Joel T Funk

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Scholarly Contributions

Chapters

• Funk, J., Twiss, C. O., Michalak, J., & Kim, S. (2017). Surgical Techniques for Interstim Placement. In Adult and Pediatric Neuromodulation. Springer International.
• Funk, J., Chaus, F., & Kim, S. (2018).

  Urologic Considerations for the General Surgeon - Malignant

  Conditions. In Scientific American Surgery.
• Funk, J., Chaus, F., & Kim, S. (2018). Urologic Considerations for the General Surgeon - Benign Conditions. . In Scientific American Surgery.
• Michalak, J. R., Kim, S., Funk, J., Twiss, C. O., & Twiss, C. O. (2018). Sacral Neuromodulation for Overactive Bladder. In Springer International. Springer, Cham. doi:10.1007/978-3-319-73266-4_3
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  Overactive bladder (OAB) is a urologic condition that negatively impacts quality of life. Sacral neuromodulation (SNM) is a safe and effective treatment option that has been studied extensively in patients with severe and refractory OAB. SNM significantly reduces urgency, frequency, and incontinence while also improving quality of life. Although SNM is not currently indicated for the treatment of OAB symptoms due to neurologic disease, recent literature suggests that these patients may also benefit from SNM. Other areas requiring further investigation include reduction of adverse events associated with SNM and the overall cost benefit ratio of SNM.
• Michalak, J. R., Twiss, C. O., Funk, J., & Kim, S. (2017). Sacral Neuromodulation for Overactive Bladder.. In Adult and Pediatric Neuromodulation.
• Michalak, J., Kim, S., Funk, J., & Twiss, C. O. (2017). Sacral Neuromodulation for Overactive Bladder. In Adult and Pediatric Neuromodulation. Springer International.
• Comiter, C. V., & Funk, J. (2008). Chapter 56 – DYNAMIC MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF PELVIC ORGAN PROLAPSE. In Urology Clinics of North America. doi:10.1016/B978-1-4160-2339-5.50105-1
• Funk, J. T., & Comiter, C. (2005). Dynamic MRI in the Evaluation of Pelvic Organ Prolapse. In Female Urology, 3rd Ed.. Elsevier Press.
• Funk, J. T., Ullrich, N., & Ramakumar, S. (2005). Urinary Biomarkers for Urologic Malignancy. In Genitourinary Oncology. Marcel Drekker.

Journals/Publications

• Delu, A., Terrani, K., Funk, J., & Twiss, C. (2024). Harvest of large fascia lata autograft: Outcomes in 108 patients. Neurourolopgy and Urodynamics, 43(5). doi:10.1002/nau.25464
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  Purpose: Due to the reclassification of transvaginal mesh as a high-risk device, there has been renewed interest in the use of fascia lata in pelvic floor reconstruction. Here we report our experience in 108 patients who underwent large fascia lata harvest for pelvic organ prolapse (POP) repair. Our primary objective was to highlight the postoperative morbidity of the large fascia lata harvest in patients who underwent POP repair using fascia lata autograft. Methods: Surgery involved harvesting a fascia lata graft through a small lateral upper thigh incision and was used for either autologous transvaginal POP repair or autologous sacrocolpopexy. To prevent seroma, a temporary Jackson-Pratt drain was intraoperatively placed and a mild compression wrap was applied to the area for 4–6 weeks postoperatively. Patient demographics were obtained preoperatively, while physical exam findings and postoperative outcomes related to the fascia lata harvest were collected at sequential follow up visits. Results: One-hundred eight patients underwent 111 large fascia lata harvests for either transvaginal or abdominal/robotic POP repair from July 2016 to January 2022. Mean follow-up was 19.6 months (range: 1–65) with 38 patients having 24 months or more of follow-up. Mean Visual Analog Pain (VAP) score was 1 (range: 0–10). Sixteen patients developed asymptomatic thigh bulges, 16 patients developed harvest site seromas (of which 14 resolved), and 59 patients experienced mild, non-bothersome paresthesia near the incision. Conclusion: Large fascia lata harvest offers a robust autograft for transvaginal or transabdominal POP repair with minimal morbidity. Harvest site complications are minor and typically resolve with expectant management. This technique can be safely utilized in patients who desire graft-augmented repair of POP without the use of synthetic mesh, allograft, or xenograft.
• Delu, A., Terrani, K., Funk, J., & Twiss, C. O. (2023). Harvest of Large Fascia Lata Autograft: Outcomes in 108 Patients. Urology.
• Delu, A., Terrani, K., Funk, J., & Twiss, C. O. (2024). Harvest of large fascia lata autograft: Outcomes in 108 patients. Neurourology and Urodynamics. doi:10.1002/nau.25464
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  Due to the reclassification of transvaginal mesh as a high-risk device, there has been renewed interest in the use of fascia lata in pelvic floor reconstruction. Here we report our experience in 108 patients who underwent large fascia lata harvest for pelvic organ prolapse (POP) repair. Our primary objective was to highlight the postoperative morbidity of the large fascia lata harvest in patients who underwent POP repair using fascia lata autograft.Surgery involved harvesting a fascia lata graft through a small lateral upper thigh incision and was used for either autologous transvaginal POP repair or autologous sacrocolpopexy. To prevent seroma, a temporary Jackson-Pratt drain was intraoperatively placed and a mild compression wrap was applied to the area for 4-6 weeks postoperatively. Patient demographics were obtained preoperatively, while physical exam findings and postoperative outcomes related to the fascia lata harvest were collected at sequential follow up visits.One-hundred eight patients underwent 111 large fascia lata harvests for either transvaginal or abdominal/robotic POP repair from July 2016 to January 2022. Mean follow-up was 19.6 months (range: 1-65) with 38 patients having 24 months or more of follow-up. Mean Visual Analog Pain (VAP) score was 1 (range: 0-10). Sixteen patients developed asymptomatic thigh bulges, 16 patients developed harvest site seromas (of which 14 resolved), and 59 patients experienced mild, non-bothersome paresthesia near the incision.Large fascia lata harvest offers a robust autograft for transvaginal or transabdominal POP repair with minimal morbidity. Harvest site complications are minor and typically resolve with expectant management. This technique can be safely utilized in patients who desire graft-augmented repair of POP without the use of synthetic mesh, allograft, or xenograft.
• Ghazi, A., Shepard, L., Ayenew, M., Funk, J., De, S., Lerner, L. B., Lingeman, J. E., Humphreys, M. R., Gilling, P., & Das, A. (2024). MP17-14 HOLEP MASTERCLASS: AN EVIDENCE-BASED EDUCATIONAL APPROACH FOR SKILL TRANSFER. AUA Annual Meeting. doi:10.1097/01.ju.0001008628.15460.84.14
• Funk, J. (2020). Pain Resolution and Recurrent Prolapse Rates Following Vaginal Mesh Removal. Urology. doi:10.1016/j.urology.2020.06.057
• Funk, J. (2020). Total Autologous Fascia Lata Anterior and Apical Pelvic Organ Prolapse Repair: A New Technique and Initial Experience. Urology. doi:10.1016/j.urology.20202.04.072
• Messing, E., Zeng, J., Chipollini, J., Hsu, C., Funk, J., & Lee, B. R. (2023). Gemcitabine as first-line therapy for high-grade non-muscle invasive bladder cancer: Results from a tertiary center in the contemporary BCG-shortage era.  . International Journal of Urology.
• Michalak, J., Edward, B., Jonathan, W., Gretzer, M., Twiss, C. O., & Funk, J. (2017). The Impact of Surgical Masks on the Rate of Postoperative Urinary Tract Infection after Cystoscopy and Ureteroscopy. Journal of Urology.
• Zeng, J., Funk, J., Lee, B. R., Hsu, C., Messing, E. M., & Chipollini, J. (2023).

  Gemcitabine as first-line therapy for high-grade non-muscle invasive bladder cancer: results from a tertiary center in the contemporary BCG-shortage era

  . Journal of Translational Urology. doi:10.21037/tau-22-772
• Patel, S., Chaus, F. M., Funk, J. T., & Twiss, C. O. (2022). Total Autologous Fascia Lata Sacrocolpopexy for Treatment of Pelvic Organ Prolapse: Experience in Thirty-Four Patients. Urology, 170, 73-77.
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  To develop a technique for open/robotic sacrocolpopexy using autologous fascia lata autograft. We report our experience in our first 34 patients.
• Zeng, J., Bergersen, A., Price, E., Callegari, M., Austin, E., Oduyemi, O., Poling, K., Hsu, C. H., Funk, J., & Twiss, C. (2022). Symptom Resolution and Recurrent Urinary Incontinence Following Removal of Painful Midurethral Slings. Urology, 159, 78-82.
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  To evaluate pain improvement and recurrent stress incontinence (SUI) following painful synthetic midurethral sling (MUS) removal.
• Batai, K., Phung, M., Bell, R., Lwin, A., Hynes, K. A., Price, E., Meiklejohn, K. M., Bracamonte, E. R., & Funk, J. T. (2021). Correlation between body mass index and prostate volume in benign prostatic hyperplasia patients undergoing holmium enucleation of the prostate surgery. BMC urology, 21(1), 88.
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  Benign prostatic obstruction (BPO) due to benign prostatic hyperplasia (BPH) is a leading cause of morbidity in men over the age of 40. This study examined whether there was an association between body mass index (BMI) and pre-operative prostate volume and whether expression of two genes, alpha-2-macroglobulin (A2M) and transforming growth factor beta 3 (TGFB3), was correlated with BMI, pre-operative prostate volume, and age at surgery.
• Bergersen, A., Price, E., Callegari, M., Austin, E., Oduyemi, O., Hsu, C. H., Funk, J. T., & Twiss, C. O. (2021). Pain Resolution and Recurrent Prolapse Rates Following Vaginal Mesh Removal. Urology, 150, 134-138.
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  To evaluate pain resolution and recurrent prolapse following removal of painful pelvic organ prolapse (POP) mesh.
• Pollock, G. R., Patel, K., & Funk, J. (2021). Holmium laser ureterocele excision with transurethral incision of the prostate. International braz j urol : official journal of the Brazilian Society of Urology, 47(4), 905-906.
• Twiss, C., Funk, J., & Chaus, F. (2021). PD32-06 LARGE FASCIA LATA THIGH HARVESTS FOR PELVIC ORGAN PROLAPSE REPAIR: ARE THEY SAFE?. Journal of Urology, 206(Supplement 3). doi:10.1097/ju.0000000000002033.06
• Arif-Tiwari, H., Twiss, C. O., Lin, F. C., Funk, J. T., Vedantham, S., Martin, D. R., & Kalb, B. T. (2020). Improved Detection of Pelvic Organ Prolapse: Comparative Utility of Defecography Phase Sequence to Nondefecography Valsalva Maneuvers in Dynamic Pelvic Floor Magnetic Resonance Imaging. Current problems in diagnostic radiology, 48(4), 342-347.
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  To evaluate the utility of a defecography phase (DP) sequence in dynamic pelvic floor MRI (DPMRI), in comparison to DPMRI utilizing only non-defecography Valsalva maneuvers (VM).
• Funk, J. T. (2020). Editorial Comment.. The Journal of urology, 203(2), 309-310. doi:10.1097/01.ju.0000612536.35187.24
• Twiss, C. O., Twiss, C. O., Funk, J., Chaus*, F., & Chaus, F. (2020). V07-03 TRANSGENDER NEOVAGINA SACROCOLPOPEXY WITH AUTOLOGOUS FASCIA LATA. The Journal of Urology, 203, e643-e644. doi:10.1097/ju.0000000000000897.03
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  INTRODUCTION AND OBJECTIVE:With the increasing prevalence of gender-affirming surgeries, management of the long-term complications of these surgeries is an important topic. One complication is prol...
• Bergersen, A., Hinkel, C., Funk, J., & Twiss, C. O. (2019). Management of vaginal mesh exposure: A systematic review. Arab journal of urology, 17(1), 40-48.
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  : To identify various predisposing factors, the clinical presentation, and the management of vaginal mesh-related complications, with special emphasis on mesh exposure and the indications for and results of vaginal mesh removal. : A systematic literature review was performed using a search strategy based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses criteria. PubMed was queried for studies regarding aetiology, risk factors, and management of vaginal mesh exposure from 1 January 2008 to June 2018. Full-text articles were obtained for eligible abstracts. Relevant articles were included, and the cited references were used to identify relevant articles not previously included. : A total of 102 abstracts were identified from the PubMed search criteria. An additional 45 studies were identified based on review of the cited references. After applying eligibility criteria and excluding impertinent articles, 58 studies were included in the final analysis. : Numerous studies have found at least some degree of symptomatic improvement regardless of the amount of mesh removed. Focal areas of exposure or pain can be successfully managed with partial mesh removal with low rates of complications. With partial mesh removal, many patients will ultimately require subsequent mesh removal procedures. For this reason, complete mesh excision is an alternative for patients with diffuse vaginal pain, large mesh exposure, and extrusion of mesh into adjacent viscera. However, when considering complete mesh removal, it is important to counsel patients regarding possible complications of removal and the increased risk of recurrent stress urinary incontinence and pelvic organ prolapse postoperatively. : MUS: midurethral sling; OR: odds ratio; POP: pelvic organ prolapse; PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-analyses; SUI: stress urinary incontinence; TOT: transobturator; TVT: tension-free vaginal tape.
• Chaus, F. M., Funk, J. T., Pangilinan, J., Lin, F. C., & Twiss, C. O. (2019). Total Autologous Fascia Lata Anterior and Apical Pelvic Organ Prolapse Repair: A New Technique and Initial Experience. Urology.
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  To address renewed interest in nonmesh transvaginal Pelvic Organ Prolapse (POP) repair since the FDA reclassification of transvaginal mesh, our goal was to develop a transvaginal sacrospinous fixation for anterior and apical POP using only autologous fascia lata. We report our experience in 33 patients.
• Funk, J. (2019). Improved Detection of Pelvic Organ Prolapse: Comparative Utility of Defecography Phase Sequence to Nondefecography Valsalva Maneuvers in Dynamic Pelvic Floor Magnetic Resonance Imaging.. Current Problems in Diagnostic Radiology, 18, S0363-0188.
• Funk, J. T. (2019). Editorial Comment. The Journal of urology, 10109701JU00006125363518724.
• Funk, J., Twiss, C. O., Pollock, G., & Kim, S. (2019). Surgery for Posterior Compartment Vaginal Prolapse: Graft Augmented Repair.. Urol Clin North Am.. doi:10.1016/j.ucl.2018.08.015
• Kim, S., Pollock, G. R., Twiss, C. O., & Funk, J. T. (2019). Surgery for Posterior Compartment Vaginal Prolapse: Graft Augmented Repair. The Urologic clinics of North America, 46(1), 87-95.
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  Posterior compartment vaginal prolapse can be approached with multiple surgical techniques, including transvaginally, transperineally, and transanally, repaired with either native tissue or with the addition of an augment. Augment material for posterior compartment prolapse includes biologic graft (dermal, porcine submucosal), absorbable mesh (Vicryl polyglactin), or nonabsorbable synthetic mesh (polypropylene). Anatomic success rates for posterior compartment repair with augment has ranged from 54% to 92%. Augmented posterior compartment repair has not been shown to have superior outcome to native tissue repair. The focus of this article is on the transvaginal approach comparing native tissue repair with graft or mesh augmented repair.
• Twiss, C. O., Funk, J., Hinkel, C., & Bergersen, A. (2019). Management of Vaginal Mesh Exposure: A Systematic Review. Arab Journal of Urology.
• Twiss, C. O., Twiss, C. O., Pangilinan, J., Funk, J., Chaus*, F., & Chaus, F. (2019). MP02-11 TOTAL AUTOLOGOUS FASCIA LATA ANTERIOR AND APICAL PELVIC ORGAN PROLAPSE REPAIR: EXPERIENCE IN THIRTY-THREE PATIENTS. The Journal of Urology, 201(Supplement 4). doi:10.1097/01.ju.0000554923.63678.01
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  INTRODUCTION AND OBJECTIVES:Since the reclassification of transvaginal mesh as a high-risk device, there is renewed interest in non-mesh pelvic organ prolapse (POP) repair. Our goal was to develop ...
• Vedantham, S., Twiss, C. O., Tiwari, H. A., Pollock, G. R., Funk, J., & Chartier, S. (2021). Comparison of magnetic resonance defecography grading with POP-Q staging and Baden-Walker grading in the evaluation of female pelvic organ prolapse.. Abdominal radiology (New York), 1-8. doi:10.1007/s00261-019-02313-8
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  The physical examination and pelvic imaging with MRI are often used in the pre-operative evaluation of pelvic organ prolapse. The objective of this study was to compare grading of prolapse on defecography phase of dynamic magnetic resonance imaging (dMRI) with physical examination (PE) grading using both the Pelvic Organ Prolapse Quantification (POP-Q) staging and Baden-Walker (BW) grading systems in the evaluation of pelvic organ prolapse (POP)..We retrospectively reviewed the charts of 170 patients who underwent dMRI at our institution. BW grading and POP-Q staging were collected for anterior, apical, and posterior compartments, along with absolute dMRI values and overall grading of dMRI. For the overall grading/staging from dMRI, BW, and POP-Q, Spearman rho (ρ) was used to assess the correlation. The correlations between dMRI grading and POP-Q staging were compared to the correlations between dMRI grading and BW grading using Fisher's Z transformation..A total of 54 patients were included. dMRI grading was not significantly correlated with BW grading for anterior, apical, and posterior compartment prolapse (p > 0.15). However, overall dMRI grading demonstrated a significant (p = 0.025) and positive correlation (ρ = 0.305) with the POP-Q staging system. dMRI grading for anterior compartment prolapse also demonstrated a positive correlation (p = 0.001, ρ = 0.436) with the POP-Q staging derived from measurement locations Aa and Ba. The overall dMRI grade is better correlated with POP-Q stage than with BW grade (p = 0.024)..Overall and anterior compartment grading from dMRI demonstrated a significant and positive correlation with the overall POP-Q staging and anterior compartment POP-Q staging, respectively. The overall dMRI grade is better correlated with POP-Q staging than with BW grading.
• Arif-Tiwari, H., Arif-Tiwari, H., Twiss, C. O., Twiss, C. O., Lin, F. C., Lin, F. C., Funk, J., Funk, J., Vedantham, S., Vedantham, S., Martin, D. R., Martin, D. R., Kalb, B. T., & Kalb, B. T. (2018). Improved Detection of Pelvic Organ Prolapse: Comparative utility of defecography phase (DP) sequence to non-defecography Valsalva maneuvers (VM) in dynamic pelvic floor MRI (dMRI). Journal: Current Problems in Diagnostic Radiology. ScienceDirect. doi:https://doi.org/10.1067/j.cpradiol.2018.08.005Get rights and content
• Bergersen, A., Price, E., Callegari, M., Austin, E., Oduyemi, O., Funk, J., & Twiss, C. O. (2018). Symptom Resolution and Recurrent Stress Incontinence Following Urethral Sling Removal. Journal of Urology, 6(199), 1577-1583.
• Funk, J. (2018). Management of Suspected Bladder Injury and Capsular Perforation After Holmium Laser Enucleation of the Prostate.. Journal of Endourology Case Reports, 4(1), 87-90.
• Funk, J., & Tzou, D. (2018). Response to Stutz et al. re: "Management of Suspected Bladder Injury and Capsular Perforation After Holmium Laser Enucleation of the Prostate".. Journal of Endourology Case Reports, 4(1), N/A-Epublication.
• Lin, F. C., Funk, J. T., Arif Tiwari, H., Kalb, B. T., & Twiss, C. O. (2018). Dynamic Pelvic MRI Evaluation of Pelvic Organ Prolapse Compared to Physical Exam Findings. Urology, 119, 49-54. doi:https://doi.org/10.1016/j.urology.2018.05.031
• Lin, F. C., Funk, J. T., Tiwari, H. A., Kalb, B. T., & Twiss, C. O. (2018). Dynamic Pelvic Magnetic Resonance Imaging Evaluation of Pelvic Organ Prolapse Compared to Physical Examination Findings. Urology, 119, 49-54.
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  To compare dynamic magnetic resonance imaging (dMRI) defecography phase findings with physical examination (PE) grading in the evaluation of pelvic organ prolapse (POP).
• Lwin, A., Tzou, D., & Funk, J. (2018). Response to Stutz et al. re: "Management of Suspected Bladder Injury and Capsular Perforation After Holmium Laser Enucleation of the Prostate". Journal of endourology case reports, 4(1), 205.
• Twiss, C. O., Funk, J., Kalb, B., Arif Tiwari, H., & Lin, F. (2018). Dynamic Pelvic MRI in the Evaluation of Pelvic Organ Prolapse and Correlation with Physical Exam Findings. Female Urology and Voiding Dysfunction, 119, 49-54. doi:doi: 10.1016/j.urology.2018.05.031. Epub 2018 Jun 23.
• Twiss, C. O., Kalb, B. T., Arif Tiwari, H., Funk, J., & Lin, F. (2017). Dynamic Pelvic MRI Evaluation of Pelvic Organ Prolapse Compared to Physical Exam Findings. Journal of Urology.
• Twiss, C. O., Twiss, C. O., Lin, F. C., & Funk, J. (2018). V10-05 TOTAL AUTOLOGOUS FASCIA LATA ROBOTIC SACROCOLPOPEXY: A NEW TECHNIQUE. The Journal of Urology, 199(4). doi:10.1016/j.juro.2018.02.2661
• Twiss, C. O., Twiss, C. O., Price, E., Oduyemi, O., Funk, J., Callegari, M., Bergersen, A., & Austin, E. T. (2018). MP33-19 SYMPTOM RESOLUTION AND RECURRENT PROLAPSE RATES FOLLOWING VAGINAL MESH REMOVAL. The Journal of Urology, 199(4S). doi:10.1016/j.juro.2018.02.1090
• Twiss, C. O., Twiss, C. O., Price, E., Phung, M., Lwin, A., Hynes, K., & Funk, J. (2018). MP62-19 HOLMIUM LASER ENUCLEATION OF THE PROSTATE: PERIOPERATIVE OUTCOMES FOR SAME DAY PROCEDURES. The Journal of Urology, 199(4). doi:10.1016/j.juro.2018.02.2020
• Funk, J. (2017). Percutaneous Management of a Pyocystic Fistulizing Continent Urinary Diversion.. Journal of Endourology Case Reports, 3(1), 162-164.
• Funk, J., Frye, J., Kunihiro, A., Brickey, J., Luis, P., & Schneider, C. (2017). Abstract P6-18-01: Site-specific activation of curcuminoids in the breast cancer bone metastases microenvironment. Cancer Research, 77(4_Supplement), P6-18-01-P6-18-01. doi:10.1158/1538-7445.sabcs16-p6-18-01
• McAdams, S., Funk, J. T., Navetta, A. F., El Tayeb, M. M., & Humphreys, M. R. (2017). Holmium Laser Enucleation of the Prostate After Prostatic Urethral Lift Surgery: Feasibility and Technical Considerations from a Multi-Institutional Case Series. Journal of Endourology.
• Tiwari, H. A., Twiss, C. O., Twiss, C. O., Tiwari, H. A., Lin, F. C., Kalb, B. T., & Funk, J. T. (2017). PD02-06 DYNAMIC PELVIC MRI IN THE EVALUATION OF PELVIC ORGAN PROLAPSE AND CORRELATION WITH PHYSICAL EXAM FINDINGS. The Journal of Urology, 197(4). doi:10.1016/j.juro.2017.02.199
• Twiss, C. O., Lin, F., & Funk, J. (2017). Autologous Anterior and Apical Pelvic Organ Prolapse Repair: A New Technique. Journal of Urology.
• Twiss, C. O., Twiss, C. O., Lin, F. C., Funk, J., & Craig, M. (2017). V2-02 TOTAL AUTOLOGOUS FASCIA LATA ANTERIOR REPAIR AND APICAL SUSPENSION: A NEW TECHNIQUE. The Journal of Urology, 197(4). doi:10.1016/j.juro.2017.02.390
• Funk, J., Tzou, D., & Michalak, J. (2015). HoLEP: the gold standard for the surgical management of BPH in the 21(st) Century. American Journal of Clinical and Experimental Urology, 3(1), 36-42.
• Lin, F., Funk, J., Arif Tiwari, H., Kalb, B. T., & Twiss, C. O. (2017). Dynamic Pelvic MRI Evaluation of Pelvic Organ Prolapse Compared to Physical Exam Findings. Journal of Urology, 197(4), e53. doi:https://doi.org/10.1016/j.juro.2017.02.199
• Michalak, J., Tzou, D., & Funk, J. (2015). HoLEP: the gold standard for the surgical management of BPH in the 21(st) Century. American journal of clinical and experimental urology, 3(1), 36-42.
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  For many years, transurethral resection of the prostate (TURP) has been accepted as the gold standard to surgically alleviate obstructive voiding dysfunction in men with benign prostatic hyperplasia (BPH). This historical standard has been challenged repeatedly over the last decade by consistent data demonstrating the superiority of Holmium enucleation of the prostate (HoLEP). This review summarizes the literature comparing HoLEP and traditional therapies for BPH that are widely used and have long term efficacy data, primarily TURP, open prostatectomy (OP), and alternative laser therapies (PVP, ThuLEP, etc).
• Pollock, G. R., Twiss, C. O., Chartier, S., Vedantham, S., Funk, J., & Arif Tiwari, H. (2021). Comparison of magnetic resonance defecography grading with POP-Q staging and Baden-Walker grading in the evaluation of female pelvic organ prolapse. Abdominal radiology (New York).
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  The physical examination and pelvic imaging with MRI are often used in the pre-operative evaluation of pelvic organ prolapse. The objective of this study was to compare grading of prolapse on defecography phase of dynamic magnetic resonance imaging (dMRI) with physical examination (PE) grading using both the Pelvic Organ Prolapse Quantification (POP-Q) staging and Baden-Walker (BW) grading systems in the evaluation of pelvic organ prolapse (POP).
• Funk, J. T. (2014). Recent Advances and Emerging Technology in the Surgical Management of BPH-Related Voiding Dysfunction. Current Bladder Dysfunction Reports, 9, 129-133.
• Twiss, C. O., Martin, D. R., Twiss, C. O., Mumtaz, H. A., Martin, D. R., Kalb, B., & Funk, J. (2014). PD29-06 ADDITION OF A DEFECOGRAPHY PHASE TO DYNAMIC PELVIC MRI ENHANCES DETECTION AND VISUALIZATION OF PELVIC ORGAN PROLAPSE. The Journal of Urology, 191(4). doi:10.1016/j.juro.2014.02.2141
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  INTRODUCTION AND OBJECTIVES: Dynamic Pelvic MRI (DPMRI) remains an emerging diagnostic modality in the evaluation of Pelvic Organ Prolapse (POP), but study quality remains variable, and is typically dependent upon performance of a proper valsalva maneuver during the dynamic phase of the procedure. We sought to determine whether the addition of a defecography phase (DP) to routine DPMRI would increase its clinical utility over standard valsalva maneuver (VM) in the evaluation of POP. METHODS: Fifty-six female patients undergoing preoperative evaluation for surgical correction of symptomatic POP were evaluated by DPMRI utilizing a protocol incorporating both VM and DP. Ultrasound gel was injected into the vagina and rectum followed by (1) steady state free precession images in the sagittal plane, (2) dynamic cine acquisitions during VM, and (3) dynamic cine acquisitions during DP. All images were separately reviewed in a blinded fashion by two radiologists experienced in DPMRI. The HMO system was used for quantification of pelvic floor descent. Inferior descent of the ano-rectal junction, bladder base and vaginal vault was recorded in all patients, utilizing the pubococcygeal line (PCL) as a fixed landmark. IRB approval was obtained for the study. RESULTS: DP produced a greater degree of pelvic organ descent compared to VM for all recorded measures in all 56 patients. 100%(56/56) demonstrated rectocele, 71% (40/56) cystocele and 71% (40/56) vaginal vault descent on DP, compared with 86% (48/56), 14% (8/56) and 43% (24/56) on VM, respectively. The average descent of the bladder base was 3.4 cm with DP, compared to 0.4 cm with VM (p
• Dyer, A., Funk, J., Twiss, C., Twisschristian, T., Funkjoel, F., & Dyeranthony, D. (2013). Endoscopic Removal of UroLume Urethral Stent Using High-Power Holmium Laser. Journal of Endourology Part B, Videourology, 27(6). doi:10.1089/vid.2013.0084
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  Abstract Introduction: The UroLume stent has been used for treatment of urethral stricture disease and benign prostatic hyperplasia since 1988.1 This procedure is not without complications, includi...
• Phull, H., Salkini, M., Purves, T., Funk, J., Copeland, D., & Comiter, C. V. (2007). Angiotensin II plays a role in acute murine experimental autoimmune cystitis. BJU international, 100(3), 664-7.
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  To investigate whether angiotensin II (AII) receptor antagonism decreases the inflammation and oedema in acute murine experimental autoimmune cystitis (EAC), as interstitial cystitis (IC) might have an autoimmune component and AII has been implicated in autoimmune-mediated vascular congestion, oedema and scarring.
• LAI, L., COPELAND, D., FUNK, J., RAMAKUMAR, S., PHULL, H., PURVES, T., ULREICH, J. B., & LIEN, Y. H. (2005). NOVEL DELIVERY OF OLIGONUCLEOTIDES USING A TOPICAL HYDROGEL TISSUE SEALANT IN A MURINE PARTIAL NEPHRECTOMY MODEL. Journal of Urology, 174(3), 1133-1136. doi:10.1097/01.ju.0000168617.17080.46
• Ramakumar, S., Phull, H., Purves, T., Funk, J., Copeland, D., Ulreich, J. B., Lai, L., & Lien, Y. H. (2005). Novel delivery of oligonucleotides using a topical hydrogel tissue sealant in a murine partial nephrectomy model. The Journal of urology, 174(3), 1133-6.
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  Ischemia/reperfusion injury is a leading cause of renal damage and antisense gene therapy has been shown to ameliorate its effects. However, this approach has been limited by current delivery methods that require high concentrations of intravenous nucleic acids lacking specificity for targeting tissues. To overcome these limitations we developed a novel murine partial nephrectomy model to evaluate polyethylene-glycol (PEG) hydrogel tissue sealant as a topical oligonucleotide delivery system.
• Funk, J. T., & Ramakumar, S. (2004). Ipsilateral Testicular Atrophy After Laparoscopic Donor Nephrectomy. Journal of Endourology.
• Batler, R. A., Campbell, S. C., Funk, J. T., Gonzalez, C. M., & Nadler, R. B. (2001). Hand-assisted vs. retroperitoneal laparoscopic nephrectomy. Journal of endourology / Endourological Society, 15(9), 899-902.
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  We retrospectively compared our initial experience with the hand-assisted and retroperitoneal laparoscopic nephrectomy techniques to determine if there are important differences between these approaches.
• Batler, R. A., Campbell, S. C., Funk, J., Gonzalez, C. M., & Nadler, R. B. (2001).

  Hand-Assisted vs. Retroperitoneal Laparoscopic Nephrectomy

  . Journal of Endourology. doi:10.1089/089277901753284107

Presentations

• Chipollini, J., Messing, E., Hsu, C., Lee, B. R., Funk, J., & Zeng, J. (2022, Fall). Gemcitabine as first-line therapy for high-grade non-muscle invasive bladder cancer: Results from a tertiary center in the contemporary BCG-shortage era .. Western Section American Urological Association.
• Chaus, F., Funk, J., & Twiss, C. O. (2021, September). Large Fascia Lata Harvests for Pelvic Organ Prolapse Repair: Are they Safe?. International Continence Society. Melbourne, Australia (Virtual On-line).
• Batai, K., Phung, M., Bell, R., Lwin, A., Hynes, K., Price, E., Bracamonte, E. R., & Funk, J. (2018, September 2018). Clinical characteristics and gene expression associated with pre-operative prostate volume in patients undergoing holmium enucleation of the prostate (HoLEP) surgery for a treatment of benign prostatic hyperplasia.. World Congress of Endourology Conference. Paris, France: World Congress of Endourology.
• Bergersen, A., Price, E., Callegari, M., Austin, E., Oduyemi, O., Funk, J., & Twiss, C. O. (2018, Winter). Symptom Resolution and Recurrent Prolapse Rates Following Vaginal Mesh Removal. SUFU Meeting 2018. San Antonio, TX.
• Bergersen, A., Price, E., Callegari, M., Austin, E., Oduyemi, O., Funk, J., & Twiss, C. O. (2018, Winter). Symptom Resolution and Recurrent Stress Incontinence Following Urethral Sling Removal. SUFU Meeting 2018. San Antonio, TX.
• Lin, F., Arif Tiwari, H., Kalb, B., Funk, J., & Twiss, C. O. (2018, May). Dynamic Pelvic MRI in the Evaluation of Pelvic Organ Prolapse and Correlation with Physical Exam Findings. Female Urology and Voiding Dysfunction. Boston, MA..
• Phung, M., Batai, K., Bell, R., Lwin, A., Hynes, K., Price, E., Bracamonte, E. R., & Funk, J. (2018, October). Clinical characteristics and gene expression associated with pre-operative prostate volume in patients undergoing holmium enucleation of the prostate (HoLEP) surgery for a treatment of benign prostatic hyperplasia.. American Urological Association Annual Meeting. Maui, Hawaii: Western Section, American Urological Association.
• Twiss, C. O., Funk, J., Oduyemi, O., Austin, E., Callegari, M., Price, E., & Bergersen, A. (2018, Spring). Symptom Resolution and Recurrent Prolapse Rates Following Vaginal Mesh Removal. American Urological Association Meeting 2018. San Francisco, CA.
• Twiss, C. O., Funk, J., Oduyemi, O., Austin, E., Callegari, M., Price, E., & Bergersen, A. (2018, Spring). Symptom Resolution and Recurrent Stress Incontinence Following Urethral Sling Removal. SUFU Meeting 2018. San Antonio, TX.
• Twiss, C. O., Funk, J., Pangilinan, J., & Chaus, F. (2018, Fall). TOTAL AUTOLOGOUS FASCIA LATA ANTERIOR AND APICAL PELVIC ORGAN PROLAPSE REPAIR: EXPERIENCE IN THIRTY-THREE PATIENTS. Western Section American Urological Association. Maui, HI.
• Twiss, C. O., Lin, F., & Funk, J. (2018, Winter). Video Submission: Total Autologous Fascia Lata Sacrocolpopexy. SUFU 2018 Winter Meeting. San Antonio, TX.
• Lin, F., Arif Tiwari, H., Kalb, B., Funk, J., & Twiss, C. O. (2017, May). Dynamic Pelvic MRI in the Evaluation of Pelvic Organ Prolapse and Correlation with Physical Exam Findings. American Urological Association 2017 Annual Meeting. Scottsdale, AZ.
• Arif Tiwari, H., Costello, J. R., Funk, J., Kalb, B. T., Martin, D. R., Meshksar, A., Petkovska, I., Czeyda-Pommersheim, F., & Twiss, C. O. (2016, April). Comparative Evaluation of Defecography Phase to Non-Defecography Valsalva Maneuver in Dynamic Pelvic Floor MRI. Canadian Association of Radiologists, 79th Annual Scientific Meeting (ASM). Montreal, QC.
• Arif Tiwari, H., Kalb, B. T., Funk, J., Twiss, C. O., & Martin, D. R. (2014, February). Addition of a Defecography Phase to Dynamic Pelvic MRI Enhances Detection and Visualization of Pelvic Organ Prolapse. Society of Urodynamics, Female Pelvic Medicine, and Urogenital Reconstruction Meeting. Miami, FL.
• Arif Tiwari, H., Kalb, B. T., Twiss, C. O., Funk, J., & Martin, D. R. (2014, May). Addition of a Defecography Phase to Dynamic Pelvic MRI Enhances Detection and Visualization of Pelvic Organ Prolapse. American Urological Association Meeting. Orlando, FL.

Poster Presentations

• Lwin, A. A., Pangilinan, J. Q., LaGrandeur, J. R., Hynes, K. A., Phung, M. C., Price, E. T., Twiss, C. O., & Funk, J. (2018, October, 2018). Holmium Laser Enucleation of the Prostate: Perioperative Outcomes for Same Day Procedures.. World Congress of Endourology. Maui, Hawaii.
• Lwin, A. A., Pangilinan, J. Q., LaGrandeur, J. R., Hynes, K. A., Phung, M. C., Price, E. T., Twiss, C. O., & Funk, J. (2018, September, 2018). Holmium Laser Enucleation of the Prostate: Perioperative Outcomes for Same Day Procedures.. Western Section, American Urological Assocation. Paris, France.
• Twiss, C. O., Funk, J., Oduyemi, O., Callegari, M., Price, E., & Bergersen, A. (2018, February). SYMPTOM RESOLUTION AND RECURRENT STRESS INCONTINENCE FOLLOWING URETHRAL SLING REMOVAL. Society for Urodynamics, Female Pelvic Medicine, and Urogenital Reconstruction. Austin, TX.
• Bergerson, A., Austin, E., Bricklin, L., Price, E., Funk, J., & Twiss, C. O. (2017, Summer). Impact of Transvaginal Mesh Removal on Vaginal Pain, Urinary Incontinence, and Pelvic Organ Prolapse. Western Section American Urological Association Meeting. Vancouver, BC.
• Funk, J. T., Mumtaz, H. A., Kalb, B., Martin, D., & Twiss, C. (2016, April). Comparison of Defocography Phase to Non-Defocography Valsalva Maneuver in Dynamic Pelvic Floor MRI. Canadian Annual Radiology Meeting.
• Funk, J. T. (2015, February). Validation of the SEAPI-S Questionnaire. Society of Urodynamics, Female Pelvic Medicine, and Urogenital Reconstruction Winter Meeting. Scottsdale, AZ.
• Funk, J. T., Twiss, C. O., Dyer, A. J., & Satyanarayan, A. (2014, February). Comparison of Success and Complication Rates of the Distal Urethral Polypropylene Sling (DUPS) and the MiniArc Sling for Female Stress Incontinence. Society of Urodynamics, Female Pelvic Medicine, and Urogenital Reconstruction Meeting. Miami, FL: SUFU.
• Funk, J. T., Twiss, C. O., Mumtaz, H. A., Kalb, B., & Martin, D. (2014, February). Addition of a Defecography Phase to Dynamic Pelvic MRI Enhances Detection and Visualization of Pelvic Organ Prolapse. Society of Urodynamics, Female Pelvic Medicine, and Urogenital Reconstruction Meeting. Miami, FL: SUFU.
• Funk, J. T. (2011, Summer). Factors Influencing Fluid Intake Among Kidney Stone Patients. 58th Annual Kimbrough Seminar. Seattle, WA.

Case Studies

• Phung, M. C., Lee, B. R., & Funk, J. (2017. Percutaneous Management of a Pyocystic Fistulizing Continent Urinary Diversion(pp 162-164).

Others

• Lin, F., Craig, M., Twiss, C. O., & Funk, J. (2017, March). Total autologous fascia lata anterior repair and vaginal vault suspension: A new technique!. Society of Urodynamics, Female Pelvic Medicine & Urogential Reconstruction.
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  Video presentation