Atherectomy for Lower Extremity Revascularization: An Adjunctive Endovascular Treatment Option. Vascular and Endovascular Surgery, 2006, 40(4):268-274

39. Mussa FF, Hedayadi N, Zhou W, Darouiche RO, Lin PH. Prevention and Treatment of Vascular Graft Infection. Expert Review of Anti-Infective Therapy, 2007, 5(2):305-15

40. Zhou W, Chai H, Courson A, Lin PH, Lumsden AB, Yao Q, Chen C. Ginkgolide A Attenuates Homocysteine-Induced Endothelial Dysfunction in Porcine Coronary Arteries. Journal of Vascular Surgery 2006, 44(4): 853-62

41. Zhou W, Reardon M, Peden EK, Lin PH, Lumsden AB. Hybrid Approach to Complex Thoracic Aortic Aneurysms in High Risk Patients: Surgical Challenges and Clinical Outcomes. Journal of Vascular Surgery, 2006, 44(4): 688-93

42. El Sayed HF, Kougias P, Zhou W, Lin PH. Utility of Retrievable Vena Cava Filters and Mechanical Thrombectomy in the Endovascular Management of Acute Deep Venous Thrombosis. Vascular 2006, 14(5): 305-12

43. Lin PH, Zhou W, Guerrero MA, McCoy SA, Felkai D, Kougias P, El Sayed HF. Carotid Artery Stenting with Distal Protection Using the Carotid Wallstent and Filterwire Neuroprotection: Single-Center Experience of 380 cases with Midterm Outcomes. Vascular. 2006, 14(5):237-44

44. Lin PH, Zhou W, Dardik A, Mussa F, Kougias P, Hedayadi N, Naoum JJ, El Sayed H, Peden EK, Huynh TT. Catheter-direct Thrombolysis Versus Pharmacomechanical Thrombectomy for Treatment of Symptomatic Lower Extremity Deep Venous Thrombosis. American Journal of Surgery, 2006, 192(6):782-8

45. Lin PH, Steinberg JL, Okada T, Zhou W, El Sayed H, Kougias P, Yao Q, Chen C. Chronically Impaired Endothelial Vasoreactivity Following Oversized Endovascular Introducer Sheath Placement in Porcine Iliac Arteries: Implications for Endovascular Therapy. Vascular. 2006, 14(6):353-61

46. Zhou W, Choi L, Lin PH, Dardik A, Eraso A, Lumsden AB. Percutaneous Transhepatic Thrombolysis and Rheolytic Thrombectomy for Symptomatic Mesenteric Venous Occlusion. Vascular 2007, 15(1): 45-49

47. Lumsden AB, Rice TW, Chen C, Zhou W, Lin PH, Bray P, Morissett J, Nambi V, Ballantyne C. Peripheral Arterial Occlusive Disease: MRI Imaging and the Role of Aggressive Medical Management. World Journal of Surgery, 2007, 31(4):695-704

48. Mussa FF, Lin PH, Hedayati N, Naoum J, Zhou W, Yao Q, Kougias P, and Chen C. Comparison of AngioJet Rheolytic Pharmacomechanical Thrombectomy versus AngioJet Rheolytic Thrombectomy in a Porcine Peripheral Arterial Model. World Journal of Surgery, 2007, 31(4):715-22

49. Lin PH, Okada T, Steinberg JL, Zhou W, El Sayed HF, Rawat A, Kougias P, Yao Q, and Chen C. Rheolytic Pharmacomechanical Thrombectomy in Experimental Chronic Deep Vein Thrombosis: Effect of L-Arginine on Thrombogenicity and Endothelial Vasomotor Function. World Journal of Surery, 2007, 31(4):664-75

50. Mussa FF, Peden EK, Zhou W, Lin PH, Lumsden AB, Bush RL. Balloon Angioplasty and Stenting for Venous Outflow Obstruction of the Lower Extremity. Texas Heart Journal 2007, 34(1):60-6

51. Guerrero MA, Zhou W, Kougias P, El Sayed H, Lin, PH. Multiple Giant Anastomotic Pseudoaneurysms of Carotid and Femoral Arteries: Combined Endovascular and Open Surgical Approach. Vascular 2007, 15(3):158-61

52. Kougias P, Lin PH, Dardik A, Lee WA, El Sayed H, Zhou W. Successful Treatment of Endotension and Aneurysm Sac Enlargement with Endovascular Stent-graft Reinforcement. Journal of Vascular Surgery 2007, 46(1): 124-7

53. Naoum JJ, Silberfein EJ, Zhou W, Sweeney JF, Albo D, Brunicardi FC, Kougias P, El Sayed HF, Lin PH. Concomitant Intraoperative Splenic Artery Embolization and Laparoscopic Splenectomy versus Laparoscopic Splenectomy: Comparison of Treatment Outcome. Am J Surgery 2007, 193(6):713-8

54. Lin PH, El Sayed HF, Kougias P, Zhou W, Lemaire SA, Coselli JS. Endovascular repair of thoracic aortic disease: overview of current devices and clinical results. Vascular. 2007;15(4):179-90

55. Kougias P, El Sayed, H, Zhou W, Lin PH. Management of Chronic Mesenteric Ischemia. The Role of Endovascular Therapy. Journal of Endovascular Therapy 2007; 14(3): 395-405

56. Silberfein EJ, Zhou W, Kougias P, El Sayed HF, Huynh TT, Albo D, Berger DH, FC Brunicardi, Lin PH. Percutaneous cholecystostomy for acute cholecystitis in high-risk patients: experience of a surgeon-initiated interventional program. The American Journal of Surgery, 2007; 194(5): 672-7

57. Kougias P, Lau D, El Sayed, H, Zhou W, Huynh TT, Lin PH. Determinants of Mortality and Treatment Outcome Following Surgical Interventions for Acute Mesenteric Ischemia. Journal of Vascular Surgery 2007; 46(3):467-474

58. Zhou W, Huynh TT, Kougias P, El Sayed HF, Lin PH. Traumatic Carotid Artery Dissection Caused by Bungee Jumping. Journal of Vascular Surgery 2007; 46(5):1044-6

59. Lin PH, Zhou W, Kougias P, El Sayed HF, Barshes NR, Huynh TT. Factors Associated with Hypotension and Bradycardia after Carotid Angioplasty and Stenting. Journal of Vascular Surgery 2007; 46(5):846-54.

60. Hedayati N, Kougias P, El Sayed HF, Zhou W, Huynh TT, Lin PH. Dual Guidewire Placement to Enhance Arch Vessel Origin Identification: A Simple Technique to Facilitate Ostial Aortic Arch Vessel Stenting. Journal of Vascular Surgery 2007, 46(6):1274-6

61. Daniel JC, Huynh TT, Zhou W, Kougias P, El Sayed HF, Huh J, and Coselli JS, Lin PH. Acute Aortic Dissection Associated with Use of Cocaine. Journal of Vascular Surgery 2007; 46(3):427-33

62. Guerrero MA, Zhou W, El-Sayed HF, Kougias P, Lin PH. Subscapsular Hematoma of the Kidney Secondary to Paintball Pellet Injuries. Journal of Emergency Medicine 2007

63. Hedayadi N, Lin PH, Lumsden AB, Zhou W. Prolonged Renal Artery Occlusion Following EVAR: Endovascular Rescue and Renal Function Salvage. Journal of Vascular Surgery 2007; 46(6):1274-6

64. Zhou W, Felkai DD, Evans M, McCoy SA, Lin PH, Kougias P, El-Sayed HF, and Lumsden AB. Ultrasound Criteria for Severe In-Stent Restenosis Following Carotid Artery Stenting. Journal of Vascular Surgery 2008; 47(1):74-80

65. Chai H, Dong Y, Wang X, Zhou W. Ginsenoside Rb1 attenuates homocysteine-augmented guidewire injury-induced intimal hyperplasia in mice. Journal of Surgical Research 2009, 157(2):193-8

66. Tedesco MM, Dalman RL, Zhou W, Coogan SM, Lane B, Lee JT. Reduction of postprocedure microemboli following retrospective quality assessment and practice improvement measures for carotid angioplasty and stenting. J Vasc Surg. 2009, 49(3): 607-12

67. Chai H, Aghaie K, Zhou W. Soluble CD40 Ligand Induces Human Coronary Artery Smooth Muscle Cells Proliferation and Migration. Surgery 2009, 146(1): 5-11

68. Zhou W, Dinishak D, Lane B, Hernandez-Boussard T, Bech F, Rosen A. Long-term Radiographic Outcomes of Microemboli following Carotid Interventions. J Vasc Surg. 2009, 50(6):1314-9

69. Casey K, Zhou W, Tedesco MM, Al-Khatib WK, Hernandez-Boussard T, Bech F. Fate of the External Carotid Artery Following Carotid Interventions. International Journal of Angiology 2009, 18(4): 173- 176

70. Chai H, Schultz, G, Aghaie K, Zhou W. In vivo assessment of the effects of ginsenoside Rb1 on intimal hyperplasia in ApoE knockout mice. Journal of Surgical Research 2010, 162(1): 26-32

71. Zhou W, Chai H, Ding R, Lam HY. Distribution of Inflammatory Mediators in Carotid and Femoral Plaques. Journal of the American College of Surgeons 2010, 211(1): 92-8

72. Zhou W. Radiation exposure of Vascular Patients: Beyond Endovascular. Journal of Vascular Surgery, 2011, 53(1suppl):39s-43s

73. Casey K, Al-Khatib, Zhou W. Hypogastric Artery Preservation during Aortoiliac Aneurysm Repair. Annual of Vascular Surgery 2010, 25(1): 133. e1-8

74. Wang AS, Liang DH, Bech F, Lee J, Zarins C, Zhou W, Taylor CA. Validation of a Power Law Model in Upper Extremity Vessels: Potential Application in Ultrasound Bleed Detection. Ultrasound in Medicine and Biology, 2012; 38(4): 692-701

75. Ding Q, Tsao J, Chai H, Mochly-Rosen D, Zhou W. Therapeutic Potential for Protein Kinas C Inhibitor in Vascular Restenosis. Journal of Cardiovascular Pharmacology and Therapeutics 2011 Jun; 16(2):160-7

76. Ding Q, Chai H, Mahmood N, Tsao J, Mochly-Rosen D, and Zhou W. Matrix Metalloproteinases Modulated by PKCε Mediate Resistin-Induced Migration of Human Coronary Artery Smooth Muscle Cells. Journal of Vascular Surgery 2011; 53(4):1044-51

77. Zhou W, Zareie R, Tedesco N, Gholibeikian S, Lane B, Hernandez-Boussard T, Rosen A. Risk Factors Predictive of CAS-associated Subclinical Microemboli. Internal Journal of Angiology 2011; 20(1):025-32

78. Ding Q, White S, Ling C, Zhou W. Resistin and cardiovascular disease. Trends in Cardiovascular Medicine, 2011, 21(1): 20-7

79. Minter RM, Angelos P, Coimbra R, Dale P, de Vera ME, Hardacre J, Hawkins W, Kirkwood K, Mathews JB, McLoughlin J, Peralta E, Zhou W, Schwarze ML. Ethical management of conflict of interest: proposed standards for academic surgical societies. J Am College of Surg. 2011; 13(5):677-82

80. Wang AS, Liang DH, Bech F, Lee JT, Zarins CK, Zhou W, Taylor CA. Validation of Power Law Model in Upper Extremity Vessels: Potential Application in Ultrasound Bleeding Detection. Ultrasound in Medicine and Biology. 2012; 38(4):692-701

81. Abbott et al. Why United States Center for Medicare and Medicaid Services Should not Extend Reimbursement Indications for Carotid Artery Angioplasty/Stenting. European Journal of Vascular and Endovascular Surgery, 2012;

82. Abbott et al. Why United States Center for Medicare and Medicaid Services Should not Extend Reimbursement Indications for Carotid Artery Angioplasty/Stenting. Vascular, 2012; 20(1): 1-7.

83. Mitkov M, Al-Khatib WK, and Zhou W. Concurrent treatment of acute pancreatitis and multiple visceral artery aneurysms using endovascular techniques. Vasc Endovascular Surg, 2012, 46(3): 283-6

84. Zhou W. Hitchner E, Gillis K, Sun L, Floyd R, Lane B, Rosen A. Prospective Neurocognitive Evaluation of Patients Undergoing Carotid Interventions, Journal of Vascular Surgery, 2012, 56(6):1571-8

85. Casey K, Hitchner E, Lane B, Zhou W. Series on Contralateral Microemboli Following CAS in Patients with Occluded ICA. Journal of Vascular Surgery, 2013; 58(3): 794-797

86. Lederle FA, Freischlag JA, Kyriakides TC, Matsumura JS, Padberg FT Jr, Kohler TR, Kougias P, Jean-Claude JM, Cikrit DF, Swanson KM; OVER Veterans Affairs Cooperative Study Group. Longterm comparison of endovascular and open repair of abdominal aortic aneurysm. N Engl J Med. 2012 Nov 22;367(21):1988-97

87. Lederle FA, Stroupe KT; Open Versus Endovascular Repair (OVER) Veterans Affairs Cooperative Study Group. Cost-effectiveness at two years in the VA Open Versus Endovascular Repair Trial. Eur J Vasc Endovasc Surg. 2012;44(6):543-8

88. Stroupe KT, Lederle FA, Matsumura JS, Kyriakides TC, Jonk YC, Ge L, Freischlag JA; Open Versus Endovascular Repair (OVER) Veterans Affairs Cooperative Study Group. Cost-effectiveness of open versus endovascular repair of abdominal aortic aneurysm in the OVER trial. J Vasc Surg. 2012 Oct;56(4):901-9

89. Ascher E, Farber A, Kalra M, Timaran CH, Zhou W. Beyond borders: Proceedings from the 2011 WFVS meeting and selected international papers. Introduction. J Vasc Surg. 2013 Feb;57(2 Suppl):1S-2S.

90. Abbott A et al. Why calls for more routine carotid stenting are currently inappropriate. Stroke, 2013 (In Press)

91. Chandra V, Dorsey C, Reed AB, Shaw P, Banghart D, Zhou W. Monitoring of Fetal Radiation Exposure During Pregnancy. Journal of Vascular Surgery, 2013; 58(3): 710-714

92. Blay E, Zhou W. Rapid renal function deterioration: an unusual presentation of coral reef plaque. Annual of Vascular Surgery, 2014; 28(1):260

93. Hitchner E, Zayed MA, Lee G, Morrison D, Lane B, Zhou W. Intravascular Ultrasound as a Clinical Adjunct For Carotid Plaque Characterization. Journal of Vascular Surgery, 2014; 59(3);774-80

94. The use of Cryopreserved Aortoiliac Allograft for Aortic Reconstruction in the United States. Journal of Vascular Surgery, 2014; 59(3): 669-74.

95. Hedayati N, Humphrey M, Zhou W. Gender and Outcomes of Carotid Artery Interventions. Vascular and Endovascular Surgery, 2014; 48(2);99-105.

96. Zhou W, Blay E, Varu V, Ali S, Jin M, Sun L, Joh J. Outcome and Clinical Significance of Delayed Endoleaks Following Endovascular Aneurysm Repair. Journal of Vascular Surgery, 2014; 59(4):915-20

97. Hitchner E, Zayed M, Varu V, Lee G, Aalami O, Zhou W. Utility of IVUS during Percutaneous Superficial Femoral Artery Interventions. Annual of Vascular Surgery, 2015; Jan;29(1):28-33

98. Zuniga M, White S, Zhou W. Design and utilization of macrophage and vascular smooth muscle cell co-culture systems in atherosclerotic cardiovascular disease investigation. Vascular Medicine, 2014. Oct;19(5):394-406

99. Zayed MA, Hitchner E, Gholibeikian S, Rosen A, Lane B, Zhou W. Patient Characteristics Can Influence the Incidence of Perioperative Microemboli during Carotid Artery Interventions. Journal of Angiology 2015

100. Hitchner E, Zhou W. Utilization of Intravascular Ultrasound during Carotid Artery Stenting. Int J Angiol. 2015 Sep;24(3):185-8. (PMID: 26417186)

101. Itoga N, Woo K, Grenon M, Bismuth J, Bechara C, Mitchell E, and Zhou W. A Rising Diverse Generation of Vascular Surgery Workforce. Annual of Vascular Surgery 2015. Oct;29(7):1484-6. PMID: 26253044

102. Lal BK, Zhou W, Li Z, Kyriakides T, Matsumura J, Lederle FA, Freischlag J; OVER Veterans Affairs Cooperative Study Group. Predictors and outcomes of endoleaks in the Veterans Affairs Open Versus Endovascular Repair (OVER) Trial of Abdominal Aortic Aneurysms. J Vasc Surg. 2015 Dec; 62(6):1394-404. (PMID: 26598115)

103. Itoga N, Colvard B, Hitchner E, Sun Q, Long B, Lee G, Aalami O, Zhou W. SPY Technology as an Adjunctive Measure for Lower extremity Perfusion. Journal Vascular Surgery, 2016; 64(1):195- 201. (PMID: 26994959)

104. Hitchner E, Morrison D, Liao P, Rosen A, Zhou W. Genetic Polymorphisms Influence Cognition in Patients Undergoing Carotid Interventions. International Journal of Angiology 2016; 25(3):168-73. (PMID: 27574384)

105. Itoga N, Ullery B, Tran K, Lee G, Aalami O, Bech F, Zhou W. Utilization of a Proactive Duplex Ultrasound Protocol for Hemodialysis Access. Journal of Vascular Surgery, 2016 May 13. (PMID: 27183858)

106. Soman S, Prasad G, Hitchner E, Massaband P, Moseley M, Zhou W, Rosen A. Brain Structural Connectivity Distinguishes Patients at Risk for Cognitive Decline after Carotid Interventions. Human Brain Mapping, 2016;37(6):2185-94 (PMID: 27028955)

107. Zuniga MC, Tran TB, Baughman BD, Raghuraman G, Hitchner E, Allyson Rosen A, Robinson W, Zhou W. A Prospective Evaluation of Systemic Biomarkers and Cognitive Function Associated with Carotid Revascularization. Annals of Surgery, 2016; 264(4): 659-65 (PMID: 27433899)

108. Hitchner E, Baughman BD, Soman S, Long B, Rosen A, Zhou W. Microembolization is associated with transient cognitive decline in patients undergoing carotid interventions. Journal of Vascular Surgery, 2016, (16): 30842-4, (PMID: 27633169)

109. Raghuraman G, Zuniga MC, Yuan H, Zhou W. PKCε mediates resistin-induced NADPH oxidase activation and inflammation leading to smooth muscle cell dysfunction and intimal hyperplasia. Atherosclerosis, 2016 Aug 20; 253: 29-37. (PMID: 27573736)

110. Tran TB, Raghuraman B, Zuniga M, Hitcher E, Soman S, Max Wintermark M, Zhou W. Systemic Biomarkers Predict Volume of Emboli Associated with Carotid Revascularizations. JACS, 2016

111. Zhou W. Baughman BD, Soman S, Wintermar M, Lazzeroni LC, Hitchner E, Bhah J, Rosen A. Volume of Subclinical Embolic Infarct Correlates to Long-term Cognitive Changes following Carotid Revascularization. Journal of Vascular Surgery 2016 (In Press)

112. Raghuraman G, Hsiung J, Zuniga MC, Baughman BD, Hitchner E, Guzman R, and Zhou W. Eotaxin augments calcification in vascular smooth muscle cells. Journal of Cellular Biochemistry 2016 Sep 28. doi: 10.1002/jcb.25752. [Epub ahead of print]. PMID: 27681294

113. Wu S, Pollak R, Frykberg R, Zhou W, Karnoub M, Jankovic V, Fischkoff S, Chitkara D. Safety and Efficacy of Intramuscular Human Placenta-Derived Mesenchymal Stromal-like Cells (cenplacel [PDA-002]) in Patients Who Have a Diabetic Foot Ulcer With Peripheral Arterial Disease. International Wound Journal, 2017 (In Press)

114. Zuniga M, Raghuraman G, Weyand C, Robinson W, Zhou W. PKC-epsilon and TLR4 synergistically Regulate Resistin-mediated Macrophage Inflammation in Human Macrophage Atherosclerosis. Atherosclerosis 2017 (In Press)

Degrees

M.D. Medical Degree

New York Medical College, Valhalla, New York, United States

B.S. (Sum Cum Laude) Biochemistry & Cell Biology/Psychology

University of California - San Diego, San Diego, California, United States

Work Experience

University of Arizona, Banner University Medical Center (2017 - Ongoing)
Stanford University, Stanford, California (2012 - 2017)
Palo Alto VA Medical Center (2007 - 2017)
Standord University (2007 - 2012)
Cardiovascular Institute - Stanford University (2007 - 2011)

Awards

Professor John B. Chang Research Achievement Award

College of International Angiology, Fall 2024

President, Western Vascular Surgery Society

Western Vascular Society, Fall 2023

President-Elect

International College of Angiology, Spring 2023

NIH NHLBI Mentored Clinical and Basic Science Review Committee

NIH, Fall 2019

NIH, BTSS Study Selection

National Institute of Health, Summer 2018

VA Merit CARB (Cardiovascular) Study Section

US Dept of Veteran Affairs, Spring 2018

Licensure & Certification

Medical License, Medical Board of Texas (2005)
General Surgery, American College of Surgeons (2004)
Medical License, Arizona Board of Medical Examiners (2016)
Medical License, Medical Board of California (2000)
Medical License, Medical Board of Arizona (2016)
Vascular Surgery, American College of Surgeons (2006)

Interests

Research

Atherosclerosis and Vulnerable Plaques Neurocognition and Neuroimaging

Courses

2021-22 Courses

Research

PS 900 (Spring 2022)
Thesis

CMM 910 (Spring 2022)
Rsrch Meth Psio Sci

PS 700 (Fall 2021)
Thesis

CMM 910 (Fall 2021)

2020-21 Courses

Thesis

CMM 910 (Summer I 2021)
Thesis

CMM 910 (Spring 2021)
Thesis

CMM 910 (Fall 2020)

2019-20 Courses

Thesis

CMM 910 (Spring 2020)

Scholarly Contributions

Chapters

Zhou, W., & DeVito, P. (2022). Carotid Surgery: Interposition/Endarterectomy (Including Eversion)/Ligation. In Operative Techniques in Vascular Surgery(pp Chapter 3). Kellie Brown (Editor).
Zhou, W., & Howell, C. (2022). Cerebral Artery Disease: Unstable carotid plaque. In Rutherford's Vascular Surgery and Endovascular Therapy(pp 1179-1184). Elsevier.
Zhou, W., & Succar, B. (2022). Does Carotid Intervention Improve Cognitive Function?. In Advances in Surgery(pp Chapter 19, Vol 57). Editor: Mark Eskandari.
Ashton, L., & Zhou, W. (2019). Acquired Abdominal Arteriovenous Fistula. In Vascular Decision Making: Medical, Endovascular and Surgical. Editor: RJ Valentine & JF Edit.
Weinkauf, C., & Zhou, W. (2019). Carotid Artery Stenting. In Scientific American Vascular and Endovascular Surgery(pp on-line). Vascular Territories: Decker.
Zhou, W. (2018). Acquired Abdominal Arteriovenous Fistula. In Vascular Decision Making: Medical, Endovascular and Surgical.

Journals/Publications

Menard, M. T., Farber, A., Powell, R. J., Rosenfield, K., Conte, M. S., Hamza, T. H., Kaufman, J. A., Cziraky, M. J., Creager, M. A., Dake, M. D., Jaff, M. R., Reid, D., Sopko, G., White, C. J., Strong, M. B., van Over, M., Chisci, E., Goodney, P. P., Gray, B., , Kayssi, A., et al. (2024). Quality of Life in Patients With Chronic Limb-Threatening Ischemia Treated With Revascularization. Circulation, 149(16), 1241-1253.
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In the BEST-CLI trial (Best Endovascular Versus Best Surgical Therapy for Patients With Chronic Limb-Threatening Ischemia), a prespecified secondary objective was to assess the effects of revascularization strategy on health-related quality of life (HRQoL).
Nguyen, D., D'Andrea, M., Joule, D., Kulwin, J., Rojas, C., & Zhou, W. (2024). Barriers to Antiplatelet and Statin Adherence Following Major Vascular Intervention. Annals of vascular surgery, 106, 360-368.
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Antiplatelets and statins therapies are associated with improved cardiovascular outcomes following major vascular intervention. Many vascular surgery institutions are reporting improved prescribing rates for aspirin (ASA), P2Y12 antagonists, and statins. Nevertheless, there remains limited publication describing rates and patient-perceived barriers for postoperative adherence. The purpose of this study is to investigate patient nonadherence to antiplatelet and statin therapies following major vascular intervention.
Secemsky, E. A., Aronow, H. D., Kwolek, C. J., Meissner, M., Muck, P. E., Parikh, S. A., Winokur, R. S., George, J. C., Salazar, G., Murphy, E. H., Costantino, M. M., Zhou, W., Li, J., Lookstein, R., & Desai, K. R. (2024). Intravascular Ultrasound Use in Peripheral Arterial and Deep Venous Interventions: Multidisciplinary Expert Opinion From SCAI/AVF/AVLS/SIR/SVM/SVS. Journal of vascular and interventional radiology : JVIR, 35(3), 335-348.
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Percutaneous revascularization is the primary strategy for treating lower extremity venous and arterial disease. Angiography is limited by its ability to accurately size vessels, precisely determine the degree of stenosis and length of lesions, characterize lesion morphology, or correctly diagnose postintervention complications. These limitations are overcome with use of intravascular ultrasound (IVUS). IVUS has demonstrated the ability to improve outcomes following percutaneous coronary intervention, and there is increasing evidence to support its benefits in the setting of peripheral vascular intervention. At this stage in its evolution, there remains a need to standardize the use and approach to peripheral vascular IVUS imaging. This manuscript represents considerations and consensus perspectives that emerged from a roundtable discussion including 15 physicians with expertise in interventional cardiology, interventional radiology, and vascular surgery, representing 6 cardiovascular specialty societies, held on February 3, 2023. The roundtable's aims were to assess the current state of lower extremity revascularization, identify knowledge gaps and need for evidence, and determine how IVUS can improve care and outcomes for patients with peripheral arterial and deep venous pathology.
Succar, B., Chou, Y. H., Hsu, C. H., Rapcsak, S., Trouard, T., & Zhou, W. (2024). Carotid Revascularization is Associated with Improved Mood in Patients with Advanced Carotid Disease. Annals of surgery.
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To investigate the impact of carotid interventions on patients' mental condition in patients with carotid stenosis.
Succar, B., D'Andrea, M., Ashouri, Y., Wolf, S., Chiu-Hsieh, H., & Zhou, W. (2024). Outcomes and Imaging Surveillance Adherence in Juxta-Renal Aortic Aneurysms Repairs: A VASQIP Retrospective Study. Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 15266028241284272.
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Fenestrated endovascular aortic repair (FEVAR) has demonstrated its value in the management of juxtarenal abdominal aortic aneurysms (JAAA), but data were largely derived from clinical trials and high-volume centers. Although routine imaging surveillance is recommended following endovascular interventions, little is known regarding follow-up compliance post-FEVAR. We examined the real-world treatment outcomes and adherence to the postoperative follow-up protocol after elective interventions for JAAA at Veteran Affairs (VA) health care facilities, the largest integrated health care system in the United State.
Wolf, S., Ashouri, Y., Succar, B., Hsu, C. H., Abuhakmeh, Y., Goshima, K., Devito, P., & Zhou, W. (2024). Follow-up compliance in patients undergoing abdominal aortic aneurysm repair at Veterans Affairs hospitals. Journal of vascular surgery, 80(1), 89-95.
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The Society for Vascular Surgery guidelines recommend annual imaging surveillance following endovascular aneurysm repair (EVAR) and every 5 years following open surgical repairs (OSR) of abdominal aortic aneurysms (AAAs). Adherence to these guidelines is low outside of clinical trials, and compliance at Veterans Affairs (VA) hospitals is not yet well-established. We examined imaging follow-up compliance and mortality rates after AAA repair at VA hospitals.
Bath, J., D'Oria, M., Rogers, R. T., Colglazier, J. J., Braet, D. J., Coleman, D. M., Scali, S. T., Back, M. R., Magee, G. A., Plotkin, A., Dueppers, P., Zimmermann, A., Afifi, R. O., Khan, S., Zarkowsky, D., Dyba, G., Soult, M. C., Mani, K., Wanhainen, A., , Setacci, C., et al. (2023). Contemporary outcomes after treatment of aberrant subclavian artery and Kommerell's diverticulum. Journal of vascular surgery, 77(5), 1339-1348.e6.
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Aberrant subclavian artery (ASA) and Kommerell's diverticulum (KD) are rare vascular anomalies that may be associated with lifestyle-limiting and life-threatening complications. The aim of this study is to report contemporary outcomes after invasive treatment of ASA/KD using a large international dataset.
Fermawi, S. A., Tolson, J. P., Knapp, S. M., Marrero, D., Zhou, W., Armstrong, D. G., & Tan, T. W. (2023). Disparities in preventative diabetic foot examination. Seminars in vascular surgery, 36(1), 84-89.
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The objective of this study was to assess the overall differences in the standard of preventive foot care for patients at risk of diabetic foot ulceration and to identify specific demographic factors affecting these health care practices, including race and ethnicity. The National Health and Nutrition Examination Survey data for 2011 to 2018 were analyzed. Participants (20 years and older) with diabetes were categorized as White, Black, Hispanic, Asian, and others (including multiracial participants) based on self-reported race and ethnicity. The primary outcome was foot examination over the past year administered by a medical professional. Logistic regression was performed to examine the effects of race and ethnicity on the annual diabetic foot examination, controlling for age (65 years and older), gender, and health insurance status. Among the 2,836 participants included in the study (weighted percentage: 61.1% were White, 13.9% were Black, 15.1% were Hispanic, 5.4% were Asian, and 4.5% were other), 2,018 (weighted percentage: 71.6%) received annual diabetic foot examination over the past year. Hispanic participants (adjusted odds ratio [aOR] = 0.685; 95% CI, 0.52-0.90) were significantly less likely than White participants to receive an annual foot examination (Black participants: aOR = 1.11; 95% CI, 0.83-1.49; Asian participants: aOR = 0.80; 95% CI, 0.60-1.07; other participants: aOR = 0.66; 95% CI, 0.40-1.10). Factors associated with receipt of foot examination were age 65 years or older (aOR = 1.42; 95% CI, 1.05-1.92) and having health insurance (aOR = 3.02; 95% CI, 2.27-4.03). Our findings suggest that Hispanic adults with diabetes are receiving disproportionately lower rates of preventive foot care compared with their White counterparts. This significant variation in the standard of care for individuals with diabetes reflects the need to further identify factors driving the disparities in preventive foot care services among racial and ethnic minority groups.
Hsu, C. H., He, Y., Hu, C., & Zhou, W. (2023). A multiple imputation-based sensitivity analysis approach for regression analysis with a missing not at random covariate. Statistics in medicine, 42(14), 2275-2292.
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Missing covariate problems are common in biomedical and electrical medical record data studies while evaluating the relationship between a biomarker and certain clinical outcome, when biomarker data are not collected for all subjects. However, missingness mechanism is unverifiable based on observed data. If there is a suspicion of missing not at random (MNAR), researchers often perform sensitivity analysis to evaluate the impact of various missingness mechanisms. Under the selection modeling framework, we propose a sensitivity analysis approach with a standardized sensitivity parameter using a nonparametric multiple imputation strategy. The proposed approach requires fitting two working models to derive two predictive scores: one for predicting missing covariate values and the other for predicting missingness probabilities. For each missing covariate observation, the two predictive scores along with the pre-specified sensitivity parameter are used to define an imputing set. The proposed approach is expected to be robust against mis-specifications of the selection model and the sensitivity parameter since the selection model and the sensitivity parameter are not directly used to impute missing covariate values. A simulation study is conducted to study the performance of the proposed approach when MNAR is induced by Heckman's selection model. Simulation results show the proposed approach can produce plausible regression coefficient estimates. The proposed sensitivity analysis approach is also applied to evaluate the impact of MNAR on the relationship between post-operative outcomes and incomplete pre-operative Hemoglobin A1c level for patients who underwent carotid intervetion for advanced atherosclerotic disease.
Lu, W., Lin, Y., Haider, N., Moly, P., Wang, L., & Zhou, W. (2023). Ginsenoside Rb1 protects human vascular smooth muscle cells against resistin-induced oxidative stress and dysfunction. Frontiers in cardiovascular medicine, 10, 1164547.
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Resistin has been shown to play a key role in inducing vascular smooth muscle cells (VSMCs) malfunction in the atherosclerosis progression. Ginsenoside Rb1 is the main component of ginseng, which has been used for thousands of years and has been reported to have a powerful vascular protective effect. The aim of this study was to explore the protective effect of Rb1 on VSMCs dysfunction induced by resistin. In the presence or absence of Rb1, human coronary artery smooth muscle cells (HCASMC) were treated at different time points with or without 40 ng/ml resistin and acetylated low-density lipoprotein (acetylated LDL). Cell migration and proliferation were analyzed using wound healing test and CellTiter Aqueous Cell Proliferation Assay (MTS) test, respectively. Intracellular reactive oxygen species (ROS) (H2DCFDA as a dye probe) and superoxide dismutase (SOD) activities were measured by a microplate reader and the differences between groups were compared. Rb1 significantly reduced resistin-induced HCASMC proliferation. Resistin increased HCASMC migration time-dependently. At 20 µM, Rb1 could significantly reduce HCASMC migration. Resistin and Act-LDL increased ROS production to a similar level in HCASMCs, while Rb1 pretreated group reversed the effects of resistin and acetyl-LDL. Besides, the mitochondrial SOD activity was significantly reduced by resistin but was restored when pretreated with Rb1. We confirmed the protection of Rb1 on HCASMC and suggested that the mechanisms involved might be related to the reduction of ROS generation and increased activity of SOD. Our study clarified the potential clinical applications of Rb1 in the control of resistin-related vascular injury and in the treatment of cardiovascular disease.
Moffatt, C., Bath, J., Rogers, R. T., Colglazier, J. J., Braet, D. J., Coleman, D. M., Scali, S. T., Back, M. R., Magee, G. A., Plotkin, A., Dueppers, P., Zimmermann, A., Afifi, R. O., Khan, S., Zarkowsky, D., Dyba, G., Soult, M. C., Mani, K., Wanhainen, A., , Setacci, C., et al. (2023). International Multi-Institutional Experience with Presentation and Management of Aortic Arch Laterality in Aberrant Subclavian Artery and Kommerell's Diverticulum. Annals of vascular surgery, 95, 23-31.
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Aberrant subclavian artery (ASA) with or without Kommerell's diverticulum (KD) is a rare anatomic aortic arch anomaly that can cause dysphagia and/or life-threatening rupture. The objective of this study is to compare outcomes of ASA/KD repair in patients with a left versus right aortic arch.
Succar, B., Chou, Y. H., Hsu, C. H., Rapcsak, S., Trouard, T., & Zhou, W. (2023). Cognitive effects of carotid revascularization in octogenarians. Surgery, 174(4), 1078-1082.
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Cognitive impairment is the epitome of cerebrovascular diseases, causing a significant economic burden on our health care system. Growing evidence has indicated the benefits of carotid interventions in patients with severe carotid atherosclerosis. However, the neurocognitive outcome of carotid revascularization in octogenarians is not clearly understood. We aim to evaluate postintervention cognitive changes in seniors older than 80 years.
Chhabra, J. S., & Zhou, W. (2022). Complicated Open Repair of Type B Aortic Dissection in a Patient With Ehlers-Danlos Syndrome Rescued by Endovascular Intervention. Vascular and endovascular surgery, 56(5), 525-528.
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Ehlers-Danlos is a connective tissue disorder characterized by hypermobile joints, hyperextensible skin, and increased bleeding tendency. We report a case involving endovascular repair of an intussusception of aortic dissection that occurred in an Ehlers-Danlos patient following surgical repair of an intercostal artery bleed. Given the rarity of Ehlers-Danlos, continued reporting of treatment outcomes is important for refining complication management in this population. Our experience lends support for endovascular rescue of failed aortic repair that may arise in Ehlers-Danlos patients and contributes to the otherwise small body of literature concerning endovascular intervention in this population overall.
Eid, M. A., Barnes, J. A., Mehta, K., Wanken, Z., Columbo, J., Kang, R., Newhall, K., Halpern, V., Raffetto, J., Kougias, P., Henke, P., Tang, G., Mureebe, L., Johanning, J., Tzeng, E., Scali, S., Stone, D., Suckow, B., Lee, E., , Arya, S., et al. (2022). Factors associated with preference of choice of aortic aneurysm repair in the PReference for Open Versus Endovascular repair of AAA (PROVE-AAA) study. Journal of vascular surgery, 76(6), 1556-1564.
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Patients can choose between open repair and endovascular repair (EVAR) of abdominal aortic aneurysm (AAA). However, the factors associated with patient preference for one repair type over another are not well-characterized. Here we assess the factors associated with preference of choice for open or endovascular AAA repair among veterans exposed to a decision aid to help with choosing surgical treatment.
Eid, M. A., Barry, M. J., Tang, G. L., Henke, P. K., Johanning, J. M., Tzeng, E., Scali, S. T., Stone, D. H., Suckow, B. D., Lee, E. S., Arya, S., Brooke, B. S., Nelson, P. R., Spangler, E. L., Murebee, L., Dosluoglu, H. H., Raffetto, J. D., Kougais, P., Brewster, L. P., , Alabi, O., et al. (2022). Effect of a Decision Aid on Agreement Between Patient Preferences and Repair Type for Abdominal Aortic Aneurysm: A Randomized Clinical Trial. JAMA surgery, 157(9), e222935.
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Patients with abdominal aortic aneurysm (AAA) can choose open repair or endovascular repair (EVAR). While EVAR is less invasive, it requires lifelong surveillance and more frequent aneurysm-related reinterventions than open repair. A decision aid may help patients receive their preferred type of AAA repair.
Farber, A., Menard, M. T., Conte, M. S., Kaufman, J. A., Powell, R. J., Choudhry, N. K., Hamza, T. H., Assmann, S. F., Creager, M. A., Cziraky, M. J., Dake, M. D., Jaff, M. R., Reid, D., Siami, F. S., Sopko, G., White, C. J., van Over, M., Strong, M. B., Villarreal, M. F., , McKean, M., et al. (2022). Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia. The New England journal of medicine, 387(25), 2305-2316.
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Patients with chronic limb-threatening ischemia (CLTI) require revascularization to improve limb perfusion and thereby limit the risk of amputation. It is uncertain whether an initial strategy of endovascular therapy or surgical revascularization for CLTI is superior for improving limb outcomes.
Janko, M. R., Hubbard, G., Back, M., Shah, S. K., Pomozi, E., Szeberin, Z., DeMartino, R., Wang, L. J., Crofts, S., Belkin, M., Davila, V. J., Lemmon, G. W., Wang, S. K., Czerny, M., Kreibich, M., Humphries, M. D., Shutze, W., Joh, J. H., Cho, S., , Behrendt, C. A., et al. (2022). In-situ bypass is associated with superior infection-free survival compared with extra-anatomic bypass for the management of secondary aortic graft infections without enteric involvement. Journal of vascular surgery, 76(2), 546-555.e3.
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The optimal revascularization modality following complete resection of aortic graft infection (AGI) without enteric involvement remains unclear. The purpose of this investigation is to determine the revascularization approach associated with the lowest morbidity and mortality using real-world data in patients undergoing complete excision of AGI.
Succar, B., Abuhakmeh, Y., Khreiss, M., & Zhou, W. (2022). Mobile primary renal vein lipoma with an accelerated growth pattern. Journal of vascular surgery cases and innovative techniques, 8(4), 670-673.
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Primary intravascular lipoma is a rare proliferation of adipose tissue originating from the wall of blood vessels. We have described an unusual case of a benign, but fast-growing, primary intravascular lipoma of the left renal vein with the mobile edge extending to the cavoatrial junction within just a few months. We have discussed the surgical indications, management, and technical considerations and highlighted the importance of surgical planning for similar cases.
Tan, T. W., Calhoun, E. A., Knapp, S. M., Lane, A. I., Marrero, D. G., Kwoh, C. K., Zhou, W., & Armstrong, D. G. (2022). Rates of Diabetes-Related Major Amputations Among Racial and Ethnic Minority Adults Following Medicaid Expansion Under the Patient Protection and Affordable Care Act. JAMA network open, 5(3), e223991.
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It is not known whether implementation of Medicaid expansion under the Patient Protection and Affordable Care Act (ACA) was associated with improvements in the outcomes among racial and ethnic minority adults at risk of diabetes-related major amputations.
Weise, L., Chiapaikeo, D., Tan, T. W., Weinkauf, C., Goshima, K. R., & Zhou, W. (2022). Role of late renal revascularization in functional renal salvage. Journal of vascular surgery cases and innovative techniques, 8(1), 121-124.
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The duration that renal parenchyma will tolerate ischemia has continued to be debated. We have reported the cases of three patients who had undergone revascularization procedures with successful return of baseline renal function after prolonged renal artery occlusion of 14 days to 3 months. These cases highlight that aggressive revascularization can lead to successful renal salvage in selected patients. We examined the characteristics of these patients and those of others in the literature and reviewed the factors favoring recovery.
Zhou, W., Succar, B., Murphy, D. P., Ashouri, Y., Chou, Y. H., Hsu, C. H., Rapcsak, S., & Trouard, T. (2022). Carotid Intervention Improves Cognitive Function in Patients With Severe Atherosclerotic Carotid Disease. Annals of surgery, 276(3), 539-544.
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Carotid revascularization procedures are effective in stroke prevention in appropriately selected patients. We sought to understand the effects of the carotid intervention on cognitive function in a well-defined cohort of prospectively recruited patients.
AbuRahma, A. F., Avgerinos, E. D., Chang, R. W., Darling, R. C., Duncan, A. A., Forbes, T. L., Malas, M. B., Perler, B. A., Powell, R. J., Rockman, C. B., & Zhou, W. (2021). The Society for Vascular Surgery implementation document for management of extracranial cerebrovascular disease. Journal of vascular surgery.
AbuRahma, A. F., Avgerinos, E. M., Chang, R. W., Darling, R. C., Duncan, A. A., Forbes, T. L., Malas, M. B., Murad, M. H., Perler, B. A., Powell, R. J., Rockman, C. B., & Zhou, W. (2021). SOCIETY FOR VASCULAR SURGERY CLINICAL PRACTICE GUIDELINES FOR MANAGEMENT OF EXTRACRANIAL CEREBROVASCULAR DISEASE. Journal of vascular surgery.
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Management of carotid bifurcation stenosis in stroke prevention has been the subject of extensive investigations, including multiple randomized controlled trials. The proper treatment of patients with carotid bifurcation disease is of major interest to vascular surgeons and other vascular specialists. In 2011, the Society for Vascular Surgery published guidelines for treatment of carotid artery disease. At the time, several randomized trials, comparing carotid endarterectomy (CEA) and carotid artery stenting (CAS), were published. Since that publication, several studies and a few systematic reviews comparing CEA and CAS have been published, and the role of medical management has been re-emphasized. The current publication updates and expands the 2011 guidelines with specific emphasis on five areas: is carotid endarterectomy recommended over maximal medical therapy in low risk patients; is carotid endarterectomy recommended over trans-femoral carotid artery stenting in low surgical risk patients with symptomatic carotid artery stenosis of >50%; timing of carotid Intervention in patients presenting with acute stroke; screening for carotid artery stenosis in asymptomatic patients; and optimal sequence for intervention in patients with combined carotid and coronary artery disease. A separate implementation document will address other important clinical issues in extracranial cerebrovascular disease. Recommendations are made using the GRADE (Grades of Recommendation Assessment, Development and Evaluation) approach, as has been done with other Society for Vascular Surgery guidelines. The committee recommends CEA as the first-line treatment for symptomatic low risk surgical patients with stenosis of 50% to 99% and asymptomatic patients with stenosis of 70% to 99%. The perioperative risk of stroke and death in asymptomatic patients must be
Chen, W., Dyniewski, B., Bobka, T., Kraemer, C., Tan, T. W., & Zhou, W. (2021). Aneurysmal Degeneration After Paclitaxel-Eluting Balloon Angioplasty. Vascular and endovascular surgery, 55(4), 410-414.
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Aneurysmal degeneration after peripheral angioplasty is a potentially serious complication. In this case, the patient underwent repeated angioplasty of a prior vein bypass graft utilizing a paclitaxel-coated balloon. He subsequently developed a progressive aneurysmal degeneration, threatening his bypass, which ultimately required an urgent exclusion with a covered stent. This case represents a rare complication of peripheral bypass graft related to percutaneous intervention as well as paclitaxel-coated devices and warns other practitioners of the increased scrutiny and caution one should exercise in the use of such interventions.
Chen, Z., Chen, L., Shirakawa, M., Liu, W., Ortega, D., Chen, J., Balu, N., Trouard, T., Hatsukami, T. S., Zhou, W., & Yuan, C. (2021). Intracranial vascular feature changes in time of flight MR angiography in patients undergoing carotid revascularization surgery. Magnetic resonance imaging, 75, 45-50.
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To characterize the intracranial vascular features extracted from time of flight (TOF) images and their changes from baseline to follow-up in patients undergoing carotid revascularization, using arterial spin labeling (ASL) cerebral blood flow (CBF) measurement as a reference.
Janko, M. R., Woo, K., Hacker, R. I., Baril, D., Bath, J., Smeds, M. R., Kashyap, V. S., Szeberin, Z., Magee, G. A., Elsayed, R., Wishy, A., St John, R., Beck, A., Farber, M., Motta, F., Zhou, W., Lemmon, G., Coleman, D., Behrendt, C. A., , Aziz, F., et al. (2021). In situ bypass and extra-anatomic bypass procedures result in similar survival in patients with secondary aortoenteric fistulas. Journal of vascular surgery, 73(1), 210-221.e1.
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The optimal revascularization modality in secondary aortoenteric fistula (SAEF) remains unclear in the literature. The purpose of this investigation was to determine the revascularization approach associated with the lowest morbidity and mortality using real-world data in patients with SAEF.
O'Banion, L. A., Dirks, R., Farooqui, E., Saldana-Ruiz, N., Yoon, W. J., Pozolo, C., Fox, C., Crally, A., Siada, S., Nehler, M. R., Brooke, B. S., Beckstrom, J. L., Kiang, S., Boggs, H. K., Chandra, V., Ho, V. T., Zhou, W., Lee, A., Bowens, N., , Cho, Y., et al. (2021). Popliteal scoring assessment for vascular extremity injuries in trauma study. Journal of vascular surgery, 74(3), 804-813.e3.
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Traumatic popliteal vascular injuries are associated with the highest risk of limb loss of all peripheral vascular injuries. A method to evaluate the predictors of amputation is needed because previous scores could not be validated. In the present study, we aimed to provide a simplified scoring system (POPSAVEIT [popliteal scoring assessment for vascular extremity injuries in trauma]) that could be used preoperatively to risk stratify patients with traumatic popliteal vascular injuries for amputation.
O'Banion, L. A., Dirks, R., Saldana-Ruiz, N., Farooqui, E., Yoon, W. J., Pozolo, C., Fox, C. J., Crally, A., Siada, S., Nehler, M. R., Brooke, B. S., Beckstrom, J. L., Kiang, S., Boggs, H. K., Chandra, V., Ho, V. T., Zhou, W., Lee, A., Bowens, N., , Cho, Y., et al. (2021). Contemporary outcomes of traumatic popliteal artery injury repair from the popliteal scoring assessment for vascular extremity injury in trauma study. Journal of vascular surgery, 74(5), 1573-1580.e2.
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Traumatic popliteal artery injuries are associated with the greatest risk of limb loss of all peripheral vascular injuries, with amputation rates of 10% to 15%. The purpose of the present study was to examine the outcomes of patients who had undergone operative repair for traumatic popliteal arterial injuries and identify the factors independently associated with limb loss.
Patel, N., Tan, T. W., Weinkauf, C., Rice, A. H., Rottman, A. M., Pappalardo, J., Goshima, K., & Zhou, W. (2021). Economic value of podiatry service in limb salvage alliance. Journal of vascular surgery.
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Over the past decade, multidisciplinary "toe and flow" programs have gained great popularity, with proven benefits in limb salvage. Many vascular surgeons have incorporated podiatrists into their practices. The viability of this practice model requires close partnership, hospital support, and financial sustainability. We intend to examine the economic values of podiatrists in a busy safety-net hospital in the Southwest United States.
Silva, H., Tassone, C., Ross, E. G., Lee, J. T., Zhou, W., & Nelson, D. V. (2021). Collagen Fibril Orientation in Tissue Specimens from Atherosclerotic Plaque Explored Using Small Angle X-Ray Scattering. Journal of biomechanical engineering.
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Atherosclerotic plaques can gradually develop in certain arteries. Disruption of fibrous tissue in plaques can result in plaque rupture and thromboembolism, leading to heart attacks and strokes. Collagen fibrils are important tissue building blocks and tissue strength depends on how fibrils are oriented. Fibril orientation in plaque tissue may potentially influence vulnerability to disruption. While X-ray scattering has previously been used to characterize fibril orientations in soft tissues and bones, it has never been used for characterization of human atherosclerotic plaque tissue. This study served to explore fibril orientation in specimens from human plaques using small angle X-ray scattering. Plaque tissue was extracted from human femoral and carotid arteries, and each tissue specimen contained a region of calcified material. 3D collagen fibril orientation was determined along scan lines that started away from and then extended towards a given calcification. At locations several millimeters or more from a calcification, fibrils were found to be oriented predominantly in the circumferential direction of the plaque tissue. However, in a number of cases, the dominant fibril direction changed markedly near a calcification, from circumferential to longitudinal. Further study is needed to elucidate how these fibril patterns may change plaque tissue behavior.
Anderson, P. B., Wanken, Z. J., Perri, J. L., Columbo, J. A., Kang, R., Spangler, E. L., Newhall, K., Brooke, B. S., Dosluoglu, H., Lee, E. S., Raffetto, J. D., Henke, P. K., Tang, G. L., Mureebe, L., Kougias, P., Johanning, J., Arya, S., Scali, S. T., Stone, D. H., , Suckow, B. D., et al. (2020). Patient information sources when facing repair of abdominal aortic aneurysm. Journal of vascular surgery, 71(2), 497-504.
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Shared medical decision making is most important when there are competing options for repair such as in treatment of abdominal aortic aneurysm (AAA). We sought to understand the sources of patients' pre-existing knowledge about AAA to better inform treating physicians about patients' needs for preoperative counseling.
Chen, W., Lee, A., Sabat, J., DeVito, P., Kraemer, C., & Zhou, W. (2020). Diffuse Cutaneous Manifestations after Drug-Coated Balloon Angioplasty. Annals of vascular surgery, 69, 451.e1-451.e4.
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We present here a case of an uncommon cutaneous manifestation after paclitaxel-coated balloon angioplasty. In this case, the patient underwent drug-coated balloon angioplasty for stenosis of a prior vein bypass graft. The patient subsequently developed extensive cutaneous lesions not confined to a single arterial distribution. This case represents a rare complication related to paclitaxel-eluting balloons and provides a cautionary tale as well as clinical acumen for providers in using such devices in their practice.
Chun, T. T., Judelson, D. R., Rigberg, D., Lawrence, P. F., Cuff, R., Shalhub, S., Wohlauer, M., Abularrage, C. J., Anastasios, P., Arya, S., Aulivola, B., Baldwin, M., Baril, D., Bechara, C. F., Beckerman, W. E., Behrendt, C. A., Benedetto, F., Bennett, L. F., Charlton-Ouw, K. M., , Chawla, A., et al. (2020). Managing central venous access during a health care crisis. Journal of vascular surgery, 72(4), 1184-1195.e3.
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During the COVID-19 pandemic, central venous access line teams were implemented at many hospitals throughout the world to provide access for critically ill patients. The objective of this study was to describe the structure, practice patterns, and outcomes of these vascular access teams during the COVID-19 pandemic.
Fadia, R., Berman, S. S., Chong, C. C., Rybin, D., Siracuse, J. J., Zhou, W., & Tan, T. W. (2020). Upper Arm Arteriovenous Grafts are Superior over Forearm Arteriovenous Grafts in Upper Extremity Dialysis Access. Annals of vascular surgery.
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In this study, we compared the outcomes of forearm arteriovenous grafts (AVGs) and upper arm AVGs in a large, prospectively collected data set, which represents real-world experience with upper extremity prosthetic dialysis access, to determine if there are clinically significant differences in the upper arm and forearm positions.
Hsu, C. H., He, Y., Hu, C., & Zhou, W. (2020). A multiple imputation-based sensitivity analysis approach for data subject to missing not at random. Statistics in medicine, 39(26), 3756-3771.
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Missingness mechanism is in theory unverifiable based only on observed data. If there is a suspicion of missing not at random, researchers often perform a sensitivity analysis to evaluate the impact of various missingness mechanisms. In general, sensitivity analysis approaches require a full specification of the relationship between missing values and missingness probabilities. Such relationship can be specified based on a selection model, a pattern-mixture model or a shared parameter model. Under the selection modeling framework, we propose a sensitivity analysis approach using a nonparametric multiple imputation strategy. The proposed approach only requires specifying the correlation coefficient between missing values and selection (response) probabilities under a selection model. The correlation coefficient is a standardized measure and can be used as a natural sensitivity analysis parameter. The sensitivity analysis involves multiple imputations of missing values, yet the sensitivity parameter is only used to select imputing/donor sets. Hence, the proposed approach might be more robust against misspecifications of the sensitivity parameter. For illustration, the proposed approach is applied to incomplete measurements of level of preoperative Hemoglobin A1c, for patients who had high-grade carotid artery stenosisa and were scheduled for surgery. A simulation study is conducted to evaluate the performance of the proposed approach.
Jasty, V. S., Haddad, D., Mohan, B., Zhou, W., Siracuse, J. J., & Tan, T. W. (2020). Tapered and non-tapered prosthetic grafts in upper extremity dialysis access: A systematic review and meta-analysis. The journal of vascular access, 1129729820974177.
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It is unclear whether tapered arteriovenous grafts (AVGs) are superior to non-tapered AVGs when it comes to preventing upper extremity ischemic steal syndrome. We aimed to evaluate the outcomes of tapered and non-tapered AVGs using systematic review and meta-analysis.
Kraemer, C., Nisson, P., Wheeler, G., Guzmán Pérez-Carrillo, G. J., Bernstein, A., Hsu, C. H., Bock, D., Trouard, T., & Zhou, W. (2020). Patient risk factors associated with embolic stroke volumes after revascularization. Journal of vascular surgery, 72(6), 2061-2068.
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Previous research has shown that subclinical, microembolic infarcts result in long-term cognitive changes. Whereas both carotid endarterectomy (CEA) and carotid artery stenting (CAS) have potential for microembolic events, CAS has been shown to have a larger volume of infarct. We have previously shown that large-volume infarction is associated with long-term memory deterioration. The purpose of this study was to identify independent risk factors that trend toward higher embolic volumes in both procedures.
Lee, A., Haddad, D., Rybin, D., Howell, C., Ghaderi, I., Berman, S., Zhou, W., & Tan, T. W. (2020). The impact of hemoglobin A on outcomes after lower extremity bypass. Journal of vascular surgery.
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Diabetes has been shown to be associated with increased risk of postoperative complications after lower extremity bypass (LEB), although it is unclear whether medium-term glucose control affects outcomes. This study aimed to assess the association of perioperative hemoglobin A (HbA) level on perioperative outcomes after LEB.
Pandit, V., Nelson, P., Kempe, K., Gage, K., Zeeshan, M., Kim, H., Khan, M., Trinidad, B., Zhou, W., & Tan, T. W. (2020). Racial and ethnic disparities in lower extremity amputation: Assessing the role of frailty in older adults. Surgery, 168(6), 1075-1078.
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Frailty is a state of decreased physiologic reserve contributing to functional decline and is associated with adverse surgical outcomes, particularly in the elderly. Racial disparities have been reported previously both in frail individuals and in limb-salvage patients. Our goal was to assess whether race and ethnicity are disproportionately linked to frailty status in geriatric patients undergoing lower-limb amputation, leading to an increased risk of complications.
Pandit, V., Zeeshan, M., Nelson, P. R., Hamidi, M., Jhajj, S., Lee, A., Trinidad, B., Goshima, K., Horst, V., Weinkauf, C., Zhou, W., & Tan, T. W. (2020). Frailty Syndrome in Patients with Carotid Disease: Simplifying How We Calculate Frailty. Annals of vascular surgery, 62, 159-165.
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Frailty syndrome is an established predictor of adverse outcomes after carotid surgery. Recently, a modified 5-factor National Surgical Quality Improvement Program frailty index has been used; however, its utility in vascular procedures is unclear. The aim of our study was to compare the 5-factor modified frailty index (mFI-5) with the 11-factor modified frailty index (mFI-11) regarding value and predictive ability for mortality, postoperative infection, and unplanned 30-day readmission.
Tan, T. W., Armstrong, D. G., Concha-Moore, K. C., Marrero, D. G., Zhou, W., Calhoun, E., Chang, C. Y., & Lo-Ciganic, W. H. (2020). Association between race/ethnicity and the risk of amputation of lower extremities among medicare beneficiaries with diabetic foot ulcers and diabetic foot infections. BMJ open diabetes research & care, 8(1).
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This study aimed to examine the association of race and ethnicity on the risk of lower extremity amputations among Medicare beneficiaries with diabetic foot ulcers (DFUs) and diabetic foot infections (DFIs).
Yanquez, F. J., Peterson, A., Weinkauf, C., Goshima, K. R., Zhou, W., Mohler, J., Ehsani, H., & Toosizadeh, N. (2020). Sensor-Based Upper-Extremity Frailty Assessment for the Vascular Surgery Risk Stratification. The Journal of surgical research, 246, 403-410.
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Available methods for determining outcomes in vascular surgery patients are often subjective or not applicable in nonambulatory patients. The purpose of the present study was to assess the association between vascular surgery outcomes and a previously validated upper-extremity function (UEF) method, which incorporates wearable motion sensors for the physical frailty assessment.
Kraemer, C., & Zhou, W. (2019). Carotid Aneurysm Review. The International Journal of Angiology, 28(1), 17-19.
Lu, W., Wang, L., Zhou, W., & Fu, W. (2019). Augmented Reality Navigation to Assist Retrograde Peroneal Access for the Endovascular Treatment of Critical Limb Ischemia. Journal of Vascular Surgery Cases and Innovative Techniques, 5(Issue 4), 518-520.
Pandit, V., Lee, A., Zeeshan, M., Goshima, K., Tan, T. W., Jhajj, S., Trinidad, B., Weinkauf, C., & Zhou, W. (2019). Effect of frailty syndrome on the outcomes of patients with carotid stenosis. Journal of vascular surgery.
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Frailty syndrome confers a greater risk of morbidity and mortality after operative interventions. The aim of the present study was to assess the effect of frailty on the outcomes after carotid interventions, including both carotid endarterectomy (CEA) and carotid artery stenting (CAS).
Sabat, J., Bock, D., Hsu, C. H., Tan, T. W., Weinkauf, C., Trouard, T., Perez-Carrillo, G. G., & Zhou, W. (2019). Risk factors associated with microembolization after carotid intervention. Journal of vascular surgery.
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Microembolization after carotid artery stenting (CAS) and carotid endarterectomy (CEA) has been documented and may confer risk for neurocognitive impairment. Patients undergoing stenting are known to be at higher risk for microembolization. In this prospective cohort study, we compare the microembolization rates for patients undergoing CAS and CEA and perioperative characteristics that may be associated with microembolization.
Sabat, J., Hsu, C. H., Samra, N., Chu, Q., Weinkauf, C., Goshima, K., Zhou, W., & Tan, T. W. (2019). Length of Stay and ICU Stay Are Increased With Repair of Traumatic Superior Mesenteric Vein Injury. The Journal of surgical research, 242, 94-99.
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Traumatic superior mesenteric vein (SMV) injury is rare, and the ideal treatment is controversial. We compared the outcomes of ligation versus repair of SMV injury using the National Trauma Databank.
Soman, S., Dai, W., Dong, L., Hitchner, E., Lee, K., Baughman, B. D., Holdsworth, S. J., Massaband, P., Bhat, J. V., Moseley, M. E., Rosen, A., Zhou, W., & Zaharchuk, G. (2019). Identifying cardiovascular risk factors that impact cerebrovascular reactivity: An ASL MRI study. Journal of magnetic resonance imaging : JMRI.
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To maintain cerebral blood flow (CBF), cerebral blood vessels dilate and contract in response to blood supply through cerebrovascular reactivity (CR).
Tan, T. W., Shih, C. D., Concha-Moore, K. C., Diri, M. M., Hu, B., Marrero, D., Zhou, W., & Armstrong, D. G. (2019). Disparities in outcomes of patients admitted with diabetic foot infections. PloS one, 14(2), e0211481.
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The purpose of this study was to evaluate the disparities in the outcomes of White, African American (AA) and non-AA minority (Hispanics and Native Americans (NA)), patients admitted in the hospitals with diabetic foot infections (DFIs).
Tan, T., Ghaderi, I., Berman, S., Zhou, W., Zhou, W., Hu, B., Haddad, D. J., & Lee, A. (2019). IP235. The Impact of Hemoglobin A1c on Outcomes After Lower Extremity Bypass. Journal of Vascular Surgery, 69(6), e174. doi:10.1016/j.jvs.2019.04.241
Rosen, A. C., Soman, S., Bhat, J., Laird, A. R., Stephens, J., Eickhoff, S. B., Fox, P. M., Long, B., Dinishak, D., Ortega, M., Lane, B., Wintermark, M., Hitchner, E., & Zhou, W. (2018). Convergence Analysis of Micro-Lesions (CAML): An approach to mapping of diffuse lesions from carotid revascularization. NeuroImage. Clinical, 18, 553-559.
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Carotid revascularization (endarterectomy, stenting) prevents stroke; however, procedure-related embolization is common and results in small brain lesions easily identified by diffusion weighted magnetic resonance imaging (DWI). A crucial barrier to understanding the clinical significance of these lesions has been the lack of a statistical approach to identify vulnerable brain areas. The problem is that the lesions are small, numerous, and non-overlapping. Here we address this problem with a new method, the Convergence Analysis of Micro-Lesions (CAML) technique, an extension of the Anatomic Likelihood Analysis (ALE). The method combines manual lesion tracing, constraints based on known lesion patterns, and convergence analysis to represent regions vulnerable to lesions as probabilistic brain atlases. Two studies were conducted over the course of 12 years in an active, vascular surgery clinic. An analysis in an initial group of 126 patients at 1.5 T MRI was cross-validated in a second group of 80 patients at 3T MRI. In CAML, lesions were manually defined and center points identified. Brains were aligned according to side of surgery since this factor powerfully determines lesion distribution. A convergence based analysis, was performed on each of these groups. Results indicated the most consistent region of vulnerability was in motor and premotor cortex regions. Smaller regions common to both groups included the dorsolateral prefrontal cortex and medial parietal regions. Vulnerability of motor cortex is consistent with previous work showing changes in hand dexterity associated with these procedures. The consistency of CAML also demonstrates the feasibility of this new approach to characterize small, diffuse, non-overlapping lesions in patients with multifocal pathologies.
Weisbord, S. D., Gallagher, M., Jneid, H., Garcia, S., Cass, A., Thwin, S. S., Conner, T. A., Chertow, G. M., Bhatt, D. L., Shunk, K., Parikh, C. R., McFalls, E. O., Brophy, M., Ferguson, R., Wu, H., Androsenko, M., Myles, J., Kaufman, J., & Palevsky, P. M. (2018). Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine. The New England journal of medicine, 378(7), 603-614.
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Intravenous sodium bicarbonate and oral acetylcysteine are widely used to prevent acute kidney injury and associated adverse outcomes after angiography without definitive evidence of their efficacy.
Zuniga, M. C., Raghuraman, G., & Zhou, W. (2018). Physiologic levels of resistin induce a shift from proliferation to apoptosis in macrophage and VSMC co-culture. Surgery, 163(4), 906-911.
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Resistin, an adipokine with inflammatory properties, has been associated with plaque vulnerability. Vascular smooth muscle cells and macrophages are the major cellular components in advanced atherosclerotic plaques and interdependently affect plaque stability. The purpose of this study was to examine the effects of resistin on the interactions of vascular smooth muscle cells and macrophages using co-culture systems.
Zhou, W. (2017). Carotid Artery Stenting. On-Line, Scientific American Vascular and Endovascular Surgery.
Zhou, W. (2017). Eotaxin Augments Calcification in Vascular Smooth Muscel Cells. Journal of Cellular Biochemistry, 118(3), 647-654.
Zhou, W. (2017). Invited Commentary - Outcome of Endovascular Repair For Complex Abdominal Aortic Aneurysms. Journal of Vascular Surgery.
Zhou, W. (2017). Open Versus Endovascular Aneurysm Repair Trial Review. Surgery, 162(5), 974-978.
Zhou, W. (2017). PKC-Epsilon and TLR4 Synergistically Regulate Resistin-Mediated Macrophage Inflammation in Human Macrophage Atherosclerosis. Atherosclerosis, 259(4), 51-59.
Zhou, W. (2017). Safety and Efficacy of Intramuscular Human Placenta-Derived Mesenchymal Stromal-Like Cells (Cenplacel) (PDA-002) in Patients Who Have a Diabetic Foot Ulcer With Peripheral Arterial Disease. International Wound Journal, 15(3), 1419-1425.
Zhou, W. (2017). Volume of Subclinical Embolic Infarct Correlates to Long-Term Cognitive Changes Following Carotid Revascularization. Journal of Vascular Surgery, 65(3), 686-694.

Presentations

Zhou, W. (2023, April). Carotid Disease and Cognitive Function. Women's Vascular Health Summitt. Buffalo, NY.
Zhou, W. (2023, December). Revisiting Endovascular Options for Extracranial Carotid Artery Disease. Global Cardiovascular Clinical Trialists Forum. Washington DC.
Zhou, W. (2023, February). Carotid Revascularization in Symptomatic Nonocclusive Patients. International Stroke Conference. Dallas, TX.
Zhou, W. (2023, February). What do we know about desert foot?. Cardiovascular Research Technologies. Washington DC: CRT.
Zhou, W. (2023, March). Can ACS Patients Benefits from CEA or CAS? – US Vision. Veith Voice of the World. Virtual / Medellin, Columbia: Veith.
Zhou, W. (2023, March). Debate: CEA remains the gold standard. Society for Clinical Vascular Surgery. Miami, FL: SCVS.
Zhou, W. (2023, March). New Carotid Disease Guidelines: What's new?. Asociación Colombiana de Cirugía Annual Meeting. Virtual / Medellin, Columbia: Asociación Colombiana de Cirugía.
Zhou, W. (2023, May). TCAR vs. CEA; Are They Approaching Postoperative Imaging Equivalency?. Pacific Northwest Endovascular Conference. Seattle, WA.
Zhou, W. (2023, November). Debate: Carotid Intervention Improves Cognitive Function Of Patients With Severe Carotid Atherosclerosis: What About In Octogenarians: Should More ACS Patients Undergo Invasive Treatment.. Veith Annual Meeting. New York, NY: Veith.
Zhou, W. (2023, November). Debate: Not So: Silent Brain Infarcts (DW MRI Defects) After CEA/CAS Really Matter And Affect Cognitive Changes: The Size And Number Of DW MRI Defects Are Critical. . Veith Annual Meeting. New York, NY: Veith.
Zhou, W. (2023, November). Carotid Revascularization and Cognition. AHA Scientific Sessions. Philadelphia, PA: American Heart Association.
Zhou, W. (2023, September). Long-Term Followup of EVAR: Are We Underestimating Endoleaks?. International College of Angiology annual meeting. Davenport, IA: ICA.
Zhou, W. (2021, February). Symptomatic Nonstenotic Carotid Disease. Pushing the Boundary of Carotid Disease . International Stroke Conference. New Orleans, LA.
Zhou, W. (2022, April). Carotid interventions improve cognitive function in patients with severe atherosclerotic carotid disease. . American Surgical Association. Chicago IL.
Zhou, W. (2022, April). Carotid interventions improve cognitive function. Carotid Summit. Webinar: Frank Veith International Society.
Zhou, W. (2022, August). Open surgical management of abdominal aortic aneurysm. Cardiovascular Fellows' Bootcamp. Houston TX: Methodist.
Zhou, W. (2022, August). Traumatic aortic Injury. Cardiovascular Fellows' Bootcamp. Houston TX: Methodist.
Zhou, W. (2022, August). Treatment of CLTI patients with GLASS stage II Aortoiliac disease-Open first approach.
. Interactive Vascular Diagnosis and Treatment. Seoul, Korea.
Zhou, W. (2022, December). CAROTID INTERVENTIONS IMPROVE COGNITIVE FUNCTION IN PATIENTS WITH
SEVERE ATHEROSCLEROTIC CAROTID DISEASE. Annual Northwestern Vascular Symposim. Chicago, IL.
Zhou, W. (2022, February).
Endoleaks – Clinical Impact and Outcomes of Endoleaks after EVAR. . 2022 Sanctuary of Endovascular Therapy. Kiawah Island, SC.
Zhou, W. (2022, February). Retrieve a "full" EPD Filter and Managing Distal Embolization. CRT. Washington DC.
Zhou, W. (2022, February). The Cognitive Effects of TF-CAS-Related Microembolization. CRT. Washington DC.
Zhou, W. (2022, February). What do We Know about Desert Foot. . CRT. Washington DC.
Zhou, W. (2022, June). Are we missing neurocognitive changes in the setting of extracranial carotid stenosis? Unrecognized symptoms. Vascular Annual Meeting. Boston, MA: Society for Vascular Surgery.
Zhou, W. (2022, June). Simulations and Workshops in Vascular Education. World Federation of Vascular Surgery. Boston, MA.
Zhou, W. (2022, March). Cerebrovascular disease and cognitive function: is there a relation between “asymptomatic” occlusive disease and cognitive decline?. Mayo Clinic Symposium. Phoenix, AZ.
Zhou, W. (2022, March). Cognitive Effects of Carotid Endarterectomy and Carotid Stenting. XXIII Colombian Congress of Vascular Surgery and Angiology.. Virtual Event.
Zhou, W. (2022, March). Perspectives on carotid artery occlusive disease: updated from the new Society for Vascular Surgery Practice Guidelines. Mayo Clinic Symposium. Phoenix, AZ.
Zhou, W. (2022, May). Foster a Research Network. Women's Vascular Summit. Buffalo, NY.
Zhou, W. (2022, May). Vascular Research Initiative Conference Von Liebig Dinner Speaker. Vascular Research Initiative Conference Von Liebig Dinner Speaker. Seattle, WA.
Zhou, W. (2022, November). Building Your Practice: Research Programs . Veith Symposium. New York, NY.
Zhou, W. (2022, November). Debate: Carotid Intervention Improves Cognitive Function Of Patients With Severe Carotid Atherosclerosis: Should More ACS Patients Undergo Invasive Treatment? . Veith Symposium. New York, NY: Veith.
Zhou, W. (2022, November). Debates: How size and number of SBI affect congitive function.. Veith Symposium. New York, NY: Veith.
Zhou, W. (2022, October). Management of Type II endoleaks.
. Asian Vascular Surgery Society. Taipei, Taiwan: Asian Vascular Surgery Society.
Zhou, W. (2022, October). The Effects of Frailty in Carotid Interventions. International Congress of Angiology. Long Island, NY.
Zhou, W. (2022, October). The effects of carotid intervention on cognitive function. BMC2 Vascular Surgery Collaborative Meeting. Virtual Event.
Zhou, W. (2022, October). Type II endoleak management, understanding nidus. Argentinian Cardiovascular Surgery Annual Meeting. Virtual / Buenos Aires, Argentina.
Zhou, W. (2022, October). Understanding the impact of carotid intervention on cognitive function. Asian Vascular Surgery Society. Taipei, Taiwan: Asian Vascular Surgery Society.
Tan, T., Weinkauf, C. C., & Zhou, W. (2021, October). Association of Preventive Foot Care and Outcome of New Diabetic Foot Ulceration. 2021 American Public Health Association (APHA) Annual Meeting. Denver, CO: American Public Health Association.
Zhou, W. (2021, July). Type II Endoleak Prevention and Management. SVS Meet the Experts Webinar. Virtual: Society for Vascular Surgery.
Zhou, W. (2021, July). Updates on cognitive effects of carotid disease and carotid interventions. Rocky Mountain Vascular Surgery Annual Meeting. Steamboat Springs, Colorado: Rocky Mountain Vascular Society.
Zhou, W. (2021, June). Carotid Disease and Management. VA National Surgery Office Lecture Series. Virtual: VA.
Zhou, W. (2021, March). Balance Practice, Family, and Fitness. Society for Clinical Vascular Surgery Annual Meeting. Miama / Zoom: Society for Clinical Vascular Surgery.
Zhou, W. (2021, May). Identifying the High Risk Asymptomatic Carotid Patient: What Should We Look For?. Pacific Northwest Endovascular Symposium. Seattle, WA.
Zhou, W. (2021, November). How Size And Number Of Silent Brain Infarcts (DW MRI Defects) After CEA/CAS Affect Cognitive Changes: They Really Do Matter. Veith Annual Meeting. Orlando, FL: Veith Annual Meeting.
Zhou, W. (2021, November). Tool Kit for Early Career Vascular Specialists - Pearls/Pitfalls Learned from the First 5 years (senior). American Heart Association. Virtual Webinar.
Zhou, W. (2021, October). Effect of Frailty on outcome of carotid intervention. Australian and New Zealand Society for Vascular Surgery. Virtual Webinar: Australian and New Zealand Society for Vascular Surgery.
Zhou, W. (2021, October). Identifying the High Risk Asymptomatic Carotid Patient: What Should We Look For?. China Endovascular Course. Virtual.
Zhou, W., & Tan, T. (2021, October). Assessing the Association of Race and Ethnicity on Annual Preventive Diabetic Foot Examination. 2021 American Public Health Association (APHA) Annual Meeting. Denver, CO: American Public Health Association (APHA).
Zhou, W. (2020, June). Size and location of subclinical microinfarcts affect their cognitive effects.. Vascular Annual Meeting. Virtual: Society for Vascular Surgery.
Zhou, W. (2019, February 2019). What is Symptomatic Carotid Stenosis and Do We Need New Trials?. International Stroke Conference. Honolulu, HI: Iternational Stroke Conference.
Zhou, W. (2019, July 2019). EVAR surveillance and long-term follow-up. Chinese Southern Endovascular Conference. Nanning, China: Chinese Southern Endovascular Conference.
Zhou, W. (2019, July 2019). Identifying high risk asymptomatic carotid stenosis. Chinese Southern Endovascular Congress. Nanning, China: Chinese Southern Endovascular Congress.
Zhou, W. (2019, July 2019). Renal Rescue: Should we be more aggressive?. Rocky Mountain Vascular Society Annual Meeting. Coeur D'Alene, Idaho: Rocky Mountain Vascular Society.
Zhou, W. (2019, June 2019). Clinical Research Seed Grant Changes: Panelist Discussion. Vascular Annual Meeting. National Harbor, Maryland: Society for Vascular Surgery.
Zhou, W. (2019, June 2019). How to Identify High-Risk Asymptomatic Carotid Stenosis. Complex Cardiovascular Catheter Symposium. Orlando, FL: Complex Cardiovascular Catheter.
Zhou, W. (2019, June 2019). Research and a Career in Vascular Surgery. Vascular Annual Meeting. National Harbor, Maryland: Soceity for Vascular Surgery.
Zhou, W. (2019, March 2019). Management Approaches for Type II Endoleak. Chinese Vascular Surgical Complication Forum. Guangzhou, China.
Zhou, W. (2019, May 2019). Cognitive Effects After Carotid Intervention: Can Patients Actually Have Improved Function?. Pacific Northwest Endovascular Conference. Seattle, WA: Pacific Northwest Endovascular Conference.
Zhou, W. (2019, May 2019). Leadership Panel Discussion. Pacific Northwest Endovascular Conference. Seattle, WA.
Zhou, W. (2019, November 2019). An Occluded Renal Artery Does Not Mean A Lost Kidney Due To Collaterals Maintaining Its Viability: Revascularization. Veith Annual Symposium. New York, NY.
Zhou, W. (2019, November 2019). Risk Factors Predict the Volume Of Cerebral Infarct Associated With Carotid Interventions. Veith Annual Symposium. New York, NY.
Zhou, W. (2019, October 2019). Identify high risk asymptomatic carotid lesions. International College of Angiology Annual Meeting. Columbus, Ohio.
Zhou, W. (2019, October 2019). Long-term Outcomes of EVAR. Chinese Capital Vascular Symposium. Beijing, China.
Zhou, W. (2019, October 2019). Pathway to treat type II endoleak.. International College of Angiology Annual Meeting. Columbus, Ohio.
Zhou, W. (2019, October 2019). What do we know about endoleaks?. Chinese Capital Vascular Symposium. Beijing, China.
Zhou, W. (2019, September 2019). Role of late renal revascularization for functional salvage. Taiwan Soceity for Vascular Surgery. Taipei, Taiwan.
Zhou, W. (2019, September 2019). Treatment approach of type II endoleak. Taiwan Society for Vascular Surgery. Taiwan Society for Vascular Surgery. Taipei, Taiwan.
Zhou, W. (2018, April 2018). Aortic Graft Occlusion: Lesson Learned. 8th Annual China Vascular Surgical Complication Forum. Hang Zhou, China.
Zhou, W. (2018, April 2018). Being a Successful Clinical Scientist. Chinese Innovation Symposium. Beijing, China: Chinese Innovation Symposium.
Zhou, W. (2018, August 2018). Beyond Stroke, What Have We Learned about Carotid Disease?. International Congress of Angiology.
Zhou, W. (2018, February 2018). Carotid Disease and Carotid Interventions. Where Are We Now?. 2nd Annual James Seeger Visiting Professor Lecture.. University of Florida.
Zhou, W. (2018, July 2018). Cognitive Effects of Carotid Interventions. Rocky Mountain Vascular Surgery Annual Meeting. Avon, CO.
Zhou, W. (2018, July 2018). Current Outcomes of TCAR. Society of Asian Vascular Surgery. GuangZhou, China.
Zhou, W. (2018, July 2018). Debate: CAS or CEA in Recently Symptomatic Patients? - For CEA: Ross Naylor - For CAS: Wei Zhou. Society of Asian Vascular Surgery. GuangZhou, China: Society of Asian Vascular Surgery.
Zhou, W. (2018, July 2018). How to Prevent Contrast-Induced Nephropathy. Society of Asian Vascular Surgery. GuangZhou, China: Society of Asian Vascular Surgery.
Zhou, W. (2018, July 2018). Moderator for Vascular Surgery History Video. Society of Asian Vascular Surgery. GuangZhou, China: Society of Asian Vascular Surgery.
Zhou, W. (2018, July 2018). Pathway to Treat Type II Endoleaks. Society of Asian Vascular Surgery. GuangZhou, China: Society of Asian Vascular Surgery.
Zhou, W. (2018, June 2018). How to Evaluate Limb Perfusion Following Endovascular Interventions. Complex Catheter Catheterization. Orlando, FL.
Zhou, W. (2018, June 2018). What is the Current Strategy for Managing Asymptomatic Carotid Disease. Complex Catheter Catheterization. Orlando, FL.
Zhou, W. (2018, March 2018). Effectiveness of CEA: What do Trials Tell Us?. Transcatheter Endovascular Decisions (TED) Conference. Phoenix, AZ.
Zhou, W. (2018, May 2018). Embolization to Profunda: What Should I Do?. Master of Cardiovascular Complication Course. Washington, DC.
Zhou, W. (2018, May 2018). FEVAR Complication: Can We Save The Kidney?. Master of Cardiovascular Complication Course. Washington, DC.
Zhou, W. (2018, November). Effects of Diabetes on Changes in Cognition After CAS and CEA: Why is this so?. 2018 Veith Symposium. New York, New York.
Zhou, W. (2018, November). Frailty Has Different Effects on the Outcomes for Patients Undergoing CAS and CEA: Frail Patients Needing Treatment. 2018 Veith Symposium. New York, New York.
Zhou, W. (2018, September 2018). Endovascular Approach of Limb Salvage. Round Table Community Event. Tucson, AZ.
Zhou, W. (2018, September 2018). How Carotid Disease and Carotid Interventions Affect Memory. Go Red For Women. Tucson, AZ.
Zhou, W. (2017, April). Embolic Volume and Cognitive Function. Charing Cross - April 2017. London.
Zhou, W. (2017, February). Endoleak Following EVAR: What Do We Know. CRT - February 2017. New York, NY.
Zhou, W. (2017, June). Carotid Intervention and its Cognitive Effects. Complex Cardiovascular Catheterization - June 2017. Orlando, FL.
Zhou, W. (2017, June). Carotid Intervention and its Cognitive Effects. Complex Catheter Catheterization - June 2017. Orlando, FL.
Zhou, W. (2017, June). Cognition Testing Pre and Post Intervention Will Be Routine in the Future. Vascular Annual Meeting - June 2017. San Diego, CA.
Zhou, W. (2017, June). Post-Evar Surveillance Imaging Follow-Up Is A Must! - June 2017. Master of Complication Couse. Washington, DC.
Zhou, W. (2017, June). Proceed With Caution: Crossing The Aortic Arch During TEVAR - June 2017. Master of Complication Couse. Washington DC.
Zhou, W. (2017, June). The Menace of a Tortuous Aorto-Iliac Arteries During EVAR - June 2017. Master of Complication Course. Washington DC.
Zhou, W. (2017, Novebmer 18). Role Of Digital And Tibial Artery Calcification In The Treatment Of Patients With CLTI: It Is Not All Bad. Veith Symposium. New York, NY.
Zhou, W. (2017, November 17). Volume Of Subclinical Microembolization After CAS Or CEA Correlates With Long-Term Cognitive Changes: CAS More So Than CEA: DW MRI Defects Have Consequences. Veith Symposium. New York, NY.
Zhou, W. (2017, October). Cognitive Effects of Carotid Intervensions: What Do We Know?. Asian Society for Vascular Surgery - October 2017. Kuala Lumpur, Malaysia.
Zhou, W. (2017, October). Embolization in Vascular Surgery Practice. Asian Society for Vascular Surgery - October 2017. Kuala Lumpur, Malaysia.
Zhou, W. (2017, October). What Did We Learn From OVER Trial?. Asian Society for Vascular Surgery - October 2017. Kuala Lumpur, Malaysia.
Zhou, W. (2017, September). Identification of High-Risk Patients with Asymptomatic Carotid Stenosis: Fact vs Fiction. International Congress of Angiology - September 2017. Vienna.

Poster Presentations

Hsu, C., He, Y., Hu, C., & Zhou, W. (2019, 7). An alternative sensitivity analysis approach for data subject to missing not at random. The 34th International Workshop on Statistical Modelling. Porto: Portugal.
Zhou, W., Barker, N. K., Moly, P. K., Langlais, P. R., & Haider, N. (2018, May). Resistin induced Differential Global Protein Expression in Human Macrophage. Vascular Discovery 2018 Scientific Sessions.
Trouard, T. P., Wheeler, G., Do, L., & Zhou, W. (2017, November). Semi-automated Analysis of Microembolic Lesions in Brain Diffusion Weighted MRI. University of Arizona College of Medicine Junior Investigators Forum. Tucson: University of Arizona College of MEdicine.
Wheeler, G., Do, L., Zhou, W., & Trouard, T. P. (2017, October). Semi-automated Analysis of Microembolic Lesions in Brain Diffusion Weighted MRI. Biomedical Engineering Society Annual Meeting. Phoenix AZ.

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Wei Zhou

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Wei Zhou

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Rsrch Meth Psio Sci

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