Jefferey L Burgess
- Associate Dean, Research-Public Health
- Associate Dean, Research - Mel and Enid Zuckerman College of Public Health
- Professor, Public Health
- Professor, BIO5 Institute
- Adjunct Professor, Mining and Geological Engineering
- Dr. John Granito Award for Excellence in Fire Leadership and Management Research
- International Fire Service Journal of Leadership and Management, Summer 2018
- SOT Translational Scientist Award
- Society of Toxicology (Note: The notice of award was made in the Fall of 2014 but the actual award ceremony will be made in 2015.), Fall 2014
- University of Arizona Academic Leadership Institute
- University of Arizona Administration, Spring 2012
- University of Arizona Administration, Spring 2011
No activities entered.
Independent StudyEHS 599 (Spring 2020)
Individualized Science WritingCTS 585 (Spring 2020)
Toxicology+Chem ExposureEHS 553 (Spring 2020)
Toxicology+Chem ExposurePCOL 553 (Spring 2020)
Independent StudyEHS 699 (Fall 2019)
Individualized Science WritingCTS 585 (Fall 2019)
ResearchCTS 900 (Fall 2019)
Master's ReportEHS 909 (Spring 2019)
ResearchCTS 900 (Spring 2019)
Master's ReportEHS 909 (Fall 2018)
ResearchCTS 900 (Fall 2018)
Master's ReportEHS 909 (Summer I 2018)
ResearchEHS 900 (Summer I 2018)
Toxicology+Chem ExposureEHS 553 (Spring 2018)
Toxicology+Chem ExposurePCOL 553 (Spring 2018)
ResearchEHS 900 (Fall 2017)
DissertationCPH 920 (Spring 2017)
ResearchCPH 900 (Spring 2017)
Master's ReportCPH 909 (Fall 2016)
Master's ReportCPH 909 (Summer I 2016)
Toxicology+Chem ExposureCPH 553 (Spring 2016)
Toxicology+Chem ExposurePCOL 553 (Spring 2016)
- Bui, D. P., Hu, C., Jung, A. M., Pollack Porter, K. M., Griffin, S. C., French, D. D., Crothers, S., & Burgess, J. L. (2019). Driving behaviors associated with emergency service vehicle crashes in the U.S. fire service. Traffic Injury Prevention, 19(8), 849-855. doi:10.1080/15389588.2018.1508837
- Bui, D. P., Jung, A. M., Kramer, S. S., Griffin, S., & Burgess, J. L. (2018). Interventions and Controls to Prevent Emergency Service Vehicle Incidents: A Mixed Methods Review. Accident and Injury Prevention.
- Burgess, J. L., Zhou, J., Griffin, S., & Jacobs, E. T. (2018). MicroRNA changes in firefighters. JOEM.
- Griffin, S. C., Bui, D. P., Gowrisankaran, G., Lutz, E. A., He, C., Hu, C., & Burgess, J. L. (2018). Risk Management Interventions to Reduce Injuries and Maximize Economic Benefits in U.S. Mining. Journal of occupational and environmental medicine, 60(3), 226-233.More infoRisk management (RM) is a cyclical process of identifying and ranking risks, implementing controls, and evaluating their effectiveness. This study aims to identify effective RM interventions in the U.S. mining industry.
- Griffin, S., Poplin, G., Pollack, K., & Burgess, J. L. (2017). Implementing Risk Management to Reduce Injuries in the U.S. Fire Service. Journal of Safety Research.
- Jacobs, E. T., Burgess, J. L., & Abbott, M. B. (2018). The Donora Smog Revisited: 70 Years After the Event That Inspired the Clean Air Act. American journal of public health, 108(S2), S85-S88.More infoAt a storefront museum approximately 25 miles southeast of Pittsburgh, Pennsylvania, a sign reads, "Clean Air Started Here." This is not hyperbole. At the end of October 1948, the communities of Donora and Webster in Pennsylvania were visited by a smog that changed the face of environmental protection in the United States. Conservative estimates showed that 20 individuals died, while an additional 5900-43% of the population of Donora-were affected by the smog. This event led to the first large-scale epidemiological investigation of an environmental health disaster in the United States. Questions remain about the long-term effects of the smog, because higher rates of cardiovascular disease and cancer than were expected were observed in the region in the decade following the smog. Recent work has suggested that environmental contaminants from a bygone era in Donora might have an impact even today. In addition, reports regarding air pollution have indicated that levels of pollutants similar to those estimated to have occurred in Donora are currently present in some rapidly industrializing regions of China and India. Seventy years after the smog, this event still resonates.
- Maldonado Escalante, J. F., Meza Figueroa, D., Dévora Figueroa, A. G., García Rico, L., Burgess, J. L., Lantz, R. C., Yañez Estrada, L., Martínez Cinco, M. A., Balderas Cortés, J. d., Mondaca Fernández, I., & Meza Montenegro, M. M. (2018). An integrated health risk assessment of indigenous children exposed to arsenic in Sonora, Mexico. Human and Ecological Risk Assessment: An International Journal. doi:10.1080/10807039.2018.1449098
- Poplin, G. S., Griffin, S., Pollack Porter, K., Mallett, J., Hu, C., Day-Nash, V., & Burgess, J. L. (2018). Efficacy of a proactive health and safety risk management system in the fire service. Injury epidemiology, 5(1), 18.More infoThis study evaluated the efficacy of a fire department proactive risk management program aimed at reducing firefighter injuries and their associated costs.
- Griffin, S., Griffin, S., Regan, T. L., Regan, T. L., Harber, P. I., Harber, P. I., Lutz, E. A., Lutz, E. A., Hu, C., Hu, C., Burgess, J. L., & Burgess, J. L. (2016). Evaluation of a fitness intervention for new firefighters: injury reduction and economic benefits. Inj Prev, 22(3), 181-8.
- Mehus, A. A., Reed, R. J., Lee, V. S., Littau, S. R., Hu, C., Lutz, E. A., & Burgess, J. L. (2015). Comparison of acute health effects from exposures to diesel and biodiesel fuel emissions. Journal of Occupational and Environmental Medicine (submitted).
- Poplin, G. S., Roe, D. J., Burgess, J. L., Peate, W. F., & Harris, R. B. (2016). Fire fit: assessing comprehensive fitness and injury risk in the fire service. International archives of occupational and environmental health, 89(2), 251-9.More infoThis study sought to develop a comprehensive measure of fitness that is predictive of injury risk and can be used in the fire service to assess individual-level health and fit-for-duty status.
- Jones, L., Lutz, E. A., Duncan, M., & Burgess, J. L. (2015). Respiratory protection for firefighters--evaluation of CBRN canisters for use during overhaul. Journal of occupational and environmental hygiene, 12(5), 314-22.More infoIn the United States, there are approximately 366,600 structural fires each year. After visible flames are extinguished, firefighters begin the overhaul stage of firefighting to smother remaining hot spots and initiate investigations. Typically during overhaul significant ambient concentrations of chemical contaminants remain. However, previous research suggests that the use of air purifying respirators (APR) fitted with chemical, biological, radiological, and nuclear (CBRN) canisters may reduce occupational respiratory exposures. This pilot study used large-scale prescribed burns of representative structural materials to perform simultaneous, side-by-side, filtering and service-life evaluations of commercially available CBRN filters. Three types of CBRN canisters and one cartridge were challenged in repetitive post live-fire overhaul exposure tests using a sampling manifold apparatus. At a flow rate of 80 L/min, nine tests were conducted in the breathing zone for three different exposure durations (0-15 min, 0-30 min, and 0-60 min). Fifty different chemicals were identified for evaluation and results indicate that 21 of the 50 chemicals tested were in the air of the overhaul environment. Respirable particles and formaldehyde were consistently present above the American Conference of Governmental Industrial Hygienists (ACGIH®) recommended exposure level (REL) and threshold limit ceiling value (TLVc), respectively. Each filter effectively reduced concentrations for respirable particulates below the maximum recommended level. Formaldehyde was reduced, but not consistently filtered below the TLVc. These results were consistent across all exposure durations. This study indicates that, regardless of brand, CBRN filters provide protection from the vast majority of particle and gas-phase contaminants. However, due to formaldehyde breakthrough, CBRN filters do not provide complete protection during firefighter overhaul.
- Julia, P., Griffin, S., Gary, W., Peate, W., & Burgess, J. L. (2015). Cost analysis of injury claims in the fire service. International Fire Service Journal of Leadership and Management, 9.
- Kurzius-Spencer, M., Harris, R. B., Hartz, V., Roberge, J., Hsu, C., O'Rourke, M. K., & Burgess, J. L. (2015). Relation of dietary inorganic arsenic to serum matrix metalloproteinase-9 (MMP-9) at different threshold concentrations of tap water arsenic. Journal of exposure science & environmental epidemiology.More infoArsenic (As) exposure is associated with cancer, lung and cardiovascular disease, yet the mechanisms involved are not clearly understood. Elevated matrix metalloproteinase-9 (MMP-9) levels are also associated with these diseases, as well as with exposure to water As. Our objective was to evaluate the effects of dietary components of inorganic As (iAs) intake on serum MMP-9 concentration at differing levels of tap water As. In a cross-sectional study of 214 adults, dietary iAs intake was estimated from 24-h dietary recall interviews using published iAs residue data; drinking and cooking water As intake from water samples and consumption data. Aggregate iAs intake (food plus water) was associated with elevated serum MMP-9 in mixed model regression, with and without adjustment for covariates. In models stratified by tap water As, aggregate intake was a significant positive predictor of serum MMP-9 in subjects exposed to water As≤10 μg/l. Inorganic As from food alone was associated with serum MMP-9 in subjects exposed to tap water As≤3 μg/l. Exposure to iAs from food and water combined, in areas where tap water As concentration is ≤10 μg/l, may contribute to As-induced changes in a biomarker associated with toxicity.Journal of Exposure Science and Environmental Epidemiology advance online publication, 21 January 2015; doi:10.1038/jes.2014.92.
- Lutz, E. A., Reed, R. J., Lee, V. S., & Burgess, J. L. (2015). Occupational exposures to emissions from combustion of diesel and alternative fuels in underground mining--a simulated pilot study. Journal of occupational and environmental hygiene, 12(3), D18-25.More infoDiesel fuel is commonly used for underground mining equipment, yet diesel engine exhaust is a known human carcinogen. Alternative fuels, including biodiesel, and a natural gas/diesel blend, offer the potential to reduce engine emissions and associated health effects. For this pilot study, exposure monitoring was performed in an underground mine during operation of a load-haul-dump vehicle. Use of low-sulfur diesel, 75% biodiesel/25% diesel blend (B75), and natural gas/diesel blend (GD) fuels were compared. Personal samples were collected for total and respirable diesel particulate matter (tDPM and rDPM, respectively) and total and respirable elemental and organic carbon (tEC, rEC, tOC, rOC, respectively), as well as carbon monoxide (CO), formaldehyde, acetaldehyde, naphthalene, nitric oxide (NO), and nitrogen dioxide (NO2). Compared to diesel, B75 use was associated with a 33% reduction in rDPM, reductions in rEC, tEC, and naphthalene, increased tDPM, tOC, and NO, and no change in rOC, CO, and NO2. Compared to diesel, GD was associated with a 66% reduction in rDPM and a reduction in all other exposures except CO. The alternative fuels tested both resulted in reduced rDPM, which is the basis for the current Mine Safety and Health Administration (MSHA) occupational exposure standard. Although additional study is needed with a wider variety of equipment, use of alternative fuels have the promise of reducing exposures from vehicular exhaust in underground mining settings.
- Pena, J. C., Griffin, S. C., West, G. R., Peate, W. F., & Burgess, J. L. (2015). Cost Analysis of Injury Claims in the Fire Service. International Fire Service Journal of Leadership and Management, 9.
- Poplin, G. S., Pollack, K. M., Griffin, S., Day-Nash, V., Peate, W. F., Nied, E., Gulotta, J., & Burgess, J. L. (2015). Establishing a proactive safety and health risk management system in the fire service. BMC public health, 15, 407.More infoFormalized risk management (RM) is an internationally accepted process for reducing hazards in the workplace, with defined steps including hazard scoping, risk assessment, and implementation of controls, all within an iterative process. While required for all industry in the European Union and widely used elsewhere, the United States maintains a compliance-based regulatory structure, rather than one based on systematic, risk-based methodologies. Firefighting is a hazardous profession, with high injury, illness, and fatality rates compared with other occupations, and implementation of RM programs has the potential to greatly improve firefighter safety and health; however, no descriptions of RM implementation are in the peer-reviewed literature for the North American fire service.
- Burgess, J. L., Duncan, M., Mallett, J., LaFleur, B., Littau, S., & Shiwaku, K. (2014). International Comparison of Fire Department Injuries. Fire Technology, 50(5), 1043-1059.
- Burgess, J. L., Kurzius-Spencer, M., Poplin, G. S., Littau, S. R., Kopplin, M. J., Stürup, S., Boitano, S., & Clark Lantz, R. (2014). Environmental arsenic exposure, selenium and sputum alpha-1 antitrypsin. Journal of Exposure Science and Environmental Epidemiology, 24(2), 150-155.
- Duncan, M. D., Littau, S. R., Kurzius-Spencer, M., & Burgess, J. L. (2014). Development of best practice standard operating procedures for prevention of fireground injuries. Fire Technology, 50, 1061-1076.
- Kurzius-Spencer, M., Burgess, J. L., Harris, R. B., Hartz, V., Roberge, J., Huang, S., Hsu, C., & O'Rourke, M. K. (2014). Contribution of diet to aggregate arsenic exposures - An analysis across populations. Journal of Exposure Science and Environmental Epidemiology, 24(2), 156-162.
- Poplin, G. S., Roe, D. J., Peate, W., Harris, R. B., & Burgess, J. L. (2014). The association of aerobic fitness with injuries in the fire service. American Journal of Epidemiology, 179(2), 149-155.
- White, A. G., Watts, G. S., Lu, Z., Meza-Montenegro, M. M., Lutz, E. A., Harber, P., & Burgess, J. L. (2014). Environmental arsenic exposure and microbiota in induced sputum. International Journal of Environmental Research and Public Health, 11(2), 2299-2313.
- Burgess, J. L. (2013). Arsenic compromises conducting airway epithelial barrier properties in primary mouse and immortalized human cell cultures.. PLOS ONE.More infoSherwood CL, Liguori AE, Olsen CE, Lantz RC, Burgess JL, Boitano S. Arsenic compromises conducting airway epithelial barrier properties in primary mouse and immortalized human cell cultures. PLOS ONE (online publication).
- Burgess, J. L., Kurzius-Spencer, M., O'Rourke, M. K., Littau, S. R., Roberge, J. L., Meza-Montenegro, M. M., Gutiérrez-Millán, L. E., & Harris, R. B. (2013). Environmental arsenic exposure and serum matrix metalloproteinase-9. Journal of Exposure Science and Environmental Epidemiology, 23(2), 163-169.
- Kurzius-Spencer, M., O'Rourke, M. K., Hsu, C., Hartz, V., Harris, R. B., & Burgess, J. L. (2013). Measured versus modeled dietary arsenic and relation to urinary arsenic excretion and total exposure. Journal of Exposure Science and Environmental Epidemiology, 23(4), 442-449.
- Lee, V. S., Burgess, J. L., Sterling, C. R., & Lutz, E. A. (2013). Schistosoma mansoni: Assessment of effects of oleic acid, cercarial age and water temperature on parasite-host attraction. International Journal for Parasitology, 43(10), 837-842.
- Poplin, G. S., Miller, H., Sottile, J., Hu, C., Hill, J. R., & Burgess, J. L. (2013). Enhancing severe injury surveillance: The association between severe injury events and fatalities in US coal mines. Journal of Safety Research, 44(1), 31-35.
- Burgess, J. L., Duncan, M. D., Hu, C., Littau, S. R., Caseman, D., Kurzius-Spencer, M., Davis-Gorman, G., & McDonagh, P. F. (2012). Acute cardiovascular effects of firefighting and active cooling during rehabilitation. Journal of Occupational and Environmental Medicine, 54(11), 1413-1420.
- Burgess, J. L., Kurzius-Spencer, M., Gerkin, R. D., Fleming, J. L., Peate, W. F., & Allison, M. (2012). Risk factors for subclinical atherosclerosis in firefighters. Journal of Occupational and Environmental Medicine, 54(3), 328-335.
- Lisle S. Hites, ., Brenda S. Granillo, ., Edward R. Garrison, ., Adriana D. Cimetta, ., Verena J. Serafin, ., Ralph F. Renger, ., Jessica F. Wakelee, ., & Jefferey L. Burgess, . (2012). Emergency preparedness training of tribal Community Health Representatives. Journal of Immigrant and Minority Health, 14(2), 323-329.
- Roberge, J., O'Rourke, M. K., Meza-Montenegro, M. M., Gutiérrez-Millán, L. E., Burgess, J. L., & Harris, R. B. (2012). Binational arsenic exposure survey: methodology and estimated arsenic intake from drinking water and urinary arsenic concentrations. International journal of environmental research and public health, 9(4), 1051-67.More infoThe Binational Arsenic Exposure Survey (BAsES) was designed to evaluate probable arsenic exposures in selected areas of southern Arizona and northern Mexico, two regions with known elevated levels of arsenic in groundwater reserves. This paper describes the methodology of BAsES and the relationship between estimated arsenic intake from beverages and arsenic output in urine. Households from eight communities were selected for their varying groundwater arsenic concentrations in Arizona, USA and Sonora, Mexico. Adults responded to questionnaires and provided dietary information. A first morning urine void and water from all household drinking sources were collected. Associations between urinary arsenic concentration (total, organic, inorganic) and estimated level of arsenic consumed from water and other beverages were evaluated through crude associations and by random effects models. Median estimated total arsenic intake from beverages among participants from Arizona communities ranged from 1.7 to 14.1 µg/day compared to 0.6 to 3.4 µg/day among those from Mexico communities. In contrast, median urinary inorganic arsenic concentrations were greatest among participants from Hermosillo, Mexico (6.2 µg/L) whereas a high of 2.0 µg/L was found among participants from Ajo, Arizona. Estimated arsenic intake from drinking water was associated with urinary total arsenic concentration (p < 0.001), urinary inorganic arsenic concentration (p < 0.001), and urinary sum of species (p < 0.001). Urinary arsenic concentrations increased between 7% and 12% for each one percent increase in arsenic consumed from drinking water. Variability in arsenic intake from beverages and urinary arsenic output yielded counter intuitive results. Estimated intake of arsenic from all beverages was greatest among Arizonans yet participants in Mexico had higher urinary total and inorganic arsenic concentrations. Other contributors to urinary arsenic concentrations should be evaluated.
- Burgess, J. L., Wong, S. S., Sun, N. N., Fastje, C. D., Witten, M. L., Lantz, R. C., Lu, B., Sherrill, D. L., & Gerard, C. J. (2011). Role of neprilysin in airway inflammation induced by diesel exhaust emissions. Research report (Health Effects Institute).More infoIn this study, we examined the role of neprilysin (NEP), a key membrane-bound endopeptidase, in the inflammatory response induced by diesel exhaust emissions (DEE) in the airways through a number of approaches: in vitro, animal, and controlled human exposure. Our specific aims were (1) to examine the role of NEP in inflammatory injury induced by diesel exhaust particles (DEP) using Nep-intact (wild-type) and Nep-null mice; (2) to examine which components of DEP are associated with NEP downregulation in vitro; (3) to determine the molecular impact of DEP exposure and decreased NEP expression on airway epithelial cells' gene expression in vitro, using a combination of RNA interference (RNAi) and microarray approaches; and (4) to evaluate the effects on NEP activity of human exposure to DEE. We report four main results: First, we found that exposure of normal mice to DEP consisting of standard reference material (SRM) 2975 via intratracheal installation can downregulate NEP expression in a concentration-dependent manner. The changes were accompanied by increases in the number of macrophages and epithelial cells, as well as proinflammatory cytokines, examined in bronchoalveolar lavage (BAL) fluid and cells. Nep-null mice displayed increased and/or additional inflammatory responses when compared with wild-type mice, especially in response to exposure to the higher dose of DEP that we used. These in vivo findings suggest that loss of NEP in mice could cause increased susceptibility to injury or exacerbate inflammatory responses after DEP exposure via release of specific cytokines from the lungs. Second, we found evidence, using in vitro studies, that downregulation of NEP by DEP in cultured human epithelial BEAS-2B cells was mostly attributable to DEP-adsorbed organic compounds, whereas the carbonaceous core and transition metal components of DEP had little or no effect on NEP messenger RNA (mRNA) expression. This NEP downregulation was not a specific response to DEP or its contents because the change also occurred after exposure to urban dust (SRM 1649a), which differs in physical and chemical composition from DEP. Third, we also collected the transcriptome profiles of the concentration-effects of SRM 2975 in cultured BEAS-2B cells through a 2 X 3 factorial design. DEP exposure upregulated 151 genes and downregulated 59 genes. Cells with decreased NEP expression (accomplished by transfecting an NEP-specific small interfering RNA [siRNA]) substantially altered the expression of genes (upregulating 17 and downregulating 14) associated with DNA/protein binding, calcium channel activities, and the cascade of intracellular signaling by cytokines. Data generated from the combined RNAi and microarray approaches revealed that there is a complex molecular cascade mediated by NEP in different subcellular compartments, possibly influencing the inflammatory response. Fourth, in a controlled human exposure study, we observed significant increases in soluble NEP in sputum after acute exposure to DEE, with an average net increase of 31%. We speculate that the change in NEP activity in sputum, if confirmed in larger epidemiologic investigations at ambient exposure levels to DEE, may provide a useful endpoint and promote insight into the mechanism of DEE-induced airway alterations.
- Cara L. Sherwood, ., Lantz, R. C., Burgess, J. L., & Boitano, S. A. (2011). Arsenic alters ATP-dependent Ca 2+ signaling in human airway epithelial cell wound response. Toxicological Sciences, 121(1), 191-206.
- Poplin, G. S., Harris, R. B., Pollack, K. M., Peate, W. F., & Burgess, J. L. (2011). Beyond the fireground: Injuries in the fire service. Injury Prevention.
- Burgess, J. L., Granillo, A. B., Renger, R., & Wakelee, J. (2010). Utilization of the Native American Talking Circle to teach incident command system to tribal community health representatives. Journal of community health, 35(6).More infoThe public health workforce is diverse and encompasses a wide range of professions. For tribal communities, the Community Health Representative (CHR) is a public health paraprofessional whose role as a community health educator and health advocate has expanded to become an integral part of the health delivery system of most tribes. CHRs possess a unique set of skills and cultural awareness that make them an essential first responder on tribal land. As a result of their distinctive qualities they have the capability of effectively mobilizing communities during times of crisis and can have a significant impact on the communities' response to a local incident. Although public health emergency preparedness training is a priority of federal, state, local and tribal public health agencies, much of the training currently available is not tailored to meet the unique traits of CHRs. Much of the emergency preparedness training is standardized, such as the Federal Emergency Management Agency (FEMA) Training Programs, and does not take into account the inherent cultural traditions of some of the intended target audience. This paper reports on the use of the Native American Talking Circle format as a culturally appropriate method to teach the Incident Command System (ICS). The results of the evaluation suggest the talking format circle is well received and can significantly improve the understanding of ICS roles. The limitations of the assessment instrument and the cultural adaptations at producing changes in the understanding of ICS history and concepts are discussed. Possible solutions to these limitations are provided.
- Wong, S. S., Sun, N. N., Miller, H. B., Witten, M. L., & Burgess, J. L. (2010). Acute changes in sputum collected from exposed human subjects in mining conditions. Inhalation Toxicology, 22(6), 479-485.
- Kurzius-Spencer, M., Foster, K., Littau, S. R., Richey, K. J., Clark, B. M., Sherrill, D., Boitano, S. A., Caruso, D. M., & Burgess, J. L. (2009). Tracheobronchial protease inhibitors, body surface area burns, and mortality in smoke inhalation. Journal of Burn Care and Research, 30(5), 824-831.
- Thrasher, D. L., Derau, K. v., & Burgess, J. L. (2009). Health effects from reported exposure to methamphetamine labs: A poison center-based study. Journal of Medical Toxicology, 5(4), 200-204.
- Berran Yucesoy, ., Margaret Kurzius-Spencer, ., Victor J. Johnson, ., Kara Fluharty, ., Michael L. Kashon, ., Stefano Guerra, ., Michael I. Luster, ., & Jefferey L. Burgess, . (2008). Association of cytokine gene polymorphisms with rate of decline in lung function. Journal of Occupational and Environmental Medicine, 50(6), 642-648.
- Burgess, J. L., Kurzius-Spencer, M., Foster, K., Littau, S. R., Richey, K. J., Clark, B. M., Sherrill, D. L., Goodman, R. B., & Boitano, S. A. (2008). Tracheobronchial markers of lung injury in smoke inhalation victims. Journal of burn care & research : official publication of the American Burn Association, 29(2).More infoAlthough smoke inhalation injury victims frequently develop severe hypoxemia and are at increased risk of acute respiratory distress syndrome (ARDS), no early prognostic tests are currently available. The objectives were to determine early longitudinal changes in tracheobronchial fluid inflammatory markers and assess the value of initial concentrations as predictors of subsequent lung injury. Partial pressure of arterial oxygen (Pao2) and the fraction of inspired oxygen (Fio2) were recorded approximately every 6 hours from intubated smoke inhalation victims admitted to a regional burn center. Tracheobronchial suction fluid was collected every 2 hours and assayed for interleukins (IL-1beta, -8, and -10), tumor necrosis factor-alpha, transforming growth factor-beta1, soluble Fas ligand (sFasL), and complement factor 5a. Temporal trends in marker concentrations during 36 hours and the relations between initial concentrations and lowest Pao2/Fio2 or ARDS within 72 hours were assessed using random coefficients modeling and cross-sectional analysis. In 21 subjects with tracheobronchial samples collected within 6.5 hours of intubation, 14 (66.7%) developed acute hypoxemia (Pao2/Fio2 < or =200) within 72 hours of exposure and nine (42.9%) developed ARDS, as defined by the American-European consensus conference on ARDS. IL-8 increased sharply in the first 6.5 hours postexposure (P < .001), and IL-1beta in the first 6.1 hours (P < .001). No significant temporal trends in IL-10, tumor necrosis factor-alpha, transforming growth factor-beta1, sFasL, or complement factor 5a were found. Only initial IL-8 was associated with increased Pao2/Fio2 (P = .013) and with a minimum Pao2/Fio2 >200 (P = .042) during 72 hours. In smoke inhalation victims, tracheobronchial IL-1beta and IL-8 increase rapidly and high initial IL-8 may predict improved oxygenation.
- Maria M. Meza-Montenegro, ., Michael J. Kopplin, ., Jefferey L. Burgess, ., & A. Jay Gandolfi, . (2008). Urinary arsenic methylation profile in children exposed to low arsenic levels through drinking water. Toxicological and Environmental Chemistry, 90(5), 957-970.
- Olsen, C. E., Liguori, A. E., Zong, Y., Lantz, R. C., Burgess, J. L., & Boitano, S. A. (2008). Arsenic upregulates MMP-9 and inhibits wound repair in human airway epithelial cells. American Journal of Physiology - Lung Cellular and Molecular Physiology, 295(2), L293-L302.
- Poplin, G. S., Miller, H. B., Ranger-Moore, J., Bofinger, C. M., Kurzius-Spencer, M., Harris, R. B., & Burgess, J. L. (2008). International evaluation of injury rates in coal mining: A comparison of risk and compliance-based regulatory approaches. Safety Science, 46(8), 1196-1204.
- Robinson, M. S., Anthony, T. R., Littau, S. R., Herckes, P., Nelson, X., Poplin, G. S., & Burgess, J. L. (2008). Occupational PAH exposures during prescribed pile burns. Annals of Occupational Hygiene, 52(6), 497-508.
- Anthony, T. R., Joggerst, P., James, L., Burgess, J. L., Leonard, S. S., & Shogren, E. S. (2007). Method development study for APR cartridge evaluation in fire overhaul exposures. Annals of Occupational Hygiene, 51(8), 703-716.
- Burgess, J. L., Fleming, J. E., Mulenga, E. M., Josyula, A. B., Hysong, T. A., Joggerst, P. J., Kurzius-Spencer, M., & Miller, H. B. (2007). Acute changes in sputum IL-10 following underground exposure to diesel exhaust. Clinical Toxicology, 45(3), 255-260.
- Jefferey L. Burgess, . (2007). Editorial on "exposure assessment of a mercury spill in a Nevada school - 2004". Clinical Toxicology, 45(4), 431.
- Jefferey L. Burgess, ., Maria M. Meza, ., Arun B. Josyula, ., Gerald S. Poplin, ., Michael J. Kopplin, ., Hannah E. McClellen, ., Stefan Stürup, ., & R. Clark Lantz, . (2007). Environmental arsenic exposure and urinary 8-OHdG in Arizona and Sonora. Clinical Toxicology, 45(5), 490-498.
- Josyula, A. B., Kurzius-Spencer, M., Littau, S. R., Yucesoy, B., Fleming, J., & Burgess, J. L. (2007). Cytokine genotype and phenotype effects on lung function decline in firefighters. Journal of Occupational and Environmental Medicine, 49(3), 282-288.
- R. Clark Lantz, ., Brandon J. Lynch, ., Scott Boitano, ., Gerald S. Poplin, ., Sally Littau, ., George Tsaprailis, ., & Jefferey L. Burgess, . (2007). Pulmonary biomarkers based on alterations in protein expression after exposure to arsenic. Environmental Health Perspectives, 115(4), 586-591.
- Andrew, A. S., Burgess, J. L., Meza, M. M., Demidenko, E., Waugh, M. G., Hamilton, J. W., & Karagas, M. R. (2006). Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic. Environmental Health Perspectives, 114(8), 1193-1198.
- Dart, R. C., Bevelaqua, A., DeAtley, C., Sidell, F., Goldfrank, L., Madsen, J., Alcorta, R., Keim, M., Auf der Heide, E., Joyce, S., Shannon, M., Burgess, J. L., Kirk, M., Henretig, F., Thomas, R., Geller, R., Bronstein, A. C., Eitzen, E., Kilbourne, E., , Fenton, D., et al. (2006). Countering chemical agents.. JEMS : a journal of emergency medical services, 31(12), 36-41.
- Josyula, A. B., McClellen, H., Hysong, T. A., Kurzius-Spencer, M., Poplin, G. S., Stürup, S., & Burgess, J. L. (2006). Reduction in urinary arsenic with bottled-water intervention. Journal of Health, Population and Nutrition, 24(3), 298-304.
- Josyula, A. B., Poplin, G. S., Kurzius-Spencer, M., McClellen, H. E., Kopplin, M. J., Stürup, S., Lantz, R. C., & Burgess, J. L. (2006). Environmental arsenic exposure and sputum metalloproteinase concentrations. Environmental Research, 102(3), 283-290.
- Miller, H. B., Sinkala, T., Renger, R. F., Peacock, E. M., Tabor, J. A., & Burgess, J. L. (2006). Identifying antecedent conditions responsible for the high rate of mining injuries in Zambia. International Journal of Occupational and Environmental Health, 12(4), 329-339.
- Derby, M. P., McNally, J., Ranger-Moore, J., Hulette, L., Villar, R., Hysong, T., MacNeill, E., Lebowitz, M., & Burgess, J. (2005). Poison Control Center--based syndromic surveillance for foodborne illness. MMWR. Morbidity and mortality weekly report, 54 Suppl, 35-40.More infoThis retrospective study evaluated the usefulness of a poison control center (PCC) data collection system in Tucson, Arizona for early detection of foodborne disease outbreaks.
- Mulenga, E. M., Miller, H. B., Sinkala, T., Hysong, T. A., & Burgess, J. L. (2005). Silicosis and tuberculosis in Zambian miners. International Journal of Occupational and Environmental Health, 11(3), 259-262.
- Poplin, G. S., Miller, H. D., Nintz, P. J., Martini, L., & Burgess, J. L. (2005). Dermatitis in the mining industry: Incidence, sources, and time loss. Archives of Environmental and Occupational Health, 60(2), 77-85.
- Burgess, J. L., Fierro, M. A., Lantz, R. C., Hysong, T. A., Fleming, J. E., Gerkin, R., Hnizdo, E., Conley, S. M., & Klimecki, W. (2004). Longitudinal decline in lung function: Evaluation of interleukin-10 genetic polymorphisms in firefighters. Journal of Occupational and Environmental Medicine, 46(10), 1013-1022.
- Maria Mercedes Meza, ., Michael J. Kopplin, ., Jefferey L. Burgess, ., & A. Jay Gandolfi, . (2004). Arsenic drinking water exposure and urinary excretion among adults in the Yaqui Valley, Sonora, Mexico. Environmental Research, 96(2), 119-126.
- Burgess, J. L., Witten, M. L., Nanson, C. J., Hysong, T. A., Sherrill, D. L., Quan, S. F., Gerkin, R., & Bernard, A. M. (2003). Serum pneumoproteins: A cross-sectional comparison of firefighters and police. American Journal of Industrial Medicine, 44(3), 246-253.
- Hysong, T. A., Burgess, J. L., Cebrián Garcia, M. E., & O'Rourke, M. K. (2003). House dust and inorganic urinary arsenic in two Arizona mining towns. Journal of Exposure Analysis and Environmental Epidemiology, 13(3), 211-218.
- Burgess, J. L., Kovalchick, D. F., Siegel, E. M., Hysong, T. A., & McCurdy, S. A. (2002). Medical surveillance of clandestine drug laboratory investigators. Journal of Occupational and Environmental Medicine, 44(2), 184-189.
- Burgess, J. L., Nanson, C. J., Hysong, T. A., Gerkin, R., Witten, M. L., & Lantz, R. C. (2002). Rapid decline in sputum IL-10 concentration following occupational smoke exposure. Inhalation Toxicology, 14(2), 133-140.
- Kovalchick, D. F., Burgess, J. L., Kyes, K. B., Lymp, J. F., Russo, J. E., Roy-Byrne, P. P., & Brodkin, C. A. (2002). Psychological effects of hazardous materials exposures. Psychosomatic Medicine, 64(5), 841-846.
- Burgess, J. L. (2001). Phosphine exposure from a methamphetamine laboratory investigation. Journal of Toxicology - Clinical Toxicology, 39(2), 165-168.
- Burgess, J. L., Kovalchick, D. F., Harter, L., Kyes, K. B., Lymp, J. F., & Brodkin, C. A. (2001). Hazardous materials events: Evaluation of transport to health care facility and evacuation decisions. American Journal of Emergency Medicine, 19(2), 99-105.
- Burgess, J. L., Kovalchick, D. F., Lymp, J. F., Kyes, K. B., Robertson, W. O., & Brodkin, C. A. (2001). Risk factors for adverse health effects following hazardous materials incidents. Journal of Occupational and Environmental Medicine, 43(6), 558-566.
- Burgess, J. L., Nanson, C. J., Bolstad-Johnson, D. M., Gerkin, R., Hyson, T. A., Lantz, R. C., Sherrill, D. L., Crutchfield, C. D., Quan, S. F., Bernard, A. M., & Witten, M. L. (2001). Adverse respiratory effects following overhaul in firefighters. Journal of Occupational and Environmental Medicine, 43(5), 467-473.
- Nanson, C. J., Burgess, J. L., Robin, M., & Bernard, A. M. (2001). Exercise alters serum pneumoprotein concentrations. Respiration Physiology, 127(2-3), 259-265.
- Burgess, J. L., Kovalchick, D. F., Harter, L., Kyes, K. B., & Thompson, J. N. (2000). Hazardous materials events: An industrial comparison. Journal of Occupational and Environmental Medicine, 42(5), 546-553.
- Burgess, J. L., Morrissey, B., Keifer, M. C., & Robertson, W. O. (2000). Fumigant-related illnesses: Washington State's five-year experience. Journal of Toxicology - Clinical Toxicology, 38(1), 7-14.
- D.M. Bolstad-Johnson, ., J.L. Burgess, ., C.D. Crutchfield, ., S. Storment, ., R. Gerkin, ., & J.R. Wilson, . (2000). Characterization of firefighter exposures during fire overhaul. American Industrial Hygiene Association Journal, 61(5), 636-641.
- Burgess, J. L. (1999). Hospital evacuations due to hazardous materials incidents. American Journal of Emergency Medicine, 17(1), 50-52.
- Burgess, J. L., Brodkin, C. A., Daniell, W. E., Pappas, G. P., Keifer, M. C., Stover, B. D., Edland, S. D., & Barnhart, S. (1999). Longitudinal decline in measured firefighter single-breath diffusing capacity of carbon monoxide values: A respiratory surveillance dilemma. American Journal of Respiratory and Critical Care Medicine, 159(1), 119-124.
- Burgess, J. L., Kirk, M., Borron, S. W., & Cisek, J. (1999). Emergency department hazardous materials protocol for contaminated patients. Annals of Emergency Medicine, 34(2), 205-212.
- Burgess, J. L., Kovalchick, D. F., Kyes, K. B., Thompson, J. N., & Barnhart, S. (1999). Hyperventilation following a large-scale hazardous-materials incident. International Journal of Occupational and Environmental Health, 5(3), 194-197.
- Luderer, U., Burgess, J. L., Polifka, J. E., & Robertson, W. O. (1999). Calls on reproductive and developmental toxicants to a regional Poison Center. Veterinary and Human Toxicology, 41(1), 42-46.
- Burgess, J. L., Hamner, A. P., & Robertson, W. O. (1998). Sulfhemoglobinemia after dermal application of DMSO. Veterinary and Human Toxicology, 40(2), 87-89.
- Elko, C. j., Burgess, J. L., & Robertson, W. O. (1998). Zolpidem-associated hallucinations and serotonin reuptake inhibition: A possible interaction. Journal of Toxicology - Clinical Toxicology, 36(3), 195-203.
- Burgess, J. L., Blackmon, G. M., Brodkin, C. A., & Robertson, W. O. (1997). Hospital preparedness for hazardous materials incidents and treatment of contaminated patients. Western Journal of Medicine, 167(6), 387-391.
- Burgess, J. L., Keifer, M. C., Barnhart, S., Richardson, M., & Robertson, W. O. (1997). Hazardous materials exposure information service: Development, analysis, and medical implications. Annals of Emergency Medicine, 29(2), 248-254.
- Burgess, J. L., Pappas, G. P., & Robertson, W. O. (1997). Hazardous materials incidents: The Washington Poison Center experience and approach to exposure assessment. Journal of Occupational and Environmental Medicine, 39(8), 760-766.
- Burgess, J. L., Barnhart, S., & Checkoway, H. (1996). Investigating clandestine drug laboratories: Adverse medical effects in law enforcement personnel. American Journal of Industrial Medicine, 30(4), 488-494.
- Burgess, J. L., & Crutchfield, C. D. (1995). Quantitative respirator fit tests of Tucson fire fighters and measurement of negative pressure excursions during exertion. Applied Occupational and Environmental Hygiene, 10(1), 29-36.
- Burgess, J. L., & Crutchfield, C. D. (1995). Tucson fire fighter exposure to products of combustion: A risk assessment. Applied Occupational and Environmental Hygiene, 10(1), 37-42.
- Morrissey, B., Burgess, J. L., & Robertson, W. O. (1995). Washington's experience and recommendations re: Anticoagulant rodenticides. Veterinary and Human Toxicology, 37(4), 362-363.
- Burgess, J. L., Bernstein, J. N., & Hurlbut, K. (1994). Aldicarb poisoning. A case report with prolonged cholinesterase inhibition and improvement after pralidoxime therapy. Archives of internal medicine, 154(2), 221-4.More infoAldicarb is the most potent of the commercially available carbamate pesticides and is an unusual source of acute human poisonings. We present the case of a 43-year-old man exposed to aldicarb who developed severe cholinergic symptoms and progressive weakness requiring intubation for 5 days. Both his red blood cell cholinesterase and plasma pseudocholinesterase levels were depressed for a minimum of 44 hours. He demonstrated neuromuscular improvement concurrent with pralidoxime administration. The pertinent medical literature on aldicarb poisoning is reviewed.
- Burgess, J. L., Dart, R. C., Egen, N. B., & Mayersohn, M. (1992). Effects of constriction bands on rattlesnake venom absorption: A pharmacokinetic study. Annals of Emergency Medicine, 21(9), 1086-1093.
- Burgess, J. L., & Dart, R. C. (1991). Snake venom coagulopathy: use and abuse of blood products in the treatment of pit viper envenomation. Annals of emergency medicine, 20(7), 795-801.More infoCoagulopathies are commonly encountered in victims of pit viper envenomation. In the majority of patients these defects improve with administration of antivenin. However, blood products are often transfused based on arbitrary criteria and with significant risk to the patient. This article documents the effectiveness and risks of antivenin administration and the risks of blood product transfusion. We recommend that blood products not be used except for clearly defined clinical indications.
- Haynes, P. L., Medici, K., Grandner, M., & Burgess, J. L. (2016, June). Ambient light exposure is positively associated with calmness in mental health care providers. In SLEEP.
- Caban-Martinez, A., Jung, A., Littau, S., Zhou, J., Jeong, K., Bertke, S., Morrison, P., Fahy, R., Horn, G., Griffin, S., Jahnke, S., Jacobs, E. T., Solle, N., Grant, C., Fent, K., & Burgess, J. L. (2018, Summer). Design of and Data Collection in a National Multi-Site Fire Fighter Cancer Cohort Study. American Public Health Association. San Diego, CA.
- Victory, K., Reynolds, K. A., Cabrera, N. L., Larson, D., Burgess, J. L., & Beamer, P. (2014, April). Comparison of Chemical and Microbial Contaminants in Tap, Bottled and Vended Water in a U.S.-Mexico Border Community. UA Poster Forum. Tucson, AZ.
- Victory, K., Reynolds, K. A., Cabrera, N. L., Larson, D., Latura, J., Burgess, J. L., & Beamer, P. I. (2014, October). Comparison of Chemical and Microbial Contaminants in tap, Bottled, and Vended Water in a U.S.-Mexico Border Community. International Society of Exposure Science. Cincinnati, OH.