Charles T Hennemeyer
- Associate Professor, Medical Imaging - (Clinical Scholar Track)
Contact
- (520) 626-6044
- AHSC, Rm. 21A
- chennemeyer@arizona.edu
Degrees
- M.D. Medicine
- Saint Louis University School of Medicine, St. Louis, Missouri, United States
- B.S. Major: Biologic Sciences
- Saint Louis University, Saint Louis, Missouri
Work Experience
- Department of Medical Imaging University of Arizona (2014 - Ongoing)
- Department of Medical Imaging University of Arizona (2012 - Ongoing)
- Department of Medical Imaging University of Arizona (2012 - Ongoing)
- Auburn Memorial Hospital (2010 - 2012)
- St. Lawrence Radiology Associates New York (2010 - 2012)
- IR and Diagnostic Groups (2010 - 2011)
- Renaissance Imaging Medical Associates, Inc. (2009 - 2010)
- UC Santa Monica (2006 - 2013)
- UCLA Ronald Reagan Medical Center (2006 - 2013)
- Los Robles Hospital (2006 - 2008)
Awards
- 2018 JVIR Distinguished Laboratory Investigation Award Presentation. Pilot Study of the Safety and Efficacy of Gallbladder Cryoablation in a Porcine Model: Midterm Results. SIR 2019
- Spring 2019
- Castle Connolly Top Doctor
- Spring 2019
- Chair, Interventional Radiology, AZ Radiologic Society, Chapter of the American College of Radiology (ACR)
- Spring 2019
- National Institutes of Health (NIH) Reviewer, Clinical Molecular Imaging and Probe development (CMIP)
- Spring 2018
- Journal Reviewer, BMC Cancer Journal
- Spring 2012
Licensure & Certification
- Medical License, State of Missouri (2001)
- Medical License, State of Maine (2001)
- Medical License, State of Pennsylvania (2001)
- Medical License;, State of New York (2001)
- Medical License, State of California (2001)
- Medical License, State of California (2006)
- Medical License, State of Arizona (2012)
- CAQ - Certified Vascular and Interventional Radiology (2008)
- Board Certification - Nuclear Medicine, American Board of Radiology (2006)
- Board Certification -Diagnostic Radiology, American Board of Radiology (2006)
Interests
Teaching
Vascular and Interventional Radiology training
Research
Medical equipment designing of minimally invasive surgical devicesNeuromodulationNovel image guided medical interventionsVertebral augmentation and spinal painInterventional oncology, novel devices
Courses
2020-21 Courses
-
Diagnostic Radiology
RADI 850A (Spring 2021) -
Vascular Interventional Radi
RADI 850R (Spring 2021)
Scholarly Contributions
Journals/Publications
- Brunson, C., Young, S., Hennemeyer, C., & Woodhead, G. (2023). A Novel Method of Calculating the Tumor to Normal Ratio for Radioembolization of Hepatocellular Carcinoma: A Prospective Study Comparing 2-D Perfusion Angiography and Tc-99m MAA SPECT/CT.. Journal of Vascular and Interventional Radiology.
- C, B., Shamar, Y., Hennemeyer, C., & Gregory, W. (2023). A Novel Method of Calculating the Tumor to Normal Ratio for Radioembolization of Hepatocellular Carcinoma: A Prospective Study Comparing 2-D Perfusion Angi9ography and Tc-99m MAA SPECT/CT.. Journal of Vascular and Interventional Radiology.
- Hennemeyer, C., Woodhead, G., Mahadevan, D., Haymaker, C., Babiker, H., Borazanci, E., Subbiah, V., Agarwala, S., Algazi, A., Schachter, J., Lotem, M., Maurice-Dror, C., Hendler, D., Rahimian, S., Minderman, H., Bernatchez, C., Murthy, R., Hultsch, R., Kaplan, N., , Chunduru, S., et al. (2022). Tilsotolimod Exploits the TLR9 Pathway to Promote Antigen Presentation and Type 1 IFN Signaling in Solid Tumors: A Multicenter International Phase I/II Trial (ILLUMINATE-101). Clinical Cancer Research, 28(23), 5079-5087. doi:10.1158/1078-0432.ccr-21-4486
- Kuo, P., Patel, M., Woodhead, G., Struycken, L., Mcgregor, H., & Hennemeyer, C. (2022). Clinical and Dosimetric Implications of Calculating Lung Shunt Fraction for Hepatic 90Y Radioembolization Using SPECT/CT Versus Planar Scintigraphy.. AJR. American journal of roentgenology, 218(4), 728-737. doi:10.2214/ajr.21.26663More infoBACKGROUND. Accurate assessment of hepatopulmonary shunting, typically performed by planar scintigraphy, is critical in planning 90Y radioembolization. High lung shunt fractions (LSFs) may alter treatment. OBJECTIVE. The purpose of this study is to compare LSFs calculated from planar scintigraphy versus SPECT/CT in patients with high planar LSFs (> 15%) and to describe the potential clinical and dosimetric implications of SPECT/CT LSF calculations. METHODS. This retrospective study included 36 patients (29 men and seven women; mean age, 62.4 ± 9.8 [SD] years) who underwent 99mTc-macroaggregated albumin (MAA) planar scintigraphy for planning hepatic radioembolization, had a planar LSF greater than 15%, and underwent concurrent SPECT/CT. Clinically reported planar LSFs were recorded. SPECT/CT LSFs were retrospectively calculated using automatically generated volumetric ROIs around the lungs and liver with subsequent manual adjustments. Total lung and perfused liver doses were calculated using a medical internal radiation dose model. Values derived from planar and SPECT/CT data were compared using Mann-Whitney U tests. Multivariable regression analysis was performed of factors associated with the discrepancy in LSF between the techniques. RESULTS. Mean planar LSF was 25.1% ± 11.6%, and mean SPECT/CT LSF was 16.0% ± 9.3% (p < .001). Mean lung dose was 18.8 ± 8.0 Gy for planar LSF versus 12.3 ± 7.2 Gy for SPECT/CT LSF (p < .001). Mean perfused liver dose was 92.9 ± 36.1 Gy using planar LSF versus 102.7 ± 39.1 Gy using SPECT/CT LSF (p < .001). In multivariable analysis, a larger discrepancy in LSF between planar scintigraphy and SPECT/CT was associated with a body mass index (weight in kilograms divided by the square of height in meters) of 26 or higher (p = .02), maximum tumor size of less than 9 cm (p = .05), and left hepatic intraarterial injection (p = .02). Fourteen of 36 patients did not undergo upfront radioembolization due to a planar LSF greater than 20% and instead underwent shunt-reducing embolization with subsequent radioembolization (n = 7), transarterial chemoembolization (n = 5), or no treatment (n = 2). Five of these 14 patients had a SPECT/CT LSF of less than 20% and would have been eligible for upfront radioembolization based on SPECT/CT LSF. Seven of 29 patients treated with radioembolization underwent prescribed dose reductions based on planar LSF; six of these patients would have qualified for standard radioembolization without dose reduction using SPECT/CT LSF. CONCLUSION. Planar scintigraphy yields greater LSFs compared with SPECT/CT, possibly leading to unnecessary shunt-reducing procedures and prescribed dose reductions. CLINICAL IMPACT. SPECT/CT should be considered for clinical LSF calculations before radioembolization in patients with high LSFs.
- Avery, R., Khan, A., Mcgregor, H., Woodhead, G., Palacio, D., Lecomte, M., & Hennemeyer, C. (2021). Cardiac MRI for Evaluation of Right Heart Function before and after Catheter-directed Therapy in Submassive Pulmonary Embolism: A Prospective Study of Feasibility and Potential Utility.. Radiology. Cardiothoracic imaging, 3(6), e210217. doi:10.1148/ryct.210217More infoCardiac MRI is clinically feasible in the setting of submassive pulmonary embolism and is able to demonstrate measurable differences of right heart function before and after catheter-directed therapy.
- Barton, J. K., Hennemeyer, C. T., Carlson, Q., Woodhead, G. J., Rouse, A. R., Utzinger, U., Gmitro, A. F., & Larson, M. (2021). Using FDA-approved drugs as off-label fluorescent dyes for optical biopsies: from in silico design to ex vivo proof-of-concept. Methods and Applications in Fluorescence.More infoAbstractOptical biopsies bring the microscope to the patient rather than the tissue to the microscope, and may complement or replace the tissue-harvesting component of the traditional biopsy process with its associated risks. In general, optical biopsies are limited by the lack of endogenous tissue contrast and the small number of clinically approved in vivo dyes. This study tests multiple FDA-approved drugs that have structural similarity to research dyes as off-label in situ fluorescent alternatives to standard ex vivo hematoxylin & eosin tissue stain. Numerous drug-dye combinations shown here may facilitate relatively safe and fast in situ or possibly in vivo staining of tissue, enabling real-time optical biopsies and other advanced microscopy technologies, which have implications for the speed and performance of tissue- and cellular-level diagnostics.
- Carlson, Q., Larson, M., Gmitro, A. F., Hennemeyer, C. T., Woodhead, G. J., Utzinger, U., Barton, J. K., & Rouse, A. R. (2021). Using FDA-approved drugs as off-label fluorescent dyes for optical biopsies: from in silico design to ex vivo proof-of-concept. Methods and Applications in Fluorescence.
- Hennemeyer, C. T., Woodhead, G., Karime, C., Wang, J., Mody, K., Borad, M. J., Mahadevan, D., Chandana, S. R., & Babiker, H. (2021). Tilsotolimod: an investigational synthetic toll-like receptor 9 (TLR9) agonist for the treatment of refractory solid tumors and melanoma. Expert Opinion on Investigational Drugs, 31(1), 1-13. doi:10.1080/13543784.2022.2019706
- McGregor, H., Brunson, C., Woodhead, G., Khan, A., Hennemeyer, C., & Patel, M. (2021). Quantitative Assessment of the Hemodynamic Effects of Intra-Arterial Nitroglycerin on Hepatocellular Carcinoma using Two-Dimensional Perfusion Angiography. Journal of vascular and interventional radiology : JVIR, 32(2), 198-203.More infoTo determine the hemodynamic effects of intra-arterial nitroglycerin on hepatocellular carcinoma (HCC) using 2-dimensional (2D) perfusion angiography.
- Woodhead, G. J., Yu, H., Tominna, B. S., Stavas, J. M., Sonntag, P. D., Nowakowski, F. S., Navuluri, R., Muller, R. D., Lazarowicz, M. P., Hennemeyer, C. T., Eifler, A. C., Caoili, E. M., & Bream, P. R. (2021). Safety and Feasibility of a Novel Percutaneous Locoregional Injection Technique of Renal Cellular Therapy for Chronic Kidney Disease of Diabetes.. Kidney international reports, 6(9), 2486-2490. doi:10.1016/j.ekir.2021.06.014
- Woodhead, G., Mcniel, D. B., Mcgregor, H., Hennemeyer, C., Mcgregor, H., Woodhead, G., Mcniel, D. B., & Hennemeyer, C. (2021). Gallbladder Cryoablation: A Novel Option for High-Risk Patients with Gallbladder Disease.. The American journal of medicine, 134(3), 326-331. doi:10.1016/j.amjmed.2020.10.007More infoManagement of high-risk surgical patients with cholecystitis poses a significant clinical problem. These patients are often left with the options of permanent cholecystostomy tube drainage or high-risk surgery. Numerous attempts have been made over the past 4 decades to fulfill the need for a minimally invasive, definitive treatment option for such gallbladder disease. These attempts have largely focused on endoluminal ablation with a variety of sclerosants and have been unable to reliably achieve permanent gallbladder devitalization. The advent of modern percutaneous devices and techniques have provided further opportunity to develop minimally invasive treatment options for high-risk patients. Cryoablation, a thermal ablation modality that induces cell death through tissue freezing, has recently emerged as a promising potential option to treat gallbladder disease. Early studies have demonstrated good technical and clinical success, and a prospective trial is ongoing. This manuscript explains the clinical need for gallbladder cryoablation, briefly revisits historical minimally invasive treatments, describes cryoablation technology and why it is well suited for the gallbladder, and reviews the preclinical and clinical studies evaluating the safety and efficacy of gallbladder cryoablation.
- Woodhead, G., Mcniel, D., Mcgregor, H., & Hennemeyer, C. (2021). The Reply.. The American journal of medicine, 134(11), e566. doi:10.1016/j.amjmed.2021.07.029
- Woodhead, G., Patel, M., Mcniel, D. B., Mcgregor, H., Kuo, P. H., Hennemeyer, C., Brunson, C., & Boros, D. (2021). Abstract No. 3 ▪ FEATURED ABSTRACT Clinical predictors of Yttrium-90 uptake in hepatocellular carcinoma: toward personalized dosimetry to maximize response to therapy. Journal of Vascular and Interventional Radiology, 32(5), S3. doi:10.1016/j.jvir.2021.03.414
- Woodhead, G., Struycken, L., Patel, M., Mcgregor, H., Kuo, P. H., & Hennemeyer, C. (2021). Abstract No. 34 Planar scintigraphy overestimates hepatopulmonary shunt fractions compared with quantitative SPECT/CT. Journal of Vascular and Interventional Radiology, 32(5), S16. doi:10.1016/j.jvir.2021.03.450
- Hall, E. T., Gibson, B. A., Hennemeyer, C. T., Devis, P., Black, S., & Larsen, B. T. (2020). Segmental arterial mediolysis and fibromuscular dysplasia: what comes first, the chicken or the egg?. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 25(2), 113-5.More infoSegmental arterial mediolysis (SAM) is a rare vasculopathy characterized by lysis of the outer media in splanchnic arteries and formation of dissecting pseudoaneurysms that may spontaneously rupture, leading to massive and often fatal intraabdominal hemorrhage. The pathogenesis of SAM is poorly understood. Healed SAM lesions closely resemble fibromuscular dysplasia (FMD), leading some authors to postulate that SAM represents a precursor to FMD despite distinct clinical differences between these two disorders. Herein, we present a 61-year-old woman with fatal SAM who showed histologic features in her aorta suggesting the opposite pathogenetic relationship, with an unclassified "FMD-like" arteriopathy preceding development of SAM.
- McGregor, H., Brunson, C., Woodhead, G., Patel, M. V., & Hennemeyer, C. (2020). Caudal Migration and Endovascular Retrieval of Two VIATORR CX Stent Grafts during Transjugular Intrahepatic Portosystemic Shunt Placement. Journal of vascular and interventional radiology : JVIR, 31(3), 512-515.
- McGregor, H., Hennemeyer, C., Harms, C., Woodhead, G., & Patel, M. (2020). Stent Graft Reconstruction of the Lymphovenous Junction after Complete Transection of the Cervical Thoracic Duct. Journal of vascular and interventional radiology : JVIR, 31(11), 1918-1921.e1.
- McGregor, H., Woodhead, G., Hennemeyer, C., & Patel, M. (2020). Percutaneous Translumbar Inferior Vena Cava Filter Retrieval. Journal of vascular and interventional radiology : JVIR, 31(4), 690-692.
- McGregor, H., Woodhead, G., Patel, M., & Hennemeyer, C. (2020). Thoracic duct stent-graft decompression with 3-month patency: Revisiting a historical treatment option for portal hypertension. Lymphology, 53(2), 81-87.More infoThis report introduces the rationale for thoracic duct stent-graft decompression in cirrhotic patients with portal hypertension and provides a case example with 3-month stentgraft patency. Thoracic duct flow and pressure are elevated in cirrhosis. Historically, complications of portal hypertension have been successfully treated with external drainage of the thoracic duct or surgical lymphovenous bypass. A 45-year-old woman with cirrhosis, chronic portosplenomesenteric thrombosis, and acute variceal hemorrhage underwent percutaneous thoracic duct stent-graft placement across the lymphovenous junction. The hemorrhage subsequently resolved and follow up endoscopy demonstrated decompression of the bleeding varices. Venography 40 days later demonstrated a partially patent stent-graft with fibrin sheath formation distally. The stent-graft was extended distally to the right atrium and was fully patent on venography 3 months later. The patient had no further episodes of hemorrhage.
- McGregor, H., Woodhead, G., Patel, M., Khan, A., Hannallah, J., Ruiz, D., Conrad, M., Tang, A., & Hennemeyer, C. (2020). Gallbladder Cryoablation for Chronic Cholecystitis in High-Risk Surgical Patients: 1-Year Clinical Experience with Imaging Follow-up. Journal of vascular and interventional radiology : JVIR, 31(5), 801-807.More infoTo assess the short-term safety and efficacy of gallbladder cryoablation in high-risk patients.
- McNiel, D., Hennemeyer, C., Woodhead, G., & McGregor, H. (2020). Gallbladder Cryoablation: A Novel Option for High-Risk Patients with Gallbladder Disease. The American journal of medicine.More infoManagement of high-risk surgical patients with cholecystitis poses a significant clinical problem. These patients are often left with the options of permanent cholecystostomy tube drainage or high-risk surgery. Numerous attempts have been made over the past 4 decades to fulfill the need for a minimally invasive, definitive treatment option for such gallbladder disease. These attempts have largely focused on endoluminal ablation with a variety of sclerosants and have been unable to reliably achieve permanent gallbladder devitalization. The advent of modern percutaneous devices and techniques have provided further opportunity to develop minimally invasive treatment options for high-risk patients. Cryoablation, a thermal ablation modality that induces cell death through tissue freezing, has recently emerged as a promising potential option to treat gallbladder disease. Early studies have demonstrated good technical and clinical success, and a prospective trial is ongoing. This manuscript explains the clinical need for gallbladder cryoablation, briefly revisits historical minimally invasive treatments, describes cryoablation technology and why it is well suited for the gallbladder, and reviews the preclinical and clinical studies evaluating the safety and efficacy of gallbladder cryoablation.
- Mcgregor, H., Patel, M., Woodhead, G., Patel, M., Mcgregor, H., Lecomte, M., Khan, A., & Hennemeyer, C. (2020). 3:18 PM Abstract No. 257 Fast scan cardiac magnetic resonance imaging in patients with acute pulmonary embolism undergoing catheter-directed therapy. Journal of Vascular and Interventional Radiology, 31(3), S115. doi:10.1016/j.jvir.2019.12.304
- Mcgregor, H., Patel, M., Woodhead, G., Patel, M., Oats, S., Mcgregor, H., Hennemeyer, C., & Abramyan, A. (2020). 3:45 PM Abstract No. 77 Necessity of common femoral arteriogram prior to deployment of an Angio-Seal closure device. Journal of Vascular and Interventional Radiology, 31(3), S37. doi:10.1016/j.jvir.2019.12.103
- Oats, S., Hennemeyer, C., Woodhead, G., & McGregor, H. (2020). Pulmonary Aspergilloma Removal Using a Large-Bore Suction Catheter System. Journal of vascular and interventional radiology : JVIR, 31(12), 2156-2159.
- Patel, M. V., Ahmed, O., Hennemeyer, C., Hatchett, S., Sacramento, M., & Funaki, B. (2020). IR is an Operational and Financial Hedge for Hospitals during COVID-19. Journal of vascular and interventional radiology : JVIR, 31(10), 1724-1726.
- Woodhead, G., Weise, L. B., Lecomte, M., Khan, A., & Hennemeyer, C. (2020). 3:45 PM Abstract No. 260 Survival analysis outcomes of catheter-directed therapy of submassive pulmonary embolism. Journal of Vascular and Interventional Radiology, 31(3), S116-S117. doi:10.1016/j.jvir.2019.12.307
- Hennemeyer, C., Khan, A., McGregor, H., Moffett, C., & Woodhead, G. (2019). Outcomes of Catheter-Directed Therapy Plus Anticoagulation Versus Anticoagulation Alone for Submassive and Massive Pulmonary Embolism. The American journal of medicine, 132(2), 240-246.More infoCatheter-directed therapy (CDT) offers an alternative treatment to systemic thrombolysis for patients with massive and submassive pulmonary embolism.
- McGregor, H., Woodhead, G., Conrad, M., Tang, A., Ruiz, D., Khan, A., & Hennemeyer, C. (2019). First in-Human Gallbladder Cryoablation in a Patient with Acute Calculous Cholecystitis Initially Treated with a Cholecystostomy Tube. Journal of vascular and interventional radiology : JVIR, 30(8), 1229-1232.More infoA 71-year-old poor surgical candidate with acute calculous cholecystitis was initially managed with cholecystostomy tube drainage for 28 days. He subsequently underwent gallbladder cryoablation under moderate sedation with 3 cryoprobes and 2 separate 10-8-10 freeze-thaw cycles targeting the gallbladder neck/body and fundus followed by cholecystostomy tube removal. He was discharged 1 day after ablation. Magnetic resonance and hepatobiliary iminodiacetic acid scan 1 month postablation demonstrated a thick-walled, distended gallbladder and no filling of the cystic duct. Magnetic resonance 3 months postablation demonstrated retraction of the gallbladder wall with luminal collapse. The patient denied any pain after discharge and is asymptomatic 3 months after ablation.
- Mcgregor, H., Mcgregor, H., Woodhead, G., Ruiz, D., Hennemeyer, C., Mcgregor, H., Woodhead, G., Tang, A., Ruiz, D., Khan, A., Hennemeyer, C., & Conrad, M. (2019). 04:03 PM Abstract No. 285 First in human gallbladder cryoablation to treat cholecystitis. Journal of Vascular and Interventional Radiology, 30(3), S127. doi:10.1016/j.jvir.2018.12.349
- Palmer, J., Hennemeyer, C. T., Woodhead, G. J., Patel, M. V., Ruiz, D., & McGregor, H. C. (2019). Intravascular Deployment of an Angio-Seal Device with Successful Endovascular Snare Retrieval. Journal of vascular and interventional radiology : JVIR, 30(10), 1703-1706.
- Ruiz, D., Mcgregor, H., Patel, M., Hannallah, J., Woodhead, G., Ruiz, D., Patel, M., Mcgregor, H., Khan, A., & Hennemeyer, C. (2019). 03:09 PM Abstract No. 54 Hospital utilization outcomes of catheter-based intervention plus anticoagulation versus systemic anticoagulation alone for the treatment of submassive and massive pulmonary emboli. Journal of Vascular and Interventional Radiology, 30(3), S27. doi:10.1016/j.jvir.2018.12.095
- Vercruysse, G. A., Bauman, Z. M., Hennemeyer, C. T., Devis, P., & Rhee, P. M. (2018). Man Lured with Alcohol, Takes Bait, and Gets Caught: A Cautionary Fish Tale. The American surgeon, 84(2), e85-e86.
- Nia, B. B., Nia, E. S., Avery, R. J., Kuo, P. H., & Hennemeyer, C. T. (2017). Punctate Radiation Dermatitis of the Foot and Ankle Caused by Distal Embolization of 90Y Microspheres During Liver Directed Therapy. Clinical nuclear medicine, 42(9), e422-e423.More infoA 41-year-old man with gastric adenocarcinoma presented with hepatic metastases. The metastases were refractory to systemic chemotherapy, so radioembolization with Y microspheres was performed. Because of stasis or saturation of the tumor with embolic particles, 79% of the microspheres were injected. At follow-up, the patient complained of "red bumps" that had developed on his right foot/ankle the day after the radioembolization. Because a portion of the dose was still in the catheter when withdrawn from the right femoral artery, the interventional radiologist used a Geiger counter to confirm radioactivity in the cutaneous lesions and thus the distal embolization of the microspheres.
- Frankl, J., Hennemeyer, C., Flores, M. S., & Desai, A. P. (2016). Budd-Chiari Syndrome in a Patient with Hepatitis C. Case reports in hepatology, 2016, 7493970.More infoChronic Budd-Chiari syndrome can present with cirrhosis and signs and symptoms similar to those of other chronic liver diseases. We present a case of Budd-Chiari syndrome discovered during attempted transjugular intrahepatic portosystemic shunting in a patient with decompensated cirrhosis believed to be secondary to hepatitis C. Although the patient had hepatocellular carcinoma, the Budd-Chiari syndrome was a primary disease due to hepatic venous webs. Angioplasty was performed in this case, which resolved the patient's symptoms related to portal hypertension. Follow-up venography 5 months after angioplasty demonstrated continued patency of the hepatic veins. A biopsy was obtained in the same setting, which showed centrilobular fibrosis indicating that venous occlusion was indeed the cause of cirrhosis. It is important to consider a second disease when treating a patient with difficult to manage portal hypertension.
- Frankl, J., Sakata, M. P., Choudhary, G., Hur, S., Peterson, A., & Hennemeyer, C. T. (2016). A Classification System for the Spread of Polymethyl Methacrylate in Vertebral Bodies Treated with Vertebral Augmentation. Tomography (Ann Arbor, Mich.), 2(3), 197-202.More infoIn this study, we develop a classification system for describing polymethyl methacrylate (PMMA) spread in vertebral bodies after kyphoplasty or vertebroplasty for vertebral compression fractures (VCFs) and for assessing whether PMMA spread varies between operators, VCF etiology, or vertebral level. Intraoperative fluoroscopic images of 198 vertebral levels were reviewed in 137 patients (women, 84; men, 53; mean age, 75.8 ± 12.5; and those with a diagnosis of osteoporosis, 63%) treated with kyphoplasty between January 01, 2015 and May 31, 2015 at a single center to create a 5-class descriptive system. PMMA spread patterns in the same images were then classified by 2 board-certified radiologists, and a third board-certified radiologist resolved conflicts. A total of 2 primary PMMA spread patterns were identified, namely, acinar and globular, with subtypes of localized acinar, diffuse globular, and mixed, to describe an equal combination of patterns. Interrater reliability using the system was moderate ( = 0.47). After resolving conflicts, the most common spread class was globular (n = 63), followed by mixed (n = 58), diffuse globular (n = 30), acinar (n = 27), and localized acinar (n = 20). The spread class after treatment by the 2 most frequent operators differed significantly (n = 63, n = 70; < .0001). There was no difference in the spread class between VCF etiologies or vertebral levels. PMMA spread may, therefore, be a modifiable parameter that affects kyphoplasty and vertebroplasty efficacy and adverse events.
- Hennemeyer, C., Frankl, J., Flores, M. S., & Desai, A. P. (2016). Budd-Chiari Syndrome in a Patient with Hepatitis C. Case Reports in Hepatology, 2016, 1-3. doi:10.1155/2016/7493970
- Peterson, A., & Hennemeyer, C. (2016). Denver peritoneo-venous shunt (DPVS): an essential tool in the management of malignant ascites. Journal of Vascular and Interventional Radiology, 27(3), S248-S249. doi:10.1016/j.jvir.2015.12.634
- Frankl, J., & Hennemeyer, C. (2015). Vertebral Refracture after Unipedicular Kyphoplasty Resulting in Lateralized Cement Distribution. Journal of vascular and interventional radiology : JVIR, 26(12), 1906-8.
- Lee, J. Z., Tey, K. R., Mizyed, A., Hennemeyer, C. T., Janardhanan, R., & Lotun, K. (2015). Mitral valve replacement complicated by iatrogenic left ventricular outflow obstruction and paravalvular leak: case report and review of literature. BMC cardiovascular disorders, 15, 119.More infoLeft ventricular outflow tract (LVOT) obstruction and paravalvular leak (PVL) are relatively uncommon, but are serious complications of prosthetic valve replacement.
- Parikh, V., & Hennemeyer, C. (2014). Microspheres embolization of juvenile nasopharyngeal angiofibroma in an adult. International journal of surgery case reports, 5(12), 1203-6.More infoJuvenile nasopharyngeal angiofibroma (JNA) is a benign though locally aggressive, highly vascular tumor primarily affecting adolescent males which has traditionally posed a significant intraoperative challenge during its resection due to the high risk of uncontrollable hemorrhage. Pre-operative angiographic embolization of the major feeding vessels to the tumor has become a valuable, even necessary, tool in the surgical treatment of these lesions.
- Hennemeyer, C. T., Wicklow, K., Feinberg, D. A., & Derdeyn, C. P. (2001). In vitro evaluation of platinum Guglielmi detachable coils at 3 T with a porcine model: safety issues and artifacts. Radiology, 219(3), 732-7.More infoTo evaluate safety-related issues and imaging artifacts of Guglielmi detachable coils in vitro with 3-T magnetic resonance (MR) imaging.
- Hennemeyer, C., & Sundaram, M. (2000). Radiologic case study. Post-transfusional reticuloendothelial system iron overload of sickle cell disease, secondary hemochromatosis. Orthopedics, 23(4), 303, 398-400.