Graciela Emilia Silva Torres
- Clinical Associate Professor, Nursing
- Assistant Professor, Public Health
I obtained my Doctorate degree in Epidemiology from the University of Arizona Mel and Enid Zuckerman College of Public Health in 2004. My research focus is on sleep, sleep disordered breathing, obesity, asthma, emphysema, bronchitis, chronic obstructive pulmonary disease, and infectious diseases.
- Ph.D. Doctor of Philosophy in Epidemiology
- University of Arizona, Tucson, Arizona, United States
- Association between asthma and COPD: A longitudinal evaluation of the Dutch hypothesis
- MPH Public Health
- University of Arizona, Tucson, Arizona, United States
- Antibiotic resistance along the US-Mexico border
- B.S. Medical Technologist
- University of Arizona, Tucson, Arizona, United States
- B.S. Pharmacobiological Chemistry
- Autonomous University of Guadalajara, Guadalajara, Jalisco, Mexico
- Identification of Candida albicans by means of specific antisera from clinical samples
- Clinical Associate Professor, University of Arizona, Tucson, Arizona (2012 - Ongoing)
- Assistant Professor, Arizona State University, Phoenix, Arizona (2006 - 2012)
- Postdoctoral Fellow, University of Arizona, Tucson, Arizona (2005 - 2006)
- Pre-doctoral Fellow, University of Arizona, Tucson, Arizona (2001 - 2004)
- Epidemiologist, University Medical Center (2000 - 2001)
- Microbiologist, Tucson General Hospital (1999 - 2000)
- Research Specialist, University of Arizona, Tucson, Arizona (1998 - 2000)
- Training Fellow, Arizona Department of Health Services (1998 - 1999)
- Teaching Assistant, University of Arizona, Tucson, Arizona (1997 - 2001)
- Medical Technologist, Tucson General Hospital (1992 - 1996)
- Membership to the Alpha Nu Chapter of Delta Omega, National Public Health Honorary Society
- National Public Health Honorary Society, Spring 2013
- Best of Sleep Medicine, manuscript selected for this publication
- Sleep Medicine, Spring 2010
- American Academy of Sleep Medicine’s Young Investigator Research
- American Academy of Sleep Medicine, Spring 2009
- Minority Postdoctoral Fellowship
- National Institutes of Health, Spring 2005
- American Thoracic Society Minority Travel Award
- American Thoracic Society, Spring 2004
- Minority Graduate Education at Mountain States Alliance (MGE@MSA) Scholarship
- Arizona State University, Spring 2002
- University of Arizona Graduate College Fellowship
- University of Arizona, Spring 2002
- Minority Pre-doctoral Fellowship
- National Institutes of Health, Spring 2001
Licensure & Certification
- Clinical Laboratory Scientist, National Certification Agency for Medical Laboratory Personnel, Inc. (1992)
- ASCP Board Registry, American Society for Clinical Pathologists (1992)
Asthma, Chronic Obstructive Pulmonary Diseases,Sleep and Sleep Disordered Breathing, Longitudinal Decline of Lung Function, Mixed Models, Random Effects Analyses, and Longitudinal Analyses.
My philosophy in teaching is to give students all the necessary tools for them to be able to learn and apply their new knowledge so that students may perform their own evaluations. At the same time, students should be able to apply critical thinking, perform independent studies, and interpret their results.
Applied Stats for Evid BasedNURS 502 (Fall 2016)
DNP ProjectNURS 922 (Fall 2016)
Statistic Infer Evid-Bas PractNURS 629 (Fall 2016)
Applied Stats for Evid BasedNURS 502 (Summer I 2016)
DNP ProjectNURS 922 (Summer I 2016)
Adv Stat Hlth SciNURS 631 (Spring 2016)
Applied Stats for Evid BasedNURS 502 (Spring 2016)
DNP ProjectNURS 922 (Spring 2016)
DissertationNURS 920 (Spring 2016)
Applied Stats for Evid BasedNURS 502 (Fall 2015)
DNP ProjectNURS 922 (Fall 2015)
Statistic Infer Evid-Bas PractNURS 629 (Fall 2015)
DNP ProjectNURS 922 (Summer I 2015)
Adv Stat Hlth SciNURS 631 (Spring 2015)
Applied Stats for Evid BasedNURS 502 (Spring 2015)
DNP ProjectNURS 922 (Spring 2015)
Applied Stats for Evid BasedNURS 502 (Fall 2014)
Statistic Infer Evid-Bas PractNURS 629 (Fall 2014)
Applied Stats for Evid BasedNURS 502 (Summer I 2014)
Adv Stat Hlth SciNURS 631 (Spring 2014)
Applied Stats for Evid BasedNURS 502 (Spring 2014)
Applied Stats for Evid BasedNURS 502 (Fall 2013)
Statistic Infer Evid-Bas PractNURS 629 (Fall 2013)
Applied Stats for Evid BasedNURS 502 (Summer I 2013)
- Vana, K. D., & Silva, G. E. (2014). Evaluating the use of a simulated electronic health record and online drug reference in a case study to enhance nursing students' understanding of pharmacologic concepts and resources. Nurse educator, 39(4), 160-5.More infoNursing students should learn to navigate the complexities of the healthcare arena, such as integrating use of electronic health records (EHRs) and online drug references into patient care. Using a simulated EHR in a nursing pharmacology course allowed students to interact with these technologies while learning and applying pharmacologic concepts to a case study. The authors discuss how they created and facilitated such a case study, as well as students' outcomes.
- Nahapetian, R., Silva, G. E., Vana, K. D., Parthasarathy, S., & Quan, S. F. (2016). Weighted STOP-Bang and screening for sleep-disordered breathing. Sleep & breathing = Schlaf & Atmung, 20(2), 597-603.More infoSTOP-Bang is a tool for predicting the likelihood for sleep-disordered breathing (SDB). In the conventional score, all variables are dichotomous. Our aim was to identify whether modifying the STOP-Bang scoring tool by weighting the variables could improve test characteristics.
- Silva, G. E., Goodwin, J. L., Vana, K. D., & Quan, S. F. (2016). Obstructive Sleep Apnea and Quality of Life: Comparison of the SAQLI, FOSQ, and SF-36 Questionnaires. Southwest journal of pulmonary & critical care, 13(3), 137-149.More infoThe impact of sleep on quality of life (QoL) has been well documented; however, there is a great need for reliable QoL measures for persons with obstructive sleep apnea (OSA). We compared the QoL scores between the 36-Item Short Form of the Medical Outcomes Survey (SF-36), Calgary Sleep Apnea Quality of Life Index (SAQLI), and Functional Outcomes Sleep Questionnaire (FOSQ) in persons with OSA.
- Silva, G. E., Goodwin, J. L., Vana, K. D., Vasquez, M. M., Wilcox, P. G., & Quan, S. F. (2014). Restless legs syndrome, sleep, and quality of life among adolescents and young adults. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 10(7), 779-86.More infoClinical reports in children implicate restless legs syndrome (RLS) with sleep and behavior problems. However, population-based studies on this association in adolescents and young adults are limited. Furthermore, few studies have evaluated the association between symptoms consistent with RLS and quality of life (QoL).
- Shaw, N. D., Goodwin, J. L., Silva, G. E., Hall, J. E., Quan, S. F., & Malhotra, A. (2013). Obstructive Sleep Apnea (OSA) in preadolescent girls is associated with delayed breast development compared to girls without OSA. Journal of Clinical Sleep Medicine, 9(8), 813-818.More infoPMID: 23946712;PMCID: PMC3716673;Abstract: Study Objective: Adults with obstructive sleep apnea (OSA) have lower sex steroid levels than controls. We sought to determine whether OSA also interferes with reproductive hormones in adolescence by tracking the pace of pubertal development. Methods: One hundred seventy-two children in the Tucson Children's Assessment of Sleep Apnea study (TuCASA) underwent two home polysomnographic studies, spaced 4-5 years apart. Height and weight were measured at both visits, and Tanner staging of breasts/genitals and pubic hair were self-assessed by a pictorial questionnaire at follow-up. Results: Eighty-seven girls and 85 boys, age 8.9 ± 1.6 years (mean ± SD) at baseline and 13.4 ± 1.6 years at follow-up, participated. Twenty-seven percent of participants were overweight or obese at baseline, and the majority remained so at follow-up. Twenty-six percent of girls and 28% of boys met criteria for OSA, defined as a respiratory disturbance index (RDI) ≥ 1/h associated with a 3% desaturation (RDI 3%), at baseline. There was an inverse relationship between baseline log RDI 3% and Tanner breast stage at follow-up (coefficient -1.3, p = 0.02) in girls after adjusting for age (p < 0.001), body mass index (p < 0.005), and ethnicity. Girls with OSA at baseline were more than 1 Tanner breast stage behind girls without OSA at follow-up. OSA did not affect genital development in boys or pubic hair development in either sex. Conclusions: OSA in preadolescent girls predicts delayed breast development relative to girls without OSA. Sleep fragmentation and/or hypoxia seen in OSA may interfere with reproductive development in girls.
- Vana, K. D., Silva, G. E., & Goldberg, R. (2013). Predictive abilities of the STOP-Bang and Epworth Sleepiness Scale in identifying sleep clinic patients at high risk for obstructive sleep apnea. Research in Nursing and Health, 36(1), 84-94.More infoPMID: 23007730;Abstract: This study compared the predictive abilities of the STOP-Bang and Epworth Sleepiness Scale (ESS) for screening sleep clinic patients for obstructive sleep apnea (OSA) and sleep-disordered breathing (SDB). Forty-seven new adult patients without previous diagnoses of OSA or SDB were administered the STOP-Bang and ESS and were assigned to OSA or SDB risk groups based on their scores. STOP-Bang responses were scored with two Body Mass Index cut points of 35 and 30kg/m2 (SB35 and SB30). The tools' predictive abilities were determined by comparing patients' predicted OSA and SDB risks to their polysomnographic results. The SB30 correctly identified more patients with OSA and SDB than the ESS alone. The ESS had the highest specificity for OSA and SDB. © 2012 Wiley Periodicals, Inc.
- Brown, M. A., Goodwin, J. L., Silva, G. E., Behari, A., Newman, A. B., Punjabi, N. M., Resnick, H. E., Robbins, J. A., & Quan, S. F. (2011). The Impact of Sleep-Disordered Breathing on Body Mass Index (BMI): The Sleep Heart Health Study (SHHS). Southwest journal of pulmonary & critical care, 3, 159-168.More infoINTRODUCTION: It is well known that obesity is a risk factor for sleep-disordered breathing (SDB). However, whether SDB predicts increase in BMI is not well defined. Data from the Sleep Heart Health Study (SHHS) were analyzed to determine whether SDB predicts longitudinal increase in BMI, adjusted for confounding factors. METHODS: A full-montage unattended home polysomnogram (PSG) and body anthropometric measurements were obtained approximately five years apart in 3001 participants. Apnea-hypopnea index (AHI) was categorized using clinical thresholds: < 5 (normal), ≥ 5 to
- Drescher, A. A., Goodwin, J. L., Silva, G. E., & Quan, S. F. (2011). Caffeine and screen time in adolescence: Associations with short sleep and obesity. Journal of Clinical Sleep Medicine, 7(4), 337-342.More infoPMID: 21897768;PMCID: PMC3161764;Abstract: Objective: To investigate the associations between sleep duration and obesity incidence and risk factors among preadolescents and adolescents. Design: Cross-sectional study of a community based cohort Setting: The Tucson Children's Assessment of Sleep Apnea follow-up study (TuCASA) cohort. Participants: 319 Caucasian and Hispanics between 10-17 years. Main Outcome: Parent-reported sleep duration and BMI zscore. Outcome Measures: Surveys of electronic screen time, dietary and caffeine intake, exercise and sleep habits by parents, and anthropometric measures. Results: Parent-reported total sleep time (TST) was inversely associated with BMI z-score, but not signifi cantly correlated with any of the examined nutritional variables or exercise components. Hispanic ethnicity was associated with signifi cantly lower parent-reported TST and higher BMI z-score. Parentreported TST was inversely related to electronic screen time and caffeine use, but these fi ndings were differentially related to age. Caffeine consumption was associated with decreasing parent-reported TST primarily in older adolescents. Electronic screen time was associated with lower parent-reported TST in Younger adolescents. Conclusions: Hispanic ethnicity and parental reports of TST were found to be the most closely associated with BMI z-score. Decreased TST and increased caffeine intake and screen time may result in higher obesity risk in the adolescent population.
- Silva, G. E., Goodwin, J. L., Parthasarathy, S., Sherrill, D. L., Vana, K. D., Drescher, A. A., & Quan, S. F. (2011). Longitudinal association between short sleep, body weight, and emotional and learning problems in hispanic and caucasian children. Sleep, 34(9), 1197-1205.More infoPMID: 21886357;PMCID: PMC3157661;Abstract: Study Objective: To determine the impact of lower amounts of childhood sleep assessed by polysomnogram on development of obesity, being anxious or depressed, or having learning problems 5 years later. Design: Prospective cohort. Participants: Subjects were 304 community participants from the Tucson Children's Assessment of Sleep Apnea study, aged 6-12 years old at baseline. Measurements and Results: Children were classified according to baseline sleep as those who slept ≥ 9 h/night, those who slept > 7.5 to < 9 h/ night, and those who slept ≤ 7.5 h/night. Odds of overweight/obese (≥ 85 th BMI percentile), obese (≥ 95th BMI percentile), anxious or depressed, and learning problems at follow-up were assessed according to baseline sleep categories. Children who slept ≤ 7.5 h/night had higher odds of being obese (OR = 3.3, P < 0.05) at follow-up than children who slept ≥ 9 h/night. Borderline significance for overweight/obese (OR = 2.2, P < 0.1), anxious or depressed (OR = 3.3, P < 0.1), and having learning problems (OR = 11.1, P < 0.1) were seen for children who slept ≤ 7.5 h/night as compared to those who slept ≥ 9 h/night. A mean increase in BMI of 1.7 kg/m 2 (P = 0.01) over the 5 years of follow-up was seen for children who slept ≤ 7.5 h/night compared to those who slept ≥ 9 h/night. These relationships did not differ between Hispanic and Caucasian children. Conclusions: Children with reduced amounts of sleep (≤ 7.5 h/night) had an increased risk for higher body weight in early adolescence. Similarly, children who slept ≤ 7.5 h/night had higher risk of being anxious or depressed or having learning problems in early adolescence.
- Silva, G. E., Vana, K. D., Goodwin, J. L., Sherrill, D. L., & Quan, S. F. (2011). Identification of patients with sleep disordered breathing: Comparing the four-variable screening tool, STOP, STOP-bang, and epworth sleepiness scales. Journal of Clinical Sleep Medicine, 7(5), 467-472.More infoPMID: 22003341;PMCID: PMC3190845;Abstract: Study Objective: The Epworth Sleepiness Scale (ESS) has been used to detect patients with potential sleep disordered breathing (SDB). Recently, a 4-Variable screening tool was proposed to identify patients with SDB, in addition to the STOP and STOP-Bang questionnaires. This study evaluated the abilities of the 4-Variable screening tool, STOP, STOP-Bang, and ESS questionnaires in identifying subjects at risk for SDB. Methods: A total of 4,770 participants who completed polysomnograms in the baseline evaluation of the Sleep Heart Health Study (SHHS) were included. Subjects with RDIs ≥ 15 and ≥ 30 were considered to have moderate-to-severe or severe SDB, respectively. Variables were constructed to approximate those in the questionnaires. The risk of SDB was calculated by the 4-Variable screening tool according to Takegami et al. The STOP and STOP-Bang questionnaires were evaluated including variables for snoring, tiredness/sleepiness, observed apnea, blood pressure, body mass index, age, neck circumference, and gender. Sleepiness was evaluated using the ESS questionnaire and scores were dichotomized into < 11 and ≥ 11. Results: The STOP-Bang questionnaire had higher sensitivity to predict moderate-to-severe (87.0%) and severe (70.4%) SDB, while the 4-Variable screening tool had higher specificity to predict moderate-to-severe and severe SDB (93.2% for both). Conclusions: In community populations such as the SHHS, high specificities may be more useful in excluding low-risk patients, while avoiding false positives. However, sleep clinicians may prefer to use screening tools with high sensitivities, like the STOP-Bang, in order to avoid missing cases that may lead to adverse health consequences and increased healthcare costs.
- Vana, K. D., Silva, G. E., Muzyka, D., & Hirani, L. M. (2011). Effectiveness of an audience response system in teaching pharmacology to baccalaureate nursing students. CIN - Computers Informatics Nursing, 29(SUPPL. 6), TC105-TC113.More infoPMID: 21701273;Abstract: It has been proposed that students' use of an audience response system, commonly called clickers, may promote comprehension and retention of didactic material. Whether this method actually improves students' grades, however, is still not determined. The purpose of this study was to evaluate whether a lecture format utilizing multiple-choice PowerPoint slides and an audience response system was more effective than a lecture format using only multiple-choice PowerPoint slides in the comprehension and retention of pharmacological knowledge in baccalaureate nursing students. The study also assessed whether the additional use of clickers positively affected students' satisfaction with their learning. Results from 78 students who attended lecture classes with multiple-choice PowerPoint slides plus clickers were compared with those of 55 students who utilized multiple-choice PowerPoint slides only. Test scores between these two groups were not significantly different. A satisfaction questionnaire showed that 72.2% of the control students did not desire the opportunity to use clickers. Of the group utilizing the clickers, 92.3% recommend the use of this system in future courses. The use of multiple-choice PowerPoint slides and an audience response system did not seem to improve the students' comprehension or retention of pharmacological knowledge as compared with those who used solely multiple-choice PowerPoint slides. Copyright © 2011 Wolters Kluwer Health. Lippincott Williams & Wilkins.
- Goodwin, J. L., Vasquez, M. M., Silva, G. E., & Quan, S. F. (2010). Incidence and Remission of Sleep-Disordered Breathing and Related Symptoms in 6- to 17-Year Old Children-The Tucson Children's Assessment of Sleep Apnea Study. Journal of Pediatrics, 157(1), 57-61.More infoPMID: 20304429;PMCID: PMC2886190;Abstract: Objective: To determine the incidence and remission of sleep-disordered breathing in adolescent children. Study design: A total of 319 children completed 2 home polysomnograms approximately 5 years apart. Sleep-disordered breathing (SDB) was determined to be present if a child had a respiratory disturbance index ≥ 1 event per hour associated with ≥3% oxygen desaturation. Subjective symptoms such as witnessed apnea, excessive daytime sleepiness, difficulty initiating and maintaining sleep, and habitual loud snoring were considered present if they occurred frequently or almost always. Body mass index percentiles were calculated with childhood growth charts from the Centers for Disease Control and Prevention adjusted for sex and age. Results: The mean age at assessment was 8.5 years at baseline and 13.7 years at follow-up, respectively. Incident SDB was more common in boys (odds ratio [OR] = 3.93, P = .008, confidence interval [CI] = 1.41-10.90). Children with prevalent SDB were more likely to be boys (OR = 2.48, P = .006) and had a greater increase in body mass index percentile change (OR 1.01, P = .034). Children with prevalent SDB also had 3.41 greater odds for development of obesity from baseline to follow-up in comparison with children with prevalent NoSDB. Conclusions: Adolescent boys are more likely to have persistent and incident SDB than girls. Children with prevalent SDB are more likely to have development of obesity. These risks are similar to those observed in adults. © 2010 Mosby, Inc. All rights reserved.
- Lundy, S. M., Silva, G. E., Kaemingk, K. L., Goodwin, J. L., & Quan, S. F. (2010). Cognitive Functioning and Academic Performance in Elementary School Children with Anxious/Depressed and Withdrawn Symptoms. The open pediatric medicine journal, 4, 1-9.More infoRATIONALE: Few studies have evaluated the relationship between depressive symptomatology and neuropsychological performance in children without symptomatic depression. OBJECTIVES: This study determined the relationship between anxious/depressed and withdrawn symptoms and performance on cognitive and academic achievement measures. METHODS: 335 Caucasian and Hispanic children aged 6 to 11 years who participated in the Tucson Children's Assessment of Sleep Apnea (TuCASA) study were administered a comprehensive neuropsychological battery measuring cognitive functioning and academic achievement. Their parents completed the Child Behavior Checklist (CBCL). Correlations between performance on the cognitive and academic achievement measures and two Internalizing scales from the CBCL were calculated. Comparisons were made between a "Clinical" referral group (using a T-score of ≥ 60 from the CBCL scales) and a "Normal" group, as well as between Caucasians and Hispanics. RESULTS: No differences were found between those participants with increased anxious/depressed or withdrawn symptoms on the CBCL and those without increased symptoms with respect to age, gender, ethnicity, or parental education level. However, significant negative correlations were found between these symptoms and general intellectual function, language, visual construction skills, attention, processing speed, executive functioning abilities, aspects of learning and memory, psychomotor speed and coordination, and basic academic skills. CONCLUSIONS: These findings support the hypothesis that depressive symptomatology negatively impacts performance on cognitive and academic achievement measures in school-aged children and these findings are not affected by ethnicity. The findings also reinforce the concept that the presence of anxious/depressed or withdrawn symptoms needs to be considered when evaluating poor neuropsychological performance in children.
- Silva, G. E., An, M., Goodwin, J. L., Shahar, E., Redline, S., Resnick, H., Baldwin, C. M., & Quan, S. F. (2009). Longitudinal evaluation of sleep-disordered breathing and sleep symptoms with change in quality of life: The Sleep Heart Health Study (SHHS). Sleep, 32(8), 1049-1057.More infoPMID: 19725256;PMCID: PMC2717195;Abstract: Study Objectives: Findings from population studies evaluating the progression and incidence of sleep disordered breathing have shown evidence of a longitudinal increase in the severity of sleep disordered breathing. The present study evaluates the association among changes in sleep disordered breathing, sleep symptoms, and quality of life over time. Design: Prospective cohort study. Data were from the Sleep Heart Health Study. Setting: Multicenter study. Participants: Three thousand seventy-eight subjects aged 40 years and older from the baseline and follow-up examination cycles were included. Measurements: The primary outcomes were changes in the Physical Component Summary and Mental Component Summary scales obtained from the Medical Outcomes Study Short-Form Health Survey. The primary exposure was change in the respiratory disturbance index obtained from unattended overnight polysomnograms performed approximately 5 years apart. Other covariates included measures of excessive daytime sleepiness and difficulty initiating and maintaining sleep. Results: Mean respiratory disturbance index increased from 8.1 ± 11 SD at baseline to 10.9 ± 14 (P < 0.0001) at follow-up. The mean Physical Component Summary and Mental Component Summary scores were 48.5 and 54.1 at baseline and 46.3 and 54.8 at follow-up. No associations between change in respiratory disturbance index and changes in Physical Component Summary or Mental Component Summary scores were seen. However, worsening of difficulty initiating and maintaining sleep and excessive daytime sleepiness were significantly associated with lower quality of life. Conclusions: A slight increase in severity of sleep disordered breathing was seen over 5 years; this was not associated with worsening of quality of life. However, subjective symptoms of quality of sleep and daytime sleepiness were associated with declining quality of life.
- Sharief, I., Silva, G. E., Goodwin, J. L., & Quan, S. F. (2008). Effect of sleep disordered breathing on the sleep of bed partners in the sleep heart health study. Sleep, 31(10), 1449-1456.More infoPMID: 18853943;PMCID: PMC2572736;Abstract: Objective: To study the sleep quality of bed partners of persons with sleep disordered breathing in a non-clinical population based sample in a home environment. Design: Cross-sectional study in a community sample. Methods: 110 pairs of subjects living in the same household from the Tucson, Minnesota, and Pittsburgh sites of the Sleep Heart Health Study (SHHS) were included if both partners had an in-home, unattended polysomnogram (PSG) performed as a part of SHHS exam cycle 2. Sleep disordered breathing (SDB) was considered present if the respiratory disturbance index (RDI) was ≥10 events/h and no SDB if RDI was
- Silva, G. E., Guerra, S., Keim, S., Barbee, R. A., & Sherrill, D. L. (2008). Longitudinal decline of diffusing capacity of the lung for carbon monoxide in community subjects with the PiMZ α1-antitrypsin phenotype. Chest, 133(5), 1095-1100.More infoPMID: 18263681;Abstract: Background: It is well known that homozygous deficiency of α2-antitrypsin, PiZZ, is associated with an increased risk of emphysema. However, studies evaluating associations between the heterozygous form PiMZ with emphysema and impaired lung function have provided conflicting results. Study objective: The goal of this study was to determine if the phenotype PiMZ is associated with an accelerated decline in diffusing capacity of the lung for carbon monoxide (DLCO). Design and methods: The Tucson Epidemiologic Study of Airway Obstructive Disease is a prospective, population-based cohort study initiated in 1972. Participants completed standardized questionnaires in up to 12 periodic surveys and DLCO assessments in up to 4 surveys. Random-effects models were used to determine the effects of α1-antitrypsin phenotypes on percentage of predicted (% predicted) DLCO levels among 1,075 subjects ≥ 18 years old. Results: % predicted DLCO declined more rapidly in subjects who smoked compared to nonsmoking subjects. Additionally, in smokers, the PiMZ phenotype was associated with borderline % predicted DLCO deficits at age 40 years (8.6%; p = 0.075) and significant % predicted DLCO deficits at age 60 years (15.2%; p = 0.001) and 80 years (21.9%; p = 0.003), as compared with the PiMM phenotype. Conclusions: DLCO may be a more sensitive indicator of the long-term effects of intermediate levels of α1-antitrypsin on lung function especially in subjects who smoke.
- Goodwin, J. L., Silva, G. E., Kaemingk, K. L., Sherrill, D. L., Morgan, W. J., & Quan, S. F. (2007). Comparison between reported and recorded total sleep time and sleep latency in 6- to 11-year-old children: The Tucson Children's Assessment of Sleep Apnea Study (TuCASA). Sleep and Breathing, 11(2), 85-92.More infoPMID: 17165092;Abstract: Research comparing parental report of sleep times to objectively obtained polysomnographic evidence of sleep times in schoolchildren is lacking. This report compares habitual sleep time and objectively recorded sleep time and sleep latency with parental reports of sleep time immediately after a night of polysomnography in elementary schoolchildren. Unattended home polysomnograms (PSG) were obtained from 480 children. On the night of the PSG, a parent was asked to complete a Sleep Habits Questionnaire, which inquired about the habitual total sleep time (HABTST) and habitual sleep onset latency (HABSOL) of his/her child on both school days and nonschool days. On the morning after the PSG, the parent was asked to estimate the total sleep time (ESTTST) and sleep onset latency (ESTSOL) of his/her child on the night of the recording. Comparisons were made to actual total sleep time (PSGTST) and sleep latency (PSGSOL) on the PSG. The sample was comprised of 50% girls, 42.3% Hispanic, and 53% aged 6-8 years. The mean HABTST, ESTTST, and PSGTST were 578, 547, and 480 min, respectively. HABTST was greater than both ESTST and PSGTST (p
- Silva, G. E., Goodwin, J. L., Sherrill, D. L., Arnold, J. L., Bootzin, R. R., Smith, T., Walsleben, J. A., Baldwin, C. M., & Quan, S. F. (2007). Relationship between reported and measured sleep times: the sleep heart health study (SHHS). Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 3(6), 622-30.More infoSubjective and objective assessments of sleep may be discrepant due to sleep misperception and measurement effects, the latter of which may change the quality and quantity of a person's usual sleep. This study compared sleep times from polysomnography (PSG) with self-reports of habitual sleep and sleep estimated on the morning after a PSG in adults.
- Watson, R. R., Rohdewald, P., & Silva, G. E. (2007). Asthma risk factors in Desert Southwest of USA: Role of nutritional supplement, Pycnogenol® in therapy. Journal of Nutritional and Environmental Medicine, 16(1), 33-38.More infoAbstract: Purpose: Desert environments have some unique causative agents that promote asthma. These include molds like Alternaria alternata and Dermatophagoides farinae, and Bermuda grass pollen. In addition, dietary supplements with antioxidant activities are being shown to reduce asthma symptoms with Pycnogenol being the example used. Design: Literature review. Materials and methods: This review was conducted by searching PubMed and other medical databases, as well as doing original research reviewed. It was presented at the meeting of the British Society for Ecological Medicine in London, June 2006. Results: Recent studies are defining the risk factors for asthma induction in children in the desert environment of Southwest USA. In particular, exposure to molds and pets, maternal smoking, and being overweight. Two recent studies have shown that Pycnogenol, a dietary supplement containing bioflavanoids with strong antioxidant activity, reduced asthma symptoms in adults and youths. There was evidence that the extract lowered symptoms and reduced use of rescue inhalers. In addition, Pycnogenol reduced serum leukotrienes helping explain its action. Conclusions: Exposure to desert materials, in particular Alternaria alternata, increased risk of childhood asthma while Dermatophagoides farinae had no effect. Therapy was successful using a dietary supplement, Pycnogenol, containing bioflavanoids with strong antioxidant activities. © 2007 Informa UK Ltd.
- Silva, G. E., Sherrill, D. L., Guerra, S., & Barbee, R. A. (2004). Asthma as a risk factor for COPD in a longitudinal study. Chest, 126(1), 59-65.More infoPMID: 15249443;Abstract: Background: For several years, asthma and COPD have been regarded as distinct entities, with distinct clinical courses. However, despite distinctive physiologic features at the time of diagnosis, and different risk factors, the two diseases over time may develop features that are quite similar. Study objective: To evaluate the association between physician-diagnosed asthma and the subsequent development of COPD in a cohort of 3,099 adult subjects from Tucson, AZ. Design and methods: A prospective observational study. Participants completed up to 12 standard respiratory questionnaires and 11 spirometry lung function measurements over a period of 20 years. Survival curves (with time to development of COPD as the dependent variable) were compared between subjects with asthma and subjects without asthma at the initial survey. Results: Subjects with active asthma (n = 192) had significantly higher hazard ratios than inactive (n = 156) or nonasthmatic subjects (n = 2751) for acquiring COPD. As compared with nonasthmatics, active asthmatics had a 10-times-higher risk for acquiring symptoms of chronic bronchitis (95% confidence interval [CI], 4.94 to 20.25), 17-times-higher risk of receiving a diagnosis of emphysema (95% CI, 8.31 to 34.83), and 12.5-times-higher risk of fulfilling COPD criteria (95% CI, 6.84 to 22.84), even after adjusting for smoking history and other potential confounders. Conclusions: Physician-diagnosed asthma is significantly associated with an increased risk for CB, emphysema, and COPD.
- Silva, G. E., Sherrill, D. L., Guerra, S., & Barbee, R. A. (2003). A longitudinal study of alpha1-antitrypsin phenotypes and decline in FEV1 in a community population. Chest, 123(5), 1435-40.More infoIt is well-known that the homozygous deficiency of alpha(1)-antitrypsin, phenotype PiZZ, is associated with an increased risk of COPD. However, studies evaluating the association between the heterozygous forms of the alpha(1)-antitrypsin phenotype PiMZ and rapid decline in lung function, both in patient and community populations, have yielded conflicting results.
- Silva Torres, G. E. (2015, June). Sleep disordered breathing and quality of life, comparison of the Sf-36, FOSQ, and SAQLI questionnaires.. The 29th Annual Meeting of the Associated Professional Sleep Societies. Seattle, Washington: Associated Professional Sleep Societies.