Jennifer W Bea

Interests

Research

Chronic Disease Prevention and Management Obesity Body CompositionLifestyle Interventions (i.e. Exercise, and Diet)Cancer Prevention and Survivorship Genetics

Courses

Scholarly Contributions

Books

• Budge, L., & Wright, J. A. (2002). Guidelines for the treatment of heart failure. Oakland, CA: Kaiser Permanente Care Management Institute.

Chapters

• Schwartz, A. L., Bea, J. W., & Winters-Stone, K. (2020). Long-Term and Late Effects of Cancer Treatments on Prescribing Physical Activity. In Exercise Oncology(pp 267--282). Springer, Cham.
• Bea, J. W., Cureton, K. J., Lee, V., & Milliken, L. A. (2019). Body composition models and reference methods. In Human Body Composition. Champaign, IL: Human Kinetics.
• Bea, J. W., Lohman, T. G., & Milliken, L. A. (2019). Application of body composition methods to specific populations. In Human Body Composition. Champaign, IL: Human Kinetics.
• Ligibel, J. A., Basen-Engquist, K., & Bea, J. W. (2019). Weight Management and Physical Activity for Breast Cancer Prevention and Control. In American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting(pp e22-e33).
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  Observational evidence has consistently linked excess adiposity and inactivity to increased breast cancer risk and to poor outcomes in individuals diagnosed with early-stage, potentially curable breast cancer. There is less information from clinical trials testing the effect of weight management or physical activity interventions on breast cancer risk or outcomes, but a number of ongoing trials will test the impact of weight loss and other lifestyle changes after cancer diagnosis on the risk of breast cancer recurrence. Lifestyle changes have additional benefits beyond their potential to decrease primary or secondary breast cancer risk, including improvements in metabolic parameters, reduction in the risk of comorbidities such as diabetes and heart disease, improvement of physical functioning, and mitigation of side effects of cancer therapy. Despite these myriad benefits, implementation of lifestyle interventions in at-risk and survivor populations has been limited to date. This article reviews the evidence linking lifestyle factors to breast cancer risk and outcomes, discusses completed and ongoing randomized trials testing the impact of lifestyle change in primary and secondary breast cancer prevention, and reviews efforts to implement and disseminate lifestyle interventions in at-risk and breast cancer survivor populations.
• Thomson, C. A., & Bea, J. W. (2019). The Role of Diet, Physical Activity and Body Composition in Cancer Prevention. In Fundamentals of Cancer Prevention 4th edition. Alberts DS and Hess LM. (editors).(pp 53-110). New York, NY: Springer-Verlag: Heidelberg,.
• Going, S. B., & Bea, J. W. (2017). Changes in body composition with exercise in overweight and obese children. In Body Composition: Health and Performance in Exercise and Sport. Taylor and Francis, New York, NY.
• Bea, J. W., de Heer, H., & Schwartz, A. L. (2016). Symptom Management: Weight Gain. In Cancer Supportive Care(pp 241-269). Switzerland: Springer. doi:10.1007/978-3-319-24814-1

Journals/Publications

• Arani, G., Arora, A., Yang, S., Wu, J., Kraszewski, J. N., Martins, A., Miller, A., Rahman, Z., Jafri, A., Hu, C., Farland, L. V., Bea, J. W., Coletta, D. K., Aslan, D. H., Sayre, M. K., Bharadwaj, P. K., Ally, M., Maltagliati, S., Lai, M. H., , Wilcox, R., et al. (2025). Plasma Proteomic Signatures of Physical Activity Provide Insights into Biological Impacts of Physical Activity and its Protective Role Against Dementia. medRxiv : the preprint server for health sciences.
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  Physical activity (PA), including sedentary behavior, is associated with many diseases, including Alzheimer's disease and all-cause dementia. However, the specific biological mechanisms through which PA protects against disease are not entirely understood. To address this knowledge gap, we first assessed the conventional observational associations of three self-reported and three device-based PA measures with circulating levels of 2,911 plasma proteins measured in the UK Biobank (n=39,160) and assessed functional enrichment of identified proteins. We then used bi-directional Mendelian randomization (MR) to evaluate further the evidence for causal relationships of PA with protein levels. Finally, we performed mediation analyses to identify proteins that may mediate the relationship of PA with incident all-cause dementia. Our findings revealed 41 proteins consistently associated with all PA measures and 1,027 proteins associated with at least one PA measure. Both conventional observational and MR study designs converged on proteins that appear to increase as a result of PA, including integrin proteins such as ITGAV and ITGAM, as well as MXRA8, CLEC4A, CLEC4M, GFRA1, ADGRG2, and PTGDS; and on proteins that appear to decrease as a result of PA such as LEP, LPL, INHBC, CLMP, PTGDS, ADM, OGN, and PI3. Functional enrichment analyses revealed several relevant processes, including cell-matrix adhesion, integrin-mediated signaling, and collagen binding. Finally, several proteins, including GDF15, ITGAV, HPGDS, BCAN, and MENT, were found to mediate the relationship of PA with all-cause dementia, implicating processes such as synaptic plasticity, neurogenesis and inflammation as mechanisms through which PA protects against dementia. Our results provide insights into how PA may affect biological processes and protect from all-cause dementia, and provide avenues for future research into the health-promoting effects of PA.
• Bea, J. W., Ochs-Balcom, H. M., Valencia, C. I., Chen, Z., Blew, R. M., Lind, K. E., Caan, B. J., Roe, D. J., Rohan, T. E., Reeves, K. W., Manson, J. E., Ballinger, T., Reding, K. W., Follis, S., Ziller, S. G., & Odegaard, A. O. (2025). Abdominal visceral and subcutaneous adipose tissue associations with postmenopausal breast cancer incidence. JNCI cancer spectrum.
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  Obesity, classified by body mass index (BMI), is associated with higher postmenopausal breast cancer (BCa) risk. Yet, the associations between abdominal visceral (VAT) and subcutaneous adipose tissue (SAT) with BCa are unclear.
• Quadri, M., Ariza, A. J., Tucker, J. M., Bea, J. W., King, E. C., Kirk, S., Sweeney, B. R., Santos, M., Silver, L., Roberts, K. J., Binns, H. J., & , P. W. (2025). Percent Body Fat and Weight Status of Youth Participating in Pediatric Weight Management Programs in the Pediatric Obesity Weight Evaluation Registry. Childhood obesity (Print), 21(1), 50-64.
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  Factors associated with change in percent body fat (%BF) of children in pediatric weight management (PWM) care may differ from those associated with change in weight status. To describe %BF and weight status at initial visits to 14 PWM sites, identify differences by sex, and evaluate factors associated with change over 6 months. Initial visits of 2496 males and 2821 females aged 5-18 years were evaluated. %BF was measured using bioelectrical impedance analysis. Sex-specific logistic regressions [806 males (32.3%), 837 females (29.7%)] identified associations with primary outcomes: lower %BF and metabolically impactful ≥5-point drop in percent of the 95th BMI percentile (%BMIp95) over 6 months. At the initial visit, males had lower %BF and higher %BMIp95 than females. Over 6 months, males had significantly ( < 0.001) greater median drop in %BF (-1.4% vs. -0.4%) and %BMIp95 (-3.0% vs. -1.9%) and a higher frequency of decreased %BF (68.9% vs. 57.8%), but similar percentage with ≥5-point %BMIp95 drop (36.5% vs. 32.4%; = 0.080). For males, factors significantly associated with decreased %BF (older age, ≥6 visits, lack of developmental or depression/anxiety concerns) were not related to having a ≥5-point %BMIp95 drop. For females, lack of depression/anxiety concern was significantly associated with decreased %BF but was not associated with ≥5-point %BMIp95 drop. There are differences by sex in initial visit %BF and %BMIp95 and in characteristics associated with changes in these measures. PWM interventions should consider evaluating body composition and sex-stratifying outcomes.
• Schmitz, K. H., Brown, J. C., Irwin, M. L., Robien, K., Scott, J. M., Berger, N. A., Caan, B., Cercek, A., Crane, T. E., Evans, S. R., Ligibel, J. A., Meyerhardt, J. A., Agurs-Collins, T., Basen-Engquist, K., Bea, J. W., Cai, S. F., Cartmel, B., Chinchilli, V. M., Demark-Wahnefried, W., , Dieli-Conwright, C. M., et al. (2025). Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO). Journal of the National Cancer Institute, 117(1), 9-19.
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  Chemotherapy treatment-related side effects are common and increase the risk of suboptimal outcomes. Exercise interventions during cancer treatment improve self-reported physical functioning, fatigue, anxiety, and depression, but it is unclear whether these interventions improve important clinical outcomes, such as chemotherapy relative dose intensity. The National Cancer Institute funded the Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO) Consortium to address this knowledge gap. This article describes the mechanisms hypothesized to underpin intervention effects on clinically relevant treatment outcomes, briefly outlines each project's distinct research aims, summarizes the scope and organizational structure of ENICTO, and provides an overview of the integrated common data elements used to pursue research questions collectively. In addition, the article includes a description of consortium-wide activities and broader research community opportunities for collaborative research. Findings from the ENICTO Consortium have the potential to accelerate a paradigm shift in oncology care such that patients with cancer could receive exercise and nutrition programming as the standard of care in tandem with chemotherapy to improve relative dose intensity for a curative outcome.
• Banack, H. R., Cook, C. E., Grandi, S. M., Scime, N. V., Andary, R., Follis, S., Allison, M., Manson, J. E., Jung, S. Y., Wild, R. A., Farland, L. V., Shadyab, A. H., Bea, J. W., & Odegaard, A. O. (2024). The association between reproductive history and abdominal adipose tissue among postmenopausal women: results from the Women's Health Initiative. Human reproduction (Oxford, England), 39(8), 1804-1815.
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  What is the association between reproductive health history (e.g. age at menarche, menopause, reproductive lifespan) with abdominal adiposity in postmenopausal women?
• Erdrich, J., Cordova-Marks, F. M., Carson, W. O., Bea, J. W., Montfort, W. R., & Thomson, C. A. (2024). Health Behavior Change Intervention Preferences Expressed by American Indian Cancer Survivors From a Southwest Tribal Community: Semistructured Interview Study. JMIR formative research, 8, e51669.
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  While many factors, including social determinants of health, affect cancer mortality, one modifiable risk factor that may contribute to cancer disparities is obesity. The prevalence of obesity in the American Indian/Alaska Native population is 48.1% per the Centers for Disease Control and Prevention. The overall cancer mortality for the American Indian/Alaska Native population is 18% higher than the White population as reported by the American Cancer Society. Interventions tailored to American Indian/Alaska Native communities that promote healthy lifestyle behaviors after cancer diagnosis and prior to cancer surgery (prehab) might improve cancer outcomes for this population.
• Gonzalo-Encabo, P., Vasbinder, A., Bea, J. W., Reding, K. W., Laddu, D., LaMonte, M. J., Stefanick, M. L., Kroenke, C. H., Jung, S. Y., Shadyab, A. H., Naughton, M. J., Patel, M. I., Luo, J., Banack, H. R., Sun, Y., Simon, M. S., & Dieli-Conwright, C. M. (2024). Low physical function following cancer diagnosis is associated with higher mortality risk in postmenopausal women. Journal of the National Cancer Institute, 116(7), 1035-1042.
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  Postmenopausal women with cancer experience an accelerated physical dysfunction beyond what is expected through aging alone due to cancer and its treatments. The aim of this study was to determine whether declines in physical function after cancer diagnosis are associated with all-cause mortality and cancer-specific mortality.
• Laurila, K. A., Rogers, L. D., Valencia, C. I., Lee, N., de Heer, H., Bea, J. W., Ingram, J. C., & Gachupin, F. C. (2024). Advancing Cancer Workforce Capacity for American Indians and Alaska Natives: The Development of a Validated System to Optimize Trainee Participation and Outcome Tracking. International journal of environmental research and public health, 21(6).
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  Although American Indian and Alaska Native (AIAN) students are the most underrepresented group in the U.S. in biomedical and health sciences relative to population size, little is known about long-term research education programs and outcome tracking. For over 20 years, the Partnership for Native American Cancer Prevention (NACP) has been supported under the National Cancer Institute's (NCI)-funded Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) program. Programming included hands-on mentored research and an array of development opportunities. A validated tracking system combining participation records, institutional records, and enrollment/degree attainment from the National Student Clearinghouse documents outcomes. Collectively (2002-2022) NACP engaged 367 AIAN trainees, of whom 237 individuals earned 220 bachelors, 87 masters, and 34 doctoral/professional degrees. Approximately 45% of AIAN doctoral recipients are currently engaged in academic or clinical work, and 10% in industry or tribal leadership. A total of 238 AIAN students participated in mentored research, with 85% demonstrating strong outcomes; 51% attained a degree, and 34% are currently enrolled. Implementation of a robust tracking system documented acceleration in degree attainment over time. Next steps will evaluate the most impactful training activities on student outcomes.
• Li, J., Bea, J. W., LaMonte, M., Jiang, L., Reding, K., Garcia, L., Manson, J. A., Follis, S., & Odegaard, A. O. (2024). Effects of moderate/vigorous activity on 3-year body composition changes in postmenopausal women: a target trial emulation. American journal of epidemiology.
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  Background and Objective Postmenopausal women tend to experience significant changes in body composition, particularly abdominal adipose tissue (AAT) deposition patterns, which are hypothesized to be critical factors influencing future cardiometabolic disease risk. Physical activity has a demonstrable effect on body composition and overall health. However, there is little evidence for how different intensities and durations of physical activity over a sustained period of time influence AAT patterns and other measures of body composition in postmenopausal women. We emulated a target trial of physical activity interventions, including the 2018 Physical Activity Guidelines for Americans recommendations, on 3-year changes in AAT and body composition. Methods We analyzed observational data from 4,451 postmenopausal women aged 50-79 years in the Women's Health Initiative (WHI) to emulate a three-year target trial of adhering to increasing minutes of moderate (at least 15, 30, 75, 150, 300 minutes/week) and vigorous (at least 15, 30, 75, 150 minutes/week) physical activity aligned with the physical activity guidelines. All participants had repeated whole body Dual X-Ray Absorptiometry (DXA) scans with derived abdominal visceral (VAT) and subcutaneous adipose tissue (SAT). The measured differences in average levels of VAT, SAT, and other body composition measures determined at end of follow-up were estimated with the parametric-g formula. Results Over 3 years, interventions of increasing minutes of moderate activity would result in dose-dependent reductions in abdominal VAT, SAT, and overall body fat, and increases in lean soft tissue, with the greatest estimated benefit at the 2018 physical activity guideline recommendation of 150 mins/wk or more. Compared to no intervention, if all participants had adhered to at least 150 mins/wk of moderate physical activity, they would have 16.8 cm2 lower VAT (95% CI -23.1, -10.4), 26.8 cm2 lower SAT (95% CI -36.3, -17.3), 1.3% lower total body fat% (95% CI -1.8, -0.7), 1.2 % higher total lean soft tissue% (95% CI 0.7, 1.8), and 2.6 kg lower total bodyweight (95% CI -3.6, -1.5). We saw similar patterns in our vigorous-intensity activity interventions - if all participants adhered to at least 150 mins/wk, they would have experienced 6.7 cm2 lower VAT (95% CI -17.7, 4.3), 13.3 cm2 lower SAT (95% CI -28.8, 2.1), 1.0 % lower total body fat percent (95% CI -2.0, 0.0 ), % higher total lean soft tissue percent (95% CI) and a 0.9 kg lower total bodyweight (95% CI -2.7, 0.8). Conclusion This hypothetical emulated intervention indicated that postmenopausal women who adhere to physical activity guideline recommendations would experience beneficial changes in abdominal VAT, SAT, and overall body composition over 3 years. The study results underscore the imperative to explore further how physical activity may serve as a potential determinant of body composition.
• Nehemiah, A., Pettke, E., Appel, S., Garcia, D. O., Bea, J. W., Thomson, C. A., Sun, V., & Krouse, R. S. (2024). Pilot Feasibility Study of Physical Activity to Manage Bowel Dysfunction in Survivors of Rectal Cancer. Diseases of the colon and rectum.
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  Low anterior resection syndrome can disrupt health-related quality of life for survivors of rectal cancer.
• Walker, E., Chalke, A. M., Bland, V. L., Lind, K. E., Chen, Z., Blew, R. M., Odegaard, A. O., Thomson, C. A., Caan, B., Nicholas, J. S., Valencia, C. I., Roe, D. J., Allison, M., Schnatz, P. F., Wactawski-Wende, J., & Bea, J. W. (2024). DXA-derived abdominal fat-free mass to predict MRI skeletal muscle mass in postmenopausal women. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 49(11), 1606-1610.
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  Dual-energy X-ray absorptiometry (DXA) is more available than gold-standard magnetic resonance imaging (MRI), but DXA ability to estimate abdominal skeletal muscle mass (SMM) is unknown. DXA-derived abdominal fat-free mass (FFM; Hologic QDR2000 or QDR4500w) was correlated with single-slice MRI SMM at L4 ( = 69; r QDR2000 = 0.71, QDR4500w = 0.69;  
• Banack, H. R., Bea, J. W., Chen, Z., Blew, R. M., Nicholas, S., Stefanick, M., Wild, R. A., Manson, J. E., & Odegaard, A. O. (2023). Longitudinal patterns of abdominal visceral and subcutaneous adipose tissue, total body composition, and anthropometric measures in postmenopausal women: Results from the Women's Health Initiative. International journal of obesity (2005).
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  Abdominal adiposity, including visceral and subcutaneous abdominal adipose tissue (VAT and SAT), is recognized as a strong risk factor for cardiometabolic disease, cancer, and mortality.
• Bea, J. W., Hauer, M., Rossi, A., Wertheim, B., Kleppel, H. B., & Funk, J. L. (2023). Dietary Supplement Use in Women Diagnosed with Breast Cancer. The Journal of Nutrition, 153(1), 301-311. doi:doi: 10.1016/j.tjnut.2022.12.007
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  Hauer M, Rossi A, Wertheim BC, Kleppel H, Bea JW, Funk JL; Dietary Supplement Use in Women Diagnosed with Breast Cancer; The Journal of Nutrition; 153(1); 2023; Pages 301-311.
• Bea, J. W., de Heer, H. '., Lane, T., Charley, B., Yazzie, E., Yellowhair, J., Hudson, J., Kinslow, B., Wertheim, B. C., Roe, D. J., & Schwartz, A. (2023). Restoring Balance: a physical activity intervention for Native American cancer survivors and their familial support persons. Exercise, sport, & movement, 1(2).
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  Exercise interventions among Native American cancer survivors are lacking, despite major cancer health disparities in survivorship. The purpose of this study was to evaluate a 12-week randomized controlled trial (RCT) of culturally tailored exercise on cancer risk biomarkers and quality of life among Native American cancer survivors and family members.
• Bland, V. L., Bea, J. W., Going, S. B., Yaghootkar, H., Arora, A., Ramadan, F., Funk, J. L., Chen, Z., & Klimentidis, Y. C. (2023). Metabolically favorable adiposity and bone mineral density: a Mendelian randomization analysis. Obesity (Silver Spring, Md.), 31(1), 267-278.
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  This analysis assessed the putative causal association between genetically predicted percent body fat and areal bone mineral density (aBMD) and, more specifically, the association between genetically predicted metabolically "favorable adiposity" (MFA) and aBMD at clinically relevant bone sites.
• Funk, J. L., Wertheim, B. C., Frye, J. B., Blew, R. M., Nicholas, J. S., Chen, Z., & Bea, J. W. (2023). Association of ß-glucuronidase activity with menopausal status, ethnicity, adiposity, and inflammation in women. Menopause (New York, N.Y.), 30(2), 186-192.
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  Many dietary polyphenols with potential health-promoting benefits undergo hepatic conjugation and circulate as inactive glucuronides that can be cleaved by ß-glucuronidase to reform the bioactive aglycone. Although indirect evidence suggests estrogen may induce ß-glucuronidase, little is known about ß-glucuronidase regulation across women's reproductive lifespan. Correlates of serum ß-glucuronidase activity in healthy premenopausal versus postmenopausal women were therefore examined.
• Hirschey, R., Rohweder, C., Zahnd, W. E., Eberth, J. M., Adsul, P., Guan, Y., Yeager, K. A., Haines, H., Farris, P. E., Bea, J. W., Dwyer, A., Madhivanan, P., Ranganathan, R., Seaman, A. T., Vu, T., Wickersham, K., Vu, M., Teal, R., Giannone, K., , Hilton, A., et al. (2023). Prioritizing rural populations in state comprehensive cancer control plans: a qualitative assessment. Cancer causes & control : CCC, 1-11.
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  The Centers for Disease Control and Prevention's National Comprehensive Cancer Control Program (NCCCP) requires that states develop comprehensive cancer control (CCC) plans and recommends that disparities related to rural residence are addressed in these plans. The objective of this study was to explore rural partner engagement and describe effective strategies for incorporating a rural focus in CCC plans.
• Mattick, L. J., Bea, J. W., Hovey, K. M., Wactawski-Wende, J., Cauley, J. A., Crandall, C. J., Tian, L., & Ochs-Balcom, H. M. (2023). Follicle-stimulating hormone is associated with low bone mass in postmenopausal women. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
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  We evaluated the influence of two endogenous hormones on bone health in older women. Higher FSH was associated with bone disease, especially in lower estradiol environments. FSH attenuated the relationship between estradiol and bone. This may provide a mechanism through which future clinical research intervenes on bone loss.
• Thomson, C. A., Bea, J. W., Robles-Morales, R., & Werts, S. J. (2023). Abstract A011: Lifestyle behavior change interventions among adult rural cancer survivors: A systematic review. Cancer Research, 83(2_Supplement_1), A011-A011. doi:10.1158/1538-7445.agca22-a011
• Werts, S. J., Robles-Morales, R., Bea, J. W., & Thomson, C. A. (2023). Characterization and efficacy of lifestyle behavior change interventions among adult rural cancer survivors: a systematic review. Journal of cancer survivorship : research and practice.
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  Little is known about the intersection between age and rurality as characteristics that impact lifestyle behavior change for cancer survivors. This review aims to summarize the current literature on lifestyle behavior change interventions conducted among rural survivors of cancer, with an emphasis on older survivors.
• Bea, J. W., Charley, B., Lane, T., Kinslow, B., de Heer, H. '., Yazzie, E., Yellowhair, J., Hudson, J., Wertheim, B. C., & Schwartz, A. L. (2022). Formative Evaluation and Adaptation of a Navajo Cancer Survivor Physical Activity Intervention to Serve a Broader Native American Cancer Survivor Community. Health promotion practice, 15248399221131318.
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  Although exercise has been shown to improve cancer survivorship in other communities, cancer exercise studies among Native American communities are rare. We sought to adapt a Navajo-tailored cancer exercise pilot program to serve a broader Native American cancer community.
• Bea, J. W., Charley, B., Lane, T., Kinslow, B., de Heer, H. ‘., Yazzie, E., Yellowhair, J., Hudson, J., Wertheim, B. C., & Schwartz, A. L. (2022). Formative Evaluation and Adaptation of a Navajo Cancer Survivor Physical Activity Intervention to Serve a Broader Native American Cancer Survivor Community. Health Promotion Practice, 152483992211313. doi:10.1177/15248399221131318
• Bea, J. W., Chen, Z., Blew, R. M., Nicholas, J. S., Follis, S., Bland, V. L., Cheng, T. D., Ochs-Balcom, H. M., Wactawski-Wende, J., Banack, H. R., Neuhouser, M. L., Laddu, D., Stefanick, M. L., Cauley, J. A., Caan, B., LeBoff, M. S., Chlebowski, R. T., & Odegaard, A. O. (2022). MRI Based Validation of Abdominal Adipose Tissue Measurements From DXA in Postmenopausal Women. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry, 25(2), 189-197.
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  Visceral adipose tissue (VAT) is a hypothesized driver of chronic disease. Dual-energy X-ray absorptiometry (DXA) potentially offers a lower cost and more available alternative compared to gold-standard magnetic resonance imaging (MRI) for quantification of abdominal fat sub-compartments, VAT and subcutaneous adipose tissue (SAT). We sought to validate VAT and SAT area (cm) from historical DXA scans against MRI.
• Bea, J. W., Garcia, D. O., Pichardo, M. S., Esserman, D., Ferrucci, L. M., Molina, Y., Chlebowski, R. T., Pan, K., Lane, D. S., Shadyab, A. H., Lopez‐Pentecost, M., Luo, J., Kato, I., Springfield, S., Rosal, M. C., Cespedes Feliciano, E. M., Qi, L., Nassir, R., Snetselaar, L., , Manson, J., et al. (2022). Adherence to the American Cancer Society Guidelines on nutrition and physical activity for cancer prevention and obesity‐related cancer risk and mortality in Black and Latina Women's Health Initiative participants. Cancer, 128(20), 3630-3640. doi:10.1002/cncr.34428
• Bea, J. W., LaCroix, A., & Shumaker, S. A. (2022). What We've Learned From the Women's Health Initiative Participants About Their COVID-19 Experience. The journals of gerontology. Series A, Biological sciences and medical sciences, 77(Suppl 1), S51-S53.
• Bea, J. W., Rossouw, J. E., Whitsel, E. A., Wells, G. L., Horn, L. V., Stefanick, M. L., Reiner, A. P., Prentice, R. L., Perez, M. V., Odegaard, A., Neuhouser, M. L., Limacher, M. C., LaCroix, A. Z., Kooperberg, C., Hayden, K. M., Follis, S., Eaton, C. B., Baker, L. D., Anderson, G. L., , Manson, J. E., et al. (2022). Contributions of the Women’s Health Initiative to Cardiovascular Research. Journal of the American College of Cardiology. doi:10.1016/j.jacc.2022.05.016
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  The WHI (Women's Health Initiative) enrolled 161,808 racially and ethnically diverse postmenopausal women, ages 50-79 years, from 1993 to 1998 at 40 clinical centers across the United States. In its clinical trial component, WHI evaluated 3 randomized interventions (menopausal hormone therapy; diet modification; and calcium/vitamin D supplementation) for the primary prevention of major chronic diseases, including cardiovascular disease, in older women. In the WHI observational study, numerous clinical, behavioral, and social factors have been evaluated as predictors of incident chronic disease and mortality. Although the original interventions have been completed, the WHI data and biomarker resources continue to be leveraged and expanded through ancillary studies to yield novel insights regarding cardiovascular disease prevention and healthy aging in women.
• Bea, J. W., Shumaker, S. A., & LaCroix, A. Z. (2022). The Impact, Experience, and Challenges of COVID-19 on the Women’s Health Initiative Participants: An Introduction to the Special Issue. The Journals of Gerontology: Series A, 77(Supplement_1), S1-S2. doi:10.1093/gerona/glac207
• Bea, J. W., Zhang, X., McLaughlin, E. M., Krok-Schoen, J. L., Naughton, M., Bernardo, B. M., Cheville, A., Allison, M., Stefanick, M., & Paskett, E. D. (2022). Association of Lower Extremity Lymphedema With Physical Functioning and Activities of Daily Living Among Older Survivors of Colorectal, Endometrial, and Ovarian Cancer. JAMA Network Open, 5(3), e221671. doi:10.1001/jamanetworkopen.2022.1671
• Bea, J., Laddu, D., LaMonte, M., Haring, B., Kim, H., Cawthon, P., Banack, H., Cauley, J. A., Allison, M. A., Martin, L. W., LeBoff, M., Stefanick, M. L., Phillips, S. A., & Ma, J. (2022). Abstract P081: Rethinking The Association Of Physical Performance With Blood Pressure Changes In Older Women: Findings Form The Women’S Health Initiative. Circulation, 145(Suppl_1). doi:10.1161/circ.145.suppl_1.p081
• Bland, V. L., Klimentidis, Y. C., Bea, J. W., Roe, D. J., Funk, J. L., & Going, S. B. (2022). Cross-sectional associations between adipose tissue depots and areal bone mineral density in the UK Biobank imaging study. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 33(2), 391-402.
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  The relationship between obesity and osteoporosis is poorly understood. In this study, we assessed the association between adiposity and bone. The fat-bone relationship was dependent on sex, body mass index classification, and menopausal status. Results highlight the importance of accounting for direct measures of adiposity (beyond BMI) and menopause status.
• Bucy, A. M., Valencia, C. I., Howe, C. L., Larkin, T. J., Conard, K. D., Anderlik, E. W., Valdivi, S. I., & Bea, J. W. (2022). Physical Activity in Young BRCA Carriers and Reduced Risk of Breast Cancer. American journal of preventive medicine, 63(5), 837-845.
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  A systematic literature review was conducted to determine whether physical activity levels during adolescent and young adult years were associated with a reduced lifetime risk of breast cancer among carriers of deleterious mutations in BRCA1 and BRCA2 genes.
• Funk, J. L., Bea, J. W., Mattick, L. J., Singh, L., Hovey, K. M., Banack, H. R., Wactawski-Wende, J., Manson, J. E., & Ochs-Balcom, H. M. (2022). Serum Follicle-Stimulating Hormone and 5-Year Change in Adiposity in Healthy Postmenopausal Women. The Journal of Clinical Endocrinology & Metabolism, 107(8), e3455-e3462. doi:10.1210/clinem/dgac238
• Golaszewski, N. M., LaCroix, A. Z., Godino, J. G., Allison, M. A., Manson, J. E., King, J. J., Weitlauf, J. C., Bea, J. W., Garcia, L., Kroenke, C. H., Saquib, N., Cannell, B., Nguyen, S., & Bellettiere, J. (2022). Evaluation of Social Isolation, Loneliness, and Cardiovascular Disease Among Older Women in the US. JAMA network open, 5(2), e2146461.
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  Social isolation and loneliness are increasing public health concerns and have been associated with increased risk of cardiovascular disease (CVD) among older adults.
• Klimentidis, Y. C., Chen, Z., Funk, J. L., Going, S. B., Bea, J. W., Bland, V. L., Yaghootkar, H., Arora, A., & Ramadan, F. (2022). Metabolically favorable adiposity and bone mineral density: a Mendelian randomization analysis. Obesity, 31(1), 267-278. doi:10.1002/oby.23604
• Krok-Schoen, J. L., Pennell, M. L., Saquib, N., Naughton, M., Zhang, X., Shadyab, A. H., Kroenke, C. H., Bea, J. W., Peterson, L. L., Crane, T., Wactawski-Wende, J., & Paskett, E. D. (2022). Correlates of physical activity among older breast cancer survivors: Findings from the Women's Health Initiative LILAC study. Journal of geriatric oncology, 13(2), 143-151.
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  Physical activity can attenuate cancer-related declines in physical functioning, improve emotional well-being, and prolong survival among older (≥65 years) breast cancer survivors. However, factors associated with physical activity among older breast cancer survivors are not well-understood.
• LaMonte, M. J., Manson, J. E., Anderson, G. L., Baker, L. D., Bea, J. W., Eaton, C. B., Follis, S., Hayden, K. M., Kooperberg, C., LaCroix, A. Z., Limacher, M. C., Neuhouser, M. L., Odegaard, A., Perez, M. V., Prentice, R. L., Reiner, A. P., Stefanick, M. L., Van Horn, L., Wells, G. L., , Whitsel, E. A., et al. (2022). Contributions of the Women's Health Initiative to Cardiovascular Research: JACC State-of-the-Art Review. Journal of the American College of Cardiology, 80(3), 256-275.
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  The WHI (Women's Health Initiative) enrolled 161,808 racially and ethnically diverse postmenopausal women, ages 50-79 years, from 1993 to 1998 at 40 clinical centers across the United States. In its clinical trial component, WHI evaluated 3 randomized interventions (menopausal hormone therapy; diet modification; and calcium/vitamin D supplementation) for the primary prevention of major chronic diseases, including cardiovascular disease, in older women. In the WHI observational study, numerous clinical, behavioral, and social factors have been evaluated as predictors of incident chronic disease and mortality. Although the original interventions have been completed, the WHI data and biomarker resources continue to be leveraged and expanded through ancillary studies to yield novel insights regarding cardiovascular disease prevention and healthy aging in women.
• Laddu, D. R., LaMonte, M. J., Haring, B., Kim, H., Cawthon, P., Bea, J. W., Banack, H., Cauley, J. A., Allison, M. A., Martin, L. W., & others, . (2022). Longitudinal physical performance and blood pressure changes in older women: Findings form the women's health initiative. Archives of Gerontology and Geriatrics, 98, 104576.
• Mattick, L. J., Bea, J. W., Singh, L., Hovey, K. M., Banack, H. R., Wactawski-Wende, J., Manson, J. E., Funk, J. L., & Ochs-Balcom, H. M. (2022). Serum Follicle-Stimulating Hormone and 5-Year Change in Adiposity in Healthy Postmenopausal Women. The Journal of clinical endocrinology and metabolism, 107(8), e3455-e3462.
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  Evidence from animal studies suggests that the gradual rise in follicle-stimulating hormone (FSH) during reproductive senescence may contribute to the change in adiposity distribution characteristic of menopause. The potential independent role the interrelationships of FSH and estradiol (E2) may play in postmenopausal adiposity changes are not well studied.
• Pichardo, M. S., Esserman, D., Ferrucci, L. M., Molina, Y., Chlebowski, R. T., Pan, K., Garcia, D. O., Lane, D. S., Shadyab, A. H., Lopez-Pentecost, M., Luo, J., Kato, I., Springfield, S., Rosal, M. C., Bea, J. W., Cespedes Feliciano, E. M., Qi, L., Nassir, R., Snetselaar, L., , Manson, J., et al. (2022). Adherence to the American Cancer Society Guidelines on nutrition and physical activity for cancer prevention and obesity-related cancer risk and mortality in Black and Latina Women's Health Initiative participants. Cancer, 128(20), 3630-3640.
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  Although adherence to the American Cancer Society (ACS) Guidelines on Nutrition and Physical Activity for Cancer Prevention associates with lower risk of obesity-related cancer (ORC) incidence and mortality, evidence in Black and Latina women is limited. This association was examined in Black and Latina participants in the Women's Health Initiative (WHI).
• Pichardo, M. S., Esserman, D., Ferrucci, L. M., Molina, Y., Chlebowski, R. T., Pan, K., Garcia, D. O., Lane, D. S., Shadyab, A. H., Lopez‐Pentecost, M., Luo, J., Kato, I., Springfield, S., Rosal, M. C., Bea, J. W., Cespedes Feliciano, E. M., Qi, L., Nassir, R., Snetselaar, L., , Manson, J., et al. (2022). Adherence to the American Cancer Society Guidelines on nutrition and physical activity for cancer prevention and obesity‐related cancer risk and mortality in Black and Latina Women's Health Initiative participants. Cancer, 128(20), 3630-3640. doi:10.1002/cncr.34428
• Ramadan, F. A., Bea, J. W., Garcia, D. O., Ellingson, K. D., Canales, R. A., Raichlen, D. A., & Klimentidis, Y. C. (2022). Association of sedentary and physical activity behaviours with body composition: a genome-wide association and Mendelian randomisation study. BMJ open sport & exercise medicine, 8(3), e001291.
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  Studies suggest that body composition can be independently improved through physical activity (PA). We performed a Mendelian randomisation (MR) study to test the incremental benefits of sedentary behaviour and various PA exposures on body composition outcomes as assessed by anthropometric indices, lean body mass (kg), body fat () and visceral adipose tissue (VAT) (kg).
• Shumaker, S. A., LaCroix, A. Z., & Bea, J. W. (2022). The Impact, Experience, and Challenges of COVID-19 on the Women's Health Initiative Participants: An Introduction to the Special Issue. The journals of gerontology. Series A, Biological sciences and medical sciences, 77(Suppl 1), S1-S2.
• Wactawski-wende, J., Stefanick, M. L., Odegaard, A. O., Ochs-balcom, H. M., Nicholas, J. S., Neuhouser, M. L., Leboff, M. S., Laddu, D., Follis, S., Chlebowski, R. T., Cheng, T. D., Chen, Z., Cauley, J. A., Caan, B., Blew, R. M., Bland, V. L., Bea, J. W., & Banack, H. R. (2022). MRI Based Validation of Abdominal Adipose Tissue Measurements From DXA in Postmenopausal Women.. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry, 25(2), 189-197. doi:10.1016/j.jocd.2021.07.010
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  Visceral adipose tissue (VAT) is a hypothesized driver of chronic disease. Dual-energy X-ray absorptiometry (DXA) potentially offers a lower cost and more available alternative compared to gold-standard magnetic resonance imaging (MRI) for quantification of abdominal fat sub-compartments, VAT and subcutaneous adipose tissue (SAT). We sought to validate VAT and SAT area (cm2) from historical DXA scans against MRI..Participants (n = 69) from the Women's Health Initiative (WHI) completed a 3 T MRI scan and a whole body DXA scan (Hologic QDR2000 or QDR4500; 2004-2005). A subset of 43 participants were scanned on both DXA devices. DXA-derived VAT and SAT at the 4th lumbar vertebrae (5 cm wide) were analyzed using APEX software (v4.0, Hologic, Inc., Marlborough, MA). MRI VAT and SAT areas for the corresponding DXA region of interest were quantified using sliceOmatic software (v5.0, Tomovision, Magog, Canada). Pearson correlations between MRI and DXA-derived VAT and SAT were computed, and a Bland-Altman analysis was performed..Participants were primarily non-Hispanic white (86%) with a mean age of 70.51 ± 5.79 years and a mean BMI of 27.33 ± 5.40 kg/m2. Correlations between MRI and DXA measured VAT and SAT were 0.90 and 0.92, respectively (p ≤ 0.001). Bland-Altman plots showed that DXA-VAT slightly overestimated VAT on the QDR4500 (-3.31 cm2); this bias was greater in the smaller subset measured on the older DXA model (QDR2000; -30.71 cm2). The overestimation of DXA-SAT was large (-85.16 to -118.66 cm2), but differences were relatively uniform for the QDR4500..New software applied to historic Hologic DXA scans provide estimates of VAT and SAT that are well-correlated with criterion MRI among postmenopausal women.
• Zhang, X., McLaughlin, E. M., Krok-Schoen, J. L., Naughton, M., Bernardo, B. M., Cheville, A., Allison, M., Stefanick, M., Bea, J. W., & Paskett, E. D. (2022). Association of Lower Extremity Lymphedema With Physical Functioning and Activities of Daily Living Among Older Survivors of Colorectal, Endometrial, and Ovarian Cancer. JAMA network open, 5(3), e221671.
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  Lower extremity lymphedema (LEL) is associated with decreased physical functioning (PF) and activities of daily living (ADLs) limitations. However, the prevalence of LEL in older survivors of cancer is unknown.
• Zhang, X., Wactawski-wende, J., Shadyab, A. H., Saquib, N., Peterson, L. L., Pennell, M. L., Paskett, E. D., Naughton, M., Krok-schoen, J. L., Kroenke, C. H., Crane, T., & Bea, J. W. (2022). Correlates of physical activity among older breast cancer survivors: Findings from the Women's Health Initiative LILAC study.. Journal of geriatric oncology, 13(2), 143-151. doi:10.1016/j.jgo.2021.11.012
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  Physical activity can attenuate cancer-related declines in physical functioning, improve emotional well-being, and prolong survival among older (≥65 years) breast cancer survivors. However, factors associated with physical activity among older breast cancer survivors are not well-understood..Participants were enrolled in the Women's Health Initiative (WHI) Life and Longevity After Cancer (LILAC) study. Descriptive statistics, multiple linear regression, and relative risk [RR] regression were used to assess the association of demographic, clinical, physical and psychosocial variables with the total duration of and participation in physical activity among postmenopausal breast cancer survivors. Age-specific correlates (65-74 years vs. 75-84 years vs. ≥85 years) of physical activity were also examined..The majority of participants (n = 3710, mean age = 78.8 ± 5.9) were white (90.7%) and had in situ/localized breast cancer (78.9%). Women who had higher education (RR = 1.47 for graduate/professional school versus high school or less, 95% CI: 1.32, 1.63), higher self-rated health (RR = 1.04 for 10 point increase, 95% CI:1.02, 1.07), higher physical functioning (RR = 1.03 for 5 point increase, 95% CI: 1.02, 1.04), and higher social support (RR = 1.41 for social support all of the time versus none of the time, 95% CI: 1.01, 1.96), were more likely to engage in any physical activity. Similar results were observed for duration of physical activity. Among women aged
• Bea, J. W., Chen, Z., Blew, R. M., Nicholas, J. S., Follis, S., Bland, V. L., Cheng, T. D., Ochs-Balcom, H. M., Wactawski-Wende, J., Banack, H. R., & others, . (2021). MRI based validation of abdominal adipose tissue measurements from DXA in postmenopausal women. Journal of Clinical Densitometry.
• Bea, J. W., Oh, H., Wild, R. A., Manson, J. E., Shadyab, A. H., Pfeiffer, R. M., Saquib, N., Underland, L., Anderson, G. L., Xu, X., & Trabert, B. (2021). Obesity, Height, and Serum Androgen Metabolism among Postmenopausal Women in the Women's Health Initiative Observational Study. Cancer Epidemiology, Biomarkers & Prevention, 30(11), 2018-2029. doi:10.1158/1055-9965.epi-21-0604
• Bland, V. L., Klimentidis, Y. C., Bea, J. W., Roe, D. J., Funk, J. L., & Going, S. B. (2021). Cross-sectional associations between adipose tissue depots and areal bone mineral density in the UK Biobank imaging study. Osteoporosis International, 1--12.
• Bland, V., Bea, J. W., Blew, R., Roe, D., Lee, V. L., Funk, J. L., & Going, S. B. (2021). Influence of Changes in Soft Tissue Composition on Changes in Bone Strength in Peripubertal Girls: The STAR Longitudinal Study. Journal of Bone and Mineral Research, 36, 123-132. doi:10.1002/jbmr.4168
• Crane, T. E., Bea, J. W., Kamgar, M., Greenwald, M. K., Assad, H., Hastert, T. A., McLaughlin, E. M., Reding, K. W., Paskett, E. D., Shadyab, A. H., Neuhouser, M. L., Nassir, R., Sreeram, K., & Simon, M. S. (2021). Prevalence and predictors of peripheral neuropathy after breast cancer treatment. Cancer Medicine, 10(19), 6666-6676. doi:10.1002/cam4.4202
• Funk, J. L., Bland, V. L., Bea, J. W., Roe, D. J., Lee, V. R., Going, S. B., Funk, J. L., Blew, R. M., Bland, V. L., & Bea, J. W. (2021). Influence of Changes in Soft Tissue Composition on Changes in Bone Strength in Peripubertal Girls: The STAR Longitudinal Study.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 36(1), 123-132. doi:10.1002/jbmr.4168
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  Obesity and osteoporosis remain two major public health concerns. Soft tissue composition and bone are interrelated; however, it is still not well understood how changes in adiposity during adolescence affect bone development. The aim of this study was to assess how changes in DXA-derived total body lean mass (TBLM) and total body fat mass (TBFM) associate with 2-year changes in bone outcomes at the 20% femur, 66% tibia, 66% radius, and 4% tibia, as measured by pQCT, during the years surrounding the onset of menarche in a cohort of 9- to 12-year-old (baseline) adolescent girls (70% Hispanic). From baseline to 2-year follow-up, girls showed statistically significant increases in all bone outcomes, except radial endosteal circumference. In separate linear regression models, change in TBLM and change in TBFM were both positively associated with 2-year changes in bone outcomes at all measured bone sites, after controlling for relevant covariates. However, when change in TBLM and change in TBFM were included in the same model, change in TBLM was the predominant predictor of bone outcomes, explaining 4% to 14% of the variance in bone strength outcomes. Change in TBFM remained a positive predictor of tibia polar strength strain index (SSIp) (2% variance explained). A significant interaction between change in TBFM and menarcheal status was identified at the radius for SSIp and indicated that greater gains in TBFM were beneficial for SSIp in girls that were premenarcheal at baseline but detrimental for girls who were postmenarcheal at baseline. The overall findings suggest that changes in TBLM during the peripubertal years have a greater influence on bone outcomes than changes in TBFM. While gains in TBFM might benefit the weight bearing 66% tibia, greater gains in TBFM may be detrimental to bone development at the non-weight bearing 66% radius after the onset of menarche. © 2020 American Society for Bone and Mineral Research (ASBMR).
• Kamgar, M., Greenwald, M. K., Assad, H., Hastert, T. A., McLaughlin, E. M., Reding, K. W., Paskett, E. D., Bea, J. W., Shadyab, A. H., Neuhouser, M. L., & others, . (2021). Prevalence and predictors of peripheral neuropathy after breast cancer treatment. Cancer medicine, 10(19), 6666--6676.
• Krok-Schoen, J. L., Pennell, M. L., Saquib, N., Naughton, M., Zhang, X., Shadyab, A. H., Kroenke, C. H., Bea, J. W., Peterson, L. L., Crane, T., & others, . (2021). Correlates of physical activity among older breast cancer survivors: Findings from the Women's Health Initiative LILAC study. Journal of Geriatric Oncology.
• Oh, H., Wild, R. A., Manson, J. E., Bea, J. W., Shadyab, A. H., Pfeiffer, R. M., Saquib, N., Underland, L., Anderson, G. L., Xu, X., & Trabert, B. (2021). Obesity, Height, and Serum Androgen Metabolism among Postmenopausal Women in the Women's Health Initiative Observational Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 30(11), 2018-2029.
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  Anthropometric measures, including obesity, are important risk factors for breast and endometrial cancers in postmenopausal women. It is unknown whether these risk factors are associated with androgen metabolism, another risk factor for these cancers.
• Thomson, C., Chen, Z., Bea, J., Huang, S., Jiang, L., & Odegaard, A. (2021). The Longitudinal Association of Alcohol Intake and Cigarette Smoking With Levels of Visceral and Subcutaneous Abdominal Adipose Tissue Depots in Postmenopausal Women. Current Developments in Nutrition, 5(Supplement_2), 1217-1217. doi:10.1093/cdn/nzab055_027
• Wactawski-wende, J., Stefanick, M. L., Shadyab, A. H., Schnatz, P. F., Mccloskey, E., Lorentzon, M., Liu, E., Laddu, D. R., Kanis, J. A., Johansson, H., Harvey, N. C., Feliciano, E. M., Crandall, C. J., Cooper, C., Carbone, L. D., & Bea, J. W. (2021). Predictive Value of DXA Appendicular Lean Mass for Incident Fractures, Falls, and Mortality, Independent of Prior Falls, FRAX, and BMD: Findings from the Women's Health Initiative (WHI).. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 36(4), 654-661. doi:10.1002/jbmr.4239
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  In the Women's Health Initiative (WHI), we investigated associations between baseline dual-energy X-ray absorptiometry (DXA) appendicular lean mass (ALM) and risk of incident fractures, falls, and mortality (separately for each outcome) among older postmenopausal women, accounting for bone mineral density (BMD), prior falls, and Fracture Risk Assessment Tool (FRAX® ) probability. The WHI is a prospective study of postmenopausal women undertaken at 40 US sites. We used an extension of Poisson regression to investigate the relationship between baseline ALM (corrected for height2 ) and incident fracture outcomes, presented here for major osteoporotic fracture (MOF: hip, clinical vertebral, forearm, or proximal humerus), falls, and death. Associations were adjusted for age, time since baseline and randomization group, or additionally for femoral neck (FN) BMD, prior falls, or FRAX probability (MOF without BMD) and are reported as gradient of risk (GR: hazard ratio for first incident fracture per SD increment) in ALM/height2 (GR). Data were available for 11,187 women (mean [SD] age 63.3 [7.4] years). In the base models (adjusted for age, follow-up time, and randomization group), greater ALM/height2 was associated with lower risk of incident MOF (GR = 0.88; 95% confidence interval [CI] 0.83-0.94). The association was independent of prior falls but was attenuated by FRAX probability. Adjustment for FN BMD T-score led to attenuation and inversion of the risk relationship (GR = 1.06; 95% CI 0.98-1.14). There were no associations between ALM/height2 and incident falls. However, there was a 7% to 15% increase in risk of death during follow-up for each SD greater ALM/height2 , depending on specific adjustment. In WHI, and consistent with our findings in older men (Osteoporotic Fractures in Men [MrOS] study cohorts), the predictive value of DXA-ALM for future clinical fracture is attenuated (and potentially inverted) after adjustment for femoral neck BMD T-score. However, intriguing positive, but modest, associations between ALM/height2 and mortality remain robust. © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
• Wactawski-wende, J., Tindle, H. A., Shadyab, A. H., Kohler, L. N., Klimentidis, Y. C., Hu, C., Garcia, D. O., Follis, S., Flores, M., Chen, Z., & Bea, J. W. (2021). The intersectional role of social stress in fracture risk: results from the Women's Health Initiative.. Journal of epidemiology and community health. doi:10.1136/jech-2020-216354
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  The biological consequences of stress from the social environment pattern health outcomes. This study investigated whether social stress is prospectively associated with fracture incidence among racially and ethnically diverse, postmenopausal women..Data from 160 709 postmenopausal women in the Women's Health Initiative was analysed using Cox proportional hazards regression models to examine prospective associations of social stress with time to total and hip fracture incidence. Self-reported questionnaires measuring social strain, social functioning and social support were used to assess social stress..Age and race/ethnicity modified associations between social stress and total and hip fractures. HRs for the associations between higher social support (indicating lower social stress) and total fractures among those age 50-59 years were 0.92 (95% CI: 0.90 to 0.94); HR=0.94 (95% CI: 0.93 to 0.95) for those age 60-69 years and HR=0.96 (95% CI: 0.95 to 0.98) for those age 70-79 years. Higher social strain was associated with greater hip fracture incidence among Native American women (HR=1.84, 95% CI: 1.10 to 3.10), Asian women (HR=1.37, 95% CI: 1.01 to 1.86) and white women (HR=1.04, 95% CI: 1.01 to 1.08)..Identifying population patterns of fracture incidence as biological expressions of social environments reveals how race/ethnic specific social environmental factors influence disparities in fractures.
• Xia, J., Tu, W., Manson, J. E., Nan, H., Shadyab, A. H., Bea, J. W., Gower, E. W., Qi, L., Cheng, T. D., & Song, Y. (2021). Combined associations of 25-hydroxivitamin D and parathyroid hormone with diabetes risk and associated comorbidities among U.S. white and black women. Nutrition & diabetes, 11(1), 29.
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  There is evidence of black-white differences in vitamin D status and cardiometabolic health. This study aimed to further evaluate the joint associations of 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) with risks of diabetes and related cardiometabolic comorbidities among white and black women.
• Banack, H. R., Bea, J. W., Stokes, A., Kroenke, C. H., Stefanick, M. L., Beresford, S. A., Bird, C. E., Garcia, L., Wallace, R., Wild, R. A., Caan, B., & Wactawski-Wende, J. (2020). It's Absolutely Relative: The Effect of Age on the BMI-Mortality Relationship in Postmenopausal Women. Obesity (Silver Spring, Md.), 28(1), 171-177.
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  The use of relative and absolute effect estimates has important implications for the interpretation of study findings. Likewise, examining additive and multiplicative interaction can lead to differing conclusions about the joint effects of two exposure variables. The aim of this paper is to examine the relationship between BMI and mortality on the relative and absolute scales and investigate interaction between BMI and age.
• Bea, J. W., Bellettiere, J., LaMonte, M. J., Larson, J. C., Manson, J. E., Lewis, C. E., LaCroix, A. Z., Johnson, K. C., Klein, L., Noel, C. A., Stefanick, M. L., Wactawski-Wende, J., & Eaton, C. B. (2020). Association of Sedentary Time and Incident Heart Failure Hospitalization in Postmenopausal Women. Circulation: Heart Failure, 13(12). doi:10.1161/circheartfailure.120.007508
• Bea, J. W., Ochs‐Balcom, H. M., Hovey, K. M., & Cauley, J. A. (2020). Reply to Depression and Bone Mineral Density. Journal of Bone and Mineral Research, 35(4), 822-822. doi:10.1002/jbmr.3968
• Bea, J. W., Valdez, L. A., Yazzie, E., Valdez, L. A., Schwartz, A. L., Kinslow, B., Heer, H. D., Dalgai, S., Curley, P., & Bea, J. W. (2020). Perceptions of Cancer Causes, Prevention, and Treatment Among Navajo Cancer Survivors.. Journal of cancer education : the official journal of the American Association for Cancer Education, 35(3), 493-500. doi:10.1007/s13187-019-01487-5
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  Native Americans experience cancer-related health disparities. Yet, little is known about the current cancer experience in one of the largest Native American tribe, Navajo. A qualitative study of among Navajo cancer survivors, in which focus groups and individual interviews included questions related to perceptions of cancer causes, prevention, and treatment, allowed us to evaluate several aspects of the cancer experience from the Navajo perspective. An experienced, bilingual facilitator led the discussions using a standardized guide. Discussions were audio-recorded, documented by field notes, translated, as needed, and transcribed. NVivo software was used to summarize major themes according to the PEN-3 and health belief models. Navajo cancer survivors (N = 32) were both males (n = 13) and females (n = 19) that had been previously diagnosed with a variety of cancers: colorectal, breast, ovarian, cervical, esophageal, gall bladder, stomach, prostate, kidney, and hematologic. Many survivors had accurate knowledge of risk factors for cancer. Barriers to screening and clinical care included language, expense, geography, fear, lack of information, skepticism related to Western medicine, and treatment side effects. While some survivors experienced familial support, others were isolated from the family and community due to the perspective of cancer as a contagion. However, resilience, hope, trust in select community organizations, a desire to restore balance, and to support younger generations were positive attributes expressed regarding the treatment and recovery process. These evaluations need to be replicated across a larger cross-section of the Native cancer survivor community.
• Bea, J. W., Xia, J., Tu, W., Manson, J. E., Nan, H., Shadyab, A. H., Cheng, T. D., Hou, L., & Song, Y. (2020). Race-specific associations of 25-hydroxyvitamin D and parathyroid hormone with cardiometabolic biomarkers among US white and black postmenopausal women. The American Journal of Clinical Nutrition, 112(2), 257-267. doi:10.1093/ajcn/nqaa121
• Bland, V. L., Bea, J. W., Blew, R. M., Roe, D. J., Lee, V. R., Funk, J. L., & Going, S. B. (2020). Influence of Changes in Soft Tissue Composition on Changes in Bone Strength in Peripubertal Girls: The STAR Longitudinal Study. Journal of Bone and Mineral Research.
• Bland, V. L., Bea, J. W., Roe, D. J., Lee, V. R., Blew, R. M., & Going, S. B. (2020). Physical activity, sedentary time, and longitudinal bone strength in adolescent girls. Osteoporosis International, 1--12.
• Bland, V. L., Heatherington-Rauth, M., Howe, C., Going, S. B., & Bea, J. W. (2020). Association of objectively measured physical activity and bone health in children and adolescents: a systematic review and narrative synthesis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 31(10), 1865-1894.
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  The influence of day-to-day physical activity on bone in adolescence has not been well characterized. Forty articles were identified that assessed the relationship between accelerometry-derived physical activity and bone outcomes in adolescents. Physical activity was positively associated with bone strength in peri-pubertal males, with less consistent evidence in females. Physical activity (PA) is recommended to optimize bone development in childhood and adolescence; however, the influence of day-to-day PA on bone development is not well defined. The aim of this review was to describe the current evidence for objectively measured PA on bone outcomes in healthy children and adolescents. MEDLINE, Embase, Cochrane Library, Scopus, Web of Science, CINAHL, PsycInfo, and ClinicalTrials.gov were searched for relevant articles up to April 2020. Studies assessing the relationship between accelerometry-derived PA and bone outcomes in adolescents (6-18 years old) were included. Two reviewers independently screened studies for eligibility, extracted data, and rated study quality. Forty articles met inclusion criteria (25 cross-sectional, 15 longitudinal). There was significant heterogeneity in accelerometry methodology and bone outcomes measured. Studies in males indicated a significant, positive relationship between moderate to vigorous PA (MVPA) and bone outcomes at the hip and femur, particularly during the peri-pubertal years. The results for MVPA and bone outcomes in females were mixed. There was a paucity of longitudinal studies using pQCT and a lack of data regarding how light PA and/or impact activity influences bone outcomes. The current evidence suggests that objectively measured MVPA is positively associated with bone outcomes in children and adolescents, especially in males. However, inconsistencies in methodology make it difficult to determine the amount and type of PA that leads to favorable bone outcomes. Given that the majority of research has been conducted in Caucasian adolescents, further research is needed in minority populations.
• Going, S. B., Funk, J. L., Lee, V. L., Roe, D., Blew, R., Bea, J. W., & Bland, V. (2021). Influence of Changes in Soft Tissue Composition on Changes in Bone Strength in Peripubertal Girls: The STAR Longitudinal Study. Journal of Bone and Mineral Research, 36, 123-132. doi:10.1002/jbmr.4168
• LaMonte, M. J., Larson, J. C., Manson, J. E., Bellettiere, J., Lewis, C. E., LaCroix, A. Z., Bea, J. W., Johnson, K. C., Klein, L., Noel, C. A., & others, . (2020). Association of Sedentary Time and Incident Heart Failure Hospitalization in Postmenopausal Women. Circulation: Heart Failure, 13(12), e007508.
• Miller, C. R., Wactawski-Wende, J., Manson, J. E., Haring, B., Hovey, K. M., Laddu, D., Shadyab, A. H., Wild, R. A., Bea, J. W., Tinker, L. F., & others, . (2020). Walking volume and speed are inversely associated with incidence of treated hypertension in postmenopausal women. Hypertension, 76(5), 1435--1443.
• Ochs-Balcom, H. M., Bea, J. W., Hovey, K. M., & Cauley, J. A. (2020). Reply to Depression and Bone Mineral Density. Journal of Bone and Mineral Research, 35(4), 822--822.
• Ochs-Balcom, H. M., Hovey, K. M., Andrews, C., Cauley, J. A., Hale, L., Li, W., Bea, J. W., Sarto, G. E., Stefanick, M. L., Stone, K. L., & others, . (2020). Short sleep is associated with low bone mineral density and osteoporosis in the Women's Health Initiative. Journal of Bone and Mineral Research, 35(2), 261--268.
• Petrick, J. L., McMenamin, '. C., Zhang, X., Zeleniuch-Jacquotte, A., Wactawski-Wende, J., Simon, T. G., Sinha, R., Sesso, H. D., Schairer, C., Rosenberg, L., & others, . (2020). Exogenous hormone use, reproductive factors and risk of intrahepatic cholangiocarcinoma among women: results from cohort studies in the Liver Cancer Pooling Project and the UK Biobank. British journal of cancer, 123(2), 316--324.
• Simon, M. S., Hastert, T. A., Greenwald, M. K., Bea, J. W., Sreeram, K., Simon, M. S., Shadyab, A. H., Reding, K. W., Paskett, E. D., Neuhouser, M. L., Nassir, R., Mclaughlin, E., Kamgar, M., Hastert, T. A., Greenwald, M. K., Crane, T. E., Bea, J. W., & Assad, H. (2020). Peripheral neuropathy after breast cancer: An analysis of data from the Women’s Health Initiative Life and Longevity After Cancer cohort.. Journal of Clinical Oncology, 38(15_suppl), e24093-e24093. doi:10.1200/jco.2020.38.15_suppl.e24093
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  e24093Background: There are over 3.8 million breast cancer survivors in the United States, and many experience long-term side effects from chemotherapy. Factors associated with peripheral neuropath...
• Xia, J., Tu, W., Manson, J. E., Nan, H., Shadyab, A. H., Bea, J. W., Cheng, T. D., Hou, L., & Song, Y. (2020). Race-specific associations of 25-hydroxyvitamin D and parathyroid hormone with cardiometabolic biomarkers among US white and black postmenopausal women. The American journal of clinical nutrition, 112(2), 257--267.
• Yazzie, E., Wertheim, B. C., Schwartz, A. L., Mitchell, M., Lane, T. S., Hudson, J., Heer, H. D., Charley, B., & Bea, J. W. (2020). Abstract B002: Restoring Balance, a physical activity intervention for Native cancer survivors, preliminary analysis (NNR.14.192). Cancer Epidemiology, Biomarkers & Prevention. doi:10.1158/1538-7755.disp19-b002
• Zhou, J., & Xue, Y. (2020). Depression and Bone Mineral Density. Journal of Bone and Mineral Research, 35(4), 821--821.
• Banack, H. R., Bea, J. W., Kaufman, J. S., Stokes, A., Kroenke, C. H., Stefanick, M. L., Beresford, S. A., Bird, C. E., Garcia, L., Wallace, R., Wild, R. A., Caan, B., & Wactawski-Wende, J. (2019). The Effects of Reverse Causality and Selective Attrition on the Relationship Between Body Mass Index and Mortality in Postmenopausal Women. American journal of epidemiology, 188(10), 1838-1848.
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  Concerns about reverse causality and selection bias complicate the interpretation of studies of body mass index (BMI, calculated as weight (kg)/height (m)2) and mortality in older adults. The objective of this study was to investigate methodological explanations for the apparent attenuation of obesity-related risks in older adults. We used data from 68,132 participants in the Women's Health Initiative (WHI) clinical trial for this analysis. All of the participants were postmenopausal women aged 50-79 years at baseline (1993-1998). To examine reverse causality and selective attrition, we compared rate ratios from inverse probability of treatment- and censoring-weighted Poisson marginal structural models with results from an unweighted adjusted Poisson regression model. The estimated mortality rate ratios and 95% confidence intervals for BMIs of 30.0-34.9, 35.0-39.9 and ≥40.0 were 0.86 (95% confidence interval (CI): 0.77, 0.96), 0.85 (95% CI: 0.72, 0.99), and 0.88 (95% CI: 0.72, 1.07), respectively, in the unweighted model. The corresponding mortality rate ratios were 0.96 (95% CI: 0.86, 1.07), 1.12 (95% CI: 0.97, 1.29), and 1.31 95% CI: (1.08, 1.57), respectively, in the marginal structural model. Results from the inverse probability of treatment- and censoring-weighted marginal structural model were attenuated in low BMI categories and increased in high BMI categories. The results demonstrate the importance of accounting for reverse causality and selective attrition in studies of older adults.
• Bea, J. W., Banack, H. R., Stokes, A., Kroenke, C. H., Stefanick, M. L., Beresford, S. A., Bird, C. E., Garcia, L., Wallace, R., Wild, R. A., Caan, B., & Wactawski‐Wende, J. (2019). It’s Absolutely Relative: The Effect of Age on the BMI–Mortality Relationship in Postmenopausal Women. Obesity, 28(1), 171-177. doi:10.1002/oby.22662
• Bea, J. W., Bland, V. L., Lee, V. R., Going, S. B., Blew, R. M., Blew, D. W., Bland, V. L., & Bea, J. W. (2019). Relationship Of Physical Activity With Bone Parameters In Young Hispanic Girls: 2481 Board #145 May 31 11:00 AM - 12:30 PM. Medicine and Science in Sports and Exercise, 51(Supplement), 682-683. doi:10.1249/01.mss.0000562543.68944.80
• Bea, J. W., Hetherington-rauth, M., Kohler, L. N., Funk, J. L., Lee, V. R., Kohler, L., Hetherington-rauth, M., Going, S. B., Funk, J. L., Carranza, N., Blew, R. M., & Bea, J. W. (2019). Low Cruciferous Vegetable Intake is Associated with Elevated Inflammation in Preadolescent Girls: 3140 Board #186 May 31 2:00 PM - 3:30 PM. Medicine and Science in Sports and Exercise, 51(6S), 869-869. doi:10.1249/01.mss.0000563098.53539.a8
• Bea, J. W., Ligibel, J. A., & Basen-Engquist, K. (2019). Weight Management and Physical Activity for Breast Cancer Prevention and Control. American Society of Clinical Oncology Educational Book, e22-e33. doi:10.1200/edbk_237423
• Bea, J. W., Ochs‐Balcom, H. M., Hovey, K. M., Andrews, C., Cauley, J. A., Hale, L., Li, W., Sarto, G. E., Stefanick, M. L., Stone, K. L., Watts, N. B., Zaslavsky, O., & Wactawski‐Wende, J. (2019). Short Sleep Is Associated With Low Bone Mineral Density and Osteoporosis in the Women's Health Initiative. Journal of Bone and Mineral Research, 35(2), 261-268. doi:10.1002/jbmr.3879
• Bea, J. W., Woodburn, M., & Ohl, K. (2019). Talk to Your Patients about Falls Prevention. e-Sombrero: Pima County Medical Society newsletter.
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  Talk to Your Patients about Falls Prevention was written on behalf of The Southern Chapter of the Arizona Falls Prevention Coalition
• Bea, J. W., de Heer, H. '., Kinslow, B., Valdez, L., Yazzie, E., Curley, P., Dalgai, S., & Schwartz, A. L. (2019). Perceptions of Cancer Causes, Prevention, and Treatment Among Navajo Cancer Survivors. Journal of cancer education : the official journal of the American Association for Cancer Education.
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  Native Americans experience cancer-related health disparities. Yet, little is known about the current cancer experience in one of the largest Native American tribe, Navajo. A qualitative study of among Navajo cancer survivors, in which focus groups and individual interviews included questions related to perceptions of cancer causes, prevention, and treatment, allowed us to evaluate several aspects of the cancer experience from the Navajo perspective. An experienced, bilingual facilitator led the discussions using a standardized guide. Discussions were audio-recorded, documented by field notes, translated, as needed, and transcribed. NVivo software was used to summarize major themes according to the PEN-3 and health belief models. Navajo cancer survivors (N = 32) were both males (n = 13) and females (n = 19) that had been previously diagnosed with a variety of cancers: colorectal, breast, ovarian, cervical, esophageal, gall bladder, stomach, prostate, kidney, and hematologic. Many survivors had accurate knowledge of risk factors for cancer. Barriers to screening and clinical care included language, expense, geography, fear, lack of information, skepticism related to Western medicine, and treatment side effects. While some survivors experienced familial support, others were isolated from the family and community due to the perspective of cancer as a contagion. However, resilience, hope, trust in select community organizations, a desire to restore balance, and to support younger generations were positive attributes expressed regarding the treatment and recovery process. These evaluations need to be replicated across a larger cross-section of the Native cancer survivor community.
• Bland, V. L., Bea, J. W., Lee, V. R., Going, S. B., Blew, R. M., Bland, V. L., & Bea, J. W. (2019). Sedentary Time Predicts 2-Year Longitudinal Bone Strength in Hispanic Girls: 2476 Board #140 May 31 11:00 AM - 12:30 PM. Medicine and Science in Sports and Exercise, 51(Supplement), 680-681. doi:10.1249/01.mss.0000562538.38449.da
• Follis, S. L., Bea, J., Klimentidis, Y., Hu, C., Crandall, C. J., Garcia, D. O., Shadyab, A. H., Nassir, R., & Chen, Z. (2019). Psychosocial stress and bone loss among postmenopausal women: results from the Women's Health Initiative. Journal of epidemiology and community health, 73(9), 888-892.
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  Bone loss is a major public health concern with large proportions of older women experiencing osteoporotic fractures. Previous research has established a relationship between psychosocial stressors and fractures. However, few studies have investigated bone loss as an intermediary in this relationship. This study investigates whether social stress is associated with bone loss during a 6-year period in postmenopausal women.
• Follis, S., Bea, J. W., Cauley, J. A., Shadyab, A. H., Cook, A., & Chen, Z. (2019). Reply to Effects of Hormone Replacement Therapy on Sarcopenia: Is It Real?. Journal of the American Geriatrics Society, 67(6), 1298-1299.
• Hetherington-Rauth, M., Bea, J. W., Blew, R. M., Funk, J. L., Lee, V. R., Roe, D. J., Sardinha, L. B., & Going, S. B. (2019). Relationship of cardiometabolic risk biomarkers with DXA and pQCT bone health outcomes in young girls. Bone, 120, 452-458.
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  Excess weight exerts the positive effect of mechanical loading on bone during development whereas obesity-related metabolic dysfunction may have a detrimental impact. In adults, the presence of metabolic syndrome and type 2 diabetes has been associated with compromised bone density, quality, and strength, and an increased incidence of fractures. The few studies that have investigated the role of cardio-metabolic disease risk biomarkers (CMR) on bone strength in children have given conflicting results. The aim of this study was to assess the combined and independent relationships of cardio-metabolic biomarkers with total body and regional bone parameters in young girls.
• Trevisan, C., Crippa, A., Ek, S., Welmer, A., Sergi, G., Maggi, S., Manzato, E., Bea, J. W., Cauley, J. A., Decullier, E., Hirani, V., Lamonte, M. J., Lewis, C. E., Schott, A., Orsini, N., & Rizzuto, D. (2019). Nutritional Status, Body Mass Index, and the Risk of Falls in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.. Journal of the American Medical Directors Association, 20(5), 569-582.e7. doi:10.1016/j.jamda.2018.10.027
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  To evaluate the association between nutritional status, defined on the basis of a multidimensional evaluation, and body mass index (BMI) with the risk of falls and recurrent falls in community-dwelling older people..Systematic literature review and meta-analysis..Community-dwelling older adults..A systematic literature review was conducted on prospective studies identified through electronic and hand searches until October 2017. A random effects meta-analysis was used to evaluate the relative risk (RR) of experiencing falls and recurrent falls (≥2 falls within at least 6 months) on the basis of nutritional status, defined by multidimensional scores. A random effects dose-response meta-analysis was used to evaluate the association between BMI and the risk of falls and recurrent falls..People who were malnourished or those at risk for malnutrition had a pooled 45% higher risk of experiencing at least 1 fall than were those well-nourished (9510 subjects). Increased falls risk was observed in subjects malnourished versus well-nourished [RR 1.64, 95% confidence interval (CI) 1.18-2.28; 3 studies, 8379 subjects], whereas no substantial results were observed for risk of recurrent falls. A U-shaped association was detected between BMI and the risk for falls (P < .001), with the nadir between 24.5 and 30 (144,934 subjects). Taking a BMI of 23.5 as reference, the pooled RR of falling ranged between 1.09 (95% CI 1.04-1.15) for a BMI of 17, to 1.07 (95% CI 0.92-1.24) for a BMI of 37.5. No associations were observed between BMI and recurrent falls (120,185 subjects)..The results of our work suggest therefore that nutritional status and BMI should be evaluated when assessing the risk for falls in older age.
• Xia, J., Tu, W., Manson, J. E., Nan, H., Shadyab, A. H., Bea, J. W., Cheng, T. D., Hou, L., & Song, Y. (2019). Abstract P037: Independent and Joint Associations of 25-Hydroxy Vitamin D and Parathyroid Hormone Levels With Cardiometabolic Biomarkers Among American White and Black Postmenopausal Women. Circulation, 139(Suppl_1). doi:10.1161/circ.139.suppl_1.p037
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  Introduction: Despite evidence of racial disparities in independent relationships of 25-hydroxyvitamin D (25[OH]D) and parathyroid hormone (PTH) status with cardiovascular risk, little is known abo...
• de Heer, H., Bea, J. W., Kinslow, B., Thuraisingam, R., Valdez, L., Sleeman, R., Enjady, A., Muther, S., Yazzie, E., & Schwartz, A. (2019). Development of a culturally relevant physical activity intervention among Navajo cancer survivors. Collaborations: A Journal of Community-Based Research and Practice, 2(1). doi:http://doi.org/10.33596/coll.40
• Bea, J. W., Bassford, T. L., Wright, N. C., Wertheim, B. C., Nicholas, J. S., Lacroix, A. Z., Heymsfield, S. B., Going, S. B., Chen, Z., Bea, J. W., & Bassford, T. L. (2018). Body composition and physical function in the Women's Health Initiative Observational Study.. Preventive medicine reports, 11, 15-22. doi:10.1016/j.pmedr.2018.05.007
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  Physical function is critical for mobility and quality of life. We hypothesized that higher total lean mass is associated with higher physical function, and body fat inversely associated, among postmenopausal women. Women's Health Initiative Observational Study participants at Pittsburgh, PA; Birmingham, AL; and Tucson-Phoenix, AZ (1993-1998) completed dual-energy X-ray absorptiometry scans and the Rand SF-36 questionnaire at baseline and 3 y (N = 4526). Associations between quartiles (Q1-4) of lean or fat mass and physical function were tested using linear regression, adjusted for demographics, lifestyle factors, medical history, and scanner serial number. At baseline, participants had a mean ± SD age of 63.4 ± 7.4 y and BMI of 27.4 ± 5.8 kg/m2. Higher percent lean mass was positively associated with physical function at baseline (Q4, 83.6 ± 0.6 versus Q1, 74.6 ± 0.7; p < 0.001), while fat mass (kg and %) was inversely associated (e.g., Q4, 73.7 ± 0.7 versus Q1, 84.2 ± 0.7 kg; ptrend < 0.001). Physical function had declined across the cohort at 3 y; the highest relative lean mass quartile at baseline conferred a lesser decline in physical function than the lowest (Q4, -3.3 ± 0.6 versus Q1-7.0 ± 0.6; ptrend < 0.001), while the highest fat mass quartile (% and kg) conferred greater decline (ex. Kg Q4, -6.7 ± 0.7 versus Q1-2.8 ± 0.6; ptrend < 0.001). Increased fat mass (≥5%), but not lean mass, was associated with lower physical function at 3 y (p < 0.001). Adiposity, as well as lean mass, requires consideration in the prediction of physical function among postmenopausal women over time.
• Bea, J. W., DeHeer, H., Valdez, L., Kinslow, B., Yazzie, E., Lee, M., Nez, P., Delgai, S., & Schwartz, A. (2018). Physical activity among Navajo cancer survivors, a qualitative study. American Indian and Alaska Native Mental Health Research.
• Bea, J. W., Funk, J., Hetherington-Rauth, M., Wertheim, B. C., Mosquiera, L., Thuraisingam, R., Lee, V., Blew, R., Lohman, T., Roe, D. J., & Going, S. (2018). Anthropometry Versus Imaging for Prediction of Inflammation Among Hispanic Girls. Obesity (Silver Spring, Md.), 26(10), 1594-1602.
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  This study aimed to compare total and regional estimates of body composition, by direct and indirect techniques, for the optimal prediction of C-reactive protein (CRP) among young (aged 9-12 years) Hispanic girls (N = 232).
• Bea, J. W., Hsu, C. H., Blew, R. M., Irving, A. P., Caan, B. J., Kwan, M. L., Abraham, I., & Going, S. B. (2018). Use of iDXA spine scans to evaluate total and visceral abdominal fat. American journal of human biology : the official journal of the Human Biology Council, 30(1).
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  Abdominal fat may be a better predictor than body mass index (BMI) for risk of metabolically-related diseases, such as diabetes, cardiovascular disease, and some cancers. We sought to validate the percent fat reported on dual energy X-ray absorptiometry (DXA) regional spine scans (spine fat fraction, SFF) against abdominal fat obtained from total body scans using the iDXA machine (General Electric, Madison, WI), as previously done on the Prodigy model.
• Bea, J. W., Kabat, G. C., Kim, M. Y., Stefanick, M., Ho, G. Y., Lane, D. S., Odegaard, A. O., Simon, M. S., Luo, J., Wassertheil-Smoller, S., & Rohan, T. E. (2018). Metabolic obesity phenotypes and risk of colorectal cancer in postmenopausal women: Obesity phenotypes and risk of colorectal cancer. International Journal of Cancer, 143(3), 543-551. doi:10.1002/ijc.31345
• Bea, J. W., Zaslavsky, O., Womack, C. R., Wertheim, B. C., Wassertheil-smoller, S., Thomson, C. A., Manini, T. M., Lacroix, A. Z., Kroenke, C. H., Klimentidis, Y. C., Chen, Z., & Bea, J. W. (2018). Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women.. Journal of aging research, 2018(2018), 8491092. doi:10.1155/2018/8491092
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  Studies suggest that ACE-inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) may preserve skeletal muscle with aging. We evaluated longitudinal differences in lean body mass (LBM) among women diagnosed with hypertension and classified as ACE-I/ARB users and nonusers among Women's Health Initiative participants that received dual energy X-ray absorptiometry scans to estimate body composition (n=10,635) at baseline and at years 3 and 6 of follow-up. Of those, 2642 were treated for hypertension at baseline. Multivariate linear regression models, adjusted for relevant demographics, behaviors, and medications, assessed ACE-I/ARB use/nonuse and LBM associations at baseline, as well as change in LBM over 3 and 6 years. Although BMI did not differ by ACE-I/ARB use, LBM (%) was significantly higher in ACE-I/ARB users versus nonusers at baseline (52.2% versus 51.3%, resp., p=0.001). There was no association between ACE-I/ARB usage and change in LBM over time. Reasons for higher LBM with ACE-I/ARB use cross sectionally, but not longitundinally, are unclear and may reflect a threshold effect of these medications on LBM that is attenuated over time. Nevertheless, ACE-I/ARB use does not appear to negatively impact LBM in the long term.
• Follis, S., Cook, A., Bea, J. W., Going, S. B., Laddu, D., Cauley, J. A., Shadyab, A. H., Stefanick, M. L., & Chen, Z. (2018). Association Between Sarcopenic Obesity and Falls in a Multiethnic Cohort of Postmenopausal Women. Journal of the American Geriatrics Society, 66(12), 2314-2320.
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  To investigate associations between sarcopenia, obesity, and sarcopenic obesity and incidence of falls in a racially and ethnically diverse cohort of healthy postmenopausal women.
• Going, S. B., Bea, J. W., Follis, S., Cook, A., Laddu, D., Cauley, J. A., Shadyab, A. H., Stefanick, M. L., & Chen, Z. (2018). Association Between Sarcopenic Obesity and Falls in a Multiethnic Cohort of Postmenopausal Women. Journal of the American Geriatrics Society, 66(12), 2314-2320. doi:10.1111/jgs.15613
• Going, S. B., Lohman, T. G., Altbach, M. I., Galons, J., Hetherington-Rauth, M., Bea, J. W., Lee, V., & Blew, R. (2018). Validation of Peripheral Quantitative Computed Tomography-Derived Thigh Adipose Tissue Subcompartments in Young Girls Using a 3 T MRI Scanner. Journal of Clinical Densitometry, 583-594.
• Going, S. B., Roe, D., Funk, J. L., Blew, R., Lee, V., Bea, J. W., & Hetherington-Rauth, M. (2018). Relationship between fat distribution and cardiometabolic risk in preadolescent Hispanic girls. American Journal of Human Biology.
• Hetherington-rauth, M., Bea, J. W., Funk, J. L., Lohman, T. G., Wheeler, M. D., Roe, D. J., Lohman, T. G., Lee, V. R., Hingle, M. D., Hetherington-rauth, M., Going, S. B., Funk, J. L., Blew, R. M., & Bea, J. W. (2018). Relative contributions of lean and fat mass to bone strength in young Hispanic and non-Hispanic girls.. Bone, 113, 144-150. doi:10.1016/j.bone.2018.05.023
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  With the high prevalence of childhood obesity, especially among Hispanic children, understanding how body weight and its components of lean and fat mass affect bone development is important, given that the amount of bone mineral accrued during childhood can determine osteoporosis risk later in life. The aim of this study was to assess the independent contributions of lean and fat mass on volumetric bone mineral density (vBMD), geometry, and strength in both weight-bearing and non-weight-bearing bones of Hispanic and non-Hispanic girls..Bone vBMD, geometry, and strength were assessed at the 20% distal femur, the 4% and 66% distal tibia, and the 66% distal radius of the non-dominant limb of 326, 9- to 12-year-old girls using peripheral quantitative computed tomography (pQCT). Total body lean and fat mass were measured by dual-energy x-ray absorptiometry (DXA). Multiple linear regression was used to assess the independent relationships of fat and lean mass with pQCT bone measures while adjusting for relevant confounders. Potential interactions between ethnicity and both fat and lean mass were also tested..Lean mass was a significant positive contributor to all bone outcomes (p < 0.05) with the exception of vBMD at diaphyseal sites. Fat mass was a significant contributor to bone strength at weight bearing sites, but did not significantly contribute to bone strength at the non-weight bearing radius and was negatively associated with radius cortical content and thickness. Bone measures did not significantly differ between Hispanic and non-Hispanic girls, although there was a significant interaction between ethnicity and fat mass with total bone area at the femur (p = 0.02) and 66% tibia (p = 0.005) as well as bone strength at the femur (p = 0.03)..Lean mass is the main determinant of bone strength for appendicular skeletal sites. Fat mass contributes to bone strength in the weight-bearing skeleton but does not add to bone strength in non-weight-bearing locations and may potentially be detrimental. Bone vBMD, geometry, and strength did not differ between Hispanic and non-Hispanic girls; fat mass may be a stronger contributor to bone strength in weight-bearing bones of Hispanic girls compared to non-Hispanic.
• Kabat, G. C., Kim, M. Y., Stefanick, M., Ho, G. Y., Lane, D. S., Odegaard, A. O., Simon, M. S., Bea, J. W., Luo, J., Wassertheil-Smoller, S., & Rohan, T. E. (2018). Metabolic obesity phenotypes and risk of colorectal cancer in postmenopausal women. International journal of cancer, 143(3), 543-551.
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  Obesity has been postulated to increase the risk of colorectal cancer by mechanisms involving insulin resistance and the metabolic syndrome. We examined the associations of body mass index (BMI), waist circumference, the metabolic syndrome, metabolic obesity phenotypes and homeostasis model-insulin resistance (HOMA-IR-a marker of insulin resistance) with risk of colorectal cancer in over 21,000 women in the Women's Health Initiative CVD Biomarkers subcohort. Women were cross-classified by BMI (18.5-
• Klimentidis, Y. C., Raichlen, D. A., Bea, J., Garcia, D. O., Wineinger, N. E., Mandarino, L. J., Alexander, G. E., Chen, Z., & Going, S. B. (2018). In response to: 'Information bias in measures of self-reported physical activity'. International journal of obesity (2005), 42(12), 2064-2065.
• Klimentidis, Y. C., Raichlen, D. A., Garcia, D. O., Wineinger, N. E., Wineinger, N. E., Mandarino, L. J., Alexander, G. E., Chen, Z., Going, S. B., Bea, J. W., Wineinger, N. E., Raichlen, D. A., Mandarino, L. J., Klimentidis, Y. C., Going, S. B., Garcia, D. O., Chen, Z., Alexander, G. E., & Bea, J. W. (2018). Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE.. International journal of obesity (2005), 42(6), 1161-1176. doi:10.1038/s41366-018-0120-3
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  Physical activity (PA) protects against a wide range of diseases. Habitual PA appears to be heritable, motivating the search for specific genetic variants that may inform efforts to promote PA and target the best type of PA for each individual..We used data from the UK Biobank to perform the largest genome-wide association study of PA to date, using three measures based on self-report (nmax = 377,234) and two measures based on wrist-worn accelerometry data (nmax = 91,084). We examined genetic correlations of PA with other traits and diseases, as well as tissue-specific gene expression patterns. With data from the Atherosclerosis Risk in Communities (ARIC; n = 8,556) study, we performed a meta-analysis of our top hits for moderate-to-vigorous PA (MVPA)..We identified ten loci across all PA measures that were significant in both a basic and a fully adjusted model (p < 5 × 10-9). Upon meta-analysis of the nine top hits for MVPA with results from ARIC, eight were genome-wide significant. Interestingly, among these, the rs429358 variant in the APOE gene was the most strongly associated with MVPA, whereby the allele associated with higher Alzheimer's risk was associated with greater MVPA. However, we were not able to rule out possible selection bias underlying this result. Variants in CADM2, a gene previously implicated in obesity, risk-taking behavior and other traits, were found to be associated with habitual PA. We also identified three loci consistently associated (p < 5 × 10-5) with PA across both self-report and accelerometry, including CADM2. We found genetic correlations of PA with educational attainment, chronotype, psychiatric traits, and obesity-related traits. Tissue enrichment analyses implicate the brain and pituitary gland as locations where PA-associated loci may exert their actions..These results provide new insight into the genetic basis of habitual PA, and the genetic links connecting PA with other traits and diseases.
• Lamonte, M. J., Manson, J. E., Chomistek, A. K., Larson, J. C., Lewis, C. E., Bea, J. W., Johnson, K. C., Li, W., Klein, L., Lacroix, A. Z., Stefanick, M. L., Wactawski-wende, J., & Eaton, C. B. (2018). Physical Activity and Incidence of Heart Failure in Postmenopausal Women.. JACC. Heart failure, 6(12), 983-995. doi:10.1016/j.jchf.2018.06.020
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  This study prospectively examined physical activity levels and the incidence of heart failure (HF) in 137,303 women, ages 50 to 79 years, and examined a subset of 35,272 women who, it was determined, had HF with preserved ejection fraction (HFpEF) and HF with reduced EF (HFrEF)..The role of physical activity in HF risk among older women is unclear, particularly for incidence of HFpEF or HFrEF..Women were free of HF and reported ability to walk at least 1 block without assistance at baseline. Recreational physical activity was self-reported. The study documented 2,523 cases of total HF, and 451 and 734 cases of HFrEF and HFpEF, respectively, during a mean 14-year follow-up..After controlling for age, race, education, income, smoking, alcohol, hormone therapy, and hysterectomy status, compared with women who reported no physical activity (reference group), inverse associations were observed across incremental tertiles of total physical activity for overall HF (hazard ratio [HR]: Tertile 1 = 0.89, Tertile 2 = 0.74, Tertile 3 = 0.65; trend p < 0.001), HFpEF (HR: 0.93, 0.70, 0.68; p < 0.001), and HFrEF (HR: 0.81, 0.59, 0.68; p = 0.01). Additional controlling for potential mediating factors included attenuated time-varying coronary heart disease (CHD) (nonfatal myocardial infarction, coronary revascularization) diagnosis but did not eliminate the inverse associations. Walking, the most common form of physical activity in older women, was also inversely associated with HF risks (overall: 1.00, 0.98, 0.93, 0.72; p < 0.001; HFpEF: 1.00, 0.98, 0.87, 0.67; p < 0.001; HFrEF: 1.00, 0.75, 0.78, 0.67; p = 0.01). Associations between total physical activity and HF were consistent across subgroups, defined by age, body mass index, diabetes, hypertension, physical function, and CHD diagnosis. Analysis of physical activity as a time-varying exposure yielded findings comparable to those of baseline physical activity..Higher levels of recreational physical activity, including walking, are associated with significantly reduced HF risk in community-dwelling older women.
• Lee, V., Blew, R., Hetherington-Rauth, M., Blew, D., Galons, J. P., Hagio, T., Bea, J., Lohman, T., & Going, S. (2018). Estimation of visceral fat in 9- to 13-year-old girls using dual-energy X-ray absorptiometry (DXA) and anthropometry. Obesity science & practice, 4(5), 437-447.
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  Accumulation of visceral fat (VF) in children increases the risk of cardiovascular disease and type 2 diabetes, and measurement of VF in children using computed tomography and magnetic resonance imaging (MRI) is expensive. Dual-energy X-ray absorptiometry (DXA) may provide a low-cost alternative. This study aims to determine if DXA VF estimates can accurately estimate VF in young girls, determine if adding anthropometry would improve the estimate and determine if other DXA fat measures, with and without anthropometry, could be used to estimate VF in young girls.
• Lohman, T. G., Funk, J. L., Bea, J. W., Hetherington-Rauth, M., Lee, V. R., Blew, R. M., & Going, S. B. (2018). Relationship between fat distribution and cardiometabolic risk in Hispanic girls. American Journal of Human Biology, 30(5), e23149. doi:10.1002/ajhb.23149
• Roe, D. J., Lohman, T., Funk, J., Bea, J. W., Hetherington‐Rauth, M., Wertheim, B. C., Mosquiera, L., Thuraisingam, R., Lee, V., Blew, R., & Going, S. (2018). Anthropometry Versus Imaging for Prediction of Inflammation Among Hispanic Girls. Obesity, 26(10), 1594-1602. doi:10.1002/oby.22265
• Trevisan, C., Crippa, A., Ek, S., Welmer, A. K., Sergi, G., Maggi, S., Manzato, E., Bea, J. W., Cauley, J. A., Decullier, E., Hirani, V., LaMonte, M. J., Lewis, C. E., Schott, A. M., Orsini, N., & Rizzuto, D. (2018). Nutritional Status, Body Mass Index, and the Risk of Falls in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis. Journal of the American Medical Directors Association.
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  To evaluate the association between nutritional status, defined on the basis of a multidimensional evaluation, and body mass index (BMI) with the risk of falls and recurrent falls in community-dwelling older people.
• Abraham, I., Bea, J. W., Hsu, C., Blew, R. M., Irving, A. P., Caan, B. J., Kwan, M. L., & Going, S. B. (2017). Use of iDXA spine scans to evaluate total and visceral abdominal fat. American Journal of Human Biology, 30(1), e23057. doi:10.1002/ajhb.23057
• Bea, J. W., & Sweitzer, N. K. (2017). More Appropriate Cardiovascular Risk Screening Through Understanding Complex Phenotypes: Mind the Gap. Journal of the American College of Cardiology, 70(12), 1438-1440.
• Bea, J. W., Howe, C. L., Blew, R. M., Hetherington-Rauth, M., & Going, S. B. (2017). Resistance training effects on metabolic function among youth: A systematic review. Pediatric Exercise Science, 0(0), 1-42. doi:10.1123/pes.2016-0143
• Bea, J. W., Valdez, L. A., Yazzie, E., Valdez, L. A., Schwartz, A. L., Nez, P., Lee, M. C., Kinslow, B., Heer, H. D., Delgai, S., & Bea, J. W. (2017). Physical Activity among Navajo Cancer Survivors: A Qualitative Study. Medicine and Science in Sports and Exercise, 49(5S), 1090. doi:10.1249/01.mss.0000520000.61561.ea
• Bea, J., Harris, R., Chang, Y., Beavers, K., Laddu-Patel, D., Johnson, K., LeBoff, M., Womack, C., Wallace, R., Li, W., Crandall, C., & Cauley, J. (2017). Risk of Fracture in Women with Sarcopenia, Low Bone Mass, or Both. Journal of the American Geriatrics Society, 65(12), 2673-2678. doi:10.1111/jgs.15050
• Chen, Z., Klimentidis, Y. C., Bea, J. W., Ernst, K. C., Hu, C., Chou, Y., Jackson, R., & Thomson, C. A. (2017). Body mass index, waist circumference and mortality in a large mutiethnic postmenopausal cohort - Results from the Women's Health Initiative.. Journal of the American Geriatric Society.
• Going, S. B., Bea, J. W., Blew, R. M., Howe, C., & Hetherington-Rauth, M. (2017). Resistance Training Effects on Metabolic Function Among Youth: A Systematic Review. Pediatric Exercise Science, 29(3), 297-315. doi:10.1123/pes.2016-0143
• Harris, R., Chang, Y., Beavers, K., Laddu-Patel, D., Bea, J., Johnson, K., LeBoff, M., Womack, C., Wallace, R., Li, W., Crandall, C., & Cauley, J. (2017). Risk of Fracture in Women with Sarcopenia, Low Bone Mass, or Both. Journal of the American Geriatrics Society, 65(12), 2673-2678.
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  To determine whether women with sarcopenia and low bone mineral density (BMD) are at greater risk of clinical fractures than those with sarcopenia or low BMD alone.
• Hetherington-Rauth, M. C., Bea, J. W., Blew, R., Lee, V., Funk, J. L., Going, S. B., & Lohman, T. G. (2017). Comparison of direct measures of adiposity with indirect measures for predicting cardiometabolic risk factors in preadolescent girls. Nutrition Journal.
• Jung, S. Y., Ho, G., Rohan, T., Strickler, H., Bea, J., Papp, J., Sobel, E., Zhang, Z. F., & Crandall, C. (2017). Interaction of insulin-like growth factor-I and insulin resistance-related genetic variants with lifestyle factors on postmenopausal breast cancer risk. Breast cancer research and treatment, 164(2), 475-495.
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  Genetic variants and traits in metabolic signaling pathways may interact with obesity, physical activity, and exogenous estrogen (E), influencing postmenopausal breast cancer risk, but these inter-related pathways are incompletely understood.
• Jung, S. Y., Rohan, T., Strickler, H., Bea, J., Zhang, Z. F., Ho, G., & Crandall, C. (2017). Genetic variants and traits related to insulin-like growth factor-I and insulin resistance and their interaction with lifestyles on postmenopausal colorectal cancer risk. PloS one, 12(10), e0186296.
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  Genetic variants and traits in metabolic signaling pathways may interact with lifestyle factors such as obesity, physical activity, and exogenous estrogen (E), influencing postmenopausal colorectal cancer (CRC) risk, but these interrelated pathways are not fully understood. In this case-cohort study, we examined 33 single-nucleotide polymorphisms (SNPs) in genes related to insulin-like growth factor-I (IGF-I)/ insulin resistance (IR) traits and signaling pathways, using data from 704 postmenopausal women in Women's Health Initiative Observation ancillary studies. Stratifying by the lifestyle modifiers, we assessed the effects of IGF-I/IR traits (fasting total and free IGF-I, IGF binding protein-3, insulin, glucose, and homeostatic model assessment-insulin resistance) on CRC risk as a mediator or influencing factor. Six SNPs in the INS, IGF-I, and IGFBP3 genes were associated with CRC risk, and those associations differed between non-obese/active and obese/inactive women and between E nonusers and users. Roughly 30% of the cancer risk due to the SNP was mediated by IGF-I/IR traits. Likewise, carriers of 11 SNPs in the IRS1 and AKT1/2 genes (signaling pathway-related genetic variants) had different associations with CRC risk between strata, and the proportion of the SNP-cancer association explained by traits varied from 30% to 50%. Our findings suggest that IGF-I/IR genetic variants interact with obesity, physical activity, and exogenous E, altering postmenopausal CRC risk, through IGF-I/IR traits, but also through different pathways. Unraveling gene-phenotype-lifestyle interactions will provide data on potential genetic targets in clinical trials for cancer prevention and intervention strategies to reduce CRC risk.
• Jung, S. Y., Zhang, Z., Strickler, H. D., Sobel, E. M., Rohan, T. E., Papp, J. C., Ho, G. Y., Crandall, C. J., & Bea, J. W. (2017). Abstract 1277: Interaction of insulin-like growth factor-I and insulin resistance-related genetic variants with obesity and lifestyle factors on postmenopausal breast cancer risk. Epidemiology, 77, 1277-1277. doi:10.1158/1538-7445.am2017-1277
• Kabat, G. C., Wu, W. Y., Bea, J. W., Chen, C., Qi, L., Stefanick, M. L., Chlebowski, R. T., Lane, D. S., Wactawski-Wende, J., Wassertheil-Smoller, S., & Rohan, T. E. (2017). Metabolic phenotypes of obesity: frequency, correlates and change over time in a cohort of postmenopausal women. International journal of obesity (Lond), 41(1), 170-177. doi:10.1038/ijo.2016.179
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  The possibility that a subset of persons who are obese may be metabolically healthy-referred to as the 'metabolically healthy obese' (MHO) phenotype-has attracted attention recently. However, few studies have followed individuals with MHO or other obesity phenotypes over time to assess change in their metabolic profiles. The aim of the present study was to examine transitions over a 6-year period among different states defined simultaneously by body mass index (BMI) and the presence/absence of the metabolic syndrome (MetS).
• Kabat, G. C., Xue, X., Kamensky, V., Bea, J. W., Chen, C., Qi, L., Stefanick, M. L., Chlebowski, R. T., Wactawski-wende, J., Wassertheil-smoller, S., Rohan, T. E., & Lane, D. S. (2017). Erratum to: Risk of breast, endometrial, colorectal, and renal cancers in postmenopausal women in association with a body shape index and other anthropometric measures.. Cancer causes & control : CCC, 28(9), 1007-1009. doi:10.1007/s10552-017-0931-x
• Martinez, J. A., Wertheim, B. C., Thomson, C. A., Bea, J. W., Wallace, R., Allison, M., Snetselaar, L., Chen, Z., Nassir, R., & Thompson, P. A. (2017). Physical Activity Modifies the Association between Dietary Protein and Lean Mass of Postmenopausal Women. Journal of the Academy of Nutrition and Dietetics, 117(2), 192-203e.1. doi:10.1016/j.jand.2016.10.009
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  Maintenance of lean muscle mass and related strength is associated with lower risk for numerous chronic diseases of aging in women.
• Schwartz, A. L., de Heer, H. D., & Bea, J. W. (2017). Initiating Exercise Interventions to Promote Wellness in Cancer Patients and Survivors. Oncology (Williston Park, N.Y.), 31(10), 711-7.
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  Exercise is associated with significant reductions in the recurrence and mortality rates of several common cancers. Cancer survivors who exercise can potentially benefit from reduced levels of fatigue, and improved quality of life, physical function, and body composition (ie, healthier ratios of lean body mass to fat mass). The amount of activity required to achieve protective effects is moderate (eg, walking 30 minutes per day at 2.5 miles per hour). However, many healthcare providers report a lack of awareness of the appropriate exercise recommendations across the phases of cancer survivorship, considerations regarding the timing of exercise interventions, and the ability to refer patients to exercise programs specifically aimed at cancer survivors. The American College of Sports Medicine notes that exercise is generally safe for most cancer survivors, and inactivity should be avoided. Their guidelines for exercise call for 150 minutes of moderate or 75 minutes of vigorous aerobic activity per week, and 2 days per week of resistance training (eg, with exercise bands or light weights). Survivors with lymphedema, peripheral neuropathy, breast reconstruction, central lines, and ostomies should follow specific precautions. Providing health professionals with the training and tools needed to provide adequate recommendations to their patients is essential to improving patient outcomes. To facilitate adherence among communities with the greatest need and poor access to services, cultural and environmental adaptations are critical.
• Wactawski-Wende, J., Mysiw, W. J., Jackson, R., LaMonte, M. J., Ockene, J. K., Eaton, C., LaCroix, A., Going, S. B., Wu, C., Seguin, R. A., Wallace, R. B., Thomson, C. A., & Bea, J. W. (2017). Changes in Physical Activity, Sedentary Time, and Risk of Falling in the Women’s Health Initiative Observational Study. Preventitive Medicine, 95, 103-109. doi:10.1016/j.ypmed.2016.11.025
• Azarbal, F., Stefanick, M. L., Assimes, T. L., Manson, J. E., Bea, J. W., Li, W., Hlatky, M. A., Larson, J. C., LeBlanc, E. S., Albert, C. M., Nassir, R., Martin, L. W., & Perez, M. V. (2016). Lean body mass and risk of incident atrial fibrillation in post-menopausal women. European heart journal, 37(20), 1606-13.
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  High body mass index (BMI) is a risk factor for atrial fibrillation (AF). The aim of this study was to determine whether lean body mass (LBM) predicts AF.
• Bea, J. W., Lee, M. C., Going, S. B., Hsu, C., Lohman, T. G., Blew, R. M., Lee, V. R., Caan, B., & Kwan, M. (2016). Dual energy X-ray absorptiometry spine scans to determine abdominal fat in postmenopausal women. American Journal of Human Biology, 28(6), 918-926. doi:10.1002/ajhb.22892
• Eaton, C. B., Larson, J. C., Chomistek, A. K., Manson, J. E., Li, W., Lewis, C. E., Bea, J. W., Johnson, K. C., Wactawski-wende, J., & Lamonte, M. J. (2016). Abstract 19719: Physical Activity and Risk of Heart Failure With Preserved or Reduced Ejection Fraction in the Women’s Health Initiative Study. Circulation.
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  Background: Heart failure (HF) burden is large and growing among older women. Although physical activity (PA) has consistently been associated with lower HF risk in cohort studies, it is unclear wh...
• Klimentidis, Y. C., Bea, J. W., Thompson, P., Klimecki, W. T., Hu, C., Wu, G., Nicholas, S., Ryckman, K. K., & Chen, Z. (2016). Genetic Variant in ACVR2B Is Associated with Lean Mass. Medicine and science in sports and exercise, 48(7), 1270-5.
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  Low lean mass (LM) is a risk factor for chronic disease, a major cause of disability and diminished quality of life, and is a heritable trait. However, relatively few specific genetic factors have been identified as potentially influencing this trait.
• Lamonte, M. J., Larson, J. C., Manson, J. E., Chomistek, A. K., Li, W., Bea, J. W., Lewis, C. E., Johnson, K. C., Wactawski-wende, J., & Eaton, C. B. (2016). Abstract 19444: Physical Activity and Heart Failure Incidence Among Postmenopausal Women in the Women’s Health Initiative Study. Circulation.
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  Background: Heart failure (HF) imposes a growing burden to public health, disproportionately affecting adults 65 years and older. Physical activity (PA) has been associated with lower HF risk in mi...
• Lohman, T., Hsu, C., Bea, J., Blew, R., Going, S., Lee, M., Lee, V., Caan, B., & Kwan, M. (2016). Dual energy X-ray absorptiometry spine scans to determine abdominal fat in postmenopausal women: Bea et al.. American Journal of Human Biology, 28(6), 918-926. doi:10.1002/ajhb.22892
• Marcum, Z. A., Wirtz, H. S., Pettinger, M., LaCroix, A. Z., Carnahan, R., Cauley, J. A., Bea, J. W., Gray, S. L., & Hanlon, J. (2016). Anticholinergic Medication Use and Falls in Postmenopausal Women: Findings from the Women's Health Initiative. BMC Geriatrics, 16(1), 76. doi:10.1186/s12877-016-0251-0
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  Anticholinergic medication use has been associated with several negative health outcomes in older adults, but little is known about its risk for fractures.
• Saquib, J., King, A. C., Castro, C., Tinker, L. F., Shikany, J. M., Bea, J. W., LaCroix, A., Van Horn, L., & Stefanick, M. L. (2016). A Pilot Study on Combining Go4Life® Materials with Interactive Voice Response System to Promote Physical Activity in Older Women. Journal of Women & Aging, 28(5), 454-62. doi:10.1080/08952841.2015.1018065
• Thompson, P., Rohan, T., Zaslavsky, O., Lewis, E., Vitolins, M., Johnson, K., Bell, C., Sims, S., Bea, J. W., Hingle, M. D., Wertheim, B., Caire, G., Garcia, D. O., & Thomson, C. A. (2016). Body Shape, Adiposity Index and Mortality in Post-menopausal Women: Findings from the Women’s Health Initiative. Obesity (Silver Spring). doi:10.1002/oby.21461
• Wanigatunga, A. A., Sourdet, S. S., LaMonte, M. J., Waring, M. E., Nassir, R., Garcia, L., Bea, J. W., Seguin, R. A., Ockene, J. K., Sarto, G. E., Stefanick, M. L., Limacher, M., & Manini, T. M. (2016). Physical impairment and body weight history in postmenopausal women: the Women's Health Initiative. Public health nutrition, 19(17), 3169-3177. doi:10.1017/S1368980016001415
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  To examine whether weight history and weight transitions over adult lifespan contribute to physical impairment among postmenopausal women.
• Bea, J. W., Funk, J. L., Lee, V. R., Going, S. B., Funk, J. L., Blew, R. M., & Bea, J. W. (2015). Cardiovascular Risk Related to Body Fat and Physical Activity in Young Girls. The FASEB Journal, 29.
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  Adiposity has been associated with cardiovascular (CVD) risk factors in children, but whether moderate to vigorous physical activity (MVPA) affects the association remains unclear. PURPOSE: To dete...
• Bea, J. W., Going, S. B., Wertheim, B., Bassford, T. L., LaCroix, A. Z., Wright, N., Nicholas, J. S., Heymsfield, S. B., & Chen, Z. (2017). Body composition and physical function in a cohort of multiethnic older women - a subgroup of the Women’s Health Initiative Observational Study. Preventive Medicine Reports.
• Bea, J. W., Jurutka, P. W., Hibler, E. A., Lance, P., Martínez, M. E., Roe, D. J., Sardo Molmenti, C. L., Thompson, P. A., & Jacobs, E. T. (2015). Concentrations of the Vitamin D Metabolite 1,25(OH)2D and Odds of Metabolic Syndrome and its Components. Metabolism: clinical and experimental.
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  Few epidemiological studies have investigated the association between circulating concentrations of the active vitamin D metabolite 1,25(OH)2D and metabolic syndrome. We sought to determine whether blood levels of 1,25(OH)2D are associated with metabolic syndrome and its individual components, including waist circumference, triglycerides, blood pressure, and glucose, and high-density lipoprotein. We also investigated these associations for the more abundant precursor vitamin D metabolite, 25(OH)D.
• Bea, J. W., Smoller, S., Wertheim, B. C., Klimentidis, Y. C., Chen, Z., Zaslavsky, O., Manini, T., Womack, C., Kroenke, C., LaCroix, A., & Thomson, C. A. (2017). Associations between ACE-inhibitors and angiotensin receptor blockers, and lean body mass in community dwelling older women. Journal of Aging Research.
• Bea, J. W., Thomson, C. A., Wertheim, B. C., Nicholas, J. S., Ernst, K., Hu, C., Jackson, R., Cauley, J. A., Lewis, C. E., Caan, B., Roe, D., & Chen, Z. (2015). Risk of Mortality According to Body Mass Index and Body Composition Among Postmenopausal Women. American Journal of Epidemiology.
• Blew, R., Lee, V., Bea, J. W., Hetherington-Rauth, M., Silvain, D., Galons, J., Altbach, M. I., & Going, S. B. (2017). In vivo validation of pQCT-derived thigh fat sub-compartments using a 3 T MRI scanner. Journal of Clinical Densitometry.
• Going, S. B., Chen, Z., Alexander, G. E., Mandarino, L. J., Garcia, D. O., Bea, J. W., Raichlen, D. A., & Klimentidis, Y. C. (2017). Genome-wide association study of habitual physical activity in over 277,000 UK Biobank participants indentifies novel variants and genetic correlations with chronotype and obesity related traits. International Journal of Obesity.
• Kabat, G. C., Xue, X., Kamensky, V., Lane, D., Bea, J. W., Chen, C., Qi, L., Stefanick, M. L., Chlebowski, R. T., Wactawski-Wende, J., Wassertheil-Smoller, S., & Rohan, T. E. (2015). Risk of breast, endometrial, colorectal, and renal cancers in postmenopausal women in association with a body shape index and other anthropometric measures. Cancer causes & control : CCC, 26(2), 219-29.
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  A body shape index (ABSI) has been proposed as a possible improvement over waist circumference (WC) as a marker of abdominal adiposity because it removes the correlation of WC with body mass index (BMI) and with height. We assessed the association of ABSI with four obesity-related cancers compared to that of other anthropometric measures of adiposity.
• Klimentidis, Y. C., Bea, J. W., Lohman, T., Hsieh, P., Going, S., & Chen, Z. (2015). High genetic risk individuals benefit less from resistance exercise intervention. International journal of obesity (2005), 39(9), 1371-5.
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  Genetic factors have an important role in body mass index (BMI) variation, and also likely have a role in the weight loss and body composition response to physical activity/exercise. With the recent identification of BMI-associated genetic variants, it is possible to investigate the interaction of these genetic factors with exercise on body composition outcomes.
• M, L., JC, L., JE, M., AK, C., W, L., & Bea, J. W. (2017). Physical activity and incidence of heart failure with reduced and preserved ejection fraction in older postmenopausal women: The Women’s Health Initiative Study. Journal of the American College of Cardiology.
• Marcum, Z. A., Wirtz, H. S., Pettinger, M., Lacroix, A. Z., Cauley, J. A., Bea, J. W., Gray, S. L., & Carnahan, R. M. (2015). Anticholinergic Medication Use and Fractures in Postmenopausal Women: Findings from the Women's Health Initiative.. Drugs & aging, 32(9), 755-63. doi:10.1007/s40266-015-0298-1
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  Anticholinergic medication use has been associated with several negative health outcomes in older adults, but little is known about its risk for fractures..To examine the association between anticholinergic medication use and fracture outcomes in community-dwelling postmenopausal women..Utilizing a prospective cohort design, we examined data collected from 137,408 women aged 50-79 years from the Women's Health Initiative observational study and clinical trials not reporting hip fracture at baseline. Medications with moderate or strong anticholinergic effects were identified directly from drug containers during in-person interviews. The main outcome was fractures (hip, lower arm/wrist and total fractures). We performed multivariable Cox proportional hazard survival modelling to assess the association between anticholinergic use and the risk of fractures..At baseline, 10.6% of the women were using an anticholinergic medication, of which antihistamines were the most common medication class (48.4%). The multivariable-adjusted hazard ratios for anticholinergic medication use were 1.08 (95% confidence interval [CI] 0.89-1.30) for hip fracture, 1.01 (95% CI 0.91-1.13) for lower arm/wrist fracture and 1.03 (95% CI 0.98-1.09) for total fractures. We observed no association according to subclass or count of anticholinergic medications, or trends between the duration of anticholinergic use and any of the fracture outcomes..Anticholinergic medication use was not associated with an increased risk of fractures among community-dwelling women. Future research should make efforts to capture over-the-counter medication use and the cumulative anticholinergic burden in relation to important health outcomes for older adults.
• Bea, J. W., Jacobs, L., Waits, J., Hartz, V., Martinez, S. H., Standfast, R. D., Farrell, V. A., Bawden, M., Whitmer, E., & Misner, S. (2015). Need for Specific Sugar-Sweetened Beverage Lessons for Fourth- and Fifth-Graders. JOURNAL OF NUTRITION EDUCATION AND BEHAVIOR, 47(1), 36-43.
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  Objective: Consumption of sugar-sweetened beverages (SSB) is linked to obesity. The authors hypothesized that school-based nutrition education would decrease SSB consumption.
• Bea, J. W., Martinez, S., Armstrong-Florian, T., Farrell, V., Martinez, C., Whitmer, E., Hartz, V., Blake, S., Nicolini, A., & Misner, S. (2014). US dietary and physical activity guideline knowledge and corresponding behaviors among 4th and 5th grade students: a multisite pilot study. Journal of Extension, 52(3):3RIB3.
• Bea, J. W., Misner, S., Misner, S., Martinez, S., Islas, A., Hartz, V., Bea, J. W., Bawden, M., & Alves, J. (2014). Nutrition education improves behaviors without accompanying improvements in dietary guideline recognition among rural 4th and 5th graders (273.7). The FASEB Journal, 28.
• Chase, D. M., Gibson, S. J., Sumner, D. A., Bea, J. W., & Alberts, D. S. (2014). Appropriate Use of Complementary and Alternative Medicine Approaches in Gynecologic Cancers. CURRENT TREATMENT OPTIONS IN ONCOLOGY, 15(1), 14-26.
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  Gynecologic cancer patients frequently desire alternative and/or complementary interventions or medicines to aid in relief of both cancer-related and treatment-related side effects. Furthermore, women also seek treatment to aid in superior outcomes and cure rates. Unfortunately, evidence suggests that the use of complementary and/or alternative medicine (CAM) is underreported or not discussed with physicians providing cancer care. In gynecologic cancer literature, there is a lack of scientific evidence either supporting or negating CAM. Because of the lack of information available, health care providers do not have good information regarding safety, efficacy, and dose of CAM. This leads to miscommunication or absence of communication between providers and patients. Because patients do use CAM to improve quality of life (QOL) during and after treatment, it would be educational for providers to know the specific QOL deficits among patients that require attention. Thus, with the ultimate goal of improving QOL for gynecologic cancer patients, providers should be pushed to investigate CAM and determine an honest support or rejection of these therapies.
• Jacobs, L., Bea, J. W., Misner, S., Misner, S., Martinez, S., Jacobs, L., Hartz, V., Florian, T. A., Farrell, V. A., & Bea, J. W. (2014). Change in Nutrition and Physical Activity Behaviors Among SNAP-Eligible 4th and 5th Grade Students: A Multi-County Study. Journal of Nutrition Education and Behavior, 46(4), S183-S184. doi:10.1016/j.jneb.2014.04.277
• Kabat, G. C., Kamensky, V., Heo, M., Bea, J. W., Hou, L., Lane, D. S., Liu, S., Qi, L., Simon, M. S., Wactawski-Wende, J., & Rohan, T. E. (2014). Combined conjugated esterified estrogen plus methyltestosterone supplementation and risk of breast cancer in postmenopausal women. MATURITAS, 79(1), 70-76.
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  Objectives: Testosterone supplementation is being prescribed increasingly to treat symptoms of hormone deficiency in pre- and postmenopausal women; however, studies of the association of testosterone therapy, alone or in combination with estrogen, with risk of breast cancer are limited. The current study assessed the association of combination conjugated esterified estrogen and methyltestosterone (CEE + MT) use and breast cancer risk in postmenopausal women in the Women's Health Initiative (WHI).
• Zhou, Y., Chlebowski, R., LaMonte, M. J., Bea, J. W., Qi, L., Wallace, R., Lavasani, S., Walsh, B. W., Anderson, G., Vitolins, M., Sarto, G., & Irwin, M. L. (2014). Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: Results from the Women's Health Initiative. GYNECOLOGIC ONCOLOGY, 133(1), 4-10.
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  Background. Ovarian cancer is often diagnosed at late stages and consequently the 5-year survival rate is only 44%. However, there is limited knowledge of the association of modifiable lifestyle factors, such as physical activity and obesity on mortality among women diagnosed with ovarian cancer. The purpose of our study was to prospectively investigate the association of (1) measured body mass index (BMI), and (2) self-reported physical activity with ovarian cancer-specific and all-cause mortality in postmenopausal women enrolled in the Women's Health Initiative (WHI).
• Goodman, D., Park, H. L., Stefanick, M., LeBlanc, E. S., Bea, J. W., Qi, L., Kapphahn, K., Lamonte, M., Manini, T., Desai, M., & Anton-Culver, H. (2013). Relation Between Self-Recalled Childhood Physical Activity And Adult Physical Activity: The Women’s Health Initiative. Open Journal of Epidemiology, 3(4).
• Haring, B., Pettinger, M., Bea, J. W., Wactawski-Wende, J., Carnahan, R. M., Ockene, J. K., von Ballmoos, M. W., Wallace, R. B., & Wassertheil-Smoller, S. (2013). Laxative use and incident falls, fractures and change in bone mineral density in postmenopausal women: results from the Women's Health Initiative. BMC GERIATRICS, 13.
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  Background: Laxatives are among the most widely used over-the-counter medications in the United States but studies examining their potential hazardous side effects are sparse. Associations between laxative use and risk for fractures and change in bone mineral density [BMD] have not previously been investigated.
• Jacobs, L., Misner, S., Bea, J. W., Misner, S., Martinez, S., Jacobs, L., Farrell, V. A., Bea, J. W., Bawden, M., & Armstrong-florian, T. (2013). Sugary Beverage Consumption, Not Water, Increases in Springtime among Low-Income Arizona 4th and 5th Graders. Journal of Nutrition Education and Behavior, 45(4), S29. doi:10.1016/j.jneb.2013.04.079
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  Objective: To measure change in sugary beverage consumption with nutrition education among low-income 4th and 5th graders. Theory, Prior Research, Rationale: Fifteen percent of US children aged 6 to 11 years are overweight, with an additional 30% at risk. Sugary beverage consumption is linked to obesity and US Dietary Guidelines recommend limiting intake. We hypothesized that nutrition education would result in decreased sugary beverage consumption. Study Design, Setting, Participants, and Intervention: The University of Arizona Nutrition Network (UANN) provides general nutrition education training and materials, aligned with USDA guidelines, to teachers at SNAP-Ed eligible schools. UANN administered self-report behavioral questionnaires to students in 8% of participating 4th and 5th grade classrooms in 5 Arizona counties in both Fall and Spring. Outcome, Measures and Analysis: Descriptive statistics were computed for student demographics and beverage consumption on the prior day. Paired t-tests were used to evaluate change in classroom averages between Fall and Spring. Results: Thirty-three classrooms participated (N1⁄4770 pre, 765 post, 90% complete surveys). Participant characteristics: 71% 4th graders, 50.5% female, 10.1 years of age. Fall sugary beverage consumption was 1.05 ( 0.23) times the previous day; milk and water were consumed 1.58 ( 0.24) and 5.20 ( 0.70) times, respectively. As expected, Arizona springtime beverage consumption increased overall (3.2%). Sugary beverage consumption increased 14.4% and accounted for the greatest portion of the total increase (p1⁄40.006). Small increases in milk (p1⁄40.03) and water (p1⁄40.86) were observed. Conclusions and Implications: This study suggests the need for beverage specific education to shift the children toward more healthful choices. Further research is needed to assess beverage consumption patterns longitudinally, controlling for season. Funding: Supplemental Nutrition Assistance Program Education.
• Kabat, G. C., Anderson, M. L., Heo, M., Hosgood, H. D., Kamensky, V., Bea, J. W., Hou, L., Lane, D. S., Wactawski-Wende, J., Manson, J. E., & Rohan, T. E. (2013). Adult Stature and Risk of Cancer at Different Anatomic Sites in a Cohort of Postmenopausal Women. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 22(8), 1353-1363.
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  Background: Prospective studies in Western and Asian populations suggest that height is a risk factor for various cancers. However, few studies have explored potential confounding or effect modification of the association by other factors.
• Kabat, G. C., Anderson, M. L., Heo, M., Hosgood, H. D., Kamensky, V., Bea, J. W., Hou, L., Lane, D. S., Wactawski-wende, J., Manson, J. E., & Rohan, T. E. (2013). Adult stature and risk of cancer at different anatomic sites in a cohort of postmenopausal women.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 22(8), 1353-63. doi:10.1158/1055-9965.epi-13-0305
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  Prospective studies in Western and Asian populations suggest that height is a risk factor for various cancers. However, few studies have explored potential confounding or effect modification of the association by other factors..We examined the association between height measured at enrollment in 144,701 women participating in the Women's Health Initiative and risk of all cancers combined and cancer at 19 specific sites. Over a median follow-up of 12.0 years, 20,928 incident cancers were identified. We used Cox proportional hazards models to estimate HR and 95% confidence intervals (CI) per 10 cm increase in height, with adjustment for established risk factors. We also examined potential effect modification of the association with all cancer and specific cancers..Height was significantly positively associated with risk of all cancers (HR = 1.13; 95% CI, 1.11-1.16), as well as with cancers of the thyroid, rectum, kidney, endometrium, colorectum, colon, ovary, and breast, and with multiple myeloma and melanoma (range of HRs: 1.13 for breast cancer to 1.29 for multiple myeloma and thyroid cancer). These associations were generally insensitive to adjustment for confounders, and there was little evidence of effect modification..This study confirms the positive association of height with risk of all cancers and a substantial number of cancer sites..Identification of single-nucleotide polymorphisms associated both with height and with increased cancer risk may help elucidate the association.
• Sims, S. T., Kubo, J., Desai, M., Bea, J., Beasley, J. M., Manson, J. E., Allison, M., Seguin, R. A., Chen, Z., Michael, Y. L., Sullivan, S. D., Beresford, S., & Stefanick, M. L. (2013). Changes in physical activity and body composition in postmenopausal women over time. Medicine and science in sports and exercise, 45(8), 1486-92.
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  Higher physical activity (PA) has been associated with greater attenuation of body fat gain and preservation of lean mass across the lifespan. These analyses aimed to determine relationships of change in PA to changes in fat and lean body mass in a longitudinal prospective study of postmenopausal women.
• Kabat, G. C., Kim, M. Y., Jean-Wactawski-Wende, ., Bea, J. W., Edlefsen, K. L., Adams-Campbell, L. L., De Roos, A. J., & Rohan, T. E. (2012). Anthropometric factors, physical activity, and risk of Non-Hodgkin's lymphoma in the Women's Health Initiative. CANCER EPIDEMIOLOGY, 36(1), 52-59.
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  Background: Incidence rates of non-Hodgkin's lymphoma (NHL) increased substantially in the United States and worldwide during the latter part of the 20th century, but little is known about its etiology. Obesity is associated with impaired immune function through which it may influence the risk of NHL; other factors reflecting energy homeostasis (height, abdominal adiposity, and physical activity) may also be involved. Methods: We examined the association of anthropometric factors and physical activity with risk of NHL and its major subtypes in a large cohort of women aged 50-79 years old who were enrolled at 40 clinical centers in the United States between 1993 and 1998. Over a mean follow-up period of 11 years, 1123 cases of NHL were identified among 158,975 women. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). Results: Height at baseline was positively associated with risk of all NHL and with that of diffuse large B-cell lymphoma (HRs(q4vs.q1) 1.19, 95% CI 1.00-1.43 and 1.43, 95% CI 1.01-2.03, respectively). Measures of obesity and abdominal adiposity at baseline were not associated with risk. Hazard ratios for NHL were increased for women in the highest quartile of weight and body mass index at age 18 (HRs(q4vs.q1) 1.29, 95% CI 1.01-1.65 and 1.27, 95% CI 1.01-1.59, respectively). Some measures of recreational physical activity were modestly associated with increased risk of NHL overall, but there were no clear associations with specific subtypes. Conclusion: Our findings regarding anthropometric measures are consistent with those of several previous reports, suggesting that early life influences on growth and immune function may influence the risk of NHL later in life. (C) 2011 Elsevier Ltd. All rights reserved.
• Bea, J. W., Wright, N. C., Thompson, P., Hu, C., Guerra, S., & Chen, Z. (2011). Performance evaluation of a multiplex assay for future use in biomarker discovery efforts to predict body composition. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 49(5), 817-824.
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  Background: Interest in biomarker patterns and disease has led to the development of immunoassays that evaluate multiple analytes in parallel while using little sample. However, there are no current standards for multiplex configuration, validation, and quality. Thus, validation by platform, population, and question of interest is recommended. We sought to determine the best blood fraction for multiplex evaluation of circulating biomarkers in post-menopausal women, and to explore body composition phenotype discrimination by biomarkers.
• Bea, J. W., Zhao, Q., Cauley, J. A., LaCroix, A. Z., Bassford, T., Lewis, C. E., Jackson, R. D., Tylavsky, F. A., & Chen, Z. (2011). Effect of hormone therapy on lean body mass, falls, and fractures: 6-year results from the Women's Health Initiative hormone trials. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 18(1), 44-52.
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  Objective: Loss of lean body mass with aging may contribute to falls and fractures. The objective of this analysis was to determine if taking postmenopausal hormone therapy (or HT: estrogen plus progestogen therapy or estrogen therapy alone) favorably affects age-related changes in lean body mass and if these changes partially account for decreased falls or fractures with HT.
• Bea, J. W., & Lohman, T. (2010). Long-term weight loss and chronic disease. International Journal of Body Composition Research. International Journal of Body Composition Research, 8, S21-S28.
• Bea, J. W., Cussler, E. C., Going, S. B., Blew, R. M., Metcalfe, L. L., & Lohman, T. G. (2010). Resistance Training Predicts 6-yr Body Composition Change in Postmenopausal Women. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 42(7), 1286-1295.
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  BEA, J. W., E. C. CUSSLER, S. B. GOING, R. M. BLEW, L. L. METCALFE, and T. G. LOHMAN. Resistance Training Predicts 6-yr Body Composition Change in Postmenopausal Women. Med. Sci. Sports Exerc., Vol. 42, No. 7, pp. 1286-1295, 2010. Purpose: The aim of this study was to examine the association of exercise frequency (ExFreq) and volume (total weight lifted by military press and squats (SQ)) with change in body composition among postmenopausal women participating in a progressive resistance training study. Methods: Previously, sedentary women (n = 122, age = 56.3 + 4.3 yr) were followed for 6 yr. At 6 yr, there were women who had been randomly assigned to resistance training at baseline (n = 65) controls that were permitted to cross over to the exercise program at 1 yr (n = 32) and 25 true controls. Exercisers and crossovers directed to perform eight core exercises for two sets of eight repetitions at 70%-80% of one-repetition maximum, three times weekly, plus progressive weight bearing, stretching, and balance. Body weight and fat were measured at baseline and annually using anthropometry and dual-energy x-ray absorptiometry. Results: Average change in body weight and total body fat were 0.83 +/- 5.39 and 0.64 +/- 4.95 kg at 6 yr, respectively. In multiple linear regression, ExFreq, military press, and SQ were significantly inversely associated with change in body weight (standardized beta coefficient (SBC) = -0.22 to -0.28, P < 0.01), fat (SBC = -0.25 to -0.33, P < 0.01), and trunk fat (SBC = -0.20 to -0.31, P < 0.03) after adjusting for age, years on hormone therapy, change in lean soft tissue, baseline body composition, and baseline habitual exercise. The lowest tertile of SQ (equivalent to 2.5% attendance) demonstrated significant gain in weight, fat, and trunk fat over 6 yr (P < 0.004), whereas the highest tertile SQ (equivalent to 64% attendance) was able to maintain their weight, total, and regional fat. Conclusions: We conclude that resistance training is a viable long-term method to prevent weight gain and deleterious changes in body composition in postmenopausal women.
• Bea, J. W., Lohman, T. G., Cussler, E. C., Going, S. B., & Thompson, P. A. (2010). Lifestyle Modifies the Relationship Between Body Composition and Adrenergic Receptor Genetic Polymorphisms, ADRB2, ADRB3 and ADRA2B: A Secondary Analysis of a Randomized Controlled Trial of Physical Activity Among Postmenopausal Women. BEHAVIOR GENETICS, 40(5), 649-659.
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  Genetic variations in the adrenergic receptor (ADR) have been associated with body composition in cross-sectional studies. Recent findings suggest that ADR variants may also modify body composition response to lifestyle. We assessed the role of ADR variants in body composition response to 12 months of resistance training versus control in previously sedentary postmenopausal women. Randomized trial completers were genotyped for A2B (Glu9/12) by fragment length analysis, and B2 (Gln27Glu) and B3 (Trp64Arg) by TaqMan (n = 148, 54% hormone therapy users). Associations between genotypes and body composition, by dual energy X-ray absorptiometry, were analyzed using univariate models. There was no main effect of individual genes on change in body composition, however, gene x exercise interactions were observed for A2B (Glu9/12) and B2 (Gln27Glu) on change in lean soft tissue (LST, p = 0.02); exercisers on the A2B (Glu9-) background gained LST compared to a loss among controls over 12 months (p < 0.05), with no significant intervention effect on the A2B (Glu9+) background. Similarly, there was a significant LST gain with exercise on the B2 (Glu27+) background compared to loss among controls and no intervention effect on the B2 (Glu27-) background. A non-significant association between total body fat (TBF) and B3 (Trp64Arg) persisted among sedentary controls only when intervention groups were separated (%TBF gain with B3 (Arg64+) carriage, p = 0.03); exercisers lost TBF regardless of genotype. In summary, effect modification by lifestyle was demonstrated on ADRA2B, B2, and B3 genetic backgrounds. Individuals with certain ADR genotypes may be more vulnerable to adverse changes in body composition with sedentary behavior, thus these candidate genes warrant further study.
• Bea, J. W., Stopeck, A., Thomson, C. A., Thompson, P. A., Stopeck, A., Nardi, E., May, M., Frey, G., & Bea, J. W. (2010). Abstract A119: Effect of weight‐bearing exercise on circulating biomarkers in breast cancer survivors. Cancer Prevention Research, 3. doi:10.1158/1940-6207.prev-09-a119
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  Breast cancer patients generally demonstrate a gain in body fat mass accompanied by loss of lean mass (i.e. muscle) during cancer therapy (Demark‐Wahnefried et al, J. Clin Oncol, 2001). These changes may lead to adverse metabolic and inflammatory phenotypes. The objective of this pilot study was to evaluate changes in metabolic, inflammatory, and growth factor biomarkers among breast cancer survivors following 8 weeks of supervised resistance training combined with self‐reported cardiovascular training. No diet or weight loss component was included in the intervention. Twenty‐seven breast cancer survivors (78.3% Caucasian, mean age 56.5 ± 8.1 yrs, mean BMI 29.8 ± 4.4kg/m 2 ) who were on average 5 years post‐cancer treatment were recruited to participate in a prospective behavioral intervention trial to test the hypothesis that weight bearing activity including stretching, resistance, balance, and aerobic training would improve select metabolic and inflammatory indicators over an 8 week period. Height, weight, body composition (dual X‐ray absorptiometry), fasting plasma glucose, insulin, IL‐6, CRP, IL‐1Ra, and IGF‐1 were measured at baseline and 8 weeks. IL‐6, IL‐1Ra and IGF‐1 were analyzed using high sensitivity ELISA and glucose was measured by a glucose oxidase‐peroxide reaction; insulin and CRP testing were performed by the local hospital clinical laboratory. The homeostasis model of insulin resistance was computed (HOMA‐IR) from glucose and insulin values. Eighty‐one percent of the sample completed the 8‐week intervention. Among completers (n=22) there was no significant change in body weight. Inflammatory response, as assessed using IL‐1Ra, was improved (76.75 ± 161.39, p Breast cancer survivors participating in a pilot, short‐term structured physical activity intervention targeting resistance training, in the absence of diet or weight change, demonstrated a significant improvement in the anti‐inflammatory biomarker IL‐1Ra without concomitant increases in pro‐inflammatory biomarkers, IL‐6 and CRP. Larger studies with sufficient sample size to detect statistically significant differences should be pursued; combining structured exercise with diet to support weight reduction may also be superior and should be evaluated. Citation Information: Cancer Prev Res 2010;3(1 Suppl):A119.
• Stendell-Hollis, N. R., Thomson, C. A., Thompson, P. A., Bea, J. W., Cussler, E. C., & Hakim, I. A. (2010). Green tea improves metabolic biomarkers, not weight or body composition: a pilot study in overweight breast cancer survivors. JOURNAL OF HUMAN NUTRITION AND DIETETICS, 23(6), 590-600.
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  Background:
• Thomson, C. A., Stopeck, A. T., Bea, J. W., Cussler, E., Nardi, E., Frey, G., & Thompson, P. A. (2010). Changes in Body Weight and Metabolic Indexes in Overweight Breast Cancer Survivors Enrolled in a Randomized Trial of Low-Fat vs. Reduced Carbohydrate Diets. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 62(8), 1142-1152.
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  Overweight status is common among women breast cancer survivors and places them at greater risk for metabolic disorders, cardiovascular morbidity, and breast cancer recurrence than nonoverweight survivors. Efforts to promote weight control in this population are needed. The objective of this research was to evaluate the effect of low-fat or low-carbohydrate diet counseling on weight loss, body composition, and changes in metabolic indexes in overweight postmenopausal breast cancer survivors. Survivors (n= 40) were randomized to receive dietitian counseling for a low-fat or a reduced carbohydrate diet for 6 mo. Weight and metabolic measures, including glucose, insulin, HbA1c, HOMA, lipids, hsCRP, as well as blood pressure were measured at baseline, 6, 12 and 24 wk. Dietary intake of fat and carbohydrate was reduced by 24 and 76g/day, respectively. Weight loss averaged 6.1 (+/- 4.8 kg) at 24 wk and was not significantly different by diet group; loss of lean mass was also demonstrated. All subjects demonstrated improvements in total/HDL cholesterol ratio, and significant reductions in HbA1c, insulin, and HOMA. Triglycerides levels were significantly reduced only in the low-carbohydrate diet group (-31.1 +/- 36.6; P= 0.01). Significant improvements in weight and metabolic indexes can be demonstrated among overweight breast cancer survivors adherent to either a carbohydrate- or fat-restricted diet.
• Thomson, C. A., Thompson, P. A., Wright-Bea, J., Nardi, E., Frey, G. R., & Stopeck, A. (2009). Metabolic syndrome and elevated C-reactive protein in breast cancer survivors on adjuvant hormone therapy. Journal of women's health (2002), 18(12), 2041-7.
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  As the efficacy of treatment for breast cancer has improved, particularly with the use of antiestrogenic therapies, there is an increasing population of long-term breast cancer survivors who seeks care with unique health issues. These patients may be at increased risk for cardiovascular disease (CVD) resulting from excess adiposity and treatment effects. Metabolic syndrome (MetS) and elevated C-reactive protein (CRP), two predictors of CVD, have not been fully evaluated in overweight breast cancer survivors on hormone-modulating agents.
• Bea, J. W., Stopeck, A., Thomson, C. A., Thompson, P. A., Stroeckens, A., Stopeck, A., Nardi, E., Frey, G., & Bea, J. W. (2007). Effect of body composition change on markers of metabolic syndrome in breast cancer survivors on either fat or carbohydrate restricted diets.. Cancer Epidemiology and Prevention Biomarkers, 16.
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  A21 Women previously treated for breast cancer are at risk for post-treatment morbidity including obesity, cardiovascular disease, diabetes, and sarcopenia or sarcopenic obesity. The encouragement of weight loss for the management of comorbidities and metabolic disturbance, without consideration of protein content or physical activity, may exacerbate sarcopenia, compromise functional status and lead to increasing risk of future fractures. The purpose of this study is to evaluate the relationship between changes in body composition and metabolic status in the survivor population. >In an ongoing, randomized, weight loss intervention of low fat or low carbohydrate diets in breast cancer survivors (N=37; Age 55.4 ± 9.7 yrs; BMI >25 kg/m2) on adjuvant hormonal therapies, standard anthropometry (height, weight, waist, and hip circumferences) and total and region body fat, lean, and bone mass measures were performed (dual X-ray absorptiometry). Total cholesterol, triglycerides (TG), high density lipoprotein cholesterol (HDL), insulin, glycosylated hemoglobin, and glucose were also measured by the clinical diagnostic laboratory. >At baseline, we found that 32% of participants had elevated (>3.5) TG/HDL values, a sensitive and specific surrogate measure for insulin resistant, dyslipidemic individuals. In intervention completers thus far (N=14), using the new ATP III criterion, cases of metabolic syndrome were cut by 56% following intervention (metabolic syndrome by ATP III 64% at baseline, 29% at 24weeks) in this survivor group. >At 24 weeks, completers also demonstrated significant improvements in weight and body fat, with suggested loss in lean mass. Although measures of glucose were not altered, fasting insulin and glycosylated hemoglobin were significantly reduced, consistent with improved insulin sensitivity. >Investigations of high protein diets in cancer survivors for the preservation of lean mass during weight loss are limited. This preliminary analysis indicates that markers of metabolic syndrome can be improved by diet in breast cancer survivors, but there is a trend toward loss of lean mass accompanying loss of fat. >Variable Change; p-value >Weight (kg) -8.46 ± 4.08; BMI (kg/m2) -3.05 ± 1.6; %Total Body Fat -4.8 ± 3.0; Trunk Fat (kg) -3.4 ± 1.8; Lean Mass (kg) -0.86 ± 1.6; 0.06 >Fasting Plasma Glucose (mg/dl) -3.00 ± 8.99; 0.18 >2hr-Post-Load Glucose (mg/dl) 8.70 ± 28.39; 0.36 >Fasting Insulin (uU/ml) -3.56 ± 5.83; 0.02 >Glycosylated Hemoglobin (%) -0.17 ± 0.34; 0.05 >Total Cholesterol (mg/dl) -8.61 ± 29.95; 0.24 >Triglycerides (mg/dl) 0.06 ± 77.26; 1.0 >High-density lipoprotein cholesterol (mg/dl) 1.56 ± 9.08; 0.48
• Lohman, T. G., & Wright, J. (2004). Maintenance of long-term weight loss: future directions. Quest: Official Journal of the National Association for Kinesiology and Physical Education in Higher Education, 56 (1), 105-119.

Proceedings Publications

• Bea, J. W., Heer, H., Lane, T., Charley, B., Yazzie, E., Hudson, J., Mitchell, M., Wertheim, B., & Schwartz, A. (2020). Restoring Balance, a physical activity intervention for Native cancer survivors, preliminary analysis (NNR. 14.192). In CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 29.
• Bland, V., Klimentidis, Y., Bea, J., Roe, D., & Going, S. (2020). Cross-sectional associations between visceral adipose tissue and bone mineral density in the UK Biobank Imaging Study. In JOURNAL OF BONE AND MINERAL RESEARCH, 35.
• Bea, J. W., Kohler, L. N., Hetherington-Rauth, M., Funk, J. L., Carranza, N., Lee, V., Blew, R., & Going, S. B. (2019, June 2019). Low Cruciferous Vegetable Intake is Associated with Elevated Inflammation in Preadolescent Girls. In ACSM, 51.

Presentations

• Bea, J. W. (2023, March). Role of FSH in postmenopausal obesity and breast cancer. University of Arizona College of Medicine, Research Day,. Tucson, AZ: University of Arizona.
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  Bea JW. Role of FSH in postmenopausal obesity and breast cancer. Data Blitz Theme: Research to Optimize Health Throughout the Lifespan I; University of Arizona College of Medicine, Research Day, Tucson, AZ March 29, 2023
• Bea, J. W. (2023, March). The Cancer Prevention and Control Program at the University of Arizona Cancer Center; CCSG Application Symposium—Population Science Programs. Associate Director/Program Leader Workshop; ASPO Annual Meeting. San Diego, CA.
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  Bea JW, The Cancer Prevention and Control Program at the University of Arizona Cancer Center in CCSG Application—Population Science Programs. Moderator Scarlett Gomez, UCSF; additional panelists John Groopman, Sidney Kimmel Comprehensive Cancer Center, Susan Neuhausen, City of Hope Comprehensive Cancer Center. American Society for Preventive Oncology Annual Meeting, Hilton San Diego Bayfront in San Diego, California, March 12, 2023.
• Bea, J. W. (2023, May). WHI Soft Tissue & Cancer (WHISC Study): Ancillary Study Update. WHI Annual Investigator Meeting. Seattle, WA.
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  Dissemination of initial findings.
• Bea, J. W. (2020, March). Restoring Balance in Indian Country. Community Science Initiatives Symposia. 2020 American Society of Preventive Oncology Annual Conference. Virtual due to COVID-19: American Society of Preventive Oncology.
• Bea, J. W. (2019, June). Impact of BMI Reduction in Primary Breast Cancer Prevention; Part I of Education Session: Furthering Fitness: Implementing Wellness to Improve Breast Cancer Outcomes. American Society for Clinical Oncology Annual Meeting. Chicago, IL: ASCO.
• Bea, J. W., Gachupin, F. C., Teufel-Shone, N., & von Hippel, F. (2019, August). Best Practices Working with Communities. The Partnership for Native American Cancer Prevention Summer Research Retreat. Scottsdale, AZ.
• Haskie, K., Thuraisingam, R., Lane, T., Bea, J. W., de Heer, H., & Schwarz, A. (2017, September). Physical Activity and Cancer among Native American cancer survivors: a pilot study (phase 2)—Preliminary baseline results. American Indian Science and Engineering Society National Conference. Denver, CO: American Indian Science and Engineering Society.
• Eaton, C., Bea, J. W., Larson, J. C., Chomistek, A. K., Manson, J. E., Li, W., Lewis, C. E., Johnson, K. C., Wactkawski-Wende, J., & Lamonte, M. (2016, Nov). Physical Activity and Risk of Heart Failure with Preserved or Reduced Ejection Fraction in the Combined Women’s Health Initiative Clinical Trial and Observational Studies. American Heart Association National Meeting. New Orleans, LA.
• Lamonte, M., Bea, J. W., Larson, J. C., Manson, J. E., Chomistek, A. K., Li, W., Lewis, C. E., Johnson, K. C., Wactkawski-Wende, J., & Eaton, C. (2016, Nov). Physical Activity and Heart Failure Incidence Among Postmenopausal Women in the Women’s Health Initiative Studies. American Heart Association National Meeting. New Orleans, LA.
• Solomon, T. G., Gachupin, F. C., Bea, J. W., & Koithan, M. S. (2015, March). Cancer care disparities among Native American populations. UA College of Nursing Health Equity Research Seminar Series..

Poster Presentations

• Bea, J. W., & Yung, A. K. (2023, November). Behavioral Measurement and Intervention Shared Resource. University of Arizona Cancer Center Annual Scientific Retreat. Tucson, AZ: University of Arizona Cancer Center.
• Bea, J. W., Archibeque, S., Roe, D., Hsu, C., Lin, L., Linde, K., & Odegaard, A. (2023, May). Comparing Imputation Approaches and Model Types for Survival Analysis Using Obesity-Related Cancer Mortality Data from the Women’s Health Initiative. Women’s Health Initiative Annual Meeting and 30th Anniversary. Seattle, WA: Women's Health Initiative.
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  Archibeque S, Roe D, Hsu CH, Lin L, Lind KE, Odegaard A, Bea JW. Comparing Imputation Approaches and Model Types for Survival Analysis Using Obesity-Related Cancer Mortality Data from the Women’s Health Initiative. Women’s Health Initiative Annual Meeting and 30th Anniversary, Seattle, WA, May 4-5, 2023. Winner of two travel awards, Midwest Regional Center travel grant from Ohio State University and the Vosilla Family Fund travel grant from the Department of Epidemiology and Biostatistics at the Mel and Enid Zuckerman College of Public Health at the University of Arizona.
• Bea, J. W., Decker, D., Valencia, C., Odegaard, A., Wactawski-Wende, J., Ochs-Balcom, H., Caan, B., Chen, Z., Pichardo, M., & Harris, H. (2023, November). DXA-derived visceral and subcutaneous adipose tissue association with postmenopausal breast cancer mortality. University of Arizona Cancer Center Annual Scientific Retreat. Tucson, AZ: University of Arizona Cancer Center.
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  Also accepted for presentation at ASPO 2024 Annual Conference, March 17-19, 2024, in Chicago.
• Bea, J. W., Ziller, S. G., Blew, R., Walker, E., Archebeque, S., Roe, D., Odegaard, A., Caan, B., Chen, Z., Rohan, T., Lane, D., Felix, A., Harris, H., Luo, J., & Manson, J. (2023, November). Associations between DXA-derived visceral and subcutaneous adipose tissue and obesity-related cancer incidence in postmenopausal women Poster presentation. University of Arizona Cancer Center Annual Scientific Retreat;. Tucson, AZ: University of Arizona.
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  Also presented at ASPO 2024 Annual Conference, March 17-19, 2024, in Chicago.
• Bea, J. W., Ziller, S., Linde, K., Blew, R., Jacobs, E., Odegaard, A., Caan, B., Chen, Z., Luo, J., Manson, J., Neuhouser, M., & Rohan, T. (2023, March). DXA-derived abdominal visceral and subcutaneous adipose tissue and postmenopausal colorectal cancer. American Society of Preventive Oncology Annual Meeting. San Diego, CA: American Society of Preventative Oncology.
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  Ziller SG, Lind K, Blew R, Jacobs E, Odegaard A, Caan B, Chen Z, Luo J, Manson J, Neuhouser M, Rohan T,Bea JW. DXA-derived abdominal visceral and subcutaneous adipose tissue and postmenopausal colorectal cancer. American Society of Preventive Oncology (Poster 98-T), Hilton San Diego Bayfront in San Diego, California, March 13, 2023
• Bea, J. W., Ziller, S., Standage-Beier, S., Bakashi, B., McLelland, J., & Coletta, D. (2023, April). Body composition associations with incident colorectal cancer: A systematic review. University of Arizona Student Showcase. Tucson, AZ: The University of Arizona.
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  Ziller SG, Standage-Beier S, Bakhshi B, McClelland J, Coletta D, Bea JW. Body composition associations with incident colorectal cancer: A systematic review. University of Arizona Student Showcase, Tucson, AZ April 21, 2023 (competing for Willock Library Research Award)
• Benashley, L., Bucy, A., Schwartz, A., Chalasani, P., Blew, R., Thomson, C. A., & Bea, J. W. (2021, March). Functional effects of paclitaxel treatment on breast cancer patients. Western Alliance to Expand Student Opportunities (WAESO) Annual Conference. virtual: Western Alliance to Expand Student Opportunities.
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  Virtual poster presentation. Awarded 2nd Place at the WAESO poster competition.
• Lane, T., deHeer, H., Schwartz, A., Charley, B., Yazzie, E., Yellowhair, J., Hudson, J., Mitchell, M., Wertheim, B., & Bea, J. W. (2020, March). Restoring Balance, a physical activity intervention for Native cancer survivors and their familial support persons (NNR.14.192). American Society of Preventive Oncology Annual Meeting. Tucson, AZ: ASPO.
• Thomson, C. A., Yung, A., Lind, K. E., Ehiri, J. E., Harris, R. B., Dickeson, K., & Bea, J. W. (2020, Fall). In-person versus virtual training for the next generation of U3 cancer prevention scientists.. University of Arizona Cancer Center Fall Retreat. Tucson, AZ.
  More info

  Bea JW, Dickeson KM, Harris RB, Ehiri JE, Lind KE, Yung AK, Thomson CA. In-person versus virtual training for the next generation of U3 cancer prevention scientists. UACC Fall Retreat. (November 2020).
• Bea, J. W., deHeer, H., Lane, T., Charley, B., Yazzie, E., Hudson, J., Mitchell, M., Wertheim, B., & Schwartz, A. (2019, September). Restoring Balance, a Physical Activity Intervention for Native Cancer Survivors, Preliminary Analysis (NNR.14.192). The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved Conference. San Francisco, CA: AACR.
• Bland, V., Bea, J. W., Blew, R., Lee, V., & Going, S. B. (2019, November). Changes in Soft Tissue Mass Predict 2-Year Bone Strength Change in Hispanic and Non-Hispanic Girls. The Obesity Society ObesityWeek. Las Vegas, NV: The Obesity Society.
• Bland, V., Lee, V., Bea, J. W., Blew, R., & Going, S. B. (2019, May). Sedentary time predicts 2-year longitudinal bone strength in Hispanic girls. American College of Sports Medicine Annual Meeting. Orlando, FL: ACSM.
• Blew, D., Lee, V., Blew, R., Bea, J. W., Bland, V., & Going, S. B. (2019, May). Relationship of physical activity with bone parameters in young Hispanic girls. American College of Sports Medicine Annual Meeting. Orlando, FL: ACSM.
• Bea, J. W., Wertheim, B., Mosqueria, L., Lee, V., Blew, R., Hetherington-Rauth, M., & Going, S. B. (2018, April). Comparison of Field Measures Versus Imaging and Total Versus Regional Body Composition in Predicting Inflammation in Preadolescent Hispanic Girls. Experimental Biology 2018. San Diego, CA: FASEB.
• Thomson, C. A., Lefkowits, C., Hile, E., Walker, J., Crane, T. E., & Bea, J. W. (2018, Fall). Abstract: Design of PrEvention of Falls among OldeR Multiethnic gynecologic cANcEr patients (PErFORM ANEw). UACC Scientific Retreat. Tucson, AZ: UACC.
• Hetherington-Rauth, M., Bea, J. W., Lee, V., Funk, J. L., Blew, R., & Going, S. B. (2017, October). Effect of cardiometabolic risk factors on relationship between adiposity and bone measures in girls. Obesity Week. Washington, DC: The Obesity Society.
• Irving, A., Blew, R., Lee, V., Going, S. B., & Bea, J. W. (2017, January). Using dual x-ray absorptiometry spine scans to determine total abdominal fat. Annual Undergraduate Biology Research Program (UBRP) Conference, University of Arizona. Tucson Arizona.
• Mosqueria, L., Bea, J. W., Lee, V., Blew, R., & Going, S. (2017, August). Total Body Fat and Abdominal Obesity are Associated with Increased Subclinical Chronic Inflammation in Hispanic Girls. Undergraduate Research Opportunities Consortium Annual Conference. Tucson, AZ: Undergraduate Biology Research Program.
• Valdez, L., de Heer, H., Schwartz, A., Kinslow, B., Yazzie, E., Lee, M., Nez, P., Delgai, S., & Bea, J. W. (2017, June). Physical activity among Navajo cancer survivors: a qualitative study. American College of Sports Medicine Annual Conference. Denver, CO: American College of Sports Medicine.
• Bea, J. W., Crane, T. E., Jacobs, E. T., Thompson, P. A., Garcia, D. O., & Thomson, C. A. (2016, November). Abstract: Cruciferous vegetable intake is associated with changes in inflammatory biomarkers among breast cancer survivors in a physical activity program. American Institute for Cancer Research. Washington DC.
• Bea, J. W., Crane, T. E., Jacobs, E. T., Thompson, P., Garcia, D. O., & Thomson, C. A. (2016, Nov). Cruciferous vegetable intake is associated with changes in inflammatory biomarkers among breast cancer survivors in a physical activity program. American Institute for Cancer Research Annual Conference. North Bethesda, MD.
• Harris, R., Bea, J. W., Chang, Y., Johnson, K., Beavers, K., Laddu, D., LeBoff, M., Womack, C., Wallace, R., Li, W., & Cauley, J. (2016, September). The Risk of Fracture among Women with Sarcopenia, Low Bone Mass or Both. American Society for Bone and Mineral Research. Denver, CO.
• Hetherington-Rauth, M. C., Bea, J. W., Blew, R., Lee, V., Funk, J. L., & Going, S. B. (2016, October 31). Comparison of direct measures of adiposity with indirect measures for predicting cardiometabolic risk factors in preadolescent girls. The Obesity Society, Obesity Week. New Orleans, LA.
• Irving, A., Blew, R., Lee, V., Going, S. B., & Bea, J. W. (2016, August). Using dual x-ray absorptiometry spine scans to determine total abdominal fat. Native American Cancer Prevention Program (NACP) BRIDGES Summer Conference. Flagstaff, AZ.
• Lee, M., Cleaveland, S., Nez, P., Delgai, S., Haski, K., Yazzie, E., Valdez, L., Schwartz, A., de Heer, H., & Bea, J. W. (2016, January). Physical Activity Among Native American Cancer Survivors: Discussion of Preliminary Findings of Focus Groups. Annual Undergraduate Biology Research Program (UBRP) Conference. Tucson, AZ.
• Bea, J. W., Bea, J. W., Thompson, P., Thompson, P., Garcia, D. O., Garcia, D. O., Stopeck, A. T., Stopeck, A. T., Thomson, C. A., & Thomson, C. A. (2015, March). Factors influencing skeletal muscle improvements among breast cancer survivors involved in weight-bearing physical activity. American Society of Preventive Oncology.
• Bea, J. W., Kohler, L. N., Hetherington-Rauth, M., Funk, J. L., Carranza, N., Lee, V., Blew, R., & Going, S. B. (2019, May). Cruciferous vegetable intake association with inflammation in preadolescent girls. American College of Sports Medicine Annual Meeting. Orlando, FL: ACSM.
• Bea, J. W., Lee, V., Blew, R. M., Funk, J., & Going, S. B. (2015, April). Cardiovascular Risk Related to Body Fat and Physical Activity in Young Girls. Experimental Biology. Boston, MA.
• Hingle, M., Wertheim, B., Bea, J. W., Garcia, D. O., Neuhouser, M., Seguin, R., Snetsaalar, L., Tinker, L., Waring, M., & Thomson, C. A. (2015, November). Dietary energy density and weight change in the Women’s Health Init. The Obesity Society, Obesity Week Conference. Los Angeles, CA.
• Lee, M., Bea, J. W., Lee, V., Blew, R., Schiferl, D., & Going, S. B. (2015, November). Peripheral QCT Estimates of Subcutaneous and Intermuscular Fat is highly correlated with MRI measures in Young Girls. The Obesity Society, Obesity Week Conference. Los Angeles, CA.
• Martinez, S., Farrell, V., Misner, S. L., Bea, J. W., Armstrong Florian, T. L., & Jacobs, L. E. (2014, July). Change in Nutrition and Physical Activity Behaviors Among SNAP - Eligible 4th and 5th Grade Students: A Multi - County Study. Society for Nutrition Education and Behavior Annual Conference. Milwaukee: Society for Nutrition Education and Behavior.
• Farrell, V., Bawden, M., Martinez, S., Misner, S. L., Bea, J. W., Armstrong Florian, T. L., & Jacobs, L. E. (2013, August). Sugary Beverage Consumption, Not Water, Increases in Springtime Among Low - income Arizona 4th and 5th graders. Society for Nutrition Education and Behavior. Portland: Society for Nutrition Education and Behavior.
• Nurss, E., Farrell, V., Bea, J. W., Going, S. B., & Jacobs, L. E. (2011, June). Strategies from Teachers to Increase Partici pation in School - based Supplemental Nutrition Assistance Program Nutrition Education (SNAP - Ed): Excerpts from a Pilot Study. Childhood Obesity Conference. San Diego: California Department of Public Health, California Department of Education, Nutrition Policy Institute UC Division of Agriculture and Natural Resources, The California Endowment, and Kaiser Permanente.

Others

• Bea, J. W. (2023, June).

  Research Opportunities for women at the University of Arizona Cancer Center

  . SHERA: Scientific Hub for Empowering Research on female health Advancement.
  More info

  Bea JW, Research Opportunities for women at the University of Arizona Cancer Center, SHERA: Scientific Hub for Empowering Research on female health Advancement, University of Arizona, Tucson, AZ
• Bea, J. W., Heer, H., Lane, T., Charley, B., Yazzie, E., Hudson, J., Mitchell, M., Wertheim, B., & Schwartz, A. (2020). Abstract B002: Restoring Balance, a physical activity intervention for Native cancer survivors, preliminary analysis (NNR. 14.192).
• Kamgar, M., Assad, H., Hastert, T. A., McLaughlin, E., Reding, K., Paskett, E. D., Bea, J. W., Shadyab, A. H., Neuhouser, M. L., Nassir, R., & others, . (2020, June). Peripheral neuropathy after breast cancer: An analysis of data from the Women’s Health Initiative Life and Longevity After Cancer cohort..