Zhao Chen

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• Khan, S. M., Farland, L. V., Catalfamo, C. J., Austhof, E., Bell, M. L., Chen, Z., Cordova-Marks, F., Ernst, K. C., Garcia-Filion, P., Heslin, K. M., Hoskinson, J., Jehn, M. L., Joseph, E. C., Kelley, C. P., Klimentidis, Y., Russo Carroll, S., Kohler, L. N., Pogreba-Brown, K., & Jacobs, E. T. (2022). Elucidating symptoms of COVID-19 illness in the Arizona CoVHORT: a longitudinal cohort study. BMJ open, 12(1), e053403.
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  To elucidate the symptoms of laboratory-confirmed COVID-19 cases as compared with laboratory-confirmed negative individuals and to the untested general population among all participants who reported symptoms within a large prospective cohort study.
• Bea, J. W., Chen, Z., Blew, R. M., Nicholas, J. S., Follis, S., Bland, V. L., Cheng, T. D., Ochs-Balcom, H. M., Wactawski-Wende, J., Banack, H. R., Neuhouser, M. L., Laddu, D., Stefanick, M. L., Cauley, J. A., Caan, B., LeBoff, M. S., Chlebowski, R. T., & Odegaard, A. O. (2021). MRI based validation of abdominal adipose tissue measurements from DXA in postmenopausal women. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.
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  Visceral adipose tissue (VAT) is a hypothesized driver of chronic disease. Dual-energy X-ray absorptiometry (DXA) potentially offers a lower cost and more available alternative compared to gold-standard magnetic resonance imaging (MRI) for quantification of abdominal fat sub-compartments, VAT and subcutaneous adipose tissue (SAT). We sought to validate VAT and SAT area (cm) from historical DXA scans against MRI.
• Carbone, L. D., Johnson, K., Larson, J. C., Thomas, F., Wactawski-Wende, J., Bollinger, K., Chen, Z., & Watsky, M. (2021). Association of vitamin D with incident glaucoma: findings from the Women's Health Initiative. Journal of investigative medicine : the official publication of the American Federation for Clinical Research.
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  The relationship between vitamin D and glaucoma is controversial. The objective of this study was to examine women from the Women's Health Initiative (WHI) to determine if there is an association between vitamin D and incident glaucoma in postmenopausal women. We examined the association between dietary vitamin D intake, vitamin D supplements and serum 25 hydroxyvitamin D (25(OH)D) levels and the risk of developing glaucoma. 143,389 postmenopausal women from the WHI including a subset with serum 25(OH) D measurements were examined to determine the association of dietary, supplemental and serum levels of vitamin D to the development of glaucoma. Dietary intakes of vitamin D, use of vitamin D supplements and serum levels of 25(OH) D were predictors examined for the main outcome of incident glaucoma. In multivariable models adjusted for demographic, clinical variables and medication use, dietary vitamin D, vitamin D supplements, total vitamin D intake (diet plus supplements) and serum 25 (OH) D measurements were not significantly associated with incident glaucoma. In the CaD placebo-controlled intervention clinical trial, there was also no association in the active intervention arm with glaucoma. We conclude that dietary vitamin D intake, supplements and serum levels are not significantly related to the risk of developing glaucoma in postmenopausal women.
• Catalfamo, C. J., Heslin, K. M., Shilen, A., Khan, S. M., Hunsaker, J. R., Austhof, E., Barraza, L., Cordova-Marks, F. M., Farland, L. V., Garcia-Filion, P., Hoskinson, J., Jehn, M., Kohler, L. N., Lutrick, K., Harris, R. B., Chen, Z., Klimentidis, Y. C., Bell, M. L., Ernst, K. C., , Jacobs, E. T., et al. (2021). Design of the Arizona CoVHORT: A Population-Based COVID-19 Cohort. Frontiers in public health, 9, 620060.
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  This study is a prospective, population-based cohort of individuals with a history of SARS-CoV-2 infection and those without past infection through multiple recruitment sources. The main study goal is to track health status over time, within the diverse populations of Arizona and to identify the long-term consequences of COVID-19 on health and well-being. A total of 2,881 study participants (16.2% with a confirmed SARS-CoV-2 infection) have been enrolled as of December 22, 2020, with a target enrollment of 10,000 participants and a planned follow-up of at least 2 years. This manuscript describes a scalable study design that utilizes a wide range of recruitment sources, leveraging electronic data collection to capture and link longitudinal participant data on the current and emerging issues associated with the COVID-19 pandemic. The cohort is built within a collaborative infrastructure that includes new and established partnerships with multiple stakeholders, including the state's public universities, local health departments, tribes, and tribal organizations. Challenges remain for ensuring recruitment of diverse participants and participant retention, although the electronic data management system and timing of participant contact can help to mitigate these problems.
• Follis, S., Chen, Z., Mishra, S., Howe, C. L., Toosizadeh, N., & Dohm, M. (2021). Comparison of wearable sensor to traditional methods in functional outcome measures: A systematic review. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 39(10), 2093-2102.
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  Traditional methods of collecting functional outcome measures are widely used for lower extremity arthroplasty outcome assessment. Wearable sensors are emerging as viable tools for functional outcome measures in monitoring of postarthroplasty recovery. The objective of this review was to compare the efficacy of wearable sensors with traditional methods for monitoring postarthroplasty functional recovery. Articles were searched for inclusion in this review that used both traditional and wearable sensor functional outcome measures to assess lower extremity function before and after lower extremity arthroplasty. Two independent screeners reviewed all articles, and resolved differences through consensus and consultation with the senior author. Studies that met inclusion criteria were evaluated for methodologic quality using performed risk of bias assessments. Results from several traditional and wearable sensor functional outcome measures from baseline through follow-up were normalized across studies. Fourteen articles met the inclusion criteria. Six studies used statistical methods to directly compare functional outcome measures and eight studies used qualitative description of comparisons. This review found evidence that wearable sensors detected nuanced functional outcome information on the specific biomechanics and timing of recovery, which were unaccounted for using traditional methods. Wearable sensors have shown promising utility in providing additional recovery information from lower extremity arthroplasty compared with traditional functional outcome measures, but future research is needed to assess the clinical significance of this additional information. Wearable sensor technology is an emerging clinical tool providing advanced and determinative data with the potential for advancing the assessment of lower extremity arthroplasty outcomes.
• Follis, S. L., Bea, J., Klimentidis, Y., Hu, C., Crandall, C. J., Garcia, D. O., Shadyab, A. H., Nassir, R., & Chen, Z. (2019). Psychosocial stress and bone loss among postmenopausal women: results from the Women's Health Initiative. Journal of epidemiology and community health, 73(9), 888-892.
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  Bone loss is a major public health concern with large proportions of older women experiencing osteoporotic fractures. Previous research has established a relationship between psychosocial stressors and fractures. However, few studies have investigated bone loss as an intermediary in this relationship. This study investigates whether social stress is associated with bone loss during a 6-year period in postmenopausal women.
• LaMonte, M. J., Wactawski-Wende, J., Larson, J. C., Mai, X., Robbins, J. A., LeBoff, M. S., Chen, Z., Jackson, R. D., LaCroix, A. Z., Ockene, J. K., Hovey, K. M., Cauley, J. A., & , W. H. (2019). Association of Physical Activity and Fracture Risk Among Postmenopausal Women. JAMA network open, 2(10), e1914084.
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  Physical activity is inversely associated with hip fracture risk in older women. However, the association of physical activity with fracture at other sites and the role of sedentary behavior remain unclear.
• Klimentidis, Y. C., Raichlen, D. A., Bea, J. W., Garcia, D. O., Mandarino, L. J., Alexander, G. E., Chen, Z., & Going, S. B. (2017). Genome-wide association study of habitual physical activity in over 277,000 UK Biobank participants indentifies novel variants and genetic correlations with chronotype and obesity related traits. International Journal of Obesity.
• Chen, Z., & Chen, Z. (2017). INCIDENT ATRIAL FIBRILLATION AND THE RISK OF FRACTURE IN THE CARDIOVASCULAR HEALTH STUDY.. International Osteoporosis, 28(2), 719-725.
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  AdvancedHelpResult FiltersFormat: AbstractSend toOsteoporos Int. 2017 Feb;28(2):719-725. doi: 10.1007/s00198-016-3778-1. Epub 2016 Oct 7.Incident atrial fibrillation and the risk of fracture in the cardiovascular health study.Wallace ER1, Siscovick DS2,3,4, Sitlani CM3, Dublin S4,5, Mitchell P6, Robbins JA7, Fink HA8,9, Cauley JA10, Bůžková P11, Carbone L12, Chen Z13, Heckbert SR4,5.Author informationAbstractIn this prospective cohort of 4462 older adults, incident atrial fibrillation (AF) was not statistically significantly associated with subsequent risk of incident fracture.INTRODUCTION: AF is associated with stroke, heart failure, dementia, and death, but its association with fracture is unknown. Therefore, we examined the association of incident AF with the risk of subsequent fracture in the Cardiovascular Health Study (CHS) cohort.METHODS: Of the CHS participants aged ≥65 years, 4462 were followed between 1991 and 2009, mean follow-up 8.8 years. Incident AF was identified by annual study electrocardiogram (ECG), hospital discharge diagnosis codes, or Medicare claims. Fractures of the hip, distal forearm, humerus, or pelvis were identified using hospital discharge diagnosis codes or Medicare claims. We used Cox proportional hazard models to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for the association between incident AF (time-varying) and the risk of subsequent fracture. We also evaluated whether AF was associated with risk of sustaining a fall.RESULTS: Crude incident fracture rate was 22.9 per 1000 person-years in participants with AF and 17.7 per 1000 person-years in participants without AF. Individuals with incident AF were not at significantly higher risk of hip fracture (adjusted HR = 1.09, 95 % CI 0.83-1.42) or fracture at any selected site (adjusted HR = 0.97, 95 % CI 0.77-1.22) or risk of sustaining a fall (adjusted HR = 1.00, 95 % CI = 0.87-1.16) compared with those without AF.CONCLUSION: In this cohort of older, community-dwelling adults, incident AF was not shown to be associated with falls or hip or other fractures.KEYWORDS: Arrhythmia; Atrial fibrillation; Fracture; Hip fracturePMID: 27714443 PMCID: PMC5782802 DOI: 10.1007/s00198-016-3778-1 Free PMC Article
• Chen, Z., & Chen, Z. (2017). Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.. Nat Commun, 8(1), 80. doi:10.1038/s41467-017-00031-7
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  Nat Commun. 2017 Jul 19;8(1):80. doi: 10.1038/s41467-017-00031-7.Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.Zillikens MC1,2, Demissie S3, Hsu YH4,5,6, Yerges-Armstrong LM7, Chou WC4,5,8, Stolk L1,2, Livshits G9,10, Broer L11, Johnson T12,13,14, Koller DL15, Kutalik Z12,13,14, Luan J16, Malkin I9, Ried JS17, Smith AV18,19, Thorleifsson G20, Vandenput L21, Hua Zhao J16, Zhang W22,23, Aghdassi A24, Åkesson K25,26, Amin N11, Baier LJ27, Barroso I28,29,30, Bennett DA31, Bertram L32,33, Biffar R34, Bochud M14, Boehnke M35, Borecki IB36,37, Buchman AS31, Byberg L38, Campbell H39, Campos Obanda N1, Cauley JA40, Cawthon PM41, Cederberg H42, Chen Z43, Cho NH44, Jin Choi H45,46, Claussnitzer M4,5,8,47,48,49, Collins F50, Cummings SR41, De Jager PL5,51,52, Demuth I53,54, Dhonukshe-Rutten RAM55, Diatchenko L56,57, Eiriksdottir G18, Enneman AW1, Erdos M50, Eriksson JG58,59,60,61,62, Eriksson J21, Estrada K1,11, Evans DS41, Feitosa MF36, Fu M7, Garcia M63, Gieger C17,64,65, Girke T66,67, Glazer NL68, Grallert H17,64,67,69,70,71, Grewal J23,72, Han BG73, Hanson RL27, Hayward C74, Hofman A2,11, Hoffman EP75, Homuth G76, Hsueh WC27, Hubal MJ77,78, Hubbard A79, Huffman KM80, Husted LB81, Illig T64,82,83, Ingelsson E84,85, Ittermann T86, Jansson JO87, Jordan JM88, Jula A62, Karlsson M89, Khaw KT90, Kilpeläinen TO16,91,92, Klopp N64,83, Kloth JSL1, Koistinen HA93,94,95,96, Kraus WE97, Kritchevsky S98, Kuulasmaa T42, Kuusisto J42, Laakso M42, Lahti J99, Lang T100, Langdahl BL81, Launer LJ63, Lee JY73, Lerch MM24, Lewis JR101,102, Lind L84, Lindgren C103, Liu Y104, Liu T105,106, Liu Y88, Ljunggren Ö84, Lorentzon M21, Luben RN90, Maixner W57, McGuigan FE25, Medina-Gomez C1,11, Meitinger T48,107, Melhus H84, Mellström D21, Melov S108,109, Michaëlsson K38, Mitchell BD7,110, Morris AP103,111, Mosekilde L81, Newman A112, Nielson CM113, O'Connell JR7, Oostra BA114,115, Orwoll ES113, Palotie A116,117, Parker SCJ118, Peacock M119, Perola M62,116,120,121, Peters A17,64, Polasek O122, Prince RL101,123, Räikkönen K99, Ralston SH124, Ripatti S116,125,28, Robbins JA126, Rotter JI127, Rudan I39, Salomaa V62, Satterfield S128, Schadt EE129, Schipf S86, Scott L35, Sehmi J23,72, Shen J113, Soo Shin C45, Sigurdsson G19,130, Smith S131, Soranzo N28, Stančáková A42, Steinhagen-Thiessen E53, Streeten EA7,132, Styrkarsdottir U20, Swart KMA133, Tan ST23,72, Tarnopolsky MA134, Thompson P135, Thomson CA43, Thorsteinsdottir U19,20, Tikkanen E62,116,124, Tranah GJ41, Tuomilehto J61,136,137,138, van Schoor NM133, Verma A23, Vollenweider P139, Völzke H86, Wactawski-Wende J140, Walker M141, Weedon MN142, Welch R35, Wichmann HE17,143,144, Widen E116, Williams FMK10, Wilson JF39,74, Wright NC145, Xie W142, Yu L31, Zhou Y3, Chambers JC22,23,146,147, Döring A17,148, van Duijn CM11,115, Econs MJ149, Gudnason V18,19, Kooner JS23,72,147, Psaty BM150,151, Spector TD10, Stefansson K19,20, Rivadeneira F1,2,11, Uitterlinden AG1,2,11, Wareham NJ16, Ossowski V27, Waterworth D152, Loos RJF16,153,154,155,156, Karasik D4,5,157, Harris TB63, Ohlsson C21, Kiel DP158,159,160.Author informationErratum inErratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. [Nat Commun. 2017]AbstractLean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p 
• Martinez, J. A., Wertheim, B. C., Thomson, C. A., Bea, J. W., Wallace, R., Allison, M., Snetselaar, L., Chen, Z., Nassir, R., & Thompson, P. A. (2017). Physical Activity Modifies the Association between Dietary Protein and Lean Mass of Postmenopausal Women. Journal of the Academy of Nutrition and Dietetics, 117(2), 192-203.e1.
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  Maintenance of lean muscle mass and related strength is associated with lower risk for numerous chronic diseases of aging in women.
• Thomson, C. A., Jackson, R., Chou, Y., Hu, C., Ernst, K. C., Bea, J. W., Klimentidis, Y. C., & Chen, Z. (2017). Body mass index, waist circumference and mortality in a large mutiethnic postmenopausal cohort - Results from the Women's Health Initiative.. Journal of the American Geriatric Society.
• Crandall, C. J., LaMonte, M. J., Snively, B. M., LeBoff, M. S., Cauley, J. A., Lewis, C. E., Wallace, R., Li, W., Chen, Z., Robbins, J. A., & Wactawski-Wende, J. (2016). Physical Functioning Among Women Aged 80 Years and Older With Previous Fracture. The journals of gerontology. Series A, Biological sciences and medical sciences, 71 Suppl 1, S31-41.
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  The oldest old are the fastest growing segment of the elderly population. Little is known regarding the associations of fracture history with physical functioning assessed after age 80.
• Klimentidis, Y. C., Bea, J. W., Thompson, P., Klimecki, W. T., Hu, C., Wu, G., Nicholas, S., Ryckman, K. K., & Chen, Z. (2016). Genetic Variant in ACVR2B Is Associated with Lean Mass. Medicine and science in sports and exercise.
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  Low lean mass (LM) is a risk factor for chronic disease, a major cause of disability and diminished quality of life, and is a heritable trait. However, relatively few specific genetic factors have been identified as potentially influencing this trait.
• Vasquez, M. M., Hu, C., Roe, D. J., Chen, Z., Halonen, M., & Guerra, S. (2016). Least absolute shrinkage and selection operator type methods for the identification of serum biomarkers of overweight and obesity: simulation and application. BMC medical research methodology, 16(1), 154.
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  The study of circulating biomarkers and their association with disease outcomes has become progressively complex due to advances in the measurement of these biomarkers through multiplex technologies. The Least Absolute Shrinkage and Selection Operator (LASSO) is a data analysis method that may be utilized for biomarker selection in these high dimensional data. However, it is unclear which LASSO-type method is preferable when considering data scenarios that may be present in serum biomarker research, such as high correlation between biomarkers, weak associations with the outcome, and sparse number of true signals. The goal of this study was to compare the LASSO to five LASSO-type methods given these scenarios.
• Chen, Z. (2015). Effect of Age of Self-Reported, Non-Surgical Menopause on Time to First Fracture and areal Bone Mineral Density in the Women’s Health Initiative Observational Study. Menopause, 22(10), 1035-44.
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  Menopause. 2015 Oct;22(10):1035-44. doi: 10.1097/GME.0000000000000451.EFFECTS OF SELF-REPORTED AGE AT NONSURGICAL MENOPAUSE ON TIME TO FIRST FRACTURE AND BONE MINERAL DENSITY IN THE WOMEN'S HEALTH INITIATIVE OBSERVATIONAL STUDY.Sullivan SD1, Lehman A, Thomas F, Johnson KC, Jackson R, Wactawski-Wende J, Ko M, Chen Z, Curb JD, Howard BV.
• Chen, Z. (2015). Fusion of clinical and stochastic finite element data for hip fracture risk prediction. Biomechanics, 48(15), 4043.
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  Jiang, P., Missoum, S. and Chen, Z., “Fusion of clinical and stochastic finite element data for hip fracture risk prediction”, Journal of Biomechanics, Volume 48, Issue 15, 26 November 2015, Pages 4043. PMID: 26482733 http://www.ncbi.nlm.nih.gov/pubmed/26482733
• Chen, Z. (2015). Postmenopausal Risk for Mortality Based on BMI and Body Composition.. American Journal of Epidemiology, 182(7), 585-596.
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  Bea, J. W., Thomson, C. A., Wertheim, B. C., Nicholas, J. S., Ernst, K. C., Hu, C., ... Chen, Z. (2015). Risk of mortality according to body mass index and body composition among postmenopausal women. American Journal of Epidemiology, 182(7), 585-596. 10.1093/aje/kwv103
• Crandall, C. J., Yildiz, V. O., Wactawski-Wende, J., Johnson, K. C., Chen, Z., Going, S. B., Wright, N. C., & Cauley, J. A. (2015). Postmenopausal weight change and incidence of fracture: post hoc findings from Women's Health Initiative Observational Study and Clinical Trials. BMJ (Clinical research ed.), 350, h25.
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  To determine associations between postmenopausal change in body weight and incidence of fracture and associations between voluntary and involuntary weight loss and risk of fracture.
• Going, S. B., Chen, Z., Alexander, G. E., Mandarino, L. J., Garcia, D. O., Bea, J. W., Raichlen, D. A., & Klimentidis, Y. C. (2017). Genome-wide association study of habitual physical activity in over 277,000 UK Biobank participants indentifies novel variants and genetic correlations with chronotype and obesity related traits. International Journal of Obesity.
• Klimentidis, Y. C., Bea, J. W., Lohman, T. G., Hsieh, P. S., Going, S. B., & Chen, Z. (2015). Resistance exercise intervention results in less weight loss among individuals at high genetic risk for obesity. International Journal of Obesity, 39(9), 1371-1375.
• Klimentidis, Y. C., Bea, J. W., Lohman, T., Hsieh, P., Going, S., & Chen, Z. (2015). High genetic risk individuals benefit less from resistance exercise intervention. International journal of obesity (2005), 39(9), 1371-5.
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  Genetic factors have an important role in body mass index (BMI) variation, and also likely have a role in the weight loss and body composition response to physical activity/exercise. With the recent identification of BMI-associated genetic variants, it is possible to investigate the interaction of these genetic factors with exercise on body composition outcomes.
• Jiang, P., Missoum, S., & Chen, Z. (2014). Optimal SVM Parameter Selection for Non-separable and Unbalanced Datasets.. Structural and Multidisciplinary Optimization, 50, 523-535.
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  Jiang, P., Missoum, S., and Chen, Z., Optimal SVM Parameter Selection for Non-separable and Unbalanced Datasets. Structural and Multidisciplinary Optimization, vol. 50, 2014, pp. 523-535.
• Klimentidis, Y. C., Chen, Z., Arora, A., & Hsu, C. (2014). Association of physical activity with lower type 2 diabetes incidence is weaker among individuals at high genetic risk. Diabetologia, 57(12), 2530-4.
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  We examined whether or not the association of physical activity with type 2 diabetes incidence differs according to several types of genetic susceptibility.
• Beasley, J. M., Wertheim, B. C., LaCroix, A. Z., Prentice, R. L., Neuhouser, M. L., Tinker, L. F., Kritchevsky, S., Shikany, J. M., Eaton, C., Chen, Z., & Thomson, C. A. (2013). Biomarker-calibrated protein intake and physical function in the Women's Health Initiative. Journal of the American Geriatrics Society, 61(11).
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  To determine whether preservation of physical function with aging may be partially met through modification in dietary protein intake.
• Cauley, J. A., Chlebowski, R. T., Wactawski-Wende, J., Robbins, J. A., Rodabough, R. J., Chen, Z., Johnson, K. C., O'Sullivan, M. J., Jackson, R. D., & Manson, J. E. (2013). Calcium plus vitamin D supplementation and health outcomes five years after active intervention ended: the Women's Health Initiative. Journal of women's health (2002), 22(11).
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  Clinical outcomes of the Women's Health Initiative (WHI) calcium plus vitamin D supplementation trial have been reported during 7.0 years of active intervention. We now report outcomes 4.9 years after the intervention stopped and cumulative findings.
• Chen, Z. -. (2013). Historical Relationships between Biological Anthropology and Body Composition. ACTA Anthropologica Sinica, 32(3), 16-23.
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  Chen Z. Historical Relationships between Biological Anthropology and Body Composition. ACTA Anthropologica Sinica, August 2013, 32(3).
• Ochs-Balcom, H. M., Preus, L., Wactawski-Wende, J., Nie, J., Johnson, N. A., Zakharia, F., Tang, H., Carlson, C., Carty, C., Chen, Z., Hoffman, T., Hutter, C. M., Jackson, R. D., Kaplan, R. C., Li, L., Liu, S., Neuhouser, M. L., Peters, U., Robbins, J., , Seldin, M. F., et al. (2013). Association of DXA-derived bone mineral density and fat mass with African ancestry. The Journal of clinical endocrinology and metabolism, 98(4).
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  Both genes and environment have been implicated in determining the complex body composition phenotypes in individuals of European ancestry; however, few studies have been conducted in other race/ethnic groups.
• Sims, S. T., Kubo, J., Desai, M., Bea, J., Beasley, J. M., Manson, J. E., Allison, M., Seguin, R. A., Chen, Z., Michael, Y. L., Sullivan, S. D., Beresford, S., & Stefanick, M. L. (2013). Changes in physical activity and body composition in postmenopausal women over time. Medicine and science in sports and exercise, 45(8).
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  Higher physical activity (PA) has been associated with greater attenuation of body fat gain and preservation of lean mass across the lifespan. These analyses aimed to determine relationships of change in PA to changes in fat and lean body mass in a longitudinal prospective study of postmenopausal women.
• Stern, J. H., Grant, A. S., Thomson, C. A., Tinker, L., Hale, L., Brennan, K. M., Woods, N. F., & Chen, Z. (2013). Short sleep duration is associated with decreased serum leptin, increased energy intake, and decreased diet quality in postmenopausal women. Obesity (Silver Spring, Md.).
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  Objective: Short sleep duration induces hormonal perturbations contributing to hyperphagia, insulin resistance, and obesity. The majority of these studies are conducted in young adults. This analysis in a large (n= 769) sample of postmenopausal women (median age 63y) sought to 1) confirm that sleep duration and sleep quality are negatively correlated with circulating leptin concentrations and 2) to examine the relationship between self-reported sleep, dietary energy intake, and diet quality, as well as, investigate the role of leptin in these associations. Design and Methods: Sleep duration/ quality, insomnia, and dietary intake were determined via self-report. Blood samples were collected following an overnight fast to assess serum leptin concentration. All analyses were adjusted for total body fat mass. Results: Women reporting ≤6h sleep/night had lower serum leptin concentrations than those reporting ≥8h sleep (P= 0.04). Furthermore, those with ≤6h sleep/night reported higher dietary energy intake (p=0.01) and lower diet quality (P= 0.04) than the reference group (7h sleep/night). Women sleeping ≥8h also reported lower diet quality than the reference group (P= 0.02). Importantly, serum leptin did not confound these associations. Conclusions: These results provide evidence that sleep duration is inversely associated with serum leptin and dietary energy intake in postmenopausal women.

Presentations

• Chen, Z., & Sokan, A. E. (2023, June).

  Translational Research in Public Health: Aging and Public Health.

  . Young Global Leaders: An Integrated Lab Experience Summer Program. The University of Arizona, Mel & Enid Zuckeman College of Public Health, Drachman Hall, 1295 N. Martin Ave., Tucson AZ: Global Health Institute, The University of Arizona, Mel & Enid Zuckeman College of Public Health,.
• Sokan, A. E., & Chen, Z. (2023, June).

  Translational Research in Public Health: Experience Aging, Aging Research. 

  . Young Global Leaders: An Integrated Lab Experience Summer Program.
• Chen, Z., O'Neill, L. M., Wager, M., Felix, M., Yuan, N. P., & Sokan, A. E. (2021, November). In their own words: A focus group study on COVID-19-related concerns and perceptions of risk among older employees at a large university. Gerontological Society of America 2021 Annual Scientific Meeting. Virtual.
• Odegaard, A., Odegaard, A., Thomson, C. A., Thomson, C. A., Chen, Z., Chen, Z., Bea, J. W., Bea, J. W., Jiang, L., Jiang, L., Huang, S., & Huang, S. (2021, June). Association of Alcohol Intake and Cigarette Smoking With Levels of Visceral and Subcutaneous Abdominal Adipose Tissue Depots in Postmenopausal Women. American Society for Nutrition Annual Meeting. virtual: American Society for Nutrition.
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  Huang S, Jiang L, Bea J, Chen Z, Thomson C, Odegaard A; The Longitudinal Association of Alcohol Intake and Cigarette Smoking With Levels of Visceral and Subcutaneous Abdominal Adipose Tissue Depots in Postmenopausal Women, Presented at American Society for Nutrition Annual Meeting (OR32-04-21; online) June 7-10, 2021; published in Current Developments in Nutrition, Volume 5, Issue Supplement_2, June 2021, Page 1217; https://doi.org/10.1093/cdn/nzab055_027
• et., a., Chen, Z., O'Neill, L. M., Wager, M., Felix, M., Yuan, N. P., & Sokan, A. E. (2021, November). In Their Own Words: A Study on COVID-19-Related Concerns and Perceptions of Risk Among Older University Employees.. Gerontological Society of America annual conference.. Virtual: GSA.

Poster Presentations

• Chen, Z., O'Neill, L. M., Wager, M., Felix, M., Sokan, A. E., & Yuan, N. P. (2021, October). Strategies to promote the health and well-being of older University employees during the COVID-19 pandemic: Findings from focus group interviews. American Public Health Association Annual Meeting & Expo. Denver, CO (hybrid).
• Chen, Z., Yuan, N. P., Sokan, A. E., Kang, P., Wager, M., Yang, Y., & Robles, D. (2021, October). he effect of 6-week virtual tai chi and qigong intervention on sleep quality and wellbeing among university older employees. American Public Health Association Virtual Annual Meeting & Expo. Denver, CO (hybrid).
• Chen, Z., Jiang, P., & Missoum, S. (2014, July). Hip Fracture Prediction using Finite Element Modeling and Machine Learning. Proceedings of the 7th World Congress of Biomechanics, Boston, MA, Jul. 6 - 11, 2014..
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  Jiang, P., Chen, Z., and Missoum, S. Hip Fracture Prediction using Finite Element Modeling and Machine Learning. Proceedings of the 7th World Congress of Biomechanics, Boston, MA, Jul. 6 - 11, 2014.
• Klimentidis, Y. C., Chen, Z., Arora, A., & Hsu, C. (2014, October). Association of physical activity with lower type-2 diabetes incidence is weaker in those with high genetic risk. American Society of Human Genetics Annual Meeting. San Diego, CA.
• Murakami, T., Scranton, R., Brown, H. E., Harris, R. B., Zhao, C., Musuku, S., & Oren, E. (2014, October). A Survey of Screening and Treatment Practices for Helicobacter pylori in the United States. American College of Gastroenterology.. Philadelphia, PA.
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  Murakami T, Scranton R, Brown H, Harris RB, Chen Z, Musuku S, Oren E. A Survey of Screening and Treatment Practices for Helicobacter pylori in the United States. Poster presentation at the American College of Gastroenterology 79th Annual Scientific Meeting, Philadelphia, PA, October 2014.
• Chen, Z. -., Grant, A., Klimecki, W. -., Wright, N., Hu, C. -., Wright, J., Going, S. B., Nicholas, J. S., & Thompson, P. (2013, Fall). Possible pathways for the association of appendicular skeletal muscle mass with leptin, insulin, myoglobin and inflammatory Markers. The American Society for Bone and Mineral Research (ASBMR) 2013 Annual Meeting. Baltimore, MD.
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  Zhao Chen, Andriene Grant, Walt Klimecki, Nicole C. Wright, Jennifer Bea, Scott Going, J. Skye Nicholas, Patricia Thompson. Possible pathways for the association of appendicular skeletal muscle mass with leptin, insulin, myoglobin and inflammatory markers (poster presentation). The American Society for Bone and Mineral Research Annual Meeting, Oct 2-7, 2013. Baltimore, Maryland USA.
• Klimentidis, Y. C., Klimentidis, Y. C., Thompson, P., Thompson, P., Klimecki, W. -., Klimecki, W. -., Hu, C. -., Hu, C. -., Wu, G., Wu, G., Bea, J., Bea, J., Nicholas, J. S., Nicholas, J. S., Allison, D., Allison, D., Chen, Z. -., & Chen, Z. -. (2013, Fall). Genetic variants in CAPN3 and ACVR2B are associated with lean body mass in postmenopausal women. The American Society for Bone and Mineral Research (ASBMR) 2013 Annual Meeting. Baltimore, MD.
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  Yann Klimentidis, Patricia Thompson, Walter T. Klimecki, Chengcheng Hu, Guanglin Wu, Jennifer Wright Bea, Skye Nicholas, CHARGE Consortium Musculoskeletal Working Group, Zhao Chen Genetic variants in CAPN3 and ACVR2B are associated with lean body mass in postmenopausal women. (poster presentation) The American Society for Bone and Mineral Research Annual Meeting, Oct 2-7, 2013. Baltimore, Maryland USA.
• Missoum, S. -., Jiang, P., Hu, C. -., Hsieh, P. S., & Chen, Z. -. (2013, Fall). Towards hip fracture prediction using finite element analysis and machine learning. The American Society for Bone and Mineral Research (ASBMR) 2013 Annual Meeting. Baltimore, MD.
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  Samy Missoum, Peng Jiang, Chengcheng Hu, Skye Nicholas, Zhao Chen. Towards Hip Fracture Prediction using Finite Element analysis and Machine Learning (poster presentation). The American Society for Bone and Mineral Research Annual Meeting, Oct 2-7, 2013. Baltimore, Maryland USA.
• Stern, J., Grant, A. S., Thomson, C. A., Kaplan, R., Manini, T. M., Eaton, C., Tinker, L., LeBlanc, E. S., Going, S. B., Zaslavsky, O., & Chen, Z. -. (2013, Sept). Baseline serum markers of adiposity driven immune/endocrine perturbations are not significantly correlated with longitudinal changes in lean mass in postmenopausal women. The American Society for Bone and Mineral Research Annual Meeting. Baltimore, Maryland USA: The American Society for Bone and Mineral Research.
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  Jennifer H. Stern, Andriene S. Grant, Cynthia A. Thomson, Robert Kaplan, Todd M. Manini, Charles Eaton, Lesley Tinker, Erin S. LeBlanc, Scott B. Going, Oleg Zaslavsky, Zhao Chen. Baseline serum markers of adiposity driven immune/endocrine perturbations are not significantly correlated with longitudinal changes in lean mass in postmenopausal women (poster presentation). The American Society for Bone and Mineral Research Annual Meeting, Oct 2-7, 2013. Baltimore, Maryland USA

Others

• Jason, K., Wager, M., Robles, D., Insel, K. C., Verhougstraete, M., O'Neill, L. M., Phillips, L. R., Fain, M. J., Yuan, N. P., Yang, Y., Kenning, H., Butt, H., Sokan, A. E., & Chen, Z. (2021, November). Impact of COVID-19 on Older Employees of a Large State University: Findings From a Mixed-Methods Study.. Symposium - Gerontological Society of America annual conference.
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  Symposium