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Wei Zhou

  • Professor, Surgery
  • Chief, Division of Vascular Surgery
Contact
  • (520) 626-6670
  • Arizona Health Sciences Center, Rm. 4402
  • Tucson, AZ 85724
  • zhouw@email.arizona.edu
  • Bio
  • Interests
  • Courses
  • Scholarly Contributions

Biography

1. Zhou W, Vasquez JC, O'Donnell MR, Paz BI. Clinical Manifestation of Gastrointestinal Granulocytic Sarcoma Requiring Surgical Treatment. The American Surgeon, Aug, 2001; 67(8): 764-6.

2. Du E, Overstreet K, Zhou W, Baird G, Baird S, Bouvet M, Haghighi P. A Case of Tumor-Like Splenic Extramedullary Hematopoiesis in an Asymptomatic Patient: Useage of Fine Needle Aspiration. Acta Cytologica, 2002 Nov-Dec; 46(6): 1138-42

3. Zhou W, Katz M, Baird S, Bouvet M. Metachronous Double Parathyroid Adenoma Involving Two Different Cell Types: Chief Cell and Oxyphil Cell. Endocrine Practice, 2003; 9(6): 522-525

4. Zhou W, Bush RL, Lin PH, Lumsden AB. Treatment Options of Iatrogenic Pelvic Vein Injuries: Conventional Operative versus Endovascular Approach. Vascular and Endovascular Surgery, 2004; 38(6) 569-73

5. Zhou W, Bush RL, Lin PH, Lumsden AB, Radiation Induced Venous Stenosis Treatment Options. Journal of Vascular Surgery, 2004: 40(1):179-182.

6. Bush RL, Lin PH, Bates JT, Mureebe L, Zhou W, Lumsden AB. Pharmacomechanical Thrombectomy for the Treatment of Symptomatic Lower Extremity Deep Venous Thrombosis: A Safety and Feasibility Study. Journal of Vascular Surgery, 2004; 40(4):965-70

7. Zhou W, Lin PH, Bush RL, Nguyen L, Lumsden AB. Acute Arterial Thrombosis Associated with Cocaine Abuse. Journal of Vascular Surgery, 2004: 40(2): 291-5

8. Lin PH, Bush RL, Lubbe DF, Cox MM, Zhou W, McCoy SA, Felkai D, Paladugu R, Lumsden AB. Carotid Artery Stenting with Routine Cerebral Protection in High Risk Patients. Journal of American Surgery 2004. 188 (6): 644-52

9. Watts K, Lin PH, Bush RL, Awad S, McCoy SA, Felkai D, Zhou W, Nguyen L, Guerrero M, Shenaq SA, Lumsden AB. The Impact of Anesthetic Modality on the Outcome of Carotid Endarterectomy. American Journal of Surgery 2004. 188 (6): 741-7

10. Lin PH, Bush RL, Yao Q, Lam R, Paladugu R, Zhou W, Chen C, Lumsden AB. Abdominal Aortic Surgery in Patients with Human Immunodeficiency Virus Infection. American Journal of Surgery, 2004. 188(6): 690-7

11. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Molecular Mechanisms and Clinical Applications of Ginseng Root for Cardiovascular Disease. Medical Science Monitor 2004; 10(8): 187- 92

12. Zhou W, Bush RL, Lin PH, Lumsden AB. Fibromuscular Dysplasia of the Carotid Artery – Image. Journal of American College of Surgeon 2004; 200(5): 807

13. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Effect of Ginkgo Biloba on Cardiovascular Disease. Cardiovascular Drug Review 2004; 22(4): 309-319

14. Zhou W, Bush RL, Lin PH, Lumsden AB. Inferior Vena Cava Occlusion Secondary to Filter Placement: Endovascular Therapy. Journal of Endovascular Therapy 2004; 11: 747-748

15. Zhou W, Bush RL, Lin PH, Hodge MD, Felkai DD, McCollum C, Noon, G, Lumsden AB. Fibromuscular Dysplasia of the Carotid Artery: Diagnosis with Duplex Ultrasonography. Journal for Vascular Ultrasound, 2005. 29(1): 9-13

16. Zhou W, Bush RL, Lin PH, Felkai DD, Spencer TA, Lumsden AB. Carotid Artery Pseudoaneurysm after Endovascular Stent Placement: Diagnosis and Follow-up Duplex Ultrasonography. Journal of Vascular Ultrasound, 2005. 29(1): 28-32

17. Zhou W, Terramani TT, Lin PH, Bush RL, Matsuura JH, Cox M, Lumsden AB. In-Situ Reconstruction with Cryopreserved Arterial Allograft in Mycotic Aneurysms or Aortoiliac Prosthetic Grafts Infection: a Multi-institutional Experience. Brazilian Vascular Journal 2005; 4(2): 123-128

18. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Ginsenoside Rb1 Blocks Homocysteine-Induced Endothelial Dysfunction. Journal of Vascular Surgery 2005; 41(5): 861-868

19. Chai H, Zhou W, Lin PH, Lumsden AB, Yao Q, Chen C. Ginsenosides block HIV protease inhibitor ritonavir-induced vascular dysfunction of porcine coronary arteries. American Journal of Physiology: Heart and Circulation Physiology. 2005; 288(6):2965-2971

20. Bush RL, Lin PH, Mureebe L, Zhou W, Peden EK, Lumsden AB. Routine Bivalirudin Use in Percutaneous Carotid Interventions. Journal of Endovascular Therapy, 2005 (12): 521-523

21. Lin PH, Bush RL, Zhou W, Peden EK, Lumsden AB. What’s the Learning Curve for Carotid Artery Stenting with Neuroprotection? Analysis of 200 Consecutive Cases at an Academic Institution. Perspective Vascular Surgery and Endovascular Therapy 17(2): 113-23, 2005

22. Bush RL, Kougias P, Guerrero MA, Lubbe D, Zhou W, Lumsden AB, Lin PH. A Comparison of Carotid Artery Stenting with Neuroprotection versus Carotid Endarterectomy under Local Anesthesia. American Journal of Surgery, 2005;190(5):696-700

23. Peden E, Zhou W, Bush RL, Lumsden AB, Lin PH. The case for thrombolysis for iliofemoral venous thrombosis. Semin Vasc Surg. 2005 Sep;18(3):139-47

24. Lin PH, Bush RL, Zhou W, Peden EK, Lubbe DF, Guerrero M, Henao EA, Kougias P, Mohiuddin I, and Lumsden AB. Carotid Artery Stenting with Neuroprotection: Assessing the Learning Curve and Treatment Outcome in 200 Consecutive Cases. Journal of American Surgeon, 2005. 190(6): 850-7

25. Zhou W, Rosenberg W, Lumsden AB, Li J. Successful Surgical Management of Infrarenal Inferior Vena Cava Agenesis in a Symptomatic Patient. Vascular, 2005. 13(6): 358-61

26. Zhou W, Bush RL, Bhama J, Lin PH, Safaya R, Lumsden AB. Repair of Anastomotic Abdominal Aortic Pseudoaneurysm Utilizing Sequential AneuRx Aortic Cuffs in an Overlapping Configuration. Annals of Vascular Surgery, 2006. 20(1): 17-22

27. Zhou W, Lin PH, Bush RL, Terramani TT, Matsuura JH, Cox M, Peden EK, Dardik A, Rosenthal D, Lumsden AB. In-Situ Reconstruction with Cryopreserved Arterial Allograft for Management of Mycotic Aneurysms or Aortoiliac Prosthetic Grafts Infection: a Multi-institutional Experience. Texas Heart Institution Journal, 2006. 33(1):

28. Kougias P, Lin PH, Bush BL, Peden EK, Zhou W, Lumsden AB. Carotid artery stenting - Current status and future directions. Minerva Cardioangiol, 2006. 54(1): 69-81.

29. Zhou W, Lin PH, Bush RL, Peden EK, Guerrero M, Kougias P, Lumsden AB. Management of in-sent restenosis after carotid artery stenting in high-risk patients. Journal of Vascular Surgery, 2006. 43(2): 305-12

30. Silberfein EJ, Lin PH, Bush RL, Zhou W, Lumsden AB. Aortic endograft infection due to Pasteurella multocida following a rabbit bite. Journal of Vascular Surgery, 2006. 43(2): 393-5

31. Zhou W, Lin PH, Bush RL, Chang B, Guerrero M, Terramani TT, Lubbe D, Nguyen L, Lumsden AB. Carotid Artery Aneurysm: Evolution of Management Over Two Decades. Journal of Vascular Surgery, 2006. 43(3): 493-6

32. Lin PH, Bush RL, Zhou W, Peden EK, Lumsden AB. Endovascular Treatment of Traumatic Thoracic Aortic Injury – Should this be the New Standard of Treatment? Journal of Vascular Surgery, 2006. 43(2suppl): A22-9

33. Zhou W, Reardon M, Lin PH, Bush RL, Peden EK. Endovascular Repair of a Proximal Aortic Arch Aneurysm: a Novel Approach of Supraaortic Debranching with antegrade endograft deployment. Journal of Vascular Surgery, 2006. 43(5): 1045-8

34. Zhou W, Lin PH, Bush RL, Peden EK, Lumsden AB. Endovascular Training of Vascular Surgeons: Have We Made Progress. Seminar in Vascular Surgery, 2006. 19(2): 122-6

35. Yallampalli S, Zhou W, Lin PH, Bush RL, and Lumsden AB. Delayed Deformation of Self-Expanding Stents Following Carotid Artery Stenting for Post-Endarterectomy Restenoses. Journal of Vascular Surgery, 2006, 44(2): 412-415

36. Zhou W, Lumsden AB, Li J. Laparoscopic Ligation of IMA for a Type II Endoleak: Combined Laparoscopic and Endovascular Approach. Surgical Laparoscopy, Endoscopy, and Percutaneous Techniques, 2006, 16(4): 272-275.

37. Ly T, Zhou W, Bush RL, Lumsden AB, Lin PH. Use of Parietal Peritoneum for Aortic Stump Coverage Following Removal of an Infected Aortic Prosthesis. Vascular and Endovascular Surgery, 2006, 40(4): 334-7

38. Zhou W, Bush RL, Lin PH, Lumsden AB. Laser Atherectomy for Lower Extremity Revascularization: An Adjunctive Endovascular Treatment Option. Vascular and Endovascular Surgery, 2006, 40(4):268-274

39. Mussa FF, Hedayadi N, Zhou W, Darouiche RO, Lin PH. Prevention and Treatment of Vascular Graft Infection. Expert Review of Anti-Infective Therapy, 2007, 5(2):305-15

40. Zhou W, Chai H, Courson A, Lin PH, Lumsden AB, Yao Q, Chen C. Ginkgolide A Attenuates Homocysteine-Induced Endothelial Dysfunction in Porcine Coronary Arteries. Journal of Vascular Surgery 2006, 44(4): 853-62

41. Zhou W, Reardon M, Peden EK, Lin PH, Lumsden AB. Hybrid Approach to Complex Thoracic Aortic Aneurysms in High Risk Patients: Surgical Challenges and Clinical Outcomes. Journal of Vascular Surgery, 2006, 44(4): 688-93

42. El Sayed HF, Kougias P, Zhou W, Lin PH. Utility of Retrievable Vena Cava Filters and Mechanical Thrombectomy in the Endovascular Management of Acute Deep Venous Thrombosis. Vascular 2006, 14(5): 305-12

43. Lin PH, Zhou W, Guerrero MA, McCoy SA, Felkai D, Kougias P, El Sayed HF. Carotid Artery Stenting with Distal Protection Using the Carotid Wallstent and Filterwire Neuroprotection: Single-Center Experience of 380 cases with Midterm Outcomes. Vascular. 2006, 14(5):237-44

44. Lin PH, Zhou W, Dardik A, Mussa F, Kougias P, Hedayadi N, Naoum JJ, El Sayed H, Peden EK, Huynh TT. Catheter-direct Thrombolysis Versus Pharmacomechanical Thrombectomy for Treatment of Symptomatic Lower Extremity Deep Venous Thrombosis. American Journal of Surgery, 2006, 192(6):782-8

45. Lin PH, Steinberg JL, Okada T, Zhou W, El Sayed H, Kougias P, Yao Q, Chen C. Chronically Impaired Endothelial Vasoreactivity Following Oversized Endovascular Introducer Sheath Placement in Porcine Iliac Arteries: Implications for Endovascular Therapy. Vascular. 2006, 14(6):353-61

46. Zhou W, Choi L, Lin PH, Dardik A, Eraso A, Lumsden AB. Percutaneous Transhepatic Thrombolysis and Rheolytic Thrombectomy for Symptomatic Mesenteric Venous Occlusion. Vascular 2007, 15(1): 45-49

47. Lumsden AB, Rice TW, Chen C, Zhou W, Lin PH, Bray P, Morissett J, Nambi V, Ballantyne C. Peripheral Arterial Occlusive Disease: MRI Imaging and the Role of Aggressive Medical Management. World Journal of Surgery, 2007, 31(4):695-704

48. Mussa FF, Lin PH, Hedayati N, Naoum J, Zhou W, Yao Q, Kougias P, and Chen C. Comparison of AngioJet Rheolytic Pharmacomechanical Thrombectomy versus AngioJet Rheolytic Thrombectomy in a Porcine Peripheral Arterial Model. World Journal of Surgery, 2007, 31(4):715-22

49. Lin PH, Okada T, Steinberg JL, Zhou W, El Sayed HF, Rawat A, Kougias P, Yao Q, and Chen C. Rheolytic Pharmacomechanical Thrombectomy in Experimental Chronic Deep Vein Thrombosis: Effect of L-Arginine on Thrombogenicity and Endothelial Vasomotor Function. World Journal of Surery, 2007, 31(4):664-75

50. Mussa FF, Peden EK, Zhou W, Lin PH, Lumsden AB, Bush RL. Balloon Angioplasty and Stenting for Venous Outflow Obstruction of the Lower Extremity. Texas Heart Journal 2007, 34(1):60-6

51. Guerrero MA, Zhou W, Kougias P, El Sayed H, Lin, PH. Multiple Giant Anastomotic Pseudoaneurysms of Carotid and Femoral Arteries: Combined Endovascular and Open Surgical Approach. Vascular 2007, 15(3):158-61

52. Kougias P, Lin PH, Dardik A, Lee WA, El Sayed H, Zhou W. Successful Treatment of Endotension and Aneurysm Sac Enlargement with Endovascular Stent-graft Reinforcement. Journal of Vascular Surgery 2007, 46(1): 124-7

53. Naoum JJ, Silberfein EJ, Zhou W, Sweeney JF, Albo D, Brunicardi FC, Kougias P, El Sayed HF, Lin PH. Concomitant Intraoperative Splenic Artery Embolization and Laparoscopic Splenectomy versus Laparoscopic Splenectomy: Comparison of Treatment Outcome. Am J Surgery 2007, 193(6):713-8

54. Lin PH, El Sayed HF, Kougias P, Zhou W, Lemaire SA, Coselli JS. Endovascular repair of thoracic aortic disease: overview of current devices and clinical results. Vascular. 2007;15(4):179-90

55. Kougias P, El Sayed, H, Zhou W, Lin PH. Management of Chronic Mesenteric Ischemia. The Role of Endovascular Therapy. Journal of Endovascular Therapy 2007; 14(3): 395-405

56. Silberfein EJ, Zhou W, Kougias P, El Sayed HF, Huynh TT, Albo D, Berger DH, FC Brunicardi, Lin PH. Percutaneous cholecystostomy for acute cholecystitis in high-risk patients: experience of a surgeon-initiated interventional program. The American Journal of Surgery, 2007; 194(5): 672-7

57. Kougias P, Lau D, El Sayed, H, Zhou W, Huynh TT, Lin PH. Determinants of Mortality and Treatment Outcome Following Surgical Interventions for Acute Mesenteric Ischemia. Journal of Vascular Surgery 2007; 46(3):467-474

58. Zhou W, Huynh TT, Kougias P, El Sayed HF, Lin PH. Traumatic Carotid Artery Dissection Caused by Bungee Jumping. Journal of Vascular Surgery 2007; 46(5):1044-6

59. Lin PH, Zhou W, Kougias P, El Sayed HF, Barshes NR, Huynh TT. Factors Associated with Hypotension and Bradycardia after Carotid Angioplasty and Stenting. Journal of Vascular Surgery 2007; 46(5):846-54.

60. Hedayati N, Kougias P, El Sayed HF, Zhou W, Huynh TT, Lin PH. Dual Guidewire Placement to Enhance Arch Vessel Origin Identification: A Simple Technique to Facilitate Ostial Aortic Arch Vessel Stenting. Journal of Vascular Surgery 2007, 46(6):1274-6

61. Daniel JC, Huynh TT, Zhou W, Kougias P, El Sayed HF, Huh J, and Coselli JS, Lin PH. Acute Aortic Dissection Associated with Use of Cocaine. Journal of Vascular Surgery 2007; 46(3):427-33

62. Guerrero MA, Zhou W, El-Sayed HF, Kougias P, Lin PH. Subscapsular Hematoma of the Kidney Secondary to Paintball Pellet Injuries. Journal of Emergency Medicine 2007

63. Hedayadi N, Lin PH, Lumsden AB, Zhou W. Prolonged Renal Artery Occlusion Following EVAR: Endovascular Rescue and Renal Function Salvage. Journal of Vascular Surgery 2007; 46(6):1274-6

64. Zhou W, Felkai DD, Evans M, McCoy SA, Lin PH, Kougias P, El-Sayed HF, and Lumsden AB. Ultrasound Criteria for Severe In-Stent Restenosis Following Carotid Artery Stenting. Journal of Vascular Surgery 2008; 47(1):74-80

65. Chai H, Dong Y, Wang X, Zhou W. Ginsenoside Rb1 attenuates homocysteine-augmented guidewire injury-induced intimal hyperplasia in mice. Journal of Surgical Research 2009, 157(2):193-8

66. Tedesco MM, Dalman RL, Zhou W, Coogan SM, Lane B, Lee JT. Reduction of postprocedure microemboli following retrospective quality assessment and practice improvement measures for carotid angioplasty and stenting. J Vasc Surg. 2009, 49(3): 607-12

67. Chai H, Aghaie K, Zhou W. Soluble CD40 Ligand Induces Human Coronary Artery Smooth Muscle Cells Proliferation and Migration. Surgery 2009, 146(1): 5-11

68. Zhou W, Dinishak D, Lane B, Hernandez-Boussard T, Bech F, Rosen A. Long-term Radiographic Outcomes of Microemboli following Carotid Interventions. J Vasc Surg. 2009, 50(6):1314-9

69. Casey K, Zhou W, Tedesco MM, Al-Khatib WK, Hernandez-Boussard T, Bech F. Fate of the External Carotid Artery Following Carotid Interventions. International Journal of Angiology 2009, 18(4): 173- 176

70. Chai H, Schultz, G, Aghaie K, Zhou W. In vivo assessment of the effects of ginsenoside Rb1 on intimal hyperplasia in ApoE knockout mice. Journal of Surgical Research 2010, 162(1): 26-32

71. Zhou W, Chai H, Ding R, Lam HY. Distribution of Inflammatory Mediators in Carotid and Femoral Plaques. Journal of the American College of Surgeons 2010, 211(1): 92-8

72. Zhou W. Radiation exposure of Vascular Patients: Beyond Endovascular. Journal of Vascular Surgery, 2011, 53(1suppl):39s-43s

73. Casey K, Al-Khatib, Zhou W. Hypogastric Artery Preservation during Aortoiliac Aneurysm Repair. Annual of Vascular Surgery 2010, 25(1): 133. e1-8

74. Wang AS, Liang DH, Bech F, Lee J, Zarins C, Zhou W, Taylor CA. Validation of a Power Law Model in Upper Extremity Vessels: Potential Application in Ultrasound Bleed Detection. Ultrasound in Medicine and Biology, 2012; 38(4): 692-701

75. Ding Q, Tsao J, Chai H, Mochly-Rosen D, Zhou W. Therapeutic Potential for Protein Kinas C Inhibitor in Vascular Restenosis. Journal of Cardiovascular Pharmacology and Therapeutics 2011 Jun; 16(2):160-7

76. Ding Q, Chai H, Mahmood N, Tsao J, Mochly-Rosen D, and Zhou W. Matrix Metalloproteinases Modulated by PKCε Mediate Resistin-Induced Migration of Human Coronary Artery Smooth Muscle Cells. Journal of Vascular Surgery 2011; 53(4):1044-51

77. Zhou W, Zareie R, Tedesco N, Gholibeikian S, Lane B, Hernandez-Boussard T, Rosen A. Risk Factors Predictive of CAS-associated Subclinical Microemboli. Internal Journal of Angiology 2011; 20(1):025-32

78. Ding Q, White S, Ling C, Zhou W. Resistin and cardiovascular disease. Trends in Cardiovascular Medicine, 2011, 21(1): 20-7

79. Minter RM, Angelos P, Coimbra R, Dale P, de Vera ME, Hardacre J, Hawkins W, Kirkwood K, Mathews JB, McLoughlin J, Peralta E, Zhou W, Schwarze ML. Ethical management of conflict of interest: proposed standards for academic surgical societies. J Am College of Surg. 2011; 13(5):677-82

80. Wang AS, Liang DH, Bech F, Lee JT, Zarins CK, Zhou W, Taylor CA. Validation of Power Law Model in Upper Extremity Vessels: Potential Application in Ultrasound Bleeding Detection. Ultrasound in Medicine and Biology. 2012; 38(4):692-701

81. Abbott et al. Why United States Center for Medicare and Medicaid Services Should not Extend Reimbursement Indications for Carotid Artery Angioplasty/Stenting. European Journal of Vascular and Endovascular Surgery, 2012;

82. Abbott et al. Why United States Center for Medicare and Medicaid Services Should not Extend Reimbursement Indications for Carotid Artery Angioplasty/Stenting. Vascular, 2012; 20(1): 1-7.

83. Mitkov M, Al-Khatib WK, and Zhou W. Concurrent treatment of acute pancreatitis and multiple visceral artery aneurysms using endovascular techniques. Vasc Endovascular Surg, 2012, 46(3): 283-6

84. Zhou W. Hitchner E, Gillis K, Sun L, Floyd R, Lane B, Rosen A. Prospective Neurocognitive Evaluation of Patients Undergoing Carotid Interventions, Journal of Vascular Surgery, 2012, 56(6):1571-8

85. Casey K, Hitchner E, Lane B, Zhou W. Series on Contralateral Microemboli Following CAS in Patients with Occluded ICA. Journal of Vascular Surgery, 2013; 58(3): 794-797

86. Lederle FA, Freischlag JA, Kyriakides TC, Matsumura JS, Padberg FT Jr, Kohler TR, Kougias P, Jean-Claude JM, Cikrit DF, Swanson KM; OVER Veterans Affairs Cooperative Study Group. Longterm comparison of endovascular and open repair of abdominal aortic aneurysm. N Engl J Med. 2012 Nov 22;367(21):1988-97

87. Lederle FA, Stroupe KT; Open Versus Endovascular Repair (OVER) Veterans Affairs Cooperative Study Group. Cost-effectiveness at two years in the VA Open Versus Endovascular Repair Trial. Eur J Vasc Endovasc Surg. 2012;44(6):543-8

88. Stroupe KT, Lederle FA, Matsumura JS, Kyriakides TC, Jonk YC, Ge L, Freischlag JA; Open Versus Endovascular Repair (OVER) Veterans Affairs Cooperative Study Group. Cost-effectiveness of open versus endovascular repair of abdominal aortic aneurysm in the OVER trial. J Vasc Surg. 2012 Oct;56(4):901-9

89. Ascher E, Farber A, Kalra M, Timaran CH, Zhou W. Beyond borders: Proceedings from the 2011 WFVS meeting and selected international papers. Introduction. J Vasc Surg. 2013 Feb;57(2 Suppl):1S-2S.

90. Abbott A et al. Why calls for more routine carotid stenting are currently inappropriate. Stroke, 2013 (In Press)

91. Chandra V, Dorsey C, Reed AB, Shaw P, Banghart D, Zhou W. Monitoring of Fetal Radiation Exposure During Pregnancy. Journal of Vascular Surgery, 2013; 58(3): 710-714

92. Blay E, Zhou W. Rapid renal function deterioration: an unusual presentation of coral reef plaque. Annual of Vascular Surgery, 2014; 28(1):260

93. Hitchner E, Zayed MA, Lee G, Morrison D, Lane B, Zhou W. Intravascular Ultrasound as a Clinical Adjunct For Carotid Plaque Characterization. Journal of Vascular Surgery, 2014; 59(3);774-80

94. The use of Cryopreserved Aortoiliac Allograft for Aortic Reconstruction in the United States. Journal of Vascular Surgery, 2014; 59(3): 669-74.

95. Hedayati N, Humphrey M, Zhou W. Gender and Outcomes of Carotid Artery Interventions. Vascular and Endovascular Surgery, 2014; 48(2);99-105.

96. Zhou W, Blay E, Varu V, Ali S, Jin M, Sun L, Joh J. Outcome and Clinical Significance of Delayed Endoleaks Following Endovascular Aneurysm Repair. Journal of Vascular Surgery, 2014; 59(4):915-20

97. Hitchner E, Zayed M, Varu V, Lee G, Aalami O, Zhou W. Utility of IVUS during Percutaneous Superficial Femoral Artery Interventions. Annual of Vascular Surgery, 2015; Jan;29(1):28-33

98. Zuniga M, White S, Zhou W. Design and utilization of macrophage and vascular smooth muscle cell co-culture systems in atherosclerotic cardiovascular disease investigation. Vascular Medicine, 2014. Oct;19(5):394-406

99. Zayed MA, Hitchner E, Gholibeikian S, Rosen A, Lane B, Zhou W. Patient Characteristics Can Influence the Incidence of Perioperative Microemboli during Carotid Artery Interventions. Journal of Angiology 2015

100. Hitchner E, Zhou W. Utilization of Intravascular Ultrasound during Carotid Artery Stenting. Int J Angiol. 2015 Sep;24(3):185-8. (PMID: 26417186)

101. Itoga N, Woo K, Grenon M, Bismuth J, Bechara C, Mitchell E, and Zhou W. A Rising Diverse Generation of Vascular Surgery Workforce. Annual of Vascular Surgery 2015. Oct;29(7):1484-6. PMID: 26253044

102. Lal BK, Zhou W, Li Z, Kyriakides T, Matsumura J, Lederle FA, Freischlag J; OVER Veterans Affairs Cooperative Study Group. Predictors and outcomes of endoleaks in the Veterans Affairs Open Versus Endovascular Repair (OVER) Trial of Abdominal Aortic Aneurysms. J Vasc Surg. 2015 Dec; 62(6):1394-404. (PMID: 26598115)

103. Itoga N, Colvard B, Hitchner E, Sun Q, Long B, Lee G, Aalami O, Zhou W. SPY Technology as an Adjunctive Measure for Lower extremity Perfusion. Journal Vascular Surgery, 2016; 64(1):195- 201. (PMID: 26994959)

104. Hitchner E, Morrison D, Liao P, Rosen A, Zhou W. Genetic Polymorphisms Influence Cognition in Patients Undergoing Carotid Interventions. International Journal of Angiology 2016; 25(3):168-73. (PMID: 27574384)

105. Itoga N, Ullery B, Tran K, Lee G, Aalami O, Bech F, Zhou W. Utilization of a Proactive Duplex Ultrasound Protocol for Hemodialysis Access. Journal of Vascular Surgery, 2016 May 13. (PMID: 27183858)

106. Soman S, Prasad G, Hitchner E, Massaband P, Moseley M, Zhou W, Rosen A. Brain Structural Connectivity Distinguishes Patients at Risk for Cognitive Decline after Carotid Interventions. Human Brain Mapping, 2016;37(6):2185-94 (PMID: 27028955)

107. Zuniga MC, Tran TB, Baughman BD, Raghuraman G, Hitchner E, Allyson Rosen A, Robinson W, Zhou W. A Prospective Evaluation of Systemic Biomarkers and Cognitive Function Associated with Carotid Revascularization. Annals of Surgery, 2016; 264(4): 659-65 (PMID: 27433899)

108. Hitchner E, Baughman BD, Soman S, Long B, Rosen A, Zhou W. Microembolization is associated with transient cognitive decline in patients undergoing carotid interventions. Journal of Vascular Surgery, 2016, (16): 30842-4, (PMID: 27633169)

109. Raghuraman G, Zuniga MC, Yuan H, Zhou W. PKCε mediates resistin-induced NADPH oxidase activation and inflammation leading to smooth muscle cell dysfunction and intimal hyperplasia. Atherosclerosis, 2016 Aug 20; 253: 29-37. (PMID: 27573736)

110. Tran TB, Raghuraman B, Zuniga M, Hitcher E, Soman S, Max Wintermark M, Zhou W. Systemic Biomarkers Predict Volume of Emboli Associated with Carotid Revascularizations. JACS, 2016

111. Zhou W. Baughman BD, Soman S, Wintermar M, Lazzeroni LC, Hitchner E, Bhah J, Rosen A.  Volume of Subclinical Embolic Infarct Correlates to Long-term Cognitive Changes following Carotid Revascularization. Journal of Vascular Surgery 2016 (In Press)

112. Raghuraman G, Hsiung J, Zuniga MC, Baughman BD, Hitchner E, Guzman R, and Zhou W. Eotaxin augments calcification in vascular smooth muscle cells. Journal of Cellular Biochemistry 2016 Sep 28. doi: 10.1002/jcb.25752. [Epub ahead of print]. PMID: 27681294

113. Wu S, Pollak R, Frykberg R, Zhou W, Karnoub M, Jankovic V, Fischkoff S, Chitkara D. Safety and Efficacy of Intramuscular Human Placenta-Derived Mesenchymal Stromal-like Cells (cenplacel [PDA-002]) in Patients Who Have a Diabetic Foot Ulcer With Peripheral Arterial Disease. International Wound Journal, 2017 (In Press)

114. Zuniga M, Raghuraman G, Weyand C, Robinson W, Zhou W. PKC-epsilon and TLR4 synergistically Regulate Resistin-mediated Macrophage Inflammation in Human Macrophage Atherosclerosis. Atherosclerosis 2017 (In Press)

Degrees

  • M.D. Medical Degree
    • New York Medical College, Valhalla, New York, United States
  • B.S. (Sum Cum Laude) Biochemistry & Cell Biology/Psychology
    • University of California - San Diego, San Diego, California, United States

Work Experience

  • University of Arizona, Banner University Medical Center (2017 - Ongoing)
  • Stanford University, Stanford, California (2012 - 2017)
  • Palo Alto VA Medical Center (2007 - 2017)
  • Standord University (2007 - 2012)
  • Cardiovascular Institute - Stanford University (2007 - 2011)

Awards

  • NIH, BTSS Study Selection
    • National Institute of Health, Summer 2018
  • VA Merit CARB (Cardiovascular) Study Section
    • US Dept of Veteran Affairs, Spring 2018

Licensure & Certification

  • Medical License, Arizona Board of Medical Examiners (2016)
  • Medical License, Medical Board of California (2000)
  • Medical License, Medical Board of Texas (2005)
  • General Surgery, American College of Surgeons (2004)
  • Vascular Surgery, American College of Surgeons (2006)
  • Medical License, Medical Board of Arizona (2016)

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Research

Atherosclerosis and Vulnerable Plaques Neurocognition and Neuroimaging

Courses

2019-20 Courses

  • Thesis
    CMM 910 (Spring 2020)

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UA Course Catalog

Scholarly Contributions

Chapters

  • Ashton, L., & Zhou, W. (2019). Acquired Abdominal Arteriovenous Fistula. In Vascular Decision Making: Medical, Endovascular and Surgical. Editor: RJ Valentine & JF Edit.
  • Weinkauf, C., & Zhou, W. (2019). Carotid Artery Stenting. In Scientific American Vascular and Endovascular Surgery(pp on-line). Vascular Territories: Decker.
  • Zhou, W. (2018). Acquired Abdominal Arteriovenous Fistula. In Vascular Decision Making: Medical, Endovascular and Surgical.

Journals/Publications

  • Kraemer, C., & Zhou, W. (2019). Carotid Aneurysm Review. The International Journal of Angiology, 28(1), 17-19.
  • Lu, W., Wang, L., Zhou, W., & Fu, W. (2019). Augmented Reality Navigation to Assist Retrograde Peroneal Access for the Endovascular Treatment of Critical Limb Ischemia. Journal of Vascular Surgery Cases and Innovative Techniques, 5(Issue 4), 518-520.
  • Pandit, V., Lee, A., Zeeshan, M., Goshima, K., Tan, T. W., Jhajj, S., Trinidad, B., Weinkauf, C., & Zhou, W. (2019). Effect of frailty syndrome on the outcomes of patients with carotid stenosis. Journal of vascular surgery.
    More info
    Frailty syndrome confers a greater risk of morbidity and mortality after operative interventions. The aim of the present study was to assess the effect of frailty on the outcomes after carotid interventions, including both carotid endarterectomy (CEA) and carotid artery stenting (CAS).
  • Sabat, J., Bock, D., Hsu, C. H., Tan, T. W., Weinkauf, C., Trouard, T., Perez-Carrillo, G. G., & Zhou, W. (2019). Risk factors associated with microembolization after carotid intervention. Journal of vascular surgery.
    More info
    Microembolization after carotid artery stenting (CAS) and carotid endarterectomy (CEA) has been documented and may confer risk for neurocognitive impairment. Patients undergoing stenting are known to be at higher risk for microembolization. In this prospective cohort study, we compare the microembolization rates for patients undergoing CAS and CEA and perioperative characteristics that may be associated with microembolization.
  • Sabat, J., Hsu, C. H., Samra, N., Chu, Q., Weinkauf, C., Goshima, K., Zhou, W., & Tan, T. W. (2019). Length of Stay and ICU Stay Are Increased With Repair of Traumatic Superior Mesenteric Vein Injury. The Journal of surgical research, 242, 94-99.
    More info
    Traumatic superior mesenteric vein (SMV) injury is rare, and the ideal treatment is controversial. We compared the outcomes of ligation versus repair of SMV injury using the National Trauma Databank.
  • Soman, S., Dai, W., Dong, L., Hitchner, E., Lee, K., Baughman, B. D., Holdsworth, S. J., Massaband, P., Bhat, J. V., Moseley, M. E., Rosen, A., Zhou, W., & Zaharchuk, G. (2019). Identifying cardiovascular risk factors that impact cerebrovascular reactivity: An ASL MRI study. Journal of magnetic resonance imaging : JMRI.
    More info
    To maintain cerebral blood flow (CBF), cerebral blood vessels dilate and contract in response to blood supply through cerebrovascular reactivity (CR).
  • Tan, T. W., Shih, C. D., Concha-Moore, K. C., Diri, M. M., Hu, B., Marrero, D., Zhou, W., & Armstrong, D. G. (2019). Disparities in outcomes of patients admitted with diabetic foot infections. PloS one, 14(2), e0211481.
    More info
    The purpose of this study was to evaluate the disparities in the outcomes of White, African American (AA) and non-AA minority (Hispanics and Native Americans (NA)), patients admitted in the hospitals with diabetic foot infections (DFIs).
  • Rosen, A. C., Soman, S., Bhat, J., Laird, A. R., Stephens, J., Eickhoff, S. B., Fox, P. M., Long, B., Dinishak, D., Ortega, M., Lane, B., Wintermark, M., Hitchner, E., & Zhou, W. (2018). Convergence Analysis of Micro-Lesions (CAML): An approach to mapping of diffuse lesions from carotid revascularization. NeuroImage. Clinical, 18, 553-559.
    More info
    Carotid revascularization (endarterectomy, stenting) prevents stroke; however, procedure-related embolization is common and results in small brain lesions easily identified by diffusion weighted magnetic resonance imaging (DWI). A crucial barrier to understanding the clinical significance of these lesions has been the lack of a statistical approach to identify vulnerable brain areas. The problem is that the lesions are small, numerous, and non-overlapping. Here we address this problem with a new method, the Convergence Analysis of Micro-Lesions (CAML) technique, an extension of the Anatomic Likelihood Analysis (ALE). The method combines manual lesion tracing, constraints based on known lesion patterns, and convergence analysis to represent regions vulnerable to lesions as probabilistic brain atlases. Two studies were conducted over the course of 12 years in an active, vascular surgery clinic. An analysis in an initial group of 126 patients at 1.5 T MRI was cross-validated in a second group of 80 patients at 3T MRI. In CAML, lesions were manually defined and center points identified. Brains were aligned according to side of surgery since this factor powerfully determines lesion distribution. A convergence based analysis, was performed on each of these groups. Results indicated the most consistent region of vulnerability was in motor and premotor cortex regions. Smaller regions common to both groups included the dorsolateral prefrontal cortex and medial parietal regions. Vulnerability of motor cortex is consistent with previous work showing changes in hand dexterity associated with these procedures. The consistency of CAML also demonstrates the feasibility of this new approach to characterize small, diffuse, non-overlapping lesions in patients with multifocal pathologies.
  • Weisbord, S. D., Gallagher, M., Jneid, H., Garcia, S., Cass, A., Thwin, S. S., Conner, T. A., Chertow, G. M., Bhatt, D. L., Shunk, K., Parikh, C. R., McFalls, E. O., Brophy, M., Ferguson, R., Wu, H., Androsenko, M., Myles, J., Kaufman, J., & Palevsky, P. M. (2018). Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine. The New England journal of medicine, 378(7), 603-614.
    More info
    Intravenous sodium bicarbonate and oral acetylcysteine are widely used to prevent acute kidney injury and associated adverse outcomes after angiography without definitive evidence of their efficacy.
  • Zhou, W. (2018). Physiological Levels of Resistin Induce, A Shift From Proliferation to Apoptosis in Macrophage and VSMC Co-Culture. Surgery.
  • Zuniga, M. C., Raghuraman, G., & Zhou, W. (2018). Physiologic levels of resistin induce a shift from proliferation to apoptosis in macrophage and VSMC co-culture. Surgery, 163(4), 906-911.
    More info
    Resistin, an adipokine with inflammatory properties, has been associated with plaque vulnerability. Vascular smooth muscle cells and macrophages are the major cellular components in advanced atherosclerotic plaques and interdependently affect plaque stability. The purpose of this study was to examine the effects of resistin on the interactions of vascular smooth muscle cells and macrophages using co-culture systems.
  • Zhou, W. (2017). Carotid Artery Stenting. On-Line, Scientific American Vascular and Endovascular Surgery.
  • Zhou, W. (2017). Eotaxin Augments Calcification in Vascular Smooth Muscel Cells. Journal of Cellular Biochemistry, 118(3), 647-654.
  • Zhou, W. (2017). Invited Commentary - Outcome of Endovascular Repair For Complex Abdominal Aortic Aneurysms. Journal of Vascular Surgery.
  • Zhou, W. (2017). Open Versus Endovascular Aneurysm Repair Trial Review. Surgery, 162(5), 974-978.
  • Zhou, W. (2017). PKC-Epsilon and TLR4 Synergistically Regulate Resistin-Mediated Macrophage Inflammation in Human Macrophage Atherosclerosis. Atherosclerosis, 259(4), 51-59.
  • Zhou, W. (2017). Safety and Efficacy of Intramuscular Human Placenta-Derived Mesenchymal Stromal-Like Cells (Cenplacel) (PDA-002) in Patients Who Have a Diabetic Foot Ulcer With Peripheral Arterial Disease. International Wound Journal, 15(3), 1419-1425.
  • Zhou, W. (2017). Volume of Subclinical Embolic Infarct Correlates to Long-Term Cognitive Changes Following Carotid Revascularization. Journal of Vascular Surgery, 65(3), 686-694.

Presentations

  • Zhou, W. (2019, February 2019). What is Symptomatic Carotid Stenosis and Do We Need New Trials?. International Stroke Conference. Honolulu, HI: Iternational Stroke Conference.
  • Zhou, W. (2019, July 2019). EVAR surveillance and long-term follow-up. Chinese Southern Endovascular Conference. Nanning, China: Chinese Southern Endovascular Conference.
  • Zhou, W. (2019, July 2019). Identifying high risk asymptomatic carotid stenosis. Chinese Southern Endovascular Congress. Nanning, China: Chinese Southern Endovascular Congress.
  • Zhou, W. (2019, July 2019). Renal Rescue: Should we be more aggressive?. Rocky Mountain Vascular Society Annual Meeting. Coeur D'Alene, Idaho: Rocky Mountain Vascular Society.
  • Zhou, W. (2019, June 2019). Clinical Research Seed Grant Changes: Panelist Discussion. Vascular Annual Meeting. National Harbor, Maryland: Society for Vascular Surgery.
  • Zhou, W. (2019, June 2019). How to Identify High-Risk Asymptomatic Carotid Stenosis. Complex Cardiovascular Catheter Symposium. Orlando, FL: Complex Cardiovascular Catheter.
  • Zhou, W. (2019, June 2019). Research and a Career in Vascular Surgery. Vascular Annual Meeting. National Harbor, Maryland: Soceity for Vascular Surgery.
  • Zhou, W. (2019, March 2019). Management Approaches for Type II Endoleak. Chinese Vascular Surgical Complication Forum. Guangzhou, China.
  • Zhou, W. (2019, May 2019). Cognitive Effects After Carotid Intervention: Can Patients Actually Have Improved Function?. Pacific Northwest Endovascular Conference. Seattle, WA: Pacific Northwest Endovascular Conference.
  • Zhou, W. (2019, May 2019). Leadership Panel Discussion. Pacific Northwest Endovascular Conference. Seattle, WA.
  • Zhou, W. (2019, November 2019). An Occluded Renal Artery Does Not Mean A Lost Kidney Due To Collaterals Maintaining Its Viability: Revascularization. Veith Annual Symposium. New York, NY.
  • Zhou, W. (2019, November 2019). Risk Factors Predict the Volume Of Cerebral Infarct Associated With Carotid Interventions. Veith Annual Symposium. New York, NY.
  • Zhou, W. (2019, October 2019). Identify high risk asymptomatic carotid lesions. International College of Angiology Annual Meeting. Columbus, Ohio.
  • Zhou, W. (2019, October 2019). Long-term Outcomes of EVAR. Chinese Capital Vascular Symposium. Beijing, China.
  • Zhou, W. (2019, October 2019). Pathway to treat type II endoleak.. International College of Angiology Annual Meeting. Columbus, Ohio.
  • Zhou, W. (2019, October 2019). What do we know about endoleaks?. Chinese Capital Vascular Symposium. Beijing, China.
  • Zhou, W. (2019, September 2019). Role of late renal revascularization for functional salvage. Taiwan Soceity for Vascular Surgery. Taipei, Taiwan.
  • Zhou, W. (2019, September 2019). Treatment approach of type II endoleak. Taiwan Society for Vascular Surgery. Taiwan Society for Vascular Surgery. Taipei, Taiwan.
  • Zhou, W. (2018, April 2018). Aortic Graft Occlusion: Lesson Learned. 8th Annual China Vascular Surgical Complication Forum. Hang Zhou, China.
  • Zhou, W. (2018, April 2018). Being a Successful Clinical Scientist. Chinese Innovation Symposium. Beijing, China: Chinese Innovation Symposium.
  • Zhou, W. (2018, August 2018). Beyond Stroke, What Have We Learned about Carotid Disease?. International Congress of Angiology.
  • Zhou, W. (2018, February 2018). Carotid Disease and Carotid Interventions. Where Are We Now?. 2nd Annual James Seeger Visiting Professor Lecture.. University of Florida.
  • Zhou, W. (2018, July 2018). Cognitive Effects of Carotid Interventions. Rocky Mountain Vascular Surgery Annual Meeting. Avon, CO.
  • Zhou, W. (2018, July 2018). Current Outcomes of TCAR. Society of Asian Vascular Surgery. GuangZhou, China.
  • Zhou, W. (2018, July 2018). Debate: CAS or CEA in Recently Symptomatic Patients? - For CEA: Ross Naylor - For CAS: Wei Zhou. Society of Asian Vascular Surgery. GuangZhou, China: Society of Asian Vascular Surgery.
  • Zhou, W. (2018, July 2018). How to Prevent Contrast-Induced Nephropathy. Society of Asian Vascular Surgery. GuangZhou, China: Society of Asian Vascular Surgery.
  • Zhou, W. (2018, July 2018). Moderator for Vascular Surgery History Video. Society of Asian Vascular Surgery. GuangZhou, China: Society of Asian Vascular Surgery.
  • Zhou, W. (2018, July 2018). Pathway to Treat Type II Endoleaks. Society of Asian Vascular Surgery. GuangZhou, China: Society of Asian Vascular Surgery.
  • Zhou, W. (2018, June 2018). How to Evaluate Limb Perfusion Following Endovascular Interventions. Complex Catheter Catheterization. Orlando, FL.
  • Zhou, W. (2018, June 2018). What is the Current Strategy for Managing Asymptomatic Carotid Disease. Complex Catheter Catheterization. Orlando, FL.
  • Zhou, W. (2018, March 2018). Effectiveness of CEA: What do Trials Tell Us?. Transcatheter Endovascular Decisions (TED) Conference. Phoenix, AZ.
  • Zhou, W. (2018, May 2018). Embolization to Profunda: What Should I Do?. Master of Cardiovascular Complication Course. Washington, DC.
  • Zhou, W. (2018, May 2018). FEVAR Complication: Can We Save The Kidney?. Master of Cardiovascular Complication Course. Washington, DC.
  • Zhou, W. (2018, November). Effects of Diabetes on Changes in Cognition After CAS and CEA: Why is this so?. 2018 Veith Symposium. New York, New York.
  • Zhou, W. (2018, November). Frailty Has Different Effects on the Outcomes for Patients Undergoing CAS and CEA: Frail Patients Needing Treatment. 2018 Veith Symposium. New York, New York.
  • Zhou, W. (2018, September 2018). Endovascular Approach of Limb Salvage. Round Table Community Event. Tucson, AZ.
  • Zhou, W. (2018, September 2018). How Carotid Disease and Carotid Interventions Affect Memory. Go Red For Women. Tucson, AZ.
  • Zhou, W. (2017, April). Embolic Volume and Cognitive Function. Charing Cross - April 2017. London.
  • Zhou, W. (2017, February). Endoleak Following EVAR: What Do We Know. CRT - February 2017. New York, NY.
  • Zhou, W. (2017, June). Carotid Intervention and its Cognitive Effects. Complex Cardiovascular Catheterization - June 2017. Orlando, FL.
  • Zhou, W. (2017, June). Carotid Intervention and its Cognitive Effects. Complex Catheter Catheterization - June 2017. Orlando, FL.
  • Zhou, W. (2017, June). Cognition Testing Pre and Post Intervention Will Be Routine in the Future. Vascular Annual Meeting - June 2017. San Diego, CA.
  • Zhou, W. (2017, June). Post-Evar Surveillance Imaging Follow-Up Is A Must! - June 2017. Master of Complication Couse. Washington, DC.
  • Zhou, W. (2017, June). Proceed With Caution: Crossing The Aortic Arch During TEVAR - June 2017. Master of Complication Couse. Washington DC.
  • Zhou, W. (2017, June). The Menace of a Tortuous Aorto-Iliac Arteries During EVAR - June 2017. Master of Complication Course. Washington DC.
  • Zhou, W. (2017, Novebmer 18). Role Of Digital And Tibial Artery Calcification In The Treatment Of Patients With CLTI: It Is Not All Bad. Veith Symposium. New York, NY.
  • Zhou, W. (2017, November 17). Volume Of Subclinical Microembolization After CAS Or CEA Correlates With Long-Term Cognitive Changes: CAS More So Than CEA: DW MRI Defects Have Consequences. Veith Symposium. New York, NY.
  • Zhou, W. (2017, October). Cognitive Effects of Carotid Intervensions: What Do We Know?. Asian Society for Vascular Surgery - October 2017. Kuala Lumpur, Malaysia.
  • Zhou, W. (2017, October). Embolization in Vascular Surgery Practice. Asian Society for Vascular Surgery - October 2017. Kuala Lumpur, Malaysia.
  • Zhou, W. (2017, October). What Did We Learn From OVER Trial?. Asian Society for Vascular Surgery - October 2017. Kuala Lumpur, Malaysia.
  • Zhou, W. (2017, September). Identification of High-Risk Patients with Asymptomatic Carotid Stenosis: Fact vs Fiction. International Congress of Angiology - September 2017. Vienna.

Poster Presentations

  • Zhou, W., Barker, N. K., Moly, P. K., Langlais, P. R., & Haider, N. (2018, May). Resistin induced Differential Global Protein Expression in Human Macrophage. Vascular Discovery 2018 Scientific Sessions.
  • Trouard, T. P., Wheeler, G., Do, L., & Zhou, W. (2017, November). Semi-automated Analysis of Microembolic Lesions in Brain Diffusion Weighted MRI. University of Arizona College of Medicine Junior Investigators Forum. Tucson: University of Arizona College of MEdicine.
  • Wheeler, G., Do, L., Zhou, W., Trouard, T. P., Wheeler, G., Do, L., Zhou, W., Trouard, T. P., Wheeler, G., Do, L., Zhou, W., & Trouard, T. P. (2017, October). Semi-automated Analysis of Microembolic Lesions in Brain Diffusion Weighted MRI. Biomedical Engineering Society Annual Meeting. Phoenix AZ.

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